peroxiredoxin 6 is a crucial factor in the initial step...

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Original Research Communication

Peroxiredoxin 6 is a crucial factor in the initial step of mitochondrial clearance and is

upstream of the PINK1-Parkin pathway

Shuaipeng Ma1#

, Xuefei Zhang1#

, Liangjun Zheng1, Zeyang Li

1, Xuyang Zhao

3, Wenjia Lai

4,

Hongyan Shen5, Junniao Lv

1, Guofeng Yang

2, *, Qingsong Wang

1, *, Jianguo Ji

1, *

1State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking

University, Beijing, 100871, China

2Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang,

050000, China

3Institute of System Biomedicine, School of Basic Medical Sciences, Peking University,

Beijing, 100191, China

4National Center for Nanoscience and Technology, Beijing, 100190, China

5CAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics,

Chinese Academy of Sciences, Beijing, 100101, China

#These authors contributed equally to this work

*To whom correspondence may be addressed: Guofeng Yang, Phone: 0311-66002906; Fax:

0311-66002906; E-mail: [email protected]

*To whom correspondence may be addressed: Qingsong Wang, Phone: +86-10-62759172;

Fax: +86-10-62751526; E-mail: [email protected]

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*To whom correspondence may be addressed: Jianguo Ji, Phone: +86-10-62755470; Fax:

+86-10-62751526; E-mail: [email protected]

Running Title: Peroxiredoxin 6 is a regulator of mitophagy

Word count: 5542; reference numbers: 54; grayscale illustrations: 1; color illustrations: 7

(online 7 and hardcopy 0)

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ABSTRACT

Aims: PINK1-Parkin-mediated mitophagy is crucial for the clearance of damaged

mitochondria. However, the mechanisms underlying PINK1-Parkin-mediated mitophagy are

not fully understood. The goal of this study is to identify new regulators and to elucidate the

regulatory mechanisms of mitophagy.

Results: Quantitative mitochondrial proteomic analysis revealed that 63 proteins showed

increased levels and 36 proteins showed decreased levels in cells subjected to carbonyl

cyanide m-chlorophenyl hydrazone (CCCP) treatment. Peroxiredoxin 6 (PRDX6 or Prx6), a

unique member of the ubiquitous peroxiredoxin family, was recruited to depolarized

mitochondria. Reactive oxygen species (ROS) generated by CCCP promoted PRDX6

accumulation and PTEN-putative kinase 1 (PINK1) stabilization in damaged mitochondria

and induced mitophagy. In addition, depletion of PRDX6 resulted in the stabilization of

PINK1, accumulation of autophagic marker p62, translocation of Parkin to mitochondria and

lipidation of microtubule-associated protein 1 light chain 3 (LC3). Furthermore, these events

were blocked upon supplementation with antioxidant N-acetyl cysteine (NAC) or depletion

of PINK1.

Innovation: This is the first study to demonstrate that PRDX6 is the only member of the

PRDX family that relocates to damaged mitochondria, where it plays a crucial role in the

initial stage of mitophagy by controlling ROS homeostasis.

Conclusion: ROS induce the recruitment of PRDX6 to mitochondria, where PRDX6 controls

ROS homeostasis in the initial step of PINK1-Parkin-mediated mitophagy. Our study

provides new insight into the initial regulatory mechanisms of mitophagy and reveals the

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protective role of PRDX6 in the clearance of damaged mitochondria.

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INTRODUCTION

Mitochondrial quality control (MQC) is essential for proper cellular function and cell fate

decisions. Mitophagy, a selective process for the removal of damaged mitochondria, is

critical to MQC. Previous studies have shown that a loss of mitochondrial potential initiates

mitophagy in mammalian cells (28,29,42,44). The PINK1-Parkin pathway plays a key role in

mitophagy. In damaged mitochondria, PTEN-putative kinase 1 (PINK1) accumulates on the

mitochondrial outer membrane (MOM), where it promotes Parkin recruitment from the

cytoplasm and activates Parkin’s E3 activity (44). Parkin ubiquitinates numerous substrates

with canonical and noncanonical Ub chains and activates proteasomal turnover of MOM

proteins (19,28,36). In addition, the transcription factor high mobility group box-1 protein

(HMGB1) regulates MQC through the PINK1-Parkin pathway by controlling heat shock

protein beta-1 (HSPB1) expression (40). Damaged mitochondria are sequestered into

autophagosomes via Ub and LC3-binding adaptor proteins for degradation via the

autophagy-lysosome system (19,49).

Reactive oxygen species (ROS), as intracellular signaling molecules, are closely related to

autophagy. Previous studies have shown that ROS are implicated as a signal for regulating

macroautophagy (3,8,20,52), and recent studies have indicated that ROS are involved in the

process of mitophagy. Ma et al. have shown that short bursts of superoxide production causes

mitochondrial damage (26). Moreover, Wang and colleagues have found that mitochondrial

ROS play a role in activating Parkin-dependent mitophagy. Supplementation with ROS

scavengers, such as NAC and SOD2, blocks ROS-induced mitophagy (45). In addition, DJ-1

is another important ROS regulator. The loss of DJ-1 leads to enhanced stress-induced Parkin

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recruitment and mitophagy (22). Normally, excessive ROS are removed by endogenous

antioxidants, which protect cells from intracellular oxidative damage. Peroxiredoxin (Prx)

represents a class of thiol-specific antioxidant enzymes that utilize redox-reactive cysteine

residues to eliminate peroxides. Prxs are closely linked to oxidative stress-mediated neuronal

cell death. Phosphorylation of Prx2 by the Cdk5-p25 complex leads to the decreased

antioxidant activity of Prx2 and increased ROS accumulation, which contributes to

dopaminergic neuron loss in Parkinson’s disease (PD) (33). S-nitrosylation of Prx2 impairs

its antioxidant activity and enhances oxidative stress-induced neuronal cell death (15).

Mitochondrial Prx5 may modulate mitochondria-ER crosstalk in MPP+-induced cell death

(12,13). The calcium-independent phospholipase A2 (iPLA2) activity of Prx6 activates

NADPH oxidase in the pathogenesis of PD and Alzheimer’s disease (AD) (50,51).

Nonetheless, the machinery involved in ROS- and Parkin-dependent mitophagy and the role

of Prxs under oxidative stress remain unclear.

Mass spectrometry (MS)-based quantitative proteomics is currently the most powerful

technology for unbiased protein analysis and quantitation on a large scale (2,4,11). Cell

culture-based quantitative proteomic approaches with stable isotope-labeling amino acids

have been widely used to study the mechanisms of mitophagy. Chan et al. have shown that

activation of the ubiquitin-proteasome system (UPS) by Parkin is essential for the

degradation of MOM proteins, independently of the autophagy pathway (6). Vincow et al.

have reported that the PINK1-Parkin pathway promotes mitophagy and also mediates

selective respiratory chain protein turnover in in vivo (43). In addition, Sarraf et al. have

provided a systematic view of the Parkin-dependent ubiquitylome in response to CCCP (36).

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To monitor purified mitochondrial proteins that may be involved in

PINK1-Parkin-mediated mitophagy and to determine whether antioxidant proteins play a role

in mitophagy, we performed tandem mass tags (TMT)-based quantitative mitochondrial

proteomics in a GFP-Parkin overexpressing HeLa cell line subjected to CCCP treatment. We

identified 63 proteins that exhibited increased levels and 36 proteins that exhibited decreased

levels. We verified the accumulation of PRDX6 in the mitochondria in response to CCCP.

Furthermore, we found that ROS recruited PRDX6 and induced PINK1 stabilization in

damaged mitochondria. The depletion of PRDX6 led to increased PINK1 accumulation and

promoted mitophagy via the loss of ROS homeostasis. In summary, PRDX6 is a key regulator

of mitophagy, and it plays a vital role in maintaining mitochondrial ROS homeostasis.

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RESULTS

Proteomic profiling of mitochondria in Parkin-mediated mitophagy

GFP-Parkin is a characteristic marker of depolarized mitochondria, and previous studies

have shown that GFP-Parkin relocates to the mitochondria in response to CCCPs. After

CCCP treatment, GFP-Parkin translocated to lysosomes in a time-dependent manner (Figure

1A). Therefore, we treated cells with 10 μM CCCP for 12 h for the initial quantitative

proteomics analysis.

To investigate the protein changes of mitochondrial components, we used TMT-based

quantitative mitochondrial proteomics in GFP-Parkin overexpressing HeLa cells subjected to

CCCP treatment. As depicted in Fig. 1B, our workflow included mitochondrial enrichment

and 2-plex TMT-based quantitative proteomics. Mitochondrial lysates prepared from

GFP-Parkin overexpressing HeLa cells treated with DMSO or CCCP were processed using

the FASP method (46). Digested peptides were labeled with 2-plex TMT reagents,

fractionated by peptide isoelectric electrophoresis focusing (IEF), and analyzed by

high-resolution nano LC-MS/MS. Raw data sets (36; 12 × 3 replicates) were compiled for

analysis by Proteome Discoverer. We identified 1493, 1090, and 951 proteins in three

independent biological measurements, respectively (Figure 1C). A total of 1797 proteins were

identified with a TMT labeling efficiency of more than 99%, whereas the false discovery rate

was less than 1% (Supplementary Table S1) and 1772 proteins (98.6%) were quantified

(Supplementary Table S2).

According to the level of quantified proteins, the distribution of the average relative

abundance ratios of CCCP/DMSO was approximately normal (Figure 1D). Proteins identified

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in at least two of three independent biological replicates were selected for the estimation of

the variance. The number of reproducibly identified proteins was 1063 (60% of 1772),

corresponding to 69%, 87%, and 89% of the identified proteins in each replicate (Figure 1C

& Supplementary Table S3). The distribution of these proteins is illustrated in Supplementary

Figure S1A. A 1.5-fold change was used as the criterion for selection of the candidates

involved in the PINK1-Parkin pathway. We found 63 proteins with increased levels and 36

proteins with decreased levels (Supplementary Table S4 & Table S5). Linear regression

analysis was performed on the log2-transformed 131/128 ratios of three independent

experiments to determine the biological reproducibility of the differential proteome. As

illustrated in Supplementary Figure S1B, the Pearson correlation coefficients between

samples 1 and 2, 2 and 3, and 1 and 3 are 0.7540, 0.8174, and 0.8368, respectively (p <

0.0001), indicating good biological reproducibility in our model of CCCP-induced

mitophagy.

Bioinformatics

Ninety-nine differentially abundant proteins were subjected to gene ontology (GO)

analysis. These proteins were further categorized according to molecular function, biological

processes, cellular components, and KEGG pathways by GeneCoDis3 (Supplementary Figure

S2A~D & Table S6) (5,30,39). As expected, the biological processes of these proteins match

their molecular function classification, such as protein synthesis and degradation, cytoskeletal

regulation, and oxidative resistance.

According to our results, many candidate proteins are involved in the PINK1-Parkin

pathway. For example, the broad activation of the UPS by Parkin is critical for mitophagy,

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and several subunits (PSMD3, PSMD5, PSMC1 and PSMC5) of the 26S proteasome

(Supplementary Table S5, Table S7 & Table S8) were found in the increased group of

mitochondrial proteins (6). Moreover, our data were consistent with the previous report that

the levels of four cytoplasmic proteins (FASN, PRDX6, LDHA, and ANXA3) were increased,

and two mitochondrial proteins (OPA1 and AK2) showed decreased levels (Supplementary

Table S5) (6). More importantly, we identified nine Parkin-dependent targets (ENO1, NME2,

HSPA8, FASN, VCL, PSMC1, PSMC5, C1QBP, and MAOB) (Supplementary Table S5) (36),

and five proteins (HSP90AB1, HSP90AA1, HSPA8, TUBA1C, and GRP75) that interact

with PINK1 (34). Additionally, several mitochondrial membrane proteins (such as COX4)

degraded under CCCP treatment in Hela cells and 293T cells (data not shown), suggesting

that their degradation is independent of PINK1-Parkin-mediated mitophagy. A few

cytoplasmic proteins (such as HSPB1) appeared to be recruited to depolarized mitochondria

under ROS stress in a Parkin-independent manner. Interestingly, actin-associated proteins

(TPM1~4, HSPB1, TARS, PFN1, DBN1, INF2, VCL, GSN, EGFR, and ACTN4) were

identified (Supplementary Table S6~8). HSPB1 and INF2 have been reported to be involved

in regulation of mitochondrial morphology (24,40), and we propose that these proteins are

involved in mitochondrial dynamics in mitophagy.

To determine the early steps (0 h, 0.5 h, 1 h, 2 h, 6 h, and 12 h) that regulate mitophagy, we

further performed 6-plex quantitative proteomics analysis. Five proteins (PRDX6, ASS1,

PSMD5, LDHA and LDHB) identified in our 2-plex TMT quantitative proteomics analysis

were recruited to the mitochondria at the initial stage of mitophagy (Supplementary Table S7

& Table S8).

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Verification of protein candidates under CCCP treatment

To verify the differentially abundant proteins for the indicated time course, we performed

quantitative real-time PCR (Q-PCR) and western blotting. Seven proteins were selected for

Q-PCR, including Parkin and HMGB1, which play a crucial role in mitophagy (40). Changes

in transcript levels did not match our proteomics data (Supplementary Figure S3). The purity

of the enriched mitochondria was high (Supplementary Figure S4). Six candidates (two

increased and four decreased: PRDX6, HSPB1, COX4, HSPA9 (Grp75), VDAC, and ATP5B),

were chosen for validation by western blotting in the mitochondrial fraction. The results

showed that PRDX6 and HSPB1 were recruited to the mitochondria immediately under

CCCP treatment, whereas the levels of ATP5B, COX4, VDAC, and HSPA9 were decreased

(Figure 3A). Immunoblots showed the stabilization of PINK1 (full length, FL) and

accumulation of p62 and LC3A/B-II, indicative of activation of PINK1-Parkin-mediated

mitophagy, which in turn induces the degradation of oxidative phosphorylation proteins and

higher levels of PRDX6 and HSPB1. In addition, the 6-plex quantitative proteomics data (0 h,

0.5 h, 1 h, 2 h, 6 h, and 12 h) were consistent with the immunoblots (Supplementary Table S7

& Table S8). We propose that antioxidants scavenge ROS to maintain appropriate mitophagy.

ROS induce HSPB1 and thereby modulate the cytoskeletal structure, consistently with

previous findings (22,40).

Representative MS/MS spectra and TMT quantification of peptides derived from PRDX6

(increased) and cytochrome c oxidase subunit COX4 (decreased) are shown in Figure 2B &

2C. The peaks of the TMT signature ions shown in the insets (128 for DMSO-treated cells

and 131 for CCCP-treated cells) represent the relative abundance of the proteins under each

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condition, indicating that protein quantification could be achieved by quantifying unique

peptides. In response to CCCP treatment, PRDX6, GRP75, PSMB8, Ub and 14-3-3-zeta

colocalized with Parkin on the mitochondria (Figure 2D, Supplementary Figure S5A~E).

14-3-3-zeta, known as YWHAZ, regulates the activity and stability of interacting proteins by

binding to their phosphoserine/phosphothreonine-containing motifs (47). Therefore,

14-3-3-zeta may regulate the translocation of other proteins in mitophagy.

CCCP causes ROS generation and induces mitophagy

CCCP causes oxidative stress, which initiates autophagy. To address how ROS is related to

mitophagy, we first tested the generation of ROS in response to CCCP treatment. The

fluorescence intensity of 2′, 7′-dichlorofluorescein (DCF) and dihydroethidium (DHE) was

increased under CCCP treatment (Figure 3A, 3B & Supplementary Figure S6A). Under the

condition without CCCP, mitochondria generated low levels of ROS at a steady state (Figure

3A left); CCCP treatment resulted in high levels of mitochondrial ROS, which diffused

throughout the entire cell (Figure 3A right).

To determine whether ROS induces mitophagy, we used the antioxidant NAC to eliminate

ROS and then examined the localization of GFP-Parkin. When HeLa cells overexpressing

GFP-Parkin were treated with NAC, Parkin translocation was reduced (Figure 3C & 3D).

Moreover, NAC inhibited PINK1 stabilization, PRDX6 and LC3A/B-II accumulation in

damaged mitochondria, and degradation of mitochondrial proteins (Figure 3E & 3F). In

addition, NAC partially restored the mitochondrial membrane potential (Supplementary

Figure S6B). These results suggest that mitochondrial ROS induces Parkin-mediated

mitophagy, whereas NAC inhibits it. The extreme removal of ROS by NAC led to neuronal

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death under CCCP treatment (Supplementary Figure S6C). Together, our findings show that

ROS are important signaling molecules that help cells to remove damaged mitochondria and

induce mitophagy.

PRDX6 regulates mitophagy by suppressing ROS

Our proteomics analysis suggested that PRDX6, DJ-1, CLU, and NQO1 were involved in

protection against oxidative stress (Supplementary Table S5). Recent evidence has suggested

that DJ-1 functions in a complementary fashion in regulating ROS-dependent

Parkin-mediated mitophagy (22). Our immunofluorescence staining and western blotting

analysis revealed that other members of the Prx family did not significantly change in

localization and expression during mitophagy (Supplementary Figure S7). CCCP treatment

caused the accumulation of Parkin in mitochondria, stabilization of PINK1, recruitment of

p62 and LC3A/B-II to mitochondria and reduced levels of COX4. However, the abundance of

SOD2 and ATP5B was not altered (Supplementary Figure S7B~G). Therefore, we speculated

that PRDX6 may play a role in mitophagy. PRDX6 is an antioxidant enzyme that may affect

mitochondrial ROS homeostasis during mitophagy. CCCP treatment did not change PRDX6

expression (Figure 4A & 4B). The depletion of PRDX6 significantly increased ROS

production (Figure 4C & 4D). These results suggest that PRDX6 controls mitochondrial

ROS.

To explore the function of PRDX6 in mitophagy, we performed PRDX6 knockdown

experiments. The depletion of PRDX6 led to increased Parkin accumulation in mitochondria

(Figure 5A & 5B) and significant clustering of depolarized mitochondria around the nucleus

(Supplementary Figure S8A). The phenotypes were rescued by complementary mouse

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PRDX6 cDNA, which is resistant to human RNAi, confirming the specificity of PRDX6

depletion (Figure 5C). Similarly to CCCP treatment, depletion of PRDX6 led to the increased

accumulation of GFP-LC3B and p62 in depolarized mitochondria and promoted mitophagy

(Figure 5D~F). The overexpression of PRDX6 did not exert an appreciable effect on Parkin

translocation; however, the overexpression of SOD blocked Parkin translocation

(Supplementary Figure S8B). Long-term PRDX6 depletion caused a more progressive

accumulation of cleaved PARP1 (apoptotic marker) and induced cell apoptosis

(Supplementary Figure S8C~E). In addition, NAC reduced Parkin translocation under

PRDX6 knockdown (Figure 5G). Collectively, we conclude that PRDX6 regulates

Parkin-mediated mitophagy by controlling ROS.

