quoi de neuf en gériatrie ? pathologies cardio-vasculaires · quoi de neuf en gériatrie ?...
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Déclaration de relations professionnelles et liens d’intérêt
• Boston-Scientific, Novartis, Daiichi-Sankyo, Boehringer-Ingelheim, Bayer, Sanofi-Aventis, BMS, Pfizer, Astra-Zeneca, Servier, Vifor, Lilly
N = 2 656
BMC Med. 2015 Apr 9;13:78
Frailty index Cognition, dépression, comorbidités, ADL, poids, créatinine
Enrollment systolic blood pressure ≥130 mm Hg and - cardiovascular disease, - or chronic kidney disease, - or 10-year Framingham cardiovascular disease risk score ≥15%, - or age ≥75 years
Clin Trials. 2014 October ; 11(5): 532–546
This study was sponsored primarily by the National Heart, Lung, and Blood Institute of the National Institutes of Health.
N = 20 702 hypertensives without history of stroke or myocardial infarction (MI)
- 21%
JAMA. 2015;313(13):1325-1335
Eligibility included adults with an estimated life expectancy of between 1 month and 1 year, statin therapy for 3 months or more,
JAMA Intern Med. March 2015 doi:10.1001
Death from cardiovascular causes or hospitalization for heart failure
N= 8442 patients IC (1563 > 75 ans)
N Engl J Med. 2014 Aug 30
- 20%
32
Ann Intern Med. 2014;161:96-103
Case patients discontinued their index medication (n=4573) Control patients continued treatment (n=19881)
testis volume <20 mL
> 20.00 mL,
Augmentation des événements cardio-vasculaires si vol testiculaire > 20 ml
major adverse cardiovascular events (MACE)