Bibliographie

Laboratoires Eurobio7, avenue de ScandinavieLes Ulis 91953 COURTABOEUF Cedex B

Tél. + 33 (0) 1 69 07 94 77 Fax : + 33 (0) 1 69 07 95 34 www.eurobio.fr / adv@eurobio.fr

n Décretn°2004-829du19août2004

n BorderieV.,BoursierT.,BaudrimontM.,LarocheL.,TouzeauO., «Lesgreffesenophtalmologie»–EdElsevier-2004

n ThuretG.,ManissolleC.,HerragS.,DebN.,GainPh.,Campos-GuyotatL.,AcquartS., -“Controlledstudyoftheinfluenceofstoragemediumtypeonendothelialassessment duringcornealorganculture”

n BritishJournalOphtalmologic–2004;88:579-599.

n DaleyJ.P.,DannerD.J.,WeppnerD.J.,.PlavsicM.Z, «Virusinactivationbygammairradiationoffetalbovineserum»-cellculturefocus(1998) volume20,number3.

n .HwangD.G.,NakamuraT.,TrousdaleM.D,SmithT.M.,mars1993, «Combinationantibioticsupplementationofcornealstoragemedium» -Americanophtalmology115:299-308,March1993

n DelboscB.,PiquotX.,MontardM.,HervéP.,mai1995, «Conservationdelacornéehumaine»-ophtalmologie1995:9:214-220

Nousavonspu,autraversdevossuggestions,parl’analyseapprofondiedevosbesoins,faireévoluernosréactifs.Aceteffet,nousremercionstouteslesbanquesdesyeuxquinousontaccordéleurconfianceetquinousontpermisdevaliderlesdifférentesgénérationsdemilieux.

Through years, evolution of our products was guided by your suggestions and through the analysis of your needs. Therefore, we would like to take the opportunity to thank all the Eye Banks that have trust us.

15 years of expertise

Cornea

EUROBIO OFFERS A COMPLETE RANGE OF MEDIA FOR CORNEA IN ORGAN CULTURE, SAMPLING AND TRANSPORT, STORAGE, DESWELLING AND TRANSFER

EUROBIO VOUS PROPOSE UNE GAMME COMPLETE DE MILIEUX POUR LE RECUEIL,LE TRANSPORT, LA CONSERVATION ET LA DETURGESCENCE DES CORNEES

EN ORGANOCULTURE.

nCornea Prep II®

MilieudetransportdelacornéedusitepreleveuràlaBanqued’Organesàtempératureambiante.Permetd’éliminer lesgreffons fortementcontami-nésquinedoiventpasêtretransférésenorgano-culture.(6jours)Transportation media at room temperature of the graft from the sampling site to the Eye Bank just after in situ dissection of the cornea.Allows the elimination of highly contaminated grafts that should not be processed in organ-culture. ( 6 days )

nCorneaMax®

Milieudeconservationdugreffoncornéenà31°C.Saformulationoptimiséepermet:1. De maintenir l’activité endothéliale et donc depréserverunedensitécellulairemaximale, limitantainsil’éliminationdunombredegreffonspourcau-sededensitécellulairetropfaible.(30jours)2.D’éliminerlesgreffonsfaiblementcontaminésoucontaminéspardeschampignons.Medium for corneal graft conservation at 31°C.Its optimised formulation allows :1. To maintain the endothelial activity and thereby to preserve a high cell density, reducing the number of destroyed grafts for too low endothelial cell density. ( 30 days )2. To eliminate grafts lightly contaminated or conta-minated by fungus.

nCorneaJet ®

Milieudedéturgescencedugreffonavantlagreffeàtempératureambiante.La présence de dextran dans ce milieu permet latransparisationdugreffon.(4jours)Medium for graft deswelling at room temperature. The presence of dextran in the medium allows the transparency of the graft. ( 4 days )

nBouchons / CapsPourplusdeflexibilitéEurobiocommercialisetroistypesdebouchons:bouchonsavecbagued’inviolabilité,bouchonsavecinsertenchlorobutylpoursuspensiondelacornée,bouchonsavecseptumetinsertenchlorobutylpourlepré-lèvementd’unéchantillondemilieudeconservation.Touscesbouchonssontemballésindividuellementavantirradiation.For more flexibility, Eurobio sells three types of caps : secured screw caps, suspension screw caps with chlorobutyl insert for graft suspension, sampling screw caps with septum and chlorobutyl insert.All these caps are individually packed before irradiation.

nCompte goutte de bleu trypan / Trypan Blue Droppers Chaquecomptegouttecontient2mld’unesolutionà0.4%.Each dropper contains 2 ml of 0.4 % sterile trypan blue.

nCouvre-oeils / Eye-covers Utiliséspourremplacerlacornéeprélevéesurledonneur.To replace the donor-dissected cornea.

Accessoires / Accessories

Reference Description FormatEYEPRP01-AR* CorneaPrepII ® 10x60mlEYEMAX00-1C* CorneaMax® 10x100mlEYEJET00-10* CorneaJet ® 10x50mlEYEBCH01-F3 Bouchonsinsertchlorobutyl(sups.)/Suspensionscrewcaps 10EYEBCH02-F3 Bouchonsinsertchlorobutyletseptum(prélèv.)/Samplingscrewcaps 10EYEBCH03-F3 Bouchonsbagued’inviolabilitéPrepII(diamètrelarge)/Securedscrewcaps 10EYEBCH00-F3 Bouchonsbagued’inviolabilité(diamètrestandard)/Standardsecuredscrewcaps 10EYECEY00-F3 Kitcouvre-oeil/EyeCovers 10EAUCOL00-C8 BleuTrypan(flaconcomptegouttes)/TrypanBlueDroppers 10x2ml

MatièrespremièresdequalitéphamacopéeBouchonsinviolablesstériles(x2/flacon)EtiquetteaveccodeàbarresCertificatd’analyses

Pharmacopeia quality raw materialsSterile inviolable screw-caps (x2 / vial)Barre code labelsCertificate of analysis

Sampling& Transport

Storage& Control

Deswelling& Transfer Greffes/Grafts

*Expéditionsouscarboglace/Dryicedshipment

Sécurité & Traçabilité / Security & Traçability

Processus & Produits / Process & Products

J 0 J 6 J 36 J 40... 6 Days

Room TemperatureTransport

... 30 Days

31°C Storage

... 4 Days

Room TemperatureTransfer

Glass vials and adapted volumes for a better cornea integrity preservation