ROS induce PRDX6 translocation prior to the activation of the PINK1-Parkin pathway

To determine whether PRDX6 is involved in PINK1 stabilization during mitophagy, we

pretreated HeLa cells expressing GFP-Parkin with NAC for 3 h to remove ROS. Then, the

cells were subjected to CCCP for the indicated time course (0 min, 5 min, 10 min, 30 min, 1 h,

or 2 h) in the presence or absence of NAC. In the absence of NAC, the supplementation with

CCCP caused enhanced translocation of GFP-Parkin, accumulation of PRDX6, PINK1, p62

and LC3A/B-II and degradation of COX4, whereas the presence of NAC prevented these

changes over time (Figure 6 and Supplementary Figure S9). These results suggest that the

accumulation of PRDX6 and PINK1-Parkin in mitochondria are ROS-dependent and that

ROS induce mitophagy (Figure 6A, 6E & Supplementary Figure S9A).

In GFP-Parkin overexpressing HeLa cells, the depletion of PRDX6 promoted Parkin

translocation whereas the depletion of PINK1 blocked Parkin translocation. The depletion of

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PINK1 alleviated the effect of PRDX6 depletion (Figure 7A & 7B). The depletion of PRDX6

promoted mitochondrial PINK1 stabilization; however, PRDX6 translocation was not altered

in cells with depleted PINK1 (Figure 7C~E). These data suggest that PRDX6 functions

upstream of PINK1. Additionally, the depletion of PRDX6 promoted the accumulation and

transformation of LC3A/B-II on mitochondria and ubiquitination of Parkin throughout the

entire cell (Figure 7F~H). Our findings suggest that PRDX6 is a crucial factor that functions

upstream of the PINK1-Parkin pathway in the initial step of mitochondrial clearance.

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DISCUSSION

In this study, we used TMT-based quantitative proteomics to analyze the changes in

mitochondrial proteins during mitophagy induced by CCCP in GFP-Parkin-overexpressing

HeLa cells. We identified 63 proteins with increased levels and 36 with decreased levels in

mitochondrial fractions, among which PRDX6 was particularly accumulated. We also

conclude that PRDX6 regulates mitophagy by scavenging ROS. The control of ROS by

PRDX6 is a key step in the clearance of damaged mitochondria. Our findings provide a

molecular framework for understanding the distinct regulatory network of mitophagy and

shed light on the pathogenesis of neurodegenerative diseases.

CCCP is a well-known ROS generator, but how CCCP induces ROS production is unclear.

CCCP causes a collapse in mitochondrial membrane potential, interfering with ETC function,

which supplies continuous single-electrons directly to oxygen and stimulates ROS

accumulation (17,38). CCCP also causes mitochondrial fission in the absence of Parkin

overexpression. In comparison to fragmented mitochondria, elongated mitochondria are more

resistant to ROS-induced damage and mitophagy, indicating that mitochondrial morphology

plays an important role in regulating ROS and mitophagy (45). Therefore, we speculate that

mitochondrial fission also contributes to ROS production. Overexpression of the

mitochondrial antioxidant protein SOD2 blocks CCCP induced mitophagy, demonstrating

that mitochondrial ROS are responsible for mitophagy activation.

Consistently with a previous report (6), our study showed that PRDX6 was accumulated in

the mitochondrial fraction in response to CCCP treatment. PRDX6 is the only member of the

1-Cys Prx that maintains cellular homeostasis by scavenging intracellular ROS (9,16). The

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forced expression of PRDX6 attenuates radiation-induced free radicals to maintain

mitochondrial integrity (53). PRDX6 is primarily localized in the cytosol, lysosomes and

mitochondria (14,25,37). Our study showed that PINK1-Parkin-mediated mitophagy is ROS

dependent, and PRDX6 is recruited to the damaged mitochondria during mitophagy. However,

the mechanisms of PRDX6 recruitment are unclear. We observed that PRDX6 accumulated in

mitochondria in a small percentage of cells under normal conditions. CCCP treatment

induced mitochondrial ROS generation and recruited PRDX6. PRDX6 depletion experiments

indicated that PRDX6 is involved in the translocation of PINK1-Parkin and the rate of

mitophagy via ROS. The peroxidase activity of PRDX6 reduces the levels of phospholipid

hydroperoxides, H2O2, and other hydroperoxides (7,18). Overexpressed PRDX6 can block

oxidative stress-induced signaling (9,10,53). The depletion of PRDX6 led to ROS

accumulation which results in mitochondrial dysfunction by disrupting mitochondrial

respiration and producing more damaged mitochondria. The dysfunctional mitochondria

produce more ROS, which further enhances mitochondrial damage. Accumulation of PRDX6

in mitochondria may play a balancing role by ensuring appropriate mitophagy. NAC blocked

increased mitophagy induced by depletion of PRDX6, indicating that PRDX6 accumulation

is ROS-dependent and occurs immediately upon mitochondrial damage. However, the

overexpression of PRDX6 did not induce remarkable mitophagy, suggesting that additional

mechanisms may exist to regulate the local abundance of PRDX6 in the process of

mitophagy.

Previous reports have suggested that oxidative stress conditions induce antioxidant

responses in the brain. Our histological analysis suggested that the dysfunction of

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Parkin-mediated mitophagy plays a key role in the progression of AD (data not shown) (48).

In addition, PRDX6 is up-regulated in astrocytes and some neurons in PD, AD and dementia

with Lewy bodies (DLB) (31,32). Although PRDX6 is up-regulated in some cells in the brain,

the oxidative stress exceeds the antioxidant capacity of PRDX6, resulting in further cell death

and reduced total levels of PRDX6 in the cortex. Once ROS homeostasis is disturbed in the

microenvironment of the cortex, excessive mitochondrial ROS cause further damage to the

mitochondria and excessive mitophagy, which paralyzes the function of mitophagy and

eventually causes abundant Aβ deposition and neuronal loss (1,21,23). We propose that

PRDX6 is recruited to the mitochondria to balance excessive ROS and limit damage, thus

protecting cells from death due to excessive mitophagy (Fig. 8).

In summary, by using quantitative proteomic analysis, bioinformatics, and biochemical

approaches, we identified a group of candidates that exhibited increased levels. Several

candidates are involved in the PINK1-Parkin pathway. Similarly to DJ-1, PRDX6 plays a key

role in mitophagy by controlling ROS homeostasis. Future studies to determine the molecular

mechanism of PRDX6 in the pathogenesis of AD and PD may aid in the development of

effective pharmacological treatments and genetic therapies.

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INNOVATION

This study demonstrates, for the first time, that accumulated PRDX6 in damaged

mitochondria acts as a key regulator of PINK1-Parkin mediated mitophagy by controlling

ROS homeostasis, which expands the understanding of the essential role of PRDX6 in

mitophagy and suggests a potential role for PRDX6 in human diseases.

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MATERIALS AND METHODS

Reagents

Primary antibodies specific to the following proteins were used: Parkin, COX IV, HSPA9,

PRDX6, LC3A/B (Cell Signaling Technology, Danvers, USA), FLAG M2 (Sigma-Aldrich,

Steinheim, Germany), HSPB1, PRDX6 (Proteintech, Chicago, USA), GAPDH and β-actin

(CoWin Bioscience, Beijing, China). CCCP, DMSO, MG132, DAPI, 2′, 7′-dichlorofluorescin

diacetate (DCFH-DA) and NAC were obtained from Sigma-Aldrich. PRDX6 siRNA and

PINK1 siRNA were obtained from Santa Cruz Biotechnology (Dallas, USA). G418 sulfate

was obtained from Amresco (Solon, USA). Hoechst 33342 and lysosome dye Lyso-Tracker

Red were obtained from Beyotime (Haimen, China). Mitochondrial dye TMRM was obtained

from Invitrogen (Waltham, USA).

Cell culture

293T and HeLa cells were grown in Dulbecco’s modified Eagle’s medium (Hyclone,

Logan, USA) supplemented with 10% (v/v) fetal bovine serum (Hyclone) and

penicillin/streptomycin (Hyclone) in a 5% CO2 atmosphere at 37°C. Expression vector

transfection was performed with Lipofectamine LTX and PLUS Reagents (Invitrogen)

according to the manufacturer’s instructions. After 24 h of transfection, cells were treated

with CCCP for the indicated time course. siRNA was transfected into cells by

Lipofectamine™ RNAiMAX (Invitrogen) for 48 h.

Live cell imaging was performed on a Delta Vision Elite live-cell Microscope (Applied

Precision, USA). High-content live cell imaging was performed on an Image Xpress Micro

XL High-Content Screening System (Molecular Devices, Silicon Valley, USA). Images were

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analyzed by Image J.

Generation of stable cell lines

HeLa cells were transfected with pEGFP-C1-Parkin; transfectants were selected in medium

containing G418 (600 μg/mL). After 10 to 14 days, single clones exhibiting GFP fluorescence

were selected for analysis.

Plasmid constructs

pEGFP-C1-Parkin (Human) was from Professor Chen Quan (Nankai University);

pEF1/HisA-Ub and pEGFP-N1 (Clontech, Mountain View, USA) were obtained from Dr. Hu

Bin; pDsRed-mito was obtained from Professor Rao Yi. Parkin was subcloned into

pcDNA3.1 (-) (Invitrogen) with an HA tag at the N-terminus, and Parkin was inserted into

pDsRed2-C1 (Clontech) and pCMV-Tag2B (Agilent Technologies, Santa Clara, USA). Ub,

NEDD8, and SUMO1 were subcloned into pcDNA3.1 (-) with an N-terminal HA tag and

pEYFP-C1 (Clontech). PRDX6 (GenBankTM

NM_004905.2) was amplified from the 293T

cDNA bank and inserted into p3×FLAG-CMV-14 (a gift from Professor Gu Jun),

pCMV-Tag2B, and pEGFP-N1. Prdx6 (GenBankTM

NM_007453.3) was amplified from the

N2a cDNA bank and was inserted into pcDNA3.1 (-). All constructs were verified by direct

sequencing.

Mitochondrial isolation

Cells were disrupted using Dounce tissue grinders in lysis buffer containing

Tris/sucrose/EDTA (10 mM Tris, 1 mM EDTA K2, 250 mM sucrose, and freshly added

protease inhibitors). Crude mitochondria were purified by differential centrifugation and

further purified by a discontinuous Percoll gradient (23, 11, and 3% Percoll). The

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mitochondria in the 23% fraction were washed three times with Tris/sucrose/EDTA lysis

buffer to remove Percoll.

Protein digestion and TMT labeling

The mitochondrial proteins were dissolved in 2% SDS, 100 mM Tris, pH 8.5 and were

subjected to tryptic digestion by the FASP method (46). For 2-plex and 6-plex TMT labeling,

TMT-labeled peptides were combined-dried in a vacuum centrifuge. Briefly, 100 μg of

digested peptides was labeled with TMT isobaric labeling reagents (Thermo Scientific) in

buffer with anhydrous acetonitrile for 1 h at room temperature, and 8 μl of 5%

hydroxylamine was added to quench the reaction. Equivalent labeled peptides were combined

and desalted on a C18 Extraction Disk Cartridge (3M empore, Agilent Technologies, CA,

USA).

Isoelectric focusing of peptides

For 2-plex TMT-labeled samples, 200 μg peptide mixture was dissolved in focusing buffer

containing 5% glycerol and 2% IPG buffer (pH 3–10, GE Healthcare) and loaded into 12

wells over an Immobiline DryStrip (13 cm, pH 3–10; GE Healthcare). The peptide mixtures

were fractionated by peptide IEF on a 3100 OFFGEL fractionator (Agilent Technologies)

according to the manufacturer’s instructions. Twelve fractions were acidified with 1%

trifluoroacetic acid and desalted with C18 StageTips (35). The eluted peptides were dried in a

vacuum centrifuge (Thermo Savant SC110 A, Holbrook, NY).

LC-MS/MS analysis

For 2-plex TMT-labeled samples, LC-MS/MS analysis was performed as described (27).

Peptides were dissolved in 0.2% formic acid and were separated by nanoflow UHPLC (Easy

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nLC1000; ThermoFisher Scientific, USA). The peptides were separated by a 100 μm × 10 cm

in-house-made fused silica emitter packed with a reversed-phase ReproSil-Pur C18-AQ resin

(3 μm, 120 Å; Dr. Maisch GmbH, Ammerbuch, Germany). The column was eluted with

linear gradients of 5–32% acetonitrile in 0.1% formic acid at a constant flow rate of 500

nL/min for 200 min. Mass spectra were acquired on an LTQ Orbitrap mass spectrometer

(ThermoFisher Scientific) equipped with a nanoelectrospray ion source (Proxeon Biosystems,

Denmark). An electrospray voltage of 2.0 kV was applied. The instrument control was

performed with Tune 2.6.0 and Xcalibur 2.2 (ThermoFisher Scientific). Full-scan MS spectra

(from m/z 300–1650) were acquired in the Orbitrap analyzer with a resolution of 60,000 at

400 m/z after accumulation to a target value of 1,000,000. Up to five of the most-intense ions

per scan with charge states ≥2 were selected for CID fragmentation in the linear ion trap

(normalized collision energy, 35%; activation Q, 0.250; and activation time, 30 ms; target

value, 3,000) and for HCD fragmentation.

For 6-plex TMT samples, the labeled peptides were subjected to on-line strong anion

exchange (SCX)-reversed phase liquid chromatography-tandem mass spectrometry (41).

Mass spectra were acquired on a Q Exactive mass spectrometer (ThermoFisher Scientific)

equipped with a nanoelectrospray ion source (Proxeon Biosystems, Denmark). Briefly,

peptides were automatically loaded on in-house packed multi-precolumn (100 μm internal

diameter 10 cm length with 5 μm SCX resin followed by 3 cm length with 5 μm C18 resin)

from a 96-well microplate autosampler using the EASY-nLC 1000 system (Proxeon

Biosystems, Denmark) at 1.0 μL/min. Peptides were eluted from the precolumn using 2 salt

elution steps (50 mM and 500 mM ammonium acetate in 5% ACN). The precolumn was

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connected to a 15 cm analytical column (100 μm internal diameter with 1.9 μm C18 resin).

Each peptide fraction eluted from precolumn was separated on the analytical column using a

nonlinear 240 min gradient of 5–30% buffer B (0.1% (v/v) formic acid and 90% (v/v)

acetonitrile) at a flow rate of 250 nL/min were used. The Q-Exactive mass spectrometer was

operated in positive polarity mode with a capillary temperature of 25°C. The full MS survey

scan resolution was set to 70,000 with an MS1 ion target value of 3e6 for a scan range of 300

– 1700 m/z. A data-dependent top 15 method was used, during which higher-energy

collisional dissociation (HCD) (24) spectra were obtained at 17,500 MS2 resolution with an

MS2 target of 1e5 and a normalized collisional energy (NCE) of 28. Former precursor ions

targeted for HCD were dynamically excluded for 60 seconds. The maximum ion time utilized

for MS/MS scans was 100 ms.

MS data analysis

All MS and MS/MS raw files were analyzed and processed in Proteome Discovery

(Version 1.4.1.14, Thermo Scientific). The peak list files were searched against a

concatenated human UniProt database (released 2014.06) containing both forward and

reverse protein sequences. The search parameters were as follows: trypsin specified as the

digesting enzyme and two miscleavages allowed, carbamidomethylation (C) as the fixed

modification, oxidation (M) and TMT6plex labels at the lysine residues and N-terminus as

variable modifications, 10 ppm for MS tolerance, and 0.5 Da for MS/MS tolerance. The false

discovery rate for peptides and proteins was set at 0.01, and protein identification was based

on at least one unique peptide. All differentially expressed proteins were annotated with the

GO database, GeneCoDis3 (http://genecodis.cnb.csic.es/) and 34208 genes were in the

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reference list.

Q-PCR

Cells were washed three times with PBS and lysed in TRIzol reagent (Invitrogen) to

extract total RNA according to the manufacturer’s instructions. cDNA was synthesized from

total RNA (2 μg per sample) with a HiFi-MMLV cDNA first strand synthesis kit (CW Bio.).

Q-PCR was performed with the GoTaq qPCR Master Mix (Promega, Madison, USA) on a

Real-Time PCR Detection system (Bio-Rad, Hercules, USA). Transcription levels were

calculated by using the ΔΔCt method with normalization to GAPDH. Primers were designed

by using PrimerBank (CCIB, Harvard Medical School,

http://pga.mgh.harvard.edu/primerbank/); sequences are listed in Table S9.

Western blotting

Cells were harvested in lysis buffer containing 40 mM Tris, 7 M urea, 2 M thiourea, 4%

CHAPS, and protease inhibitor cocktail (Sigma-Aldrich). Cell debris was removed by

centrifugation at 21,100 × g and 4°C for 30 min. The protein concentration was measured by

the Bradford assay. Protein samples were separated by 12.5% SDS-PAGE and were

transferred to polyvinylidene fluoride membranes (Bio-Rad). After blocking for 1 h at room

temperature in 5% nonfat milk in PBST, membranes were incubated with primary antibodies

overnight at 4°C. Horseradish peroxidase-conjugated goat anti-mouse or goat anti-rabbit IgG

(H+L) antibodies were applied (Southern Biotech, 1031-05 or 4050-05, 1/5,000), and the

blots were developed with Immobilon Western Chemiluminescent HRP Substrate (Millipore,

Billerica, USA). The protein band intensity was determined with ImageJ software. The

average protein expression was calculated based on at least two independent experiments.

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Immunofluorescence staining

Cells were grown on glass coverslips, washed with phosphate-buffered saline (PBS), and

fixed in 4% paraformaldehyde (Solarbio, Beijing, China) for 20 min at room temperature.

Then, cells were permeabilized with 1% Triton X-100 (USB, Cleveland, USA) in PBS for 20

min, and saturated with 10% bovine serum albumin (BOBOGEN, BSAS 100) in 0.5% PBST

for 1 h at room temperature. The cells were incubated with primary antibodies diluted in PBS

with 0.5% Triton X-100 and 1% BSA overnight, followed by incubation with TRITC-, FITC-

or Dyligh-405 conjugated secondary antibodies (Southern Biotech and EARTHOX) in PBS

with 0.5% Triton X-100 and 1% BSA for 1 h. Finally, nuclear morphology was revealed with

DAPI stain. Coverslips were fixed onto microslides using Antifade Mounting Medium

(Solarbio), and images were acquired with LSM 710 NLO and a DuoScan confocal

laser-scanning microscope (Zeiss, Oberkochen, Germany) equipped with Zen 2009 software.

Flow cytometric analysis of ROS

ROS generation was determined by flow cytometry after cells were stained with

DCFH-DA or DHE. DCFH-DA is oxidized to green fluorescent DCF and DHE is oxidized to

red fluorescent ethidium. Cells were stained with DCFH-DA (10 μM) or DHE (5 μM) for 15

min. After staining, cells were digested by trypsin and were collected by DMEM for the

following flow cytometric analysis (54).

