l'institut pasteur de tunis et sa stratégie en biosécurité/biosûerté
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Institut Pasteur de Tunis
More than 120 years dedicated to Public Health
www.pasteur.tn
Institut Pasteur de Tunis
Charles Nicolle, directeur de l’ Institut Pasteur de Tunis de1903 à 1936. Prix Nobel de Médecine, 1928
Institut Pasteur de Tunis en 1905Depuis le départ, des découvertes majeurs ont été réalisées (la transmission du typhus, l’agent de la toxoplasmose, la leishmaniose viscérale, le concept de maladie inapparente)
Création en 1893
19/10/2016 3Institut Pasteur de Tunis
Councils: • Administrative Council (16 members)• Scientific Council : DG + 8 elected members from IPT• Enlarged Scientific Council: SC+4 Tunisians from outside IPT+4 internationals
Institut Pasteur de Tunis
Missions: • Biomedical Analysis and Public Health Activities• Production of therapeutic sera and vaccines• Research & development• Training
• Medical Ethics Committee • Communication, valorization and technology transfer• Committee on Health and Safety• Training committee• Bioressources • Quality
Committees
Institut Pasteur de Tunis
Biomedical Ethics Committee of the IPT
Since 1992 this Committee is registered at the Office of Human Research Protections (OHRP) in the United States (number IRB00005445 registration FWA00010074) and committed to follow the Declaration of Helsinki for institutional medical research involving human subjects, including research on human material and personal data.
Process: review after request the protocols, objectives and methodologies to deliver authorization
Missions:- identify and ensure the minimization of associated with the
research, - identify the benefits that would bring this research, - ensure that potential subjects will be informed of a precise and fair
manner, risks or discomforts and profit for this research.
Institut Pasteur de Tunis
Board of Health and Safety at Work
Ensures compliance with the rules of hygiene and security staff Missions: • prepare draft regulations and requirements for health and
safety at work within the Institute, • Information, awareness-raising in the field of health and safety
in the workplace. • Provide programs for the prevention of occupational risks
within the Institute and to monitor the implementation of the programs adopted.
• Manage an accident or an occupational disease serious
Institut Pasteur de Tunis
Biological Resources Committee
Created in August 2014,
- the request for the creation of a centre for clinical research (CIC)
Missions: - State of play
- of the collections (microbiological, DNA, sera, tissues, cells, other) and information related to allow the identification of the means available
- under the conditions of storage of samples and data related to the improvement of the conservation conditions
- specification to preserve these collections (conservation conditions (software for management, etc.) in respect of ethics, procedures in force and standards (protection of personal data, consent, etc.).
Institut Pasteur de Tunis
IPT Quality Program
• The Quality Assurance service was established in December 1998 for the implementation of a quality system covering the activities of development, production and control of vaccines and serums.
• In accordance with the memorandum of January, 2015, it established a Quality Management System Steering Committee (QMSC) at the Pasteur Institute in Tunis. It is called the "Committee Quality of the Pasteur Institute in Tunis."
Objectives:
- Maintaining the quality and development of the QMS approach;- Design and management of short and medium-term quality policy; and- Continuation of the accreditation process of involved laboratories.
Institut Pasteur de Tunis
Workers
Sci-en-tistsTech-
nicians
Admin-istratio-nengi-neers
Global: 502 Scientists: 119
Human ressoursesInstitut Pasteur de Tunis (2015)
Public Health
Biomedical Analysis and Public Health activities
• 18 laboratories + 2 services (35 biologists): Cover the quasi-totality of clinical biology tests. IPT is recognized for the expertise of some of the laboratories in the specialized medical biology.
• IPT hosts several national (rabies, poliomyelitis, measles, bacteria, other) or international reference centers (for the Eastern Mediterranean Region/WHO: for poliomyelitis and measles, HPV)
• IPT is a center for vaccination (for the travelers) and a center for rabies treatment and vaccination (free).