Statistical analysis

All experiments were repeated at least three times. Data were analyzed by GraphPad Prism

5.0 and are presented as the means ± SEM. One-way ANOVA was used for comparisons

between groups and Student’s t-test was used to analyze two sets of groups. A p-value < 0.05

of 313

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was considered significant.

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ACKNOWLEDGMENTS

We would like to thank Dr Shuliang Chen for editing the manuscript. We also thank Dr

Xiaocheng Li for excellent technical assistance. This work was supported by grants from the

National Natural Science Foundation of China (Nos. 31270872, 31470807, 31200610), the

National Key Basic Research Program of China (Nos. 2010CB912203, 2011CB915504) and

Beijing Natural Science Foundation (Nos. 5142010).

Supervisors: Professor J. Ji

AUTHOR DISCLOSURE STATEMENT

No competing financial interests exist.

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ABBREVIATIONS USED

PINK1 = PTEN-putative kinase 1

AD = Alzheimer’s disease

CCCP = carbonyl cyanide m-chlorophenyl hydrazone

DCF = 2′, 7′-dichlorofluorescin

DCFH-DA = 2′, 7′-dichlorofluorescin diacetate

GFP = green fluorescent protein

IEF = isoelectric electrophoresis focusing

LC3 = microtubule-associated protein 1 light chain 3

MOM = mitochondrial outer membrane

MQC = mitochondria quality control

NAC = N-acetyl-l-cysteine

PD = Parkinson’s disease

PRDX (Prx) = peroxiredoxin

Q-PCR = quantitative real-time PCR

ROS = reactive oxygen species

TMT = tandem mass tags

Ub = Ubiquitin

UPS = Ubiquitin-proteasome system

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REFERENCES

1. Algarzae N, Hebron M, Miessau M, Moussa CE. Parkin prevents cortical atrophy and Abeta-induced

alterations of brain metabolism: (1)(3)C NMR and magnetic resonance imaging studies in AD models.

Neuroscience 225: 22-34, 2012.

2. Altelaar AF, Munoz J, Heck AJ. Next-generation proteomics: towards an integrative view of proteome

dynamics. Nature reviews. Genetics 14: 35-48, 2013.

3. Azad MB, Chen Y, Gibson SB. Regulation of autophagy by reactive oxygen species (ROS):

implications for cancer progression and treatment. Antioxidants & Redox Signaling 11: 777-90, 2009.

4. Bensimon A, Heck AJ, Aebersold R. Mass spectrometry-based proteomics and network biology.

Annual review of biochemistry 81: 379-405, 2012.

5. Carmona-Saez P, Chagoyen M, Tirado F, Carazo JM, Pascual-Montano A. GENECODIS: a web-based

tool for finding significant concurrent annotations in gene lists. Genome biology 8: R3, 2007.

6. Chan NC, Salazar AM, Pham AH, Sweredoski MJ, Kolawa NJ, Graham RL, Hess S, Chan DC. Broad

activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet 20:

1726-37, 2011.

7. Chen JW, Dodia C, Feinstein SI, Jain MK, Fisher AB. 1-Cys peroxiredoxin, a bifunctional enzyme with

glutathione peroxidase and phospholipase A2 activities. The Journal of biological chemistry 275:

28421-7, 2000.

8. Chen Y, Azad MB, Gibson SB. Superoxide is the major reactive oxygen species regulating autophagy.

Cell Death and Differentiation 16: 1040-52, 2009.

9. Chhunchha B, Fatma N, Bhargavan B, Kubo E, Kumar A, Singh DP. Specificity protein, Sp1-mediated

increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

31

31

oxidative stress. Cell death & disease 2: e234, 2011.

10. Chhunchha B, Fatma N, Kubo E, Rai P, Singh SP, Singh DP. Curcumin abates hypoxia-induced

oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling

Prdx6 and NF-kappaB regulation. American journal of physiology. Cell physiology 304: C636-55,

2013.

11. Choudhary C, Mann M. Decoding signalling networks by mass spectrometry-based proteomics. Nature

reviews. Molecular cell biology 11: 427-39, 2010.

12. Davey GP, Bolanos JP. Peroxiredoxin 5 links mitochondrial redox signalling with calcium dynamics:

impact on Parkinson's disease. Journal of Neurochemistry 125: 332-3, 2013.

13. De Simoni S, Linard D, Hermans E, Knoops B, Goemaere J. Mitochondrial peroxiredoxin-5 as

potential modulator of mitochondria-ER crosstalk in MPP+-induced cell death. Journal of

Neurochemistry 125: 473-85, 2013.

14. Eismann T, Huber N, Shin T, Kuboki S, Galloway E, Wyder M, Edwards MJ, Greis KD, Shertzer HG,

Fisher AB, Lentsch AB. Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury

during ischemia-reperfusion in mice. American journal of physiology. Gastrointestinal and liver

physiology 296: G266-74, 2009.

15. Fang J, Nakamura T, Cho DH, Gu Z, Lipton SA. S-nitrosylation of peroxiredoxin 2 promotes oxidative

stress-induced neuronal cell death in Parkinson's disease. Proceedings of the National Academy of

Sciences of the United States of America 104: 18742-7, 2007.

16. Fatma N, Singh P, Chhunchha B, Kubo E, Shinohara T, Bhargavan B, Singh DP. Deficiency of Prdx6 in

lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis.

American journal of physiology. Cell physiology 301: C954-67, 2011.

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

32

32

17. Federico A, Cardaioli E, Da Pozzo P, Formichi P, Gallus GN, Radi E. Mitochondria, oxidative stress

and neurodegeneration. Journal of the neurological sciences 322: 254-62, 2012.

18. Fisher AB. Peroxiredoxin 6: a bifunctional enzyme with glutathione peroxidase and phospholipase A(2)

activities. Antioxidants & redox signaling 15: 831-44, 2011.

19. Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, Springer W.

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 12:

119-31, 2010.

20. Gibson SB. A matter of balance between life and death: targeting reactive oxygen species

(ROS)-induced autophagy for cancer therapy. Autophagy 6: 835-7, 2010.

21. Hong X, Liu J, Zhu G, Zhuang Y, Suo H, Wang P, Huang D, Xu J, Huang Y, Yu M, Bian M, Sheng Z,

Fei J, Song H, Behnisch T, Huang F. Parkin overexpression ameliorates hippocampal long-term

potentiation and beta-amyloid load in an Alzheimer's disease mouse model. Human Molecular

Genetics 23: 1056-72, 2014.

22. Joselin AP, Hewitt SJ, Callaghan SM, Kim RH, Chung YH, Mak TW, Shen J, Slack RS, Park DS.

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. Human

Molecular Genetics 21: 4888-903, 2012.

23. Khandelwal PJ, Herman AM, Hoe HS, Rebeck GW, Moussa CE. Parkin mediates beclin-dependent

autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models. Human

Molecular Genetics 20: 2091-102, 2011.

24. Korobova F, Ramabhadran V, Higgs HN. An actin-dependent step in mitochondrial fission mediated by

the ER-associated formin INF2. Science 339: 464-7, 2013.

25. Liu J, Zhan X, Li M, Li G, Zhang P, Xiao Z, Shao M, Peng F, Hu R, Chen Z. Mitochondrial proteomics

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

33

33

of nasopharyngeal carcinoma metastasis. BMC medical genomics 5: 62, 2012.

26. Ma Q, Fang H, Shang W, Liu L, Xu Z, Ye T, Wang X, Zheng M, Chen Q, Cheng H. Superoxide flashes:

early mitochondrial signals for oxidative stress-induced apoptosis. The Journal of biological chemistry

286: 27573-81, 2011.

27. Ma Y, Bao J, Zhao X, Shen H, Lv J, Ma S, Zhang X, Li Z, Wang S, Wang Q, Ji J. Activated

cyclin-dependent kinase 5 promotes microglial phagocytosis of fibrillar beta-amyloid by up-regulating

lipoprotein lipase expression. Molecular & cellular proteomics : MCP 12: 2833-44, 2013.

28. Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and

promotes their autophagy. The Journal of cell biology 183: 795-803, 2008.

29. Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is

selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 8: e1000298, 2010.

30. Nogales-Cadenas R, Carmona-Saez P, Vazquez M, Vicente C, Yang X, Tirado F, Carazo JM,

Pascual-Montano A. GeneCodis: interpreting gene lists through enrichment analysis and integration of

diverse biological information. Nucleic acids research 37: W317-22, 2009.

31. Power JH, Asad S, Chataway TK, Chegini F, Manavis J, Temlett JA, Jensen PH, Blumbergs PC, Gai

WP. Peroxiredoxin 6 in human brain: molecular forms, cellular distribution and association with

Alzheimer's disease pathology. Acta neuropathologica 115: 611-22, 2008.

32. Power JH, Shannon JM, Blumbergs PC, Gai WP. Nonselenium glutathione peroxidase in human brain :

elevated levels in Parkinson's disease and dementia with lewy bodies. The American journal of

pathology 161: 885-94, 2002.

33. Qu D, Rashidian J, Mount MP, Aleyasin H, Parsanejad M, Lira A, Haque E, Zhang Y, Callaghan S,

Daigle M, Rousseaux MW, Slack RS, Albert PR, Vincent I, Woulfe JM, Park DS. Role of

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

34

34

Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. Neuron 55: 37-52,

2007.

34. Rakovic A, Grunewald A, Voges L, Hofmann S, Orolicki S, Lohmann K, Klein C. PINK1-Interacting

Proteins: Proteomic Analysis of Overexpressed PINK1. Parkinson's disease 2011: 153979, 2011.

35. Rappsilber J, Mann M, Ishihama Y. Protocol for micro-purification, enrichment, pre-fractionation and

storage of peptides for proteomics using StageTips. Nature protocols 2: 1896-906, 2007.

36. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Landscape of the

PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature 496: 372-6,

2013.

37. Sorokina EM, Feinstein SI, Zhou S, Fisher AB. Intracellular targeting of peroxiredoxin 6 to lysosomal

organelles requires MAPK activity and binding to 14-3-3epsilon. American journal of physiology. Cell

physiology 300: C1430-41, 2011.

38. Summers DW, DiAntonio A, Milbrandt J. Mitochondrial dysfunction induces Sarm1-dependent cell

death in sensory neurons. The Journal of neuroscience : the official journal of the Society for

Neuroscience 34: 9338-50, 2014.

39. Tabas-Madrid D, Nogales-Cadenas R, Pascual-Montano A. GeneCodis3: a non-redundant and modular

enrichment analysis tool for functional genomics. Nucleic acids research 40: W478-83, 2012.

40. Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ, 3rd, Lotze MT.

High-mobility group box 1 is essential for mitochondrial quality control. Cell metabolism 13: 701-11,

2011.

41. Taylor P, Nielsen PA, Trelle MB, Horning OB, Andersen MB, Vorm O, Moran MF, Kislinger T.

Automated 2D peptide separation on a 1D nano-LC-MS system. J Proteome Res 8: 1610-6, 2009.

of 313

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ioxi

dant

s &

Red

ox S

igna

ling

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xire

doxi

n 6

is a

cru

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e in

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.108

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as y

et to

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cop

yedi

ting

and

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tion.

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fin

al p

ublis

hed

vers

ion

may

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fer

from

this

pro

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35

35

42. Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del Turco D,

Bentivoglio AR, Healy DG, Albanese A, Nussbaum R, Gonzalez-Maldonado R, Deller T, Salvi S,

Cortelli P, Gilks WP, Latchman DS, Harvey RJ, Dallapiccola B, Auburger G, Wood NW. Hereditary

early-onset Parkinson's disease caused by mutations in PINK1. Science 304: 1158-60, 2004.

43. Vincow ES, Merrihew G, Thomas RE, Shulman NJ, Beyer RP, MacCoss MJ, Pallanck LJ. The

PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo.

Proceedings of the National Academy of Sciences of the United States of America 110: 6400-5, 2013.

44. Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS,

Magrane J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, Li C, Tieu K, Przedborski S.

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proceedings of the National

Academy of Sciences of the United States of America 107: 378-83, 2010.

45. Wang Y, Nartiss Y, Steipe B, McQuibban GA, Kim PK. ROS-induced mitochondrial depolarization

initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy 8: 1462-76,

2012.

46. Wisniewski JR, Zougman A, Nagaraj N, Mann M. Universal sample preparation method for proteome

analysis. Nat Methods 6: 359-62, 2009.

47. Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ, Cantley

LC. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell 91: 961-71, 1997.

48. Ye X, Sun X, Starovoytov V, Cai Q. Parkin-Mediated Mitophagy in Mutant hAPP Neurons and

Alzheimer's Disease Patient Brains. Human Molecular Genetics, 2015.

49. Youle RJ, Narendra DP. Mechanisms of mitophagy. Nat Rev Mol Cell Biol 12: 9-14, 2011.

50. Yun HM, Choi DY, Oh KW, Hong JT. PRDX6 Exacerbates Dopaminergic Neurodegeneration in a

of 313

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ox S

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ling

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xire

doxi

n 6

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al p

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hed

vers

ion

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of.

36

36

MPTP Mouse Model of Parkinson's Disease. Molecular neurobiology, 2014.

51. Yun HM, Jin P, Han JY, Lee MS, Han SB, Oh KW, Hong SH, Jung EY, Hong JT. Acceleration of the

development of Alzheimer's disease in amyloid beta-infused peroxiredoxin 6 overexpression transgenic

mice. Molecular neurobiology 48: 941-51, 2013.

52. Zhang J, Kim J, Alexander A, Cai S, Tripathi DN, Dere R, Tee AR, Tait-Mulder J, Di Nardo A, Han JM,

Kwiatkowski E, Dunlop EA, Dodd KM, Folkerth RD, Faust PL, Kastan MB, Sahin M, Walker CL. A

tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in

response to ROS. Nature Cell Biology 15: 1186-96, 2013.

53. Zhang S, Wang W, Gu Q, Xue J, Cao H, Tang Y, Xu X, Cao J, Zhou J, Wu J, Ding WQ. Protein and

miRNA profiling of radiation-induced skin injury in rats: the protective role of peroxiredoxin-6 against

ionizing radiation. Free radical biology & medicine 69: 96-107, 2014.

54. Zhang X, Ren X, Zhang Q, Li Z, Ma S, Bao J, Li Z, Bai X, Zheng L, Zhang Z, Shang S, Zhang C,

Wang C, Cao L, Wang Q, Ji J. PGC-1alpha/ERRalpha-Sirt3 pathway regulates DAergic neuronal death

by directly deacetylating SOD2 and ATP synthase beta. Antioxid Redox Signal, 2015.

of 313

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FIGURE LEGENDS

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Figure 1. Quantitative mitochondrial proteomics analysis of mitophagy

(A) Representative images of GFP-Parkin and lysosome colocalization in HeLa cells treated

with 10 μM CCCP. Lysosomes were labeled with Lyso-tracker (red), and nuclei were stained

of 313

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39

with Hoechst 33342 (blue). Scale bar represents 5 μm. (B) A schematic workflow for

TMT-labeled mitochondrial proteomics. HeLa cells expressing GFP-Parkin were treated with

DMSO or CCCP for 12 h, and mitochondrial-enriched samples were prepared. Equal

amounts of mitochondrial lysates were digested according to the FASP method. Equal

amount of peptides were labeled with TMT reagents and mixed. The mixture was separated

into 12 fractions by peptide IEF on an OFFGEL fractionator. The 12 fractions were acidified,

desalted with C18 StageTips, and analyzed by LC-MS/MS. (C) Venn diagram shows the

proteins identified from each biological replicate and the overlap between replicates. (D)

Overall distribution of the mean expression ratios of 1772 proteins in mitochondria treated

with DMSO and CCCP as measured by repetitive TMT experiments. Ratios were calculated

as CCCP (131)/DMSO (128) on the log2 scale. (To see this illustration in color, the reader is

referred to the web version of this article at www.liebertonline.com/ars)

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40

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41

Figure 2. Verification of differentially abundant proteins

(A) Western blotting analysis of mitochondria purified from HeLa cells expressing

GFP-Parkin and treated with 10 μM CCCP for 0, 0.5, 1, 2, 6, and 12 h. Decreased proteins:

ATP5B, COX4, VDAC, and HSPA9; increased proteins: HSPB1 and PRDX6; other proteins:

Parkin (PARK2), PINK1, p62, and LC3A/B. (B and C) Representative MS/MS spectrum

identified the peptide (confidence, 99%) derived from the increased protein PRDX6 (B) and

the decreased protein COX4 (C) and its relative abundance in mitochondria treated with

DMSO or CCCP. (D) Hela cells expressing FLAG-Parkin were treated with DMSO or 10 μM

CCCP for 2 h. Immunofluorescence was performed with anti-FLAG (red) and anti-PRDX6

(green) antibodies. The scale bar represents 10 μm. (To see this illustration in color, the

reader is referred to the web version of this article at www.liebertonline.com/ars)

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Figure 3. ROS generation caused by CCCP-induced mitophagy

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(A) Representative images of HeLa cells expressing DsRed-mito that were treated with

DMSO or 10 μM CCCP for 2 h and then incubated with 10 μM DCFH-DA for 15 min.

Images were acquired by live cell imaging. Scale bar represents 5 μm. (B) HeLa cells were

incubated with 10 μM DCFH-DA for 15 min prior to treatment with DMSO or 10 μM CCCP

for 0.5 h or 1 h. Intracellular ROS levels were measured by flow cytometry as stated in the

Materials and Methods section (means ± SEM; n = 3; *** p < 0.001). (C and D)

Representative images of HeLa cells expressing GFP-Parkin treated with various

concentrations of NAC (0, 0.5, 1, 2, 5 and 10 mM) for 3 h prior to 1 h or 2 h of 10 μM CCCP

treatment. Images were acquired immediately by Image Xpress Micro XL (C). Scale bar

represents 50 μm. Cells displaying Parkin translocation were quantified (D) (means ± SEM; n

= 3; ns, not significant; *** p < 0.001). (E and F) HeLa cells expressing GFP-Parkin were

treated with various concentrations of NAC (0, 0.1, 0.2, 0.5 and 1 mM) for 3 h prior to 2 h of

DMSO or 10 μM CCCP treatment. Mitochondrial-enriched fractions were obtained through

sub-cellular fractionation and were analyzed by western blotting. Representative blots for

GFP-Parkin, PINK1 (FL), PRDX6, LC3A/B-II, COX4, ATP5B (mitochondrial loading

control) and GAPDH (loading control for WCL). (To see this illustration in color, the reader

is referred to the web version of this article at www.liebertonline.com/ars)

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Figure 4. Depletion of PRDX6 promotes mitochondrial ROS generation

(A and B) 293T cells were transfected with control or PRDX6 siRNA. Endogenous PRDX6

levels were assessed by immunoblotting. GAPDH served as an internal control. Histogram of

the western data shows the PRDX6 levels under different conditions (means ± SEM; n = 3;

*** p < 0.001). (C and D) 293T cells transfected with control or PRDX6 siRNA were treated

with DMSO or 10 μM CCCP for 2 h and were incubated with 10 μM DCFH-DA for 15 min.

Images were acquired immediately by Image Xpress Micro XL. DCF fluorescence intensity

represents the ROS levels (C). Intracellular ROS levels were measured by flow cytometry, as

stated in the Materials and Methods section (D). (means ± SEM; n = 3; * p < 0.05, ** p <

0.01, *** p < 0.001). (To see this illustration in color, the reader is referred to the web version

of 313

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45

of this article at www.liebertonline.com/ars)

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n 6

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46

Figure 5. PRDX6 regulates Parkin-mediated mitophagy by controlling ROS

(A and B) GFP-Parkin overexpressing HeLa cells transfected with control or PRDX6 siRNA

were treated with 10 μM CCCP for 0, 1 and 2 h. Images were acquired immediately by Image

of 313

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Xpress Micro XL (A). Cells displaying Parkin translocation were quantified (means ± SEM;

n = 903 to 2197 cells; ns, not significant; *** p < 0.001). Data were collected from three

independent experiments (B). Scale bar represents 50 μm. (C) 293T cells were transfected

with control or PRDX6 siRNA for 48 h and were transfected with GFP-Parkin and vector or

Prdx6 cDNA (mouse) for 24 h. Cells were treated with 10 μM CCCP for 2 h. Cells displaying

Parkin translocation were quantified (means ± SEM; n = 134 to 343 cells; * p < 0.05, *** p <

0.001). Data were collected from more than three independent experiments. (D and E) 293T

cells were transfected with control or PRDX6 siRNA for 48 h and were transfected with

GFP-LC3B and FLAG-Parkin for 24 h. Cells were treated with 10 μM CCCP for 2 h.

Immunofluorescence was performed with anti-p62 (red) antibody. Scale bar represents 10 μm

(D). Co-localization was analyzed as the average number of p62 puncta per cell (means ±

SEM; n = 58 to 76 cells from one experiment representative of 3; *** p < 0.001) (E). Data

were collected from three independent experiments. (F) PRDX6 and LC3A/B western

blotting analysis in GFP-Parkin overexpressing HeLa cells from three independent

experiments. ATP5B and GAPDH were used as a mitochondrial loading control and WCL

loading control, respectively. (G) GFP-Parkin overexpressing HeLa cells transfected with

control or PRDX6 siRNA were treated with various concentrations of NAC (0, 0.5, 1, 2, 5, 10

mM) for 3 h prior to 2 h CCCP treatment. Cells displaying Parkin translocation were

quantified. All results were compared with the control group (0 mM) and are presented as the

means ± SEM of triplicate experiments with an average of 60 cells counted per condition; ns,

not significant; * p < 0.05, ** p < 0.01, *** p < 0.001; Student’s t test. (To see this illustration

in color, the reader is referred to the web version of this article at www.liebertonline.com/ars)

of 313

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48

Figure 6. PRDX6 and PINK1-Parkin accumulation is dependent on ROS in mitophagy

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GFP-Parkin–expressing HeLa cells were treated with or without 2 mM NAC for 3 h prior to

10 μM CCCP treatment for the indicated time (0 min, 5 min, 10 min, 30 min, 1 h, and 2 h).

Mitochondrial-enriched fractions were obtained through sub-cellular fractionation and were

analyzed by immunoblotting. (A) Representative immunoblots for GFP-Parkin, PINK1,

PRDX6, p62, LC3A/B-II, COX4, GAPDH, and ATP5B (mitochondrial loading control) are

shown from three independent experiments. (B~E) Quantitative analysis showed altered

protein abundance (PINK1, PRDX6, GFP-Parkin and LC3A/B-II) in the mitochondrial

fractions (means ± SEM; n = 3; * p < 0.05, ** p < 0.01, *** p < 0.001; Student’s t test)

of 313

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Figure 7. PRDX6 functions upstream of the PINK1-Parkin pathway in mitophagy

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(A and B) GFP-Parkin overexpressing HeLa cells transfected with control siRNA, PRDX6

siRNA, PINK1 siRNA or PRDX6 siRNA plus PINK1 siRNA for 48 h were treated with 10

μM CCCP for 1 h. Images were acquired immediately by Image Xpress Micro XL, and cells

displaying Parkin translocation were quantified (means ± SEM; n = 1274 to 1548 cells; ns,

not significant; ** p < 0.01, *** p < 0.001; Student’s t test). Data were collected from three

independent experiments. (C~E) 293T cells transfected with control siRNA, PINK1 siRNA or

PRDX6 siRNA were treated with DMSO or 10 μM CCCP for 2 h. Mitochondria-enriched

fractions were obtained through sub-cellular fractionation and were analyzed by

immunoblotting. Representative immunoblots for PINK1, PRDX6, LC3A/B, COX4, and

ATP5B (mitochondrial loading control) are shown from three independent experiments (C).

Histogram of the western blotting data shows PRDX6 and PINK1 expression under different

conditions (means ± SEM; ns, not significant; *** p < 0.001; Student’s t test) (D and E).

(F~H) 293T cells were transfected with control siRNA or PRDX6 siRNA for 48 h and were

transfected with vector or Prdx6 (mouse) cDNA for 24 h. Cells were treated with DMSO or

10 μM CCCP for 2 h. Cell lysates were analyzed by immunoblotting. Representative

immunoblots for GFP-Parkin, PINK1, LC3A/B, PRDX6 and the loading control GAPDH are

shown from three independent experiments (F). Histogram of the western blotting data shows

PRDX6 and PINK1 under different conditions (means ± SEM; * p < 0.05, ** p < 0.01;

Student’s t test) (G and H). (To see this illustration in color, the reader is referred to the web

version of this article at www.liebertonline.com/ars)

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Figure 8. Schematic showing the critical role of PRDX6 in mitophagy

CCCP causes mitochondrial dysfunction and ROS generation. ROS lead to PRDX6

accumulation and PINK1 stabilization on OMM. PRDX6 depletion leads to excessive ROS

and increased mitophagy, which can induce cell death. (To see this illustration in color, the


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Supplementary Materials

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Figure S1. Proteomics reproducibility analysis

(A) A density plot of the log2 values of the mean expression ratios (CCCP/DMSO) of the

reproducibly identified proteins. Relative frequencies were determined in steps of 0.5

between -4 and 4. (B) To examine the biological reproducibility of the differentially abundant

proteins, linear regression analyses were performed on log2-transformed 131/128 ratios

(CCCP/DMSO) of three independent analyses. The pearson correlation coefficients between

samples 1 and 2 (red cycle), samples 2 and 3 (blue cycle), and samples 1 and 3 (green cycle)

were 0.7540, 0.8174, and 0.8368, respectively; p < 0.01. (To see this illustration in color, the


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Figure S2. Proteomic analysis and GO analysis

(A~D) Pie charts showing the results of the GO analysis. The genes of the 99 differentially

abundant proteins were analyzed for (A) molecular function, (B) biological process, (C)

cellular components, and (D) KEGG pathway. The reference size is 34208 genes. A total of

94 genes (showing annotations in the selected categories) are in the input list. The number in

the charts is the number of annotated genes in the input list. Significance values are shown.

(To see this illustration in color, the reader is referred to the web version of this article at

www.liebertonline.com/ars)

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Figure S3. Analysis of gene expression at the level of transcripts

(A~C) mRNA levels were measured by Q-PCR. GFP-Parkin overexpressing HeLa cells were

treated with DMSO or 10 μM CCCP for 0 h, 2 h, 6 h, and 12 h. Transcript levels were

measured for decreased proteins (ATP5B, COX6B1, COX4, and HSPA9) and increased

proteins (HSPB1, FASN, and PRDX6), as well as Parkin (PARK2) and HMGB1. Data were

collected from two independent experiments including six technical repeats. (To see this

illustration in color, the reader is referred to the web version of this article at

www.liebertonline.com/ars)

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Figure S4. Pre-mitochondrial isolation

Whole cell, mitochondrial and cytoplasmic protein fractions were collected from GFP-Parkin

overexpressing HeLa cells. Western blotting was performed to determine Lamin B (nuclear

control), β-actin and GAPDH (cytoplasmic control), PRDX6 and COX4 (mitochondrial

control) to determine the purity of the mitochondria.

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Figure S5. Immunofluorescence analysis confirmation

(A and B) 293T cells transfected with FLAG-Parkin were treated with DMSO or 10 μM

CCCP for 2 h. Cells were fixed and stained with anti-FLAG (Red) and anti-GRP75 (Green)

antibodies or anti-PSMB8 (Green) antibody; nuclei were stained with DAPI. Scale bars

represent 5 μm. (C) 293T cells transfected with DsRed2-Parkin and YFP-Ub or YFP-NEDD8

or YFP-SUMO1 were treated with DMSO or 10 μM CCCP for 2 h. Nuclei were stained with

Hoechst 33342 (blue). Live cell imaging was performed to acquire images. Scale bar

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represents 5 μm. (D) 293T cells transfected with FLAG-Parkin, PRDX6-GFP and

DsRed-mito were treated with DMSO or 10 μM CCCP for 4 h. Cells were fixed. Scale bar

represents 5 μm. (E) 293T cells transfected with FLAG-Parkin were treated with DMSO or

10 μM CCCP for 2 h. Cells were fixed and stained with anti-FLAG and anti-14-3-3 zeta/delta

antibodies; nuclei were stained with DAPI. Scale bar represents 5 μm.

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Figure S6. The key role of ROS in cell survival

(A) 293T cells transfected with control or PRDX6 siRNA were treated with DMSO or 10 μM

CCCP for 2 h and were incubated with 5 μM DHE for 15 min. Intracellular ROS were

measured by flow cytometry as stated in Materials and Methods section. DHE fluorescence

intensity represented the ROS levels (means ± SEM; n = 3; * p < 0.05, ** p < 0.01, *** p <

0.001). (B) GFP-Parkin–expressing HeLa cells were treated with various concentrations of

NAC (0, 0.1, 0.2, 0.5, 1 mM) for 3 h prior to 2 h DMSO or 10 μM CCCP treatment. Cells

were incubated with mitochondrial dye TMRM for 15 min. Images were acquired

immediately with Image Xpress Micro XL, and the TMRM fluorescence intensity represents

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mitochondrial membrane potential (means ± SEM; n = 3; * p < 0.05, ** p < 0.01, *** p <

0.001). (C) Cortical neurons were incubated with or without 2 mM NAC for 3 h prior to 1 h,

12 h or 24 h CCCP treatment. Protein lysates were sequentially blotted with antibodies

against PARP1, Caspase 3, LC3A/B and β-actin (loading control).

Figure S7. Relationship between Prxs and mitophagy

293T cells transfected with GFP-Parkin and FLAG-Prxs were treated with DMSO or 10 μM

CCCP for 2 h. (A) Cells were fixed and stained with anti-FLAG (Red) and anti-GRP75 (Blue)

antibodies. Scale bar represents 10 μm. (B~G) Cells were subjected to fractionation into

whole cell lysates (WCL), mitochondrial-enriched fraction (Mito) and cytosol supernatant

(Cytosol). Protein lysates (7.5 μg) were sequentially immunoblotted with antibodies against

GFP (Parkin), PINK1, p62, FLAG, LC3A/B, GAPDH (cytosol marker), ATP5B, SOD2 and

COX4. (To see this illustration in color, the reader is referred to the web version of this article

at www.liebertonline.com/ars)

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Figure S8. PRDX6 knockdown affects both mitophagy and apoptosis

(A) GFP-Parkin overexpressing HeLa cells transfected with control or PRDX6 siRNA were

treated with DMSO or 10 μM CCCP for 2 h. Lyso-Tracker Red was used to label lysosomes,

and Hoechst 33342 was used to label nuclei. Parkin accumulation on mitochondria increased

significantly on PRDX6 knockdown. Scale bars represent 5 μm. (B) 293T cells transfected

with DsRed-Parkin and control GFP or PRDX6 cDNA or SOD2 cDNA were treated with 10

μM CCCP for 2 h. Cells displaying Parkin translocation were quantified (means ± SEM; n =

631 to 1024 cells; ns, not significant; *** p < 0.001). Data were collected from three

independent experiments. (C~E) GFP-Parkin overexpressing HeLa cells transfected with

control or PRDX6 siRNA were treated with DMSO or 10 μM CCCP for 24 h. Protein lysates

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were sequentially immunoblotted with antibodies against PARP1, LC3A/B, PRDX6 and

β-actin (loading control) (C). Data were quantified from three independent experiments

(means ± SEM; * p < 0.05, ** p < 0.01, *** p < 0.001) (D and E). (To see this illustration in

color, the reader is referred to the web version of this article at www.liebertonline.com/ars)

of 313

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67

Figure S9. ROS induces degradation of MOM proteins and mitophagy

GFP-Parkin overexpressing HeLa cells were treated with or without 2 mM NAC for 3 h prior

to CCCP treatment for indicated time course (0 min, 5 min, 10 min, 30 min, 1 h, and 2 h).

WCL and mitochondrial-enriched fractions were obtained through sub-cellular fractionation.

Protein lysates were analyzed by immunoblotting. (A) Quantitative analysis showed altered

COX4 abundance in the mitochondria (# compared with control group; means ± SEM; * p <

0.05, ** p < 0.01). (B) Representative immunoblots for GFP-Parkin, PINK1, PRDX6, p62,

LC3A/B-II, SOD2, COX4, GAPDH and ATP5B were shown from three independent

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68

68

experiments.

Supplementary Table S1, Total proteins identified

Supplementary Table S2, Total proteins quantified

Supplementary Table S3, Reproducibly identified proteins

Supplementary Table S4, Proteins identified three times

Supplementary Table S5, Differentially abundant proteins

Supplementary Table S6, Results analyzed with GeneCoDis3

Supplementary Table S7, Differentially abundant proteins in group 1

Mitochondria purified from HeLa cells expressing GFP-Parkin treated with 10 μM CCCP for

the indicated time course (0, 0.5, 1, 2, 6, and 12 h) were processed using the FASP method.

Equal amounts of digested peptides were labeled with 6-plex TMT reagents (0 h – TMT-126,

0.5 h – TMT-127, 1 h – TMT-128, 2 h – TMT-129, 6 h – TMT-130 and 12 h – TMT-131) and

mixed. The mixture was separated into 2 fractions, followed by LC-MS/MS. Data were

collected from two independent experiments.

Supplementary Table S8, Differentially abundant proteins in group 2

Mitochondria purified from HeLa cells expressing GFP-Parkin treated with 10 μM CCCP for

the indicated time course (0, 0.5, 1, 2, 6, and 12 h) were processed using the FASP method.

Equal amounts of digested peptides were labeled with 6-plex TMT reagents (0 h – TMT-126,

0.5 h – TMT-127, 1 h – TMT-128, 2 h – TMT-129, 6 h – TMT-130 and 12 h – TMT-131) and

mixed. The mixture was acidified, desalted with C18 StageTips and separated into 2 fractions

by SCX. The 2 fractions were analyzed by LC-MS/MS. Data were collected from two

independent experiments.

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Supplementary Table S9, Primers used for Q-PCR

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70

Table S1. Total proteins identified

Accession Gene Name A: 131/128 B: 131/128 C: 131/128 AAs MW [kDa] calc. pI

Q99714 HSD17B10 0.841516 1.034407 0.721248 261 26.90611 7.782

P51149 RAB7A 0.922614 1.065166 0.846551 207 23.47484 6.698

P61604 HSPE1 0.679456 0.790736 0.699603 102 10.92487 8.924

P05787 KRT8 0.675075 0.751577 0.750807 483 53.67114 5.592

P07737 PFN1 1.938756 2.252394 1.344145 140 15.04456 8.265

P04075 ALDOA 1.431453 1.24978 1.077389 364 39.39531 8.089

P62820 ALDOA 1.092382 0.88875 1.125391 205 22.66338 6.214

Q9H0U4 RAB1B 0.918566 1.065785 0.919462 201 22.15723 5.732

F8VP99 ARL1 1.157695 1.542415 0.956203 17 1.784059 8.998

P30044-2 PRDX5 0.899533 1.151113 0.875192 162 17.02001 7.24

P35232 PHB 0.763098 0.907576 0.7709 272 29.7859 5.757

P21796 VDAC1 0.900554 0.889186 0.881584 283 30.75357 8.543

P04406 GAPDH 1.458589 1.332338 1.068676 335 36.0304 8.456

P61224 RAP1B 1.16238 1.077295 1.039023 184 20.81159 5.783

P40926 MDH2 0.664156 0.837865 0.680457 338 35.48073 8.675

H7C402 PSMA2 2.176814 36 3.629869 4.462

P05388 RPLP0 1.330471 1.475431 1.056908 317 34.2518 5.973

P62805 HIST1H4A 0.955174 1.623225 0.837629 103 11.36038 11.36

P14854 COX6B1 0.757329 0.370079 0.408104 86 10.18572 7.049

P04843 RPN1 0.913799 1.010671 0.790561 607 68.52681 6.379

P12236 SLC25A6 0.70999 1.164683 0.736293 298 32.84519 9.745

J3KPX7 PHB2 0.789382 1.248585 0.888689 299 33.38196 9.803

P61106 RAB14 0.996383 1.193794 0.894419 215 23.88193 6.214

P10809 HSPD1 0.810926 0.816132 0.726478 573 61.01639 5.872

C9J4Z3 RPL37A 1.436528 1.015617 68 7.618937 10.01

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P07355 ANXA2 1.289833 1.129487 1.003301 339 38.57982 7.752

P05783 KRT18 0.799 0.85891 0.825672 430 48.02854 5.453

P45880-2 VDAC2 0.922755 0.953553 0.777764 283 30.39304 7.196

P06733 ENO1 1.914614 1.758462 1.405665 434 47.13932 7.386

P23396 RPS3 1.488376 1.290279 1.098373 243 26.67143 9.657

P11021 HSPA5 0.956886 1.019791 0.911357 654 72.28844 5.161

P30050 RPL12 1.322301 1.463871 1.083923 165 17.80754 9.422

P05187 ALPP 1.251282 1.513109 0.854797 535 57.91729 6.291

P50991-2 CCT4 1.225267 1.121238 0.973524 509 54.6851 7.826

P04083 ANXA1 2.266094 1.746823 1.194763 346 38.68998 7.02

P61204 ARF3 1.444831 1.666886 1.051078 181 20.58773 7.43

C9JPM4 ARF4 1.024415 127 14.54377 8.119

O75947-2 ATP5H 0.765966 0.744454 0.632677 137 15.76317 7.181

P05186 ALPL 1.23596 0.987719 0.873944 524 57.26863 6.668

P22392-2 NME2 2.124502 1.754569 1.124689 267 30.11763 8.924

P62937 PPIA 1.581094 1.657079 1.266474 165 18.00089 7.811

F8W181 RPL6 1.156877 1.928758 1.269758 226 25.87584 10.67

P15328 FOLR1 1.366506 1.081038 0.923879 257 29.79922 7.972

P23284 PPIB 0.898139 0.859683 0.805036 216 23.72754 9.408

P56385 ATP5I 0.656519 0.355847 0.61265 69 7.928326 9.349

I3L405 MPDU1 0.702334 1.097506 0.747594 54 5.842343 8.543

P60709 ACTB 1.24783 1.091786 1.021016 375 41.70973 5.478

Q9BQE3 TUBA1C 2.489466 1.571135 1.267975 449 49.86346 5.097

Q04837 SSBP1 0.805241 0.95227 0.876624 148 17.24903 9.598

P78371 CCT2 1.240819 1.18594 1.00711 535 57.45213 6.456

P07437 TUBB 2.198372 1.65089 1.379771 444 49.63897 4.894

P68371 TUBB4B 2.190046 1.825049 1.414922 445 49.799 4.894

G3V1A4 CFL1 1.436668 1.604942 1.119905 149 16.80082 8.353

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Q96AG4 LRRC59 0.915084 0.993629 0.812279 307 34.90888 9.569