Bioproduction activities• BCG vaccine
- BCG + solvant- Immun BCG
• Therapeutic sera:- Anti-scorpions : Androctonus australis, Buthus occitanus - Anti-vipera: Cerastes cerastes, Vipera lebetina - Anti-rabies
Sérums antiscor-pionique
Sérums antivipérins Sérums antirabique Vaccin BCG Immun BCG TOTAL
41581299
13170
23800
6265
48692
80703284
12550
46790
7314
78008
4372 22968240
41568
8759
65235
71422627
6980
56741
9155
82645
2011 2012 2013 2014
Research and training
Training activities
• IPT linked to University Tunis El Manar
• Activities with the various universities and at international level
• Organization of theoretical and practical courses in the various domains of the biology, new technologies
• Direction of PhDs of various national and international universities (sciences, medicine, others)
Research and training
Thèse
s
Mastères
PFE/in
génieurat
Thèse
s de m
éédecine
Thése
s de m
édecine vétérin
aire
Thèse
s de pharm
acieTO
TAL
19
75
37
2 7 3
143
28
68
43
5 7 4
155
13
70
32
120 1
128
10
4033
3 4 3
93
2012 2013 2014 2015
Diplômes soutenus (2012-2015)
Research and training
Thèse
s
Mastères
PFE/in
génieurat
Thèse
s de m
édecine
Thése
s de m
édecine vétérin
aire
Thèse
s de pharm
acie Total
154
57
12 7 0 3
233
138
372 4 4 0
185180
263 3 0 5
217
158
5327
4 3 4
249
2012 2013 2014 2015
Diplômes en cours/Nombre d’étudiants
Research and training
7 6
27
10
50
10 7
25
5
47
8 7
25
11
51
8 9
27
13
57
2012 2013 2014 2015
Evénements (Formation, workshop, cours, etc.)
Research and training
Eastern Mediterranean Regional Training Centre selectedTDR news item 5 May 2015
The Institut Pasteur de Tunis in Tunis, Tunisia, has been selected to be the Eastern Mediterranean Regional Training Centre supported by TDR. This is the sixth and final centre to be chosen for the TDR network, which is designed to expand and coordinate training courses across multiple countries, leading to improved use of health interventions.
Ethics: Adapting and using the World Health Organization’s training on ethics for the Tunisian environment and improving the skills of the Tunis Institutional Review Board.Good health research practice: Training trainers and researchers with the TDR good clinical practice and good clinical laboratory practice courses, as well as the Good Health Research Practice course.Implementation research: Beginning implementation research courses using the TDR implementation research toolkit, and working with TDR and others to develop a massive open online course (MOOC) on implementation research focused on infectious diseases of poverty.
Research and training
Research & development
Field of activities Infectious diseases +++ (national health priorities)
Leishmaniasis, hydatidosis, tuberculosis, viral hepatitis, rabies, papillomavirus, enteroviruses, avian virus, other veterinary microbial diseases, etc.
Scorpion and snake biochemistry/immunology Congenital immune deficiencies/immune disorders Genetic susceptibility to metabolic and infectious
diseases, cancer R&D biotechnology and bioprocesses (rabies, measles,
Hepatitis C, veterinary vaccines) Bioinformatics and Mathematical modeling Entomology Clinical Epidemiology and Control (including clinical trials)
Research and training
Research and training
Research & development
Financial support
• National support through the eligibility of the groups to be Research Laboratories (9) supported by the Tunisian Ministry of Higher Education and Scientific Research
• International financial supports from European Commission-PCRD; World Health Organization/TDR; National Institutes of Health; Walter Reed Army Institute of Research; International Agency of Atomic Energy; The Wellcome Trust; Agence Nationale de Recherche; OTAN; The network of Pasteur Institutes-RIIP; NEPAD; TWAS; notably).
• PCI Internal Collaborative Program, 2nd year.