P35268 RPL22 1.725276 0.9945 1.187181 128 14.7778 9.188

Q04695 KRT17 0.733529 0.819907 0.869358 432 48.07605 5.021

P61019 RAB2A 1.100628 1.154274 0.894823 212 23.53077 6.537

P61586 RHOA 1.254205 0.988428 0.989212 193 21.75407 6.1

B4E2V5 STOM 1.063447 1.119375 0.952542 237 25.94779 7.386

P08758 ANXA5 2.55048 2.027943 1.387868 320 35.9144 5.046

P08238 HSP90AB1 2.032999 1.859231 1.041987 724 83.21211 5.034

P25705-2 ATP5A1 0.770641 503 54.45973 8.236

F8W1R7 MYL6 1.215575 1.126743 1.032317 145 16.2798 4.653

P06576 ATP5B 0.671661 0.96268 0.673776 529 56.52461 5.402

H7BZJ3 PDIA3 1.026889 0.806688 0.896513 123 13.51076 7.298

P51148 RAB5C 0.967067 1.122958 0.802933 216 23.46779 8.412

P05141 SLC25A5 0.787078 0.722562 0.695568 298 32.83115 9.686

P11142 HSPA8 1.676814 1.507196 1.091932 646 70.85423 5.516

P21964-2 COMT 1.006936 1.232053 0.924779 221 24.43338 5.326

P07237 P4HB 0.864308 0.920657 0.801654 508 57.08068 4.869

Q15286-2 RAB35 1.233208 1.057609 1.070747 152 17.04762 6.786

P12235 SLC25A4 1.149312 298 33.04322 9.759

C9JD32 RPL23 1.186353 1.648681 1.004362 91 9.663386 11.49

P37802 TAGLN2 1.433868 1.373952 1.19946 199 22.37717 8.25

G5EA52 PDIA3 0.782183 1.237703 0.800555 485 54.92888 6.859

P02786 TFRC 0.946452 1.213344 0.810573 760 84.81795 6.61

P60174-1 TPI1 1.484075 1.743766 1.210256 249 26.65274 6.903

P14618 PKM 2.153361 2.370428 1.58462 531 57.90003 7.84

Q13162 PRDX4 0.877084 1.101935 0.887093 271 30.52081 6.291

H0YD13 CD44 1.235225 1.198431 0.977471 185 20.21538 8.265

A8MUB1 TUBA4A 2.036923 2.142278 1.476961 433 48.2976 5.008

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P30466 HLA-B 1.109144 362 40.25002 6.756

P62899 RPL31 1.280412 1.474387 1.010627 125 14.45393 10.54

D6RAT0 RPS3A 1.391437 2.274117 1.088799 227 25.87044 9.422

P38646 HSPA9 0.643269 0.744843 0.621853 679 73.63478 6.164

P18124 RPL7 1.358129 1.350894 0.97166 248 29.2072 10.65

P19105 MYL12A 1.245813 1.22103 1.061118 171 19.78149 4.805

P63104 YWHAZ 1.862614 2.023601 2.525793 245 27.72773 4.792

E9PKZ0 RPL8 1.479458 1.201099 1.042 205 22.37522 10.76

P25705 ATP5A1 0.810155 0.964153 553 59.7136 9.129

Q06830 PRDX1 1.785254 1.352087 1.10989 199 22.09628 8.133

B7Z254 PDIA6 0.855887 1.122926 0.795077 437 47.80807 5.084

P07195 LDHB 1.964997 1.817951 1.455855 334 36.61514 6.049

D6RAN4 RPL9 1.326622 1.204954 0.967353 182 20.86141 10.2

P30492 HLA-B 362 40.35501 6.303

P30493 HLA-B 362 40.47102 5.986

Q9Y5M8 SRPRB 1.050497 1.255535 0.939115 271 29.68376 9.042

P30475 HLA-B 362 40.30295 6.151

P07900 HSP90AA1 1.836656 1.700895 1.059922 732 84.60669 5.021

P17987 TCP1 1.260682 1.379604 0.931344 556 60.30559 6.113

P68104 EEF1A1 1.623493 1.398227 1.146169 462 50.10911 9.012

Q15019 SEPT2 1.163427 1.163393 0.935111 361 41.46125 6.595

E9PN17 ATP5L 0.688519 0.850805 0.784382 76 8.446677 10.29

I3L397 EIF5A 1.252103 1.537274 1.130697 147 16.10798 4.996

P08195-2 SLC3A2 1.450345 1.55993 1.062157 529 57.90887 5.351

P09525 ANXA4 1.858302 1.494527 1.25553 319 35.86012 6.125

P30040 ERP29 0.940127 1.141007 0.762335 261 28.97516 7.313

P27348 YWHAQ 1.639264 1.764708 245 27.74677 4.78

P46781 RPS9 1.596054 1.646443 1.137516 194 22.57756 10.65

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P39019 RPS19 1.41885 2.247615 1.038056 145 16.05054 10.32

P61026 RAB10 1.023099 1.368584 0.851934 200 22.52659 8.382

P62906 RPL10A 1.426027 1.112273 1.122081 217 24.81554 9.935

P09211 GSTP1 2.264256 1.306028 1.773251 210 23.34102 5.643

F8W7C6 RPL10 1.204563 1.269058 163 18.57973 9.95

Q9UBI6 GNG12 1.043246 1.20671 0.704077 72 8.00117 8.968

Q9Y2Q5 LAMTOR2 0.980146 1.111427 0.77696 125 13.49885 5.402

Q15293 RCN1 0.990571 0.964389 0.872109 331 38.86617 4.996

P49411 TUFM 0.807198 0.801759 0.780787 452 49.51018 7.606

P50454 SERPINH1 0.947646 1.159278 0.839949 418 46.41118 8.69

P00387-2 CYB5R3 0.845523 0.670345 0.888954 278 31.60836 7.577

D6RB85 CANX 0.446045 144 15.99796 4.742

P13639 EEF2 1.692874 2.529139 1.184579 858 95.27695 6.83

P05387 RPLP2 1.395322 1.271484 1.097447 115 11.65785 4.539

P04899 GNAI2 1.21145 1.10679 0.796403 355 40.42506 5.542

Q9H3K6 BOLA2 1.005165 1.066989 86 10.11018 6.522

Q14697 GANAB 0.928261 0.940956 0.819932 944 106.8067 6.138

H0YIC4 CS 0.721654 123 14.11442 9.569

C9J9K3 RPSA 1.484789 2.096834 0.965794 264 29.487 5.25

H3BRU6 PCBP2 1.303973 2.759481 1.020001 301 31.69025 8.441

P31327 CPS1 0.738376 0.773863 0.620871 1500 164.8348 6.742

P84095 RHOG 1.043651 0.825372 191 21.29493 8.119

P27797 CALR 0.84085 0.960863 0.770204 417 48.11183 4.437

P35613-4 BSG 1.399049 1.07799 0.949404 205 22.7502 5.465

P62277 RPS13 1.678969 1.478867 1.078018 151 17.21167 10.54

P62979 RPS27A 1.440632 0.943459 1.152788 156 17.95349 9.642

C9JXB8 RPL24 1.199513 1.607222 0.984919 121 14.35982 11.31

Q99832 CCT7 1.253512 1.025571 0.931442 543 59.32893 7.65

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F5H897 TRAP1 0.694887 0.819808 0.765467 651 74.22066 7.87

Q15907 RAB11B 0.944864 1.163245 0.742528 218 24.47349 5.935

P11233 RALA 1.101317 1.210924 0.908307 206 23.55197 7.108

P14625 HSP90B1 0.892788 0.951019 0.830767 803 92.41135 4.843

P00558 PGK1 1.471019 1.379579 1.293939 417 44.58613 8.104

P62834 RAP1A 1.131845 184 20.97371 6.668

F5H867 SLC3A2 1.151961 135 14.74766 5.96

P30460 HLA-B 362 40.30583 5.707

P06899 HIST1H2BJ 1.33263 126 13.89558 10.32

O60814 HIST1H2BK 1.189797 126 13.88156 10.32

P48047 ATP5O 0.633851 1.24605 0.808641 213 23.26266 9.964

F8W1N5 NACA 1.270608 2.333095 71 7.808271 9.627

P15880 RPS2 1.664077 1.47961 1.113606 293 31.3046 10.24

P00966 ASS1 1.839589 1.676893 1.362175 412 46.50097 8.016

P08754 GNAI3 1.175651 0.804725 1.039917 354 40.50627 5.694

B4DUR8 CCT3 1.22739 1.151447 0.915537 500 55.6387 5.643

J3KPE3 GNB2L1 1.484859 1.549646 0.982292 273 30.08503 7.65

P62701 RPS4X 1.302232 2.454188 0.93498 263 29.57906 10.15

K7EJW7 RAB34 1.16037 0.794762 51 5.83202 9.378

P13667 PDIA4 0.930947 0.925643 0.89519 645 72.88698 5.072

P60953 CDC42 1.431487 1.57275 0.920497 191 21.24502 6.551

P62241 RPS8 1.47423 1.177438 1.187905 208 24.19016 10.32

B4DP11 PTGES3 1.681728 2.155438 1.223253 139 16.46559 4.805

P62081 RPS7 1.354286 1.2582 1.16434 194 22.11326 10.1

P10599-2 TXN 1.730395 1.578375 1.437973 85 9.445685 6.037

E7EPB3 RPL14 1.301225 1.305218 1.102775 124 14.5486 10.21

E9PJD9 RPL27A 1.364131 1.230209 0.96926 91 10.1206 10.21

P27635 RPL10 1.362447 214 24.58787 10.08

of 313

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Q9NS69 TOMM22 0.681845 0.776688 142 15.51179 4.335

Q13011 ECH1 0.768997 0.747662 0.814573 328 35.79338 8.001

P62826 RAN 1.649783 1.16876 1.196289 216 24.40762 7.489

O43852 CALU 0.757461 0.647413 0.615452 315 37.08354 4.64

P30519 HMOX2 1.01223 0.847264 0.881484 316 36.00983 5.415

P09923 ALPI 1.094579 1.315935 0.881478 528 56.77642 5.859

B0S7Z4 HLA-C 339 38.30708 6.303

F8W1A4 AK2 0.895767 0.521958 0.570225 232 25.61431 7.826

F8VSD4 UBE2N 1.798173 1.165616 105 11.97532 9.115

O15260-2 SURF4 0.965792 1.794887 0.832768 159 17.95813 6.049

Q00325-2 SLC25A3 0.750895 0.864622 0.675982 361 39.93264 9.364

Q96QV6 HIST1H2AA 0.903956 131 14.22491 10.86

Q8WXC6 MYEOV2 3.511982 57 6.206755 3.828

P30479 HLA-B 362 40.51405 6.537

P26038 MSN 0.997356 0.961161 0.841568 577 67.77779 6.405

Q9Y4L1 HYOU1 0.945504 1.059093 0.930768 999 111.2662 5.224

B4DT77 ANXA7 1.799431 2.522988 1.392255 336 37.78092 7.181

P20340 RAB6A 0.976054 1.189046 0.893356 208 23.57792 5.542

Q07065 CKAP4 0.828617 1.04363 0.862488 602 65.98273 5.922

O75396 SEC22B 0.901232 0.960989 0.94581 215 24.57753 6.917

P62873 GNB1 1.277162 1.015888 0.94075 340 37.35301 5.999

P62879 GNB2 1.315584 1.060956 0.898893 340 37.30706 5.999

P14314-2 PRKCSH 0.91234 1.048005 1.041739 525 59.1407 4.424

P80723-2 BASP1 1.166233 1.056561 0.901991 173 17.65361 4.767

J3KRB3 RPL17 1.489923 2.946832 0.995291 106 12.18533 10.33

Q7Z7H5-3 TMED4 1.342651 1.19789 0.815333 186 20.76759 6.874

Q15365 PCBP1 1.261067 2.948268 0.9692 356 37.47395 7.093

P08133-2 ANXA6 1.403662 1.436018 1.034728 641 72.37795 5.605

of 313

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P34897-3 SHMT2 0.685224 0.741831 0.678145 483 53.4214 8.148

P62258 YWHAE 1.992235 1.280401 1.494461 255 29.15542 4.742

Q5TGZ0-2 MINOS1 0.800924 1.149823 0.884853 24 2.807374 5.021

P42704 LRPPRC 0.690941 0.910268 0.672625 1394 157.8051 6.125

Q15836 VAMP3 0.998247 0.865657 100 11.30195 8.792

P62269 RPS18 1.346863 1.626686 1.028083 152 17.70786 10.99

H0YJW7 SLIRP 0.71013 0.971971 0.865119 76 8.686431 9.056

P08729 KRT7 1.062605 1.561058 0.950673 469 51.35431 5.478

P51151 RAB9A 0.791237 1.072214 0.935898 201 22.82317 5.465

Q96KK5 HIST1H2AH 0.735924 1.673838 0.56306 128 13.89783 10.89

P62851 RPS25 1.40709 1.856292 1.141014 125 13.7337 10.11

Q29963 HLA-C 366 40.94314 5.999

P06753-2 TPM3 1.33755 1.366747 248 29.01475 4.78

P55145 MANF 0.926633 0.909981 0.846526 182 20.68681 8.69

Q9Y277 VDAC3 0.760055 1.266825 0.695581 283 30.63929 8.661

H3BSJ9 UQCRC2 0.833404 1.259801 0.853102 336 36.36685 9.056

D6R9Z7 COX7C 0.626331 0.848862 56 6.378306 9.833

P49755 TMED10 0.944925 0.898659 0.864641 219 24.96002 7.445

P51659 HSD17B4 0.912127 1.142433 0.907175 736 79.63631 8.836

M0R3D6 RPL18A 1.374033 1.25685 0.974152 141 16.70379 10.77

P07954-2 FH 0.75616 0.821024 0.77492 467 50.18071 7.401

P61006 RAB8A 0.901174 1.246924 0.836144 207 23.65319 9.071

P18077 RPL35A 1.477323 1.059888 1.092934 110 12.52977 11.06

O00264 PGRMC1 0.896808 1.252782 0.816996 195 21.65776 4.704

P48643 CCT5 1.237512 1.01463 1.005196 541 59.63281 5.656

P00338 LDHA 1.812565 2.760047 1.429861 332 36.66536 8.265

C9J0K6 SRI 2.289808 155 17.59351 5.605

P27824 CANX 0.925213 0.986537 0.774761 592 67.52585 4.602

of 313

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E9PI90 TMEM126A 0.972535 1.250469 0.866371 95 10.5577 9.349

E9PIE4 MTCH2 0.568568 0.880562 0.724825 263 28.64363 7.606

O43707 ACTN4 1.262195 1.082558 0.9702 911 104.7885 5.44

O60493-4 SNX3 1.267295 0.705719 0.97026 140 16.30543 6.8

H7BYD0 NDUFA5 0.473911 0.506902 112 13.08984 5.148

H0YNX5 SEC11A 1.109807 1.068807 0.796946 106 11.9784 8.573

P08708 RPS17 1.448131 1.01641 135 15.54039 9.847

P40227-2 CCT6A 1.192214 0.996239 0.919703 486 53.25512 7.269

E9PPQ4 FTH1 0.622898 0.799481 0.801175 58 6.659315 5.833

P62280 RPS11 1.662973 1.502607 1.097377 158 18.41899 10.3

P36578 RPL4 1.35429 1.903045 0.988733 427 47.66743 11.06

Q9NZM1-6 MYOF 1.037945 1.021888 0.808942 2048 233.3291 6.214

P13073 COX4I1 0.483846 0.765167 0.556132 169 19.56405 9.51

Q09666 AHNAK 1.396628 1.078414 1.085748 5890 628.6994 6.151

O00299 CLIC1 1.488679 1.783422 1.075934 241 26.90575 5.173

O75340-2 PDCD6 1.339131 2.016605 0.873893 189 21.6507 5.402

Q9BVK6 TMED9 1.089255 1.206477 1.029899 235 27.26019 8.016

B0YJC4 VIM 1.04978 0.95151 0.834099 431 49.62311 5.25

P16435 POR 1.075094 1.406985 0.862966 677 76.64125 5.58

P62857 RPS28 1.611754 1.450764 1.260379 69 7.836202 10.7

E9PH29 PRDX3 1.032865 1.063725 0.964449 238 25.82229 7.459

F8VWC5 RPL18 1.362265 1.227657 1.081671 159 18.08001 11.84

E7EP42 TIMM23B 0.773211 123 12.69314 5.059

B4DJV2 CS 0.738233 0.967624 0.528491 453 50.39972 7.899

G5E9G0 RPL3 1.270871 1.237766 1.026216 351 40.24159 10.01

P62136 PPP1CA 1.343226 1.108105 1.095776 330 37.48781 6.329

P31930 UQCRC1 0.774534 0.886231 0.935639 480 52.61243 6.367

P05023-3 ATP1A1 1.294006 0.992424 1.007667 992 109.4801 5.313

of 313

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P30041 PRDX6 2.172555 2.201779 1.531302 224 25.01919 6.379

E9PE17 MRPS17 0.737873 0.985275 129 14.36487 9.847

P56381 ATP5E 0.520223 0.661011 51 5.776108 9.92

P49748-2 ACADVL 0.856184 0.941784 0.884746 633 68.01516 8.558

P24752 ACAT1 0.638064 0.687537 0.508238 427 45.17065 8.851

P62847-2 RPS24 1.28488 1.502636 1.211886 130 15.05924 10.89

J3QRU4 VAMP2 1.035579 0.87911 0.88375 113 12.24347 6.698

P38117 ETFB 0.638357 0.914762 0.756683 255 27.82615 8.104

P50990 CCT8 1.308838 1.110844 1.013766 548 59.58251 5.605

P10321 HLA-C 366 40.62295 6.037

B4DJA5 RAB5A 1.106414 201 22.16413 8.822

H3BLV0 CD55 1.328456 1.063833 0.912351 326 35.78247 5.542

K7EK18 SEPT9 1.098243 2.065827 0.89968 195 22.20265 9.364

M0R210 RPS16 1.69377 1.999538 1.206613 129 14.40996 10.23

H7C131 ACAA1 1.048769 1.409101 0.869312 290 30.31385 8.631

Q9Y3U8 RPL36 1.31536 1.586732 1.003242 105 12.24591 11.59

P63173 RPL38 1.294342 1.106003 0.869385 70 8.212732 10.1

P35579 MYH9 1.302687 1.086399 1.071008 1960 226.3916 5.605

P14923 JUP 1.086031 1.9394 0.870796 745 81.69273 6.138

E7EPK1 SEPT7 1.093627 0.907592 0.935756 436 50.53491 8.631

P60981-2 DSTN 1.581098 1.011045 1.184857 148 16.60962 8.338

P49207 RPL34 1.395191 1.314732 0.995061 117 13.28447 11.47

P62158 CALM1 1.168528 0.976215 1.043359 149 16.82684 4.221

B0V0C2 HLA-C 1.174925 1.450967 1.015708 355 39.9159 6.252

P61020 RAB5B 0.95207 1.502444 215 23.6919 8.133

P62424 RPL7A 1.271624 1.253347 1.056754 266 29.97703 10.61

P32119 PRDX2 1.699211 1.093831 1.077377 198 21.87824 5.973

E9PNW4 CD59 1.27023 1.074834 108 11.97652 5.745

of 313

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P14406 COX7A2 1.049713 0.36366 83 9.390106 9.759

P56378 MP68 0.57071 1.525767 0.537005 58 6.657592 10.08

E7EQV9 RPL15 1.487834 1.212723 1.172524 174 20.4971 11.28

P26373 RPL13 1.341332 1.017938 1.180794 211 24.24653 11.65

P04264 KRT1 0.85955 0.950506 1.147848 644 65.999 8.119

P07339 CTSD 0.787297 1.54094 0.754058 412 44.52363 6.537

Q96BM9 ARL8A 0.693297 186 21.40204 7.767

O95881 TXNDC12 0.767286 1.351947 0.708736 172 19.19358 5.402

P08107-2 HSPA1A 1.451974 1.304211 1.128996 586 63.89795 5.707

P46777 RPL5 1.4141 1.415486 0.956259 297 34.3407 9.715

P46783 RPS10 1.235944 2.429152 1.195446 165 18.88587 10.15

B8ZZT4 VAMP8 0.981127 0.644367 99 11.18456 5.034

P63000 RAC1 0.949096 1.149969 0.843695 192 21.43624 8.5

P31946-2 YWHAB 1.6004 244 27.83274 4.831

P15311 EZR 1.044674 1.131245 0.844371 586 69.36974 6.265

Q9H3R2 MUC13 0.978161 1.009123 0.874289 511 54.4823 5.072

P67936 TPM4 1.082235 248 28.50449 4.691

P51153 RAB13 0.987342 0.880775 203 22.75974 9.188

P04844-2 RPN2 0.865835 1.515186 0.790879 615 67.68143 6.062

P22626-2 HNRNPA2B1 1.46531 1.472787 1.080379 341 35.98387 8.646

Q9NVJ2 ARL8B 1.056423 186 21.52514 8.426

Q07021 C1QBP 0.539476 0.617432 0.63902 282 31.34261 4.843

B0QYW5 SLC25A17 0.80683 1.515895 0.830338 225 25.70527 10.33

P40939 HADHA 0.854214 0.933591 0.693905 763 82.94688 9.042

P18859 ATP5J 0.606499 0.905095 108 12.5796 9.525

Q8NBS9-2 TXNDC5 0.859163 1.032573 0.891072 324 36.15501 5.465

Q9NZ45 CISD1 1.052653 108 12.19121 9.085

R4GN98 S100A6 1.80781 1.242526 85 9.675063 5.453

of 313

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81

P60842 EIF4A1 1.965905 2.235364 1.377883 406 46.12456 5.478

P04792 HSPB1 1.745388 1.579063 1.377766 205 22.76849 6.405

P00505 GOT2 0.74356 1.11953 0.835989 430 47.48732 9.012

A6NNI4 CD9 1.162542 1.471833 0.875901 159 17.75198 6.291

J3KTJ8 RPL26 1.253158 1.097186 0.952303 97 11.59029 10.9

P46940 IQGAP1 1.311338 1.179563 1.051245 1657 189.1338 6.481

Q5SQT8 SAR1A 1.342855 1.036644 1.046629 121 13.65307 7.035

A2A2D0 STMN1 1.436459 1.078793 86 9.858311 7.416

E5RJ48 LYPLA1 0.974708 90 9.613937 4.894

I3L1N9 CISD2 0.948726 47 5.140685 8.587

P01891 HLA-A 1.141704 1.080213 0.870519 365 40.88311 6.698

R4GMU8 LAMTOR5 1.802162 1.58376 79 8.210105 5.681

M0R213 NAPA 1.380978 0.797603 83 9.850914 5.059

O00116 AGPS 0.916199 1.008498 0.881695 658 72.86575 7.342

O60869-2 EDF1 1.474209 139 15.47123 9.774

P36542 ATP5C1 0.794469 1.137386 0.851877 298 32.97527 9.217

Q8TBQ9 TMEM167A 0.969974 72 8.054331 8.954

Q9P0J0 NDUFA13 0.945637 1.150368 144 16.6876 8.426

P62745 RHOB 1.735407 196 22.10913 5.237

P62750 RPL23A 1.612112 1.035822 1.037671 156 17.68414 10.45

P42677 RPS27 1.229176 1.262495 1.039197 84 9.454836 9.452

F8WBT9 APOD 1.859735 108 11.78589 7.562

H0YLW1 SPG21 1.172061 1.030744 72 8.198275 8.163

P68032 ACTC1 1.34282 1.013944 1.055046 377 41.99188 5.389

P46779 RPL28 1.626481 1.301392 1.045187 137 15.73767 12.02

O00571-2 DDX3X 1.312787 1.984043 1.036829 646 71.31093 6.625

P00533 EGFR 1.313611 1.150044 0.967401 1210 134.1903 6.683

O00483 NDUFA4 0.523392 0.706709 0.775773 81 9.363911 9.378

of 313

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82

82

A1L0T0 ILVBL 0.939325 1.132552 0.986583 632 67.82475 8.148

Q9BS26 ERP44 1.071049 0.980132 0.906419 406 46.9414 5.262

P39656 DDOST 0.870036 1.214033 0.817799 456 50.76897 6.551

E5RI99 RPL30 1.335092 1.112029 1.043232 114 12.64765 9.554

P50416 CPT1A 0.78061 0.995421 0.755873 773 88.31074 8.646

H0YJ63 AHSA1 1.229447 1.349447 1.208246 90 10.13504 7.035

Q9Y5U9 IER3IP1 1.275533 82 8.962939 8.221

F8W031 2 0.947739 0.875083 0.923028 263 29.20588 7.005

P47813 EIF1AX 1.885051 1.752925 1.039483 144 16.45023 5.237

P16615 ATP2A2 0.916231 0.957004 0.913417 1042 114.6826 5.338

P25398 RPS12 1.659114 1.104536 1.065406 132 14.50548 7.21

P54886-2 ALDH18A1 0.695204 1.022175 0.785468 793 87.03444 7.123

P50897 PPT1 0.765644 0.910308 306 34.17125 6.522

H0YJ10 4 1.021539 1.300787 0.811753 91 10.72949 8.192

P12277 CKB 1.649735 3.416205 1.579158 381 42.61732 5.592

G3V5B2 LGMN 0.883774 58 6.428232 6.932

Q96D15 RCN3 0.761235 0.664588 0.875835 328 37.47 4.894

P61978-3 HNRNPK 1.293792 1.262426 1.041703 440 48.53217 5.542

Q9UJZ1 STOML2 0.938409 0.635069 0.93784 356 38.5102 7.386

Q9NUP9 LIN7C 1.20256 1.122703 197 21.82047 8.426

Q969X5-2 ERGIC1 1.119816 0.901479 0.66877 198 22.14624 9.159

C9IZG4 CUTA 0.988956 1.690078 1.10773 135 14.39131 5.453

F8WB87 CCDC66 0.945362 38 4.209334 7.24

Q9H9B4 SFXN1 0.877179 0.76235 322 35.59635 9.071

Q9BW72 HIGD2A 0.560691 106 11.52112 10.2

Q8WVC2 RPS21 2.174773 1.079974 81 8.844458 8.5

E9PK01 EEF1D 1.302939 1.516644 1.004283 261 28.8036 5.021

Q9UBQ0-2 VPS29 1.041183 0.601188 0.878376 186 20.9139 7.049

of 313

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83

83

P08559 PDHA1 0.60855 0.708728 0.778748 390 43.26761 8.06

K7ES20 CDKN2A 1.387355 2.537661 1.194942 104 11.0686 6.062

Q7KZF4 SND1 1.045645 1.052682 0.894108 910 101.9335 7.167

O00159-2 MYO1C 1.090572 1.879908 0.932649 1028 117.8338 9.408

Q05639 EEF1A2 1.264052 1.278046 463 50.43831 9.027

P13797 PLS3 1.278969 1.281915 0.894728 630 70.76621 5.605

Q71UI9-2 H2AFV 1.022639 0.894296 114 12.13865 10.46

P51809 VAMP7 0.593834 1.216902 0.666516 220 24.91897 8.602

H0YHC3 NAP1L1 1.749507 1.215395 1.242297 198 23.40282 4.805

H0YK49 ETFA 0.808242 0.650196 0.816799 229 24.14479 8.661

P55072 VCP 1.356492 1.053145 1.115978 806 89.26572 5.262

P40429 RPL13A 1.465869 1.290089 1.005122 203 23.56238 10.93

C9JTY3 TFG 1.535206 128 14.74983 5.364

Q9Y2Q3 GSTK1 0.827654 1.67774 0.733029 226 25.4803 8.412

Q15738 NSDHL 0.85239 1.055136 0.852621 373 41.87357 8.06

E5RFR7 TPD52 1.234298 111 12.38146 4.678

Q96AY3 FKBP10 0.996141 1.329693 0.892073 582 64.20419 5.618

M0R0F0 RPS5 1.166646 2.470449 1.0889 200 22.37678 9.554

P62753 RPS6 1.397225 1.387364 1.065198 249 28.66299 10.84

P16188 HLA-A 365 40.87918 6.1

E9PNM1 FDFT1 0.895386 0.707255 0.816685 410 47.25481 6.537

P26641 EEF1G 1.415485 1.530083 1.06643 437 50.08714 6.668

B8ZZQ6 PTMA 5.213533 1.279016 107 11.75182 3.815

H7BXT7 BET1L 1.055968 58 6.461192 4.881

H3BN98 4 1.438958 1.477913 1.126454 237 27.15036 9.554

P21333-2 FLNA 1.379542 1.316975 1.06758 2639 279.8435 6.049

P09972 ALDOC 1.14555 0.929752 364 39.43124 6.874

Q9BTV4 TMEM43 0.780347 1.962667 0.746693 400 44.8472 8.133

of 313

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Q9NQC3-2 RTN4 1.054777 1.248568 0.896947 373 40.29295 4.78

P05198 EIF2S1 1.355816 1.614618 1.018009 315 36.08938 5.084

F8WBD0 SELT 1.090135 45 4.854753 11.06

O75394-2 MRPL33 1.602748 54 5.961127 9.129

P05362 ICAM1 1.305694 1.302605 0.922945 532 57.78895 7.987

Q14257 RCN2 0.96242 0.623272 0.879469 317 36.85364 4.399

P50151 GNG10 1.012014 68 7.200677 7.855

B4DVE7 ANXA11 1.313376 1.152581 1.024236 472 51.20963 7.665

Q96CG1 ETF1 1.291047 1.189461 0.911591 404 45.43428 5.567

H7C342 DDT 1.587367 50 5.696016 8.734

P63092-3 GNAS 1.24904 0.974517 0.876229 379 44.15129 6.291

P06748-2 NPM1 1.232216 1.080336 265 29.44624 4.615

P60468 SEC61B 0.969906 0.935849 0.82461 96 9.968098 11.56

P28288-2 ABCD3 0.788009 0.999881 0.771997 549 62.68583 9.232

Q8NE86-3 MCU 0.419177 1.259917 0.395554 302 35.13636 7.489

P35610 SOAT1 0.95731 1.141503 0.792908 550 64.69228 8.939

E9PJK1 CD81 0.86806 1.22258 0.922512 165 17.95093 4.996

H3BPJ9 NDUFB10 0.77567 161 19.24561 8.705

Q9Y5J9 TIMM8B 0.796617 0.872531 83 9.337537 5.123

F8VZ49 HNRNPA1 1.457102 1.12016 0.929332 231 25.67093 8.265

H7BYV1 IFITM2 0.942264 1.110098 1.041262 74 8.191374 9.554

O75955 FLOT1 0.959809 1.219525 0.894697 427 47.32562 7.489

E5RIX8 TBCA 1.739399 1.326092 79 9.390927 5.376

Q9H7Z7 PTGES2 0.708644 1.222006 0.767571 377 41.91667 9.159

Q9BX68 HINT2 0.971993 1.052643 163 17.15124 9.159

K7ERU1 PTPN2 1.112802 0.919441 42 5.149685 6.494

P20674 COX5A 0.642662 0.823961 0.797611 150 16.75169 6.786

K7ELW0 PARK7 1.709521 1.716847 169 17.89849 7.87

of 313

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P21291 CSRP1 1.305284 1.28095 0.904117 193 20.55376 8.573