Research and training
ANR (Paris, France) R&DBIO-RAD (Paris, France) Patent strengtheningEuropean Commission (Brussels, Belgium) R&DFondation Mérieux (Lyon, France) Euro-Mediterranean Public Health
Information SystemFort Dodge Animal Health Vaccine development and validationInternational Atomic Energy Agency (Vienna, Austria) R&D capacity building and trainingInstitut Pasteur International Network(Paris, France) R&D and Public Health Activities (control)Joint WHO/EMRO-COMSTECH(Islamabad, Pakistan) R&DNational Institutes of Health (Maryland, USA) R&D, clinical researchNorth Atlantic Treaty Organization (Brussel, Belgium) R&DThe New Partnership for Africa’s Development (Johannesburg, South Africa) R&DWalter Reed Army Institute Of Research (USA) Clinical trials (phase II and phase III)Welcome Trust (London, UK) R&D, trainingWHO/EMRO (Cairo, Egypt) R&D for controlWorld Health Organization TDR (Geneva, Switzerland) R&D, capacity building, training
Funding agencies (alphabetic order) Nature of the grant
Research and trainingCSE-Juin 2011
International Partners of Institut Pasteur de Tunis
17 funding agencies~ 50 ongoing research projects
More than 75 partners institutions in 28 countries
Research and training
Publications, Citations, (Source Wos, Mars 2016)
Research and training
201: Partners Institutions: 64 countries
Austria
Nigeria
Qatar
Singapore
South Korea
Brazil
Lebanon
Oman
Uruguay
Kuwait
Russia
Saudi Arabia
Canada
India
Greece
Iran
Belgium
Germany
England
USA
222222222233333334444455666
9101011111213
1616
2124
35113
International Partners in IPT publications (Wos; 5 years: 2011-2014: 418 publications)
Research and training
Chimeric polypeptide useful as a medicament comprises a selectin C-type lectin domain joined through a linker to an integrin von Willebrand A domain having a metal ion-dependent adhesion site (FR2909672, 2008-06-13) FATHALLAH MOHAMED DAHMANI; JARBOUI MOHAMED ALI; DELLAGI MOHAMED KOUSSAY
METHOD FOR PREPARING RECOMBINANT MYCOBACTERIAL POLYPEPTIDES IN YEAST AND THEIR USE IN DIAGNOSIS OF MYCOBACTERIAL RELATED DISEASES (WO2008010096, 2008-01-24 ). FATHALLAH MOHAMED DAHMANI (TN); BARBOUCHE MOHAMED RIDHA (TN); HO JOHN L (US); BENABDESSELEM CHAOUKI (TN); DELLAGI KOUSSAY (TN); LARGUECHE BEYA (TN)
RECOMBINANT PICHIA PASTORIS STRAINS AND PROCESS FOR THE PRODUCTION OF RECOMBINANT HUMAN INTERFERON ALPHA (WO2007099462, 2007-09-07) FATHALLAH MOHAMED DAHMANI (TN); KALLEL HELA (TN); DELLAGI KOUSSAY (TN); REBHI IMEN (TN); AYED ATEF (TN)
MAUROCALCINE, ANALOGUES THEREOF AND THEIR THERAPEUTICAL USES (DE60126067D, 2007-03-08) KHARRAT RIAD (TN); MABROUK KAMEL (FR); EL-AYEB MOHAMMED (TN); ROCHAT HERVE (FR); SABATIER JEAN-MARC (FR)
GENE ASSOCIATED WITH LEISHMANIA PARASITE VIRULENCE (YU99603, 2006-05-25) BEN ACHOUR YOSSER (TN); CHENIK MEHDI (TN); LOUZIR HECHMI (TN); DELLAGI KOUSSAY (TN)
POLYPEPTIDES OF LEISHMANIA MAJOR AND POLYNUCLEOTIDES ENCODING SAME AND VACCINAL, THERAPEUTICAL AND DIAGNOSTIC APPLICATIONS THEREOF (WO2006108720, 2006-10-19) CHENIK MEHDI (TN); LAKHAL SAMI (TN); LOUZIR HECHMI (TN); DELLAGI KOUSSAY (TN)
COMPOSITION COMPRISING THE N-TERMINAL REGION OF LEISHMANIA HISTONE H2B, USE THEREOF FOR INDUCING AN IMMUNE RESPONSE (WO2006097642, 2006-09-21) CHENIK MEHDI (TN); LOUZIR HECHMI (TN); DELLAGI KOUSSAY (TN)
LEISHMANIA ANTIGENS SUITABLE FOR A DIAGNOSTIC KIT OF LEISHMANIA (WO2006079565, 2006-08-03) DELLAGI KOUSSAY (TN); KAMOUN-ESSGHAIER SAYDA (TN); GUIZANI IKRAM (TN)