H0YJC4 PSMA6 0.875222 85 9.33469 4.412

E9PRJ5 NDUFC2 1.275935 71 8.260498 9.876

P30453 HLA-A 365 41.0291 6.303

Q9NVI7-3 ATAD3A 0.736017 0.95477 0.758229 507 57.91198 9.247

O60506-4 SYNCRIP 1.439233 1.325961 1.109899 527 58.69934 7.562

P43121-2 MCAM 0.888794 527 57.56921 5.516

Q00610-2 CLTC 1.264943 1.277724 1.081325 1639 187.7708 5.694

D6RG34 SLC35B1 0.745193 76 8.437234 8.573

P11940-2 PABPC1 1.51283 1.56743 0.845456 547 61.14204 9.071

P52907 CAPZA1 1.176207 2.293021 1.045937 286 32.90233 5.694

P47755 CAPZA2 1.297423 0.592928 286 32.92861 5.846

P62266 RPS23 1.216428 2.655464 1.01516 143 15.79772 10.49

O14745 SLC9A3R1 1.260811 1.01792 1.042626 358 38.84461 5.77

P62854 RPS26 1.351794 0.788218 115 13.00708 11

O95816 BAG2 1.272411 1.042008 1.089469 211 23.75721 6.698

B1AK87 CAPZB 1.603968 1.278082 260 29.27683 6.917

Q15758 SLC1A5 1.308418 1.492866 1.055568 541 56.56225 5.478

P00403 MT-CO2 0.70371 1.021196 0.80279 227 25.54821 4.818

P08240-2 SRPR 0.957363 1.306896 0.943597 610 66.5166 9.042

P20338 RAB4A 1.124238 218 24.37422 6.075

P31040 SDHA 0.710747 0.800021 0.515262 664 72.64529 7.386

P46778 RPL21 1.327984 160 18.55306 10.49

J3QRD1 ALDH3A2 0.739254 0.922268 0.81764 393 44.61966 5.529

Q9P2E9-2 RRBP1 0.963369 0.97999 0.774962 1407 152.0976 8.661

P61353 RPL27 1.418572 1.185726 1.319388 136 15.78775 10.56

H0YE73 REPS1 146 15.70382 5.681

O60568 PLOD3 0.984509 0.966926 0.997824 738 84.73148 6.049

of 313

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86

86

Q7Z451 AP2B1 1.095112 1.00145 880 98.05567 5.237

P21266 GSTM3 1.957089 0.908341 225 26.54214 5.542

P43121 MCAM 1.271354 1.833761 0.94972 646 71.5626 5.757

P28066 PSMA5 1.174746 1.323802 241 26.39421 4.792

Q99720-3 SIGMAR1 0.907501 1.012009 192 21.46903 5.986

H0YDT8 EMC7 0.745164 0.727399 0.818959 192 20.98168 9.364

C9JKI3 CAV1 0.962885 0.926635 138 15.91812 5.25

Q96C01 FAM136A 1.339867 138 15.63066 7.606

Q8N5N7 MRPL50 0.873347 1.175161 0.730664 158 18.31337 7.884

Q9UDT1 WUGSC:H_RG122E10.2a 0.955392 79 8.374288 7.87

Q96A33 CCDC47 0.925467 1.238405 0.965277 483 55.83831 4.869

O43175 PHGDH 1.747724 2.068921 1.496959 533 56.61441 6.712

H7C463 IMMT 0.877231 0.809576 0.904617 613 68.13328 6.062

P09669 COX6C 0.728532 75 8.77569 10.39

K7ESJ4 PDCD5 0.907409 0.995335 65 7.463784 8.25

P07686 HEXB 0.741613 0.992336 0.75352 556 63.07118 6.756

Q9BUF5 TUBB6 1.672282 2.65095 1.110157 446 49.825 4.881

P32322-2 PYCR1 0.845045 0.642088 0.695944 316 33.3195 6.8

Q14344 GNA13 1.227688 0.797547 377 44.02167 8.001

Q53GQ0 HSD17B12 0.970736 0.911635 312 34.30219 9.32

K7EPV6 SLC44A2 1.068303 0.984311 146 16.72829 8.661

O75915 ARL6IP5 0.964027 1.020583 1.120619 188 21.60041 9.774

B4DLN1 SLC25A10 0.858637 0.915177 0.867875 442 48.06871 9.525

E9PP23 ACP2 0.827875 1.245691 0.514516 305 35.13374 7.606

P51571 SSR4 0.914168 1.083905 0.770754 173 18.98661 6.151

H0YID2 AK1 1.369342 51 5.828051 5.313

P15941-7 MUC1 1.044978 2.078388 0.85959 255 27.54883 6.379

P07099 EPHX1 0.999873 1.231505 0.831531 455 52.91497 7.254

of 313

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87

P49720 PSMB3 1.0479 1.238449 0.807103 205 22.93345 6.551

I3L294 ABHD12 0.977071 159 18.02189 5.948

P63096 GNAI1 1.312397 1.01678 354 40.33523 5.973

P20645 M6PR 0.989309 0.783721 0.824571 277 30.97338 5.833

J3KTD9 ALDH3A2 1.14157 62 7.077955 5.719

P60866 RPS20 1.455372 1.259972 1.211516 119 13.36431 9.935

P30084 ECHS1 0.883418 1.356612 0.867611 290 31.36713 8.075

K7EJN0 ZNF383 1.612734 114 13.15237 4.539

Q9UBS4 DNAJB11 0.972224 1.029518 358 40.48862 6.176

P07203 GPX1 1.062831 203 22.07511 6.551

P04040 CAT 0.850883 0.954433 0.938398 527 59.71876 7.386

P62070 RRAS2 1.266491 1.827886 1.19924 204 23.38472 6.011

O95295 SNAPIN 0.956505 0.88864 0.963864 136 14.86489 9.305

P60059 SEC61G 0.944746 68 7.736173 9.994

Q9BWM7 SFXN3 0.531569 1.297676 0.717848 325 35.95574 9.085

D6RFH4 CYB5B 1.229277 1.121125 0.872535 131 14.83656 6.189

Q9H488-2 POFUT1 1.008152 0.897625 0.79064 194 22.32318 8.763

P31949 S100A11 2.030099 1.585923 1.773105 105 11.73283 7.123

P26885 FKBP2 1.060719 0.988314 0.97951 142 15.63932 9.129

J3QL14 ATP6V0D1 0.866587 0.826526 0.729162 232 26.79831 4.945

E3W990 SQSTM1 1.018551 190 20.92407 6.507

Q96B49 TOMM6 1.217067 0.519094 74 7.997054 4.894

G3V1U5 GOLT1B 1.450358 74 8.208504 10.26

P07602 PSAP 0.683775 0.629512 0.706638 524 58.07385 5.173

P54136-2 RARS 1.198519 1.2051 1.051643 588 67.09754 6.551

P35241 RDX 1.144341 0.789788 0.79542 583 68.52139 6.367

Q05682-5 CALD1 1.137854 0.959064 532 61.17615 6.712

Q7Z7F7 MRPL55 0.786156 0.729764 128 15.11912 11.15

of 313

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88

H7C5U3 MFSD1 0.754188 0.65536 64 6.817588 4.831

K7EMN2 PGD 2.315309 0.984759 160 17.28195 8.441

Q9NYU2-2 UGGT1 0.966708 1.082893 0.827887 1531 174.867 5.605

Q49AN9 SNRPG 1.06565 64 7.096674 7.181

H3BTL1 MAP1LC3B 1.202473 1.328199 0.978317 75 9.005942 9.818

Q16143 SNCB 0.609864 134 14.27902 4.412

Q9Y3B3-2 TMED7 1.068593 188 21.21938 6.202

B4E241 SFRS3 1.073649 124 14.19419 10.08

P01111 NRAS 1.312077 1.099683 1.02401 189 21.21552 5.173

P11177-2 PDHB 0.801466 0.826505 0.686171 341 37.17589 5.897

O95573 ACSL3 1.005102 0.842287 0.750326 720 80.3683 8.382

Q5QNZ2 ATP5F1 1.016849 0.861305 0.934918 195 22.26079 9.261

F5H895 DAD1 0.941767 1.090094 0.921763 65 7.283816 6.507

Q04941 PLP2 1.11339 1.166644 0.873699 152 16.6797 7.24

Q15363 TMED2 1.129736 0.691615 0.857814 201 22.74638 5.173

Q9Y3D7 PAM16 0.499786 125 13.81625 9.701

H0YAL7 EEF1E1 0.983966 136 15.32889 8.397

Q8NBJ5 COLGALT1 1.034208 1.152908 0.94246 622 71.59049 7.313

P16403 HIST1H1C 1.104125 0.964902 213 21.35175 10.93

P21912 SDHB 0.78746 0.688895 0.585378 280 31.60884 8.763

Q99735-2 MGST2 1.108131 77 8.353378 9.452

Q99643-5 SDHC 1.05488 116 12.46562 8.983

Q8NI22-2 MCFD2 0.873529 94 10.71107 4.412

D3YTB1 RPL32 1.46215 1.225551 1.090284 133 15.60672 11.44

P68036-2 UBE2L3 1.29082 122 14.1123 8.924

A8MXH2 NAP1L4 1.024651 156 18.14119 5.097

P54709 ATP1B3 0.862547 1.39039 0.692303 279 31.4921 8.353

Q6PIU2 NCEH1 0.983177 1.03137 0.951544 408 45.77873 7.225

of 313

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89

89

P10301 RRAS 0.982982 218 23.46589 6.932

F5GX33 SLC25A13 0.957621 0.688932 0.827212 567 62.20553 9.012

P05556 ITGB1 1.158754 1.035265 0.917412 798 88.35701 5.389

Q10589 BST2 1.017301 0.804819 0.929134 180 19.75632 5.605

O14717-6 TRDMT1 1.173837 1.692801 0.93187 107 12.07936 9.408

F2Z388 RPL35 1.250751 1.521157 1.170053 96 10.63799 10.29

P25789 PSMA4 1.638164 1.269063 261 29.46518 7.723

J3QR09 RPL19 1.070284 0.939773 1.179406 193 23.12009 11.47

P60903 S100A10 1.135403 0.850453 1.076286 97 11.19551 7.372

Q15006 EMC2 0.863007 0.726281 0.875542 297 34.81137 6.566

Q9GZY8-4 MFF 0.739802 0.53782 0.695619 218 25.05105 5.58

Q9P035 PTPLAD1 0.877567 1.337144 0.857696 362 43.13156 8.939

Q96QK1 VPS35 1.003638 1.242269 0.838696 796 91.64894 5.491

O60762 DPM1 0.851512 0.83312 0.902944 260 29.61578 9.569

P05534 HLA-A 1.27307 0.891351 365 40.66303 6.341

P06280 GLA 0.884287 0.768463 0.781778 429 48.73487 5.605

P07951 TPM2 0.820195 284 32.83057 4.704

Q8WUH6 C12orf23 0.815821 116 11.7411 9.32

Q96IX5 USMG5 1.416234 1.690851 58 6.453373 9.759

F8VZL6 SLC11A2 0.841982 87 9.529282 6.507

P17931 LGALS3 1.461607 1.151114 0.995674 250 26.13605 8.558

P07741-2 APRT 1.912567 1.645471 134 14.54781 7.342

H0YAG0 OSCP1 0.904197 94 10.27113 4.488

Q9UII2 ATPIF1 0.999876 0.587263 0.953559 106 12.24131 9.349

H0YCU8 ZFPL1 1.030018 53 6.09175 4.145

P62861 FAU 1.083569 2.505195 1.002681 59 6.643817 12.15

Q9Y3L5 RAP2C 1.022952 2.862522 183 20.7314 4.945

P22314 UBA1 1.679951 1.436978 1.088012 1058 117.7743 5.757

of 313

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90

90

Q12974-3 PTP4A2 1.853871 136 15.6589 8.485

F5H7F6 MGST1 1.09648 0.754375 77 8.880476 8.792

B4DLR8 NQO1 1.86144 2.576048 1.108224 202 22.7789 8.5

O15400-2 STX7 1.134266 1.059861 239 27.38366 5.123

M0R1C0 SARS2 1.048859 90 10.26025 9.525

H3BRM6 GSTM1 1.831089 102 11.97895 5.262

B7Z9S8 ATP1B1 0.987011 1.162697 0.775269 247 28.60945 7.591

Q9HBH0 RHOF 0.955615 211 23.61022 8.646

E5RHW4 ERLIN2 1.075576 1.673551 0.91896 338 37.70141 5.618

Q15067 ACOX1 0.820907 0.853837 0.80665 660 74.37619 8.163

Q8NF37 LPCAT1 0.968721 0.940151 0.824247 534 59.11339 6.024

B3KUK2 SOD2 0.983114 1.068819 0.875183 176 19.718 8.031

Q9NP58-4 ABCB6 0.866446 0.735973 0.921757 796 88.54343 8.69

P53007 SLC25A1 0.657693 0.838483 0.552905 311 33.991 9.891

C9JDI6 ARHGEF7 1.054952 61 7.059381 5.237

I3L2F4 EDC4 1.135017 135 14.88059 8.88

Q02818 NUCB1 0.746638 0.571069 0.704151 461 53.84633 5.25

P34931 HSPA1L 1.29594 641 70.33133 6.024

Q9Y3E5 PTRH2 1.195788 0.669064 0.835644 179 19.18096 8.734

B7Z371 SEPT10 1.00586 0.998061 321 37.86738 8.104

P57088 TMEM33 0.828436 1.442192 0.868994 247 27.95981 9.701

Q6IAA8 LAMTOR1 1.24942 0.816071 0.786799 161 17.73383 5.148

Q9NR28-2 DIABLO 0.635184 186 21.2195 4.805

P59998 ARPC4 1.341496 1.09597 1.045125 168 19.6543 8.426

I3L0U2 PRSS21 0.691442 0.583658 0.82809 218 24.80035 8.309

B4E2W0 HADHB 0.850703 0.886421 0.451736 452 48.84822 9.173

Q16836 HADH 0.792688 0.742475 0.744782 314 34.27194 8.851

P13645 KRT10 1.28587 0.939907 0.591393 584 58.7917 5.211

of 313

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J3KNT0 FSCN1 1.29256 1.174877 0.981105 472 52.22991 7.445