USE OF ZKW PEPTIDE FOR PREPARING AN INHIBITOR DRUG AGAINST PLATELET AGGREGATION (WO2005014021, 2005-02-17) MARRAKCHI NAZIHA (TN); MABROUK KAMEL (FR); SABATIER JEAN-MARC (FR); EL AYEB MOHAMED (TN); ROCHAT HERVE (FR)
Amino-butyrate derivatives of venoms (GB2335923, 1999-10-06) SABATIER JEAN-MARC (FR); EL-AYEB MODHAMMED (TN); VAN RIETSCHOTEN JURPHAAS (FR); ROCHAT HERVE (FR)
LEBETIN PEPTIDES AS PLATELET AGGREGATION INHIBITORS (WO9829436, 1998-07-09) ROCHAT HERVE (FR); MABROUK KAMEL (FR); EL-AYEB MOHAMMED (TN)
VACCINE COMPOSITION COMPRISING RECOMBINANT BCG EXPRESSING GP63 FUSION PROTEIN (WO9610081, 1996-04-04) GICQUEL BRIGITTE (FR); ABDELHAK SONIA (FR); DELLAGI KOUSSAY (TN); LOUZIR HECHMI (TN)
Patents
Research and training
The Institut PasteurInternational Network
Research and training
ANDI Centre of Excellence for Bio-molecules Discovery
Institut Pasteur de Tunis
African Network for Drugs and Diagnostics Innovation (ANDI), United Nations Economic Commission for Africa (UNECA), Menelik II Avenue, PO Box 3001, Addis Ababa, Ethiopia. Tel: +251 11 544 362; E-mail: [email protected]
Promote African-led health product innovation to address African’s public health needs through efficient use of local knowledge, research networks and building of capacity
Research and training
The American Association for Advancement in Science with Institut Pasteur in Tunis, the Faculty of Sciences in Tunis & The University of Cairo , organized a workshop : International Engagement: Responsible BioScience for a Safe and Secure Society. December, 31th octobre – November, 1st 2011.
Aims to bring together researchers and scientists from American and MENA Regions in biological sciences around themes such as bioethics, biosafety related to Public Health.
legal, ethical and security issues related to research in the field of infectious diseases, as well as the establishment of international networks between scientists from the Middle East, North Africa, Afghanistan, Pakistan and the American and European continents.
IPT commitment in B&B
Research and training
May, 24 - 25 2012, the Faculty of Science of Tunis (Tunis El Manar University), in collaboration with Georgetown University, organized a seminar on "Ensuring safe driving, safe and ethical biomedical and behavioral research in Tunisia “ at the Institut Pasteur inTunis.
• Awareness Tunisian researchers, clinicians, research administrators, policy makers, and students of bioethics and biosafety
• Help ensure that participants will examine these aspects in their work using the best practices in the field of bioethics and biosafety
Research and training
IPT and biological risk management
WHO: The training of trainers in biological risk management and biosecurity of laboratories: 2 Experts trainers
UNICRI, EU Centre of Excellence CBRN: project 3: the development of knowledge and the transfer of best practices for the biological risk management, biosafety and biosecurity: 2 national experts and an e-learning plate-form hosted at IPT
Tunisian-German co-operation and partnership MAE / IPT / DSSB / ONMNE / GIZ / RKI): Excellence in the management of biological and health risks
Research and training
IPT and RKI collaboration: Biosecurity, Biosafety, Detection and Diagnosis
• Acquisition of skills and equipment: Clinical Virology and Rabies laboratories
• Joint training in B & B and BM in Tunis and Berlin
• responsible research / dual use of concern / code of conduct
Improving : the diagnostic ability of highly
pathogenic virus the ability to prevent biological risks