B4DJP7 SNRPD3 1.222577 2.00277 0.961715 120 13.28287 8.91

O96008-2 TOMM40 1.011459 0.843353 0.925812 329 34.41926 7.24

P09493-2 TPM1 1.324331 0.743304 228 26.66351 4.818

P53999 SUB1 1.527801 1.221018 127 14.38641 9.598

Q92820 GGH 0.839025 1.22591 0.82501 318 35.94117 7.108

P60891 PRPS1 2.22903 1.813701 1.35476 318 34.81193 6.976

J3KNJ2 EIF3M 1.620833 2.034655 1.076182 191 21.67855 7.767

Q96GS4 C17orf59 0.854628 0.76674 357 37.20361 5.757

B4DL37 AKR1C3 0.987396 2.243348 1.180967 204 23.34887 7.987

F5H780 TXNRD1 1.297551 1.226029 459 50.63389 6.625

Q969V3-2 NCLN 0.894773 0.958908 0.953311 562 62.80652 6.888

Q96AP7 ESAM 1.027231 1.020602 390 41.15057 9.32

C9JT62 HDLBP 0.96782 96 10.62135 5.415

Q96HY6 DDRGK1 0.986476 1.127326 314 35.5895 5.123

O43399-2 TPD52L2 1.061307 1.272973 0.957152 186 19.8891 5.478

Q01650 SLC7A5 1.431562 1.133416 1.266765 507 54.97428 7.723

H7C0D5 YIPF4 0.89801 58 6.443188 4.424

P21281 ATP6V1B2 0.917239 1.985412 0.827157 511 56.46488 5.808

P30153 PPP2R1A 1.46472 1.401303 589 65.26692 5.11

O14818-4 PSMA7 1.652808 149 16.12523 8.016

E5RJR5 SKP1 0.83808 163 18.7083 4.704

D6RAW0 UBE2D3 1.458593 72 8.208111 8.88

Q9UBV2-2 SEL1L 0.957267 0.94284 301 33.50934 4.831

P22307-4 SCP2 0.926588 0.997557 0.801347 466 50.30939 7.02

P33316-2 DUT 1.286103 1.06712 164 17.73693 6.566

P62263 RPS14 1.753372 1.312114 1.238416 151 16.26253 10.05

K7EMV3 H3F3B 1.138243 92 10.32783 11.82

of 313

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92

92

P12814-2 ACTN1 1.286 1.051952 887 102.6444 5.503

E9PN68 EPS8L2 1.150686 79 8.599192 8.016

O60664-4 PLIN3 1.365876 0.982602 1.202173 422 45.77523 5.427

F5H587 TM7SF3 0.930398 66 7.269389 3.98

P62306 SNRPF 2.06344 86 9.718777 4.666

P42765 ACAA2 0.664527 0.989564 0.733337 397 41.89765 8.089

P49257 LMAN1 1.063775 0.783376 0.907985 510 57.51298 6.771

P83881 RPL36A 1.429071 106 12.43281 10.58

O00560-3 SDCBP 1.00285 1.337478 0.9725 292 31.74152 7.533

Q14108 SCARB2 0.91485 0.796744 478 54.25546 5.135

P15291-2 B4GALT1 0.852987 0.735356 385 42.51059 8.5

P51572 BCAP31 0.946674 1.001908 0.936711 246 27.97401 8.441

E9PQW0 PEX16 0.739747 60 6.828543 8.69

Q9H4G0-4 EPB41L1 1.079995 0.94112 0.691207 701 78.78222 7.093

Q5TB53 TM9SF3 1.044122 1.176811 1.01852 254 29.91872 5.821

Q96E11-2 MRRF 1.006137 0.813755 201 22.43575 9.715

B4DSN5 PTPN1 0.975514 1.198382 1.02545 362 41.23352 5.973

Q13740-2 ALCAM 1.304214 1.065807 1.040666 570 63.62447 7.298

Q9HDC9 APMAP 1.059751 1.719589 0.767649 416 46.45085 6.164

C9JFR7 CYCS 0.500598 0.686837 0.429284 101 11.32596 9.657

P09382 LGALS1 1.711321 2.920376 135 14.7062 5.503

P60201 PLP1 0.911351 277 30.0571 8.353

Q9Y5L4 TIMM13 1.143695 1.50709 0.927134 95 10.493 8.177

P10606 COX5B 0.823219 0.631925 0.835023 129 13.68694 8.807

K7EJ78 RPS15 0.925059 129 14.72883 10.24

C9IZ01 GFM1 0.587804 0.935326 0.620201 591 65.9928 8.06

P06744 GPI 1.348222 1.828248 1.178758 558 63.10725 8.324

Q9UL25 RAB21 1.085956 225 24.33226 7.943

of 313

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93

93

G8JLQ3 BLOC1S1 1.164209 75 8.562332 5.973

O95831-3 AIFM1 0.940237 0.661734 1.070264 609 66.25356 8.939

A6NLH6 CNIH4 0.526879 1.017896 137 15.75993 6.961

Q9BSJ8 ESYT1 0.941908 0.91924 0.810372 1104 122.78 5.833

P61981 YWHAG 1.142905 247 28.28491 4.894

P18669 PGAM1 3.402846 2.572908 1.775781 254 28.78584 7.181

P06865 HEXA 0.741061 1.292861 0.744929 529 60.66428 5.161

Q9Y2T3-2 GDA 1.566466 380 42.41842 5.478

C9J388 GALNT3 1.545813 90 10.78688 10.37

P43487 RANBP1 1.57851 2.930969 2.310803 201 23.29557 5.288

H3BNE1 SNAP23 1.377626 97 11.13347 4.945

J3QQY2 TMCO1 0.474765 104 11.36482 9.657

K7EQB1 STX8 0.998855 125 14.15518 4.526

B3KP87 MDS025 1.39529 153 17.80015 6.049

Q92599-3 SEPT8 1.120498 369 43.49215 6.341

P61769 B2M 1.401427 119 13.70591 6.522

G3V576 HNRNPC 1.169722 2.128537 0.967671 231 25.24106 9.818

D6R9X5 G3BP2 1.120781 56 6.446252 9.129

H0Y2L7 HMGCL 1.296851 182 19.0678 8.558

F8W8K9 AP1S3 0.807881 63 7.753411 10.55

Q5BJF2 TMEM97 0.875928 0.795105 0.757884 176 20.83417 9.378

B4DHW1 TMEM165 0.974704 1.003516 0.941358 261 28.41395 6.537

O95716 RAB3D 0.760676 219 24.25181 4.932

P11279 LAMP1 0.608898 1.120847 0.706852 417 44.85382 8.749

D6RFY5 PIN4 0.694351 106 11.91329 9.217

Q8IVT2 MISP 1.199723 0.98305 1.110681 679 75.31095 6.83

Q9BQB6-3 VKORC1 0.876945 92 9.868119 8.397

Q562R1 ACTBL2 0.9542 376 41.97597 5.592

of 313

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94

94

G3V1I3 FAM9C 0.945348 128 14.75897 4.412

P05386 RPLP1 1.205217 2.053789 0.964117 114 11.50669 4.323

E9PPH5 ANP32E 1.637476 114 13.12044 4.221

O75489 NDUFS3 0.592567 0.923178 264 30.22271 7.503

C9JNK6 MTX2 0.767573 207 23.62804 6.786

P13284 IFI30 0.963744 0.568155 0.601458 250 27.94501 4.881

O95292 VAPB 1.125427 0.969664 243 27.21109 7.298

O75439 PMPCB 0.659306 0.939695 0.498041 489 54.3315 6.83

O15173 PGRMC2 0.827862 1.932896 0.829608 223 23.80373 4.881

Q6YN16 HSDL2 0.823101 0.762803 418 45.36552 7.987

Q13637 RAB32 1.051914 1.252506 0.905242 225 24.98169 6.537

P16278-3 GLB1 0.840196 0.913291 0.761187 647 72.70454 6.252

Q99536 VAT1 1.187142 0.901623 1.084757 393 41.89342 6.291

Q8N4H5 TOMM5 0.591459 51 6.031371 9.701

Q96HS1-2 PGAM5 0.454368 1.187436 255 28.00246 7.254

P31947 SFN 3.446891 248 27.75669 4.742

Q96CS3 FAF2 1.089111 1.28199 0.972315 445 52.59055 5.618

Q7Z650 MTHFD2 0.605882 0.492332 1.147144 248 26.83225 7.181

F5H1S8 MLEC 0.980032 1.037988 146 16.71859 5.567

P30049 ATP5D 0.934173 0.710515 168 17.47919 5.491

C9JP16 CRTAP 1.000826 1.113831 358 41.40646 5.872

P48449-2 LSS 0.915827 1.416043 0.777651 652 74.16963 6.456

K7EP16 EIF3G 1.661915 118 13.20375 9.349

Q16850 CYP51A1 0.662896 0.698398 0.722726 503 56.76947 8.529

O75531 BANF1 0.762528 89 10.05202 6.087

O75844 ZMPSTE24 0.86299 0.817096 0.784706 475 54.77753 7.489

Q86UE4 MTDH 0.907267 0.715012 0.654347 582 63.79881 9.32

F8W6E4 GPD2 0.899309 0.75753 0.803208 500 55.72346 6.252

of 313

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95

95

D6RA82 ANXA3 2.968576 2.210312 1.509352 284 32.09853 5.935

Q9Y3D5 MRPS18C 0.82206 142 15.83928 9.554

Q12965 MYO1E 1.157812 1.586147 0.860113 1108 126.982 8.924

E9PCY7 HNRNPH1 1.363449 1.306548 1.101049 429 47.05745 6.341

E9PI87 HTATIP2 0.865647 0.838961 196 21.96233 7.401

P00167-2 CYB5A 0.906793 98 11.26149 5.135

P63218 GNG5 1.272266 68 7.313805 9.847

P61619 SEC61A1 0.879768 0.896405 0.827963 476 52.23052 8.06

H3BRS6 ADPGK 0.893255 204 21.90121 5.542

P13489 RNH1 1.652398 1.238122 461 49.94109 4.818

O95167 NDUFA3 1.14379 84 9.272854 8.456

B1AK63 MEAF6 1.387248 169 19.15251 9.071

H0YGH6 A2M 0.730294 200 21.88479 6.164

P62913-2 RPL11 1.272692 1.258457 0.902436 177 20.11158 9.598

F8WE40 PPP1R21 1.686818 54 5.996114 8.148

Q9UM22 EPDR1 1.020808 1.082312 0.768408 224 25.42059 6.595

Q9HCU5 PREB 1.062268 1.629471 0.735926 417 45.43967 7.884

C9J4I9 PXDN 0.821855 224 25.55339 9.071

Q9UQ80 PA2G4 1.590945 1.198977 1.160384 394 43.75919 6.551

Q14974 KPNB1 1.22989 1.503563 1.088321 876 97.10802 4.78

P24534 EEF1B2 1.585491 1.279222 1.094085 225 24.74826 4.666

Q12797-10 ASPH 1.043348 1.189876 0.813744 729 83.21622 4.919

J3QLD9 FLOT2 1.032759 1.570063 0.976805 428 47.11269 5.313

I3L1P8 SLC25A11 1.077713 0.696175 296 32.16176 9.774

C9J3L8 SSR1 0.93948 1.461099 0.808455 265 29.55479 4.297

Q7L2E3-3 DHX30 0.849954 0.940023 0.934964 1155 129.3572 8.529

Q16401-2 PSMD5 1.194932 1.623917 461 51.27975 5.44

C9JAG1 EPT1 0.751895 180 20.54343 6.507

of 313

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96

96

P47985 UQCRFS1 0.652977 274 29.64937 8.324

Q9Y281-3 CFL2 1.417396 1.240597 149 16.90597 8.617

Q9BQC6 MRP63 0.859636 102 12.25851 11.44

Q68CR9 DKFZp781B11202 1.19292 0.795632 0.839561 401 45.7421 5.707

P22234 PAICS 1.702885 425 47.04914 7.225

O15427 SLC16A3 1.232511 1.776773 0.928498 465 49.43689 7.958

O00410 IPO5 1.463066 1.30058 0.90374 1097 123.5499 4.945

H3BNK3 NDUFAB1 0.729937 1.041921 111 12.20118 4.627

K7EKI4 MRPL4 0.721064 127 14.04731 7.401

O43752 STX6 0.887754 255 29.15782 4.932

H0Y4R1 IMPDH2 1.902177 1.154282 1.101765 470 51.03521 8.177

Q8TF09 DYNLRB2 1.842978 0.831149 96 10.84772 7.503

H7C3P4 GNS 0.696256 0.943496 0.683875 496 56.33784 7.914

P25788-2 PSMA3 2.155845 248 27.62974 5.326

H0YD64 SLC43A3 0.840539 0.847195 137 15.77293 9.042

P13674-3 P4HA1 0.892033 0.747971 0.914487 516 58.92102 6.024

O14828 SCAMP3 0.890442 0.891977 347 38.26233 7.635

O43615 TIMM44 0.861854 0.602304 452 51.32346 8.324

Q5T0M2 SFTPD 1.430391 218 20.98747 9.334

H0YA96 HNRNPD 0.899992 2.609714 0.891389 210 23.90618 9.583

Q5T7C0 HMGB1 1.619916 97 11.34476 9.891

O94874-2 UFL1 1.047756 1.340076 0.869645 729 82.04688 6.961

O00186 STXBP3 1.092524 1.366247 0.949951 592 67.72085 7.796

H0YD18 NUCB2 0.551343 0.921066 0.543678 73 8.61033 5.034

O00303 EIF3F 1.370267 1.308429 0.918465 357 37.54015 5.453

B4DXI5 HACL1 1.011871 0.775829 0.904438 496 54.68875 7.386

O14908-2 GIPC1 0.833121 0.748431 236 26.0554 5.567

J3QT77 PON2 0.861767 0.894472 0.683039 342 37.95661 5.719

of 313

Ant

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Pero

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doxi

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cru

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The

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may

dif

fer

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97

97

P31942-6 HNRNPH3 1.127698 139 15.40311 6.405

P31948 STIP1 1.849264 0.868017 543 62.59941 6.8

C9JH92 CRYZ 1.182705 0.995488 206 21.91846 8.763

Q9NTJ5 SACM1L 0.965358 0.756503 0.77892 587 66.92401 7.123

Q12907 LMAN2 0.983969 1.472574 0.593896 356 40.2031 6.947

H0YL72 IDH3A 0.749484 331 35.76304 6.443

Q9NVX0-2 HAUS2 0.648186 141 16.52282 8.441

E9PK34 ARCN1 1.916516 83 9.096853 9.496

Q8IV08 PLD3 0.73999 0.772273 0.894603 490 54.67051 6.468

P61225 RAP2B 1.225306 183 20.49121 4.805

C9J151 CLASP1 1.95138 1.10518 150 16.47028 5.681

E5RFI3 PPP2CB 0.856556 125 14.48235 5.846

Q13813-3 SPTAN1 1.139287 1.219372 1.1031 2452 282.108 5.338

K7EJE8 LONP1 0.829917 1.016024 0.519841 829 93.23797 6.494

Q9UNE7 STUB1 1.148392 0.866995 303 34.83425 5.872

Q3ZAQ7 VMA21 0.810308 1.110932 101 11.34687 7.24

Q5RI15 COX20 1.256363 0.797828 118 13.2828 8.763

O95832 CLDN1 1.142394 0.875745 211 22.72858 8.089

Q53GA4 PHLDA2 0.940372 0.863586 152 17.08185 9.173

E7EPW2 MRPS25 0.661211 0.804902 110 12.93769 9.745

H7C1H2 PSMD2 1.011241 2.326836 203 22.42748 6.888

P25786 PSMA1 2.193811 263 29.53686 6.61

Q9H3N1 TMX1 0.844979 2.043181 280 31.7708 4.983

B4DJ81 NDUFS1 0.974395 0.790292 0.38251 611 66.87901 5.376

Q12805-2 EFEMP1 0.801188 1.250061 0.854084 485 53.6867 5.021

B4DDG7 AP1M1 0.933933 1.013888 0.758721 351 40.22886 7.196

E5RIU6 CDK1 1.693136 1.248107 189 21.7245 8.514

Q96N66-3 MBOAT7 0.846529 1.232302 0.640309 344 38.44495 8.866

of 313

Ant

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Pero

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The

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may

dif

fer

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98

98

Q5T8R5 SLC16A1 1.263313 2.216101 456 49.18659 9.159

P27449 ATP6V0C 0.967412 1.412399 0.842574 155 15.72546 8.441

G3V5Q1 APEX1 1.136659 1.255624 0.974198 242 27.10788 8.763

Q02809 PLOD1 0.877053 0.822037 0.784821 727 83.49739 6.947

G3V2B8 MTHFD1 1.347932 1.357394 1.207432 935 101.4673 7.298

A8MUF7 HBE1 0.656514 2.016002 87 9.463879 9.129

P51398-2 DAP3 0.575503 0.867781 357 41.01839 8.983

Q5HY57 EMD 0.857364 0.682404 219 24.92288 5.021

P10109 FDX1 0.806776 184 19.38062 5.833

B7Z6A8 ABHD10 0.814569 149 16.89883 6.727

P35527 KRT9 0.97582 623 62.02682 5.237

Q9ULV4 CORO1C 0.991697 0.92873 474 53.21506 7.079

Q8NC51-4 SERBP1 1.738228 1.416782 1.265482 387 42.40128 8.441

B7Z3G9 RASA3 1.17287 132 15.40668 8.763

O60220 TIMM8A 0.68574 1.020334 0.682477 97 10.9913 5.161

Q9Y305-2 ACOT9 1.137077 0.758182 406 46.32453 7.972

Q9BZ62 FKSG61 0.770369 124 13.83909 9.203

P19338 NCL 1.040359 1.025532 0.933224 710 76.56836 4.704

R4GN43 NDUFA6 0.668874 1.001193 71 8.50446 9.466

Q9P0L0 VAPA 1.398465 1.527194 0.837129 249 27.87521 8.617

Q5SQT6 PPA1 1.184002 178 19.96892 5.25

H7C4G5 RUVBL1 1.037621 1.736831 267 30.00456 5.554

Q15043-2 SLC39A14 1.264436 1.01454 1.024396 481 52.80448 5.77

Q8NBP7-2 PCSK9 0.88743 0.750024 196 20.81377 8.397

Q99584 S100A13 1.212684 98 11.46409 6.164

Q01813-2 PFKP 1.616762 1.886669 1.278092 776 85.26146 8.587

Q27J81-2 INF2 1.445221 1.514672 0.958636 1240 134.5334 5.529

P38919 EIF4A3 1.32645 411 46.84118 6.727

of 313

Ant

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Pero

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The

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99

99

Q8NBX0 SCCPDH 0.817882 1.056136 429 47.12145 9.144

J3QLR8 MRPS23 0.789258 152 17.50639 9.627

B7Z1R5 ATP6V1A 1.237055 584 64.69478 5.656

J3KNB5 GPX8 1.291884 0.919668 90 10.06874 10.24

Q10567-4 AP1B1 0.791809 919 101.2835 5.11

Q96CW1-2 AP2M1 1.102053 1.818434 0.835605 433 49.35791 9.54

P49327 FASN 1.882644 1.564007 1.401742 2511 273.2543 6.443

Q9BTU6 PI4K2A 0.652547 1.177311 0.596076 479 53.98861 8.294

B4DT69 DLD 0.743285 0.989039 0.76888 461 49.25137 7.679

B1ANR0 PABPC4 1.481386 615 67.92792 9.452

Q9UMX5 NENF 1.037892 1.048986 1.05816 172 18.84479 5.694

B4DLW8 DDX5 1.271055 1.583436 1.034134 535 60.52538 9.071

O00592-2 PODXL 1.223322 1.00787 0.985307 526 55.35142 5.58

R4GN99 PPIF 0.734405 0.925852 145 15.34077 9.247

Q92520 FAM3C 0.858676 1.058761 227 24.66458 8.294

O60701-2 UGDH 1.486766 2.369461 0.754955 427 47.57231 5.922

F5H7M3 DLAT 0.802293 0.975184 0.665679 418 44.6336 6.443

K7EIN4 TMED1 0.97612 82 9.629161 8.968

Q92598-2 HSPH1 1.486035 1.487949 1.475798 814 92.05745 5.554

Q9UNN8 PROCR 0.910456 2.103759 0.758776 238 26.65458 7.181

O75414-2 NME6 0.605335 119 13.50185 5.783

P07858 CTSB 0.86307 339 37.79684 6.303

B7Z5W8 DLST 0.903802 1.609263 0.387486 367 39.52787 9.554

H3BPA9 NUP93 1.363568 0.839605 230 26.39812 5.922

H7C531 PSMD6 1.37871 138 15.95713 6.138

A1L3A6 NUFIP2 1.511288 120 14.63392 8.075

F5H826 NOMO3 1.048414 0.90546 0.948643 1100 121.943 5.694

P46977 STT3A 0.920142 1.377587 0.849084 705 80.47685 8.075

of 313

Ant

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100

100

F8WEV7 SUMF2 0.955361 102 10.86275 10.15

D6RC06 HINT1 3.252862 65 7.318954 9.408

H7C0D9 POLR1B 1.155853 308 34.42123 6.417

M0QXF7 C19orf10 0.808628 1.538965 0.684605 84 9.663568 4.996

Q9BRQ8-2 AIFM2 1.285245 1.03152 0.868966 336 36.49731 9.261

D6RH20 MRPS27 0.929614 1.810816 0.631838 299 34.43659 5.58

Q14696 MESDC2 1.137482 0.851096 0.685203 234 26.06031 7.782

Q9UBR2 CTSZ 0.757963 0.79509 0.796878 303 33.84622 7.108

Q6PI48 DARS2 0.843445 1.476624 0.729804 645 73.5161 8.016

Q03519 TAP2 0.946329 1.038205 0.874849 686 75.61581 8.016

Q15800-2 MSMO1 0.780947 162 19.45783 7.708

O43795-2 MYO1B 1.190268 1.057615 1078 124.8719 9.203

B4E2S7 LAMP2 0.649824 0.942853 0.612689 363 39.78684 5.668

P49721 PSMB2 1.719065 201 22.82168 7.02

E7ENA9 NCSTN 1.006023 1.166959 0.903849 451 50.22973 5.643

P82932 MRPS6 0.694656 125 14.21759 9.261

Q9H4A6 GOLPH3 0.47583 0.894545 298 33.7895 6.443

H3BRV3 MAN2C1 1.181813 77 8.696426 8.573

Q7Z7H8 MRPL10 0.901762 1.028103 261 29.26368 9.583

K7EJ83 CDK3 1.328211 213 24.42697 8.016

G3V1S6 GALNT2 1.260822 0.94241 1.033844 533 60.75543 7.65

P29992 GNA11 1.031481 0.880584 359 42.09652 5.694

P62330 ARF6 1.008838 175 20.06944 8.954

I3L1H3 LITAF 0.874305 68 7.367382 7.445

P28074 PSMB5 1.580678 263 28.46221 6.917

Q01082-3 SPTBN1 1.179103 1.175346 0.976195 2155 251.2412 5.529

Q99653 CHP1 0.576249 195 22.44234 5.097

Q2TB90 HKDC1 0.676628 0.573985 917 102.4785 7.123

of 313

Ant

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Pero

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101

101

P82675 MRPS5 1.022344 0.662661 430 47.9761 9.92

C9JJ54 WDFY1 0.892774 0.759744 215 24.24417 7.796

Q96TA1-2 FAM129B 1.326602 1.318136 1.052594 733 82.63093 6.151

Q5SZE1 CERS2 0.896112 0.877504 0.681865 324 38.49522 9.144

O60716-32 CTNND1 1.107563 1.054132 0.918675 589 65.60001 8.133

F2Z3J9 PTGR1 1.458885 118 13.43588 5.554

H7BZ72 NOP58 0.92172 187 21.20553 5.148

E9PNW8 FAR1 0.922818 1.628174 0.887954 335 37.45766 6.917

O15270 SPTLC2 0.755711 0.816155 1.022249 562 62.88386 7.782

P60602 ROMO1 1.114651 79 8.176862 9.334

O60831 PRAF2 0.940022 0.997831 0.994865 178 19.24552 9.188

Q5T1M3 SLC31A1 1.538724 188 20.99112 7.152

Q9HB71 CACYBP 1.536034 228 26.19365 8.25

Q16864 ATP6V1F 1.926234 119 13.36195 5.516

Q9NZ01 TECR 0.768905 2.079845 0.833769 308 36.01078 9.452

M0R1L7 CHMP2A 1.126957 1.16744 159 18.7266 9.481

Q00765 REEP5 0.877974 0.83712 189 21.47904 8.104

H0YD97 PDHX 0.797406 189 20.65991 7.342

Q9Y3A6 TMED5 1.077755 1.190711 0.91123 229 25.98819 4.843

P18206-2 VCL 1.768811 1.923924 0.879547 1066 116.6493 6.087

F5GZY7 GABARAPL1 1.129263 70 8.571752 9.95

K7ES82 CAPNS1 1.699408 0.745452 100 11.39149 5.415

O14773-2 TPP1 1.130555 320 34.44196 6.087

B4DWJ2 QARS 1.23714 1.016419 0.882057 764 86.52421 7.049

E9PFD2 UMPS 1.726265 0.985496 342 37.61611 8.089

Q9BV43 PDIA5 0.924283 1.824159 0.774782 262 30.10461 8.924

J3QSF2 SLC12A4 0.840389 91 9.81709 8.719

P78310-2 CXADR 1.268586 0.901349 0.987165 344 38.09933 7.547

of 313

Ant

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Pero

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102

102

P35908 KRT2 1.019978 0.856203 0.984704 639 65.39322 8.001

Q13724-2 MOGS 1.044736 1.298356 0.884982 731 80.65263 7.108

H0YFP4 GPR89C 1.276886 122 13.67608 9.92

H7BXQ8 ARMC10 0.901244 193 20.85772 7.84

P42126-2 ECI1 0.792812 0.673548 285 30.87627 8.895

E7EQS5 DMD 1.264136 2.239666 1.017674 1225 141.3109 6.024

E9PEF9 AKR1B1 1.352448 102 10.99773 6.756

Q14204 DYNC1H1 1.372133 1.438188 1.102725 4646 532.0719 6.405

B1AXG2 RPS6KA3 1.568099 133 15.25818 8.836

P17813-2 ENG 1.124942 1.066038 625 67.49872 6.566

D6RDM7 UBE2K 1.087814 123 14.02619 7.181

F5H801 OGDH 0.736426 0.751363 0.683379 974 110.5408 6.844

O75521-2 ECI2 1.254443 359 39.58436 8.646

O15127 SCAMP2 1.231236 0.734023 329 36.62534 6.1

F5H702 MRPL48 0.875202 113 12.76165 5.237

Q8WTV0-4 SCARB1 0.981031 1.959415 0.775127 474 53.54381 7.254

O15258 RER1 0.752135 196 22.94286 9.54

I3L3Z1 SHCBP1 1.165636 155 17.6855 4.627

Q15056-2 EIF4H 1.523391 1.372811 228 25.18452 8.089

Q96JB5-3 CDK5RAP3 0.843484 0.955776 281 31.18103 4.513

Q8NFQ8 TOR1AIP2 0.9361 470 51.23215 4.958

Q9BWD1 ACAT2 2.192211 1.162535 397 41.32439 6.917

P49591 SARS 1.651656 1.390755 514 58.74005 6.43

Q13217 DNAJC3 1.106552 1.231576 0.930653 504 57.54417 6.151

Q5R3B4 MPC2 0.37012 0.799854 105 11.67318 10.2

H0YE35 RIC8A 1.29523 147 16.24857 4.615

O95858 TSPAN15 294 33.14284 5.478

P50395-2 GDI2 1.413569 400 45.59022 6.24

of 313

Ant

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Pero

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The

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from

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of.

103

103

Q8WUK0-2 PTPMT1 1.248374 137 15.67942 9.847

H0YMJ5 IGF1R 1.086405 190 21.24445 5.11

Q9BSD7 NTPCR 1.008314 190 20.70011 9.54

D6R9X9 RPL37 1.470178 74 8.474352 10.35

Q9Y2R0 COA3 0.623199 0.654097 106 11.72413 9.598

M0R2T8 HOMER3 1.432533 85 9.530911 10.43

H7BZ81 RETSAT 0.919355 0.936578 320 35.15895 8.06

P11166 SLC2A1 1.158881 2.739135 1.030393 492 54.04854 8.719

P55884 EIF3B 1.63804 1.291677 814 92.42382 4.996

O15144 ARPC2 1.214495 1.441681 1.216683 300 34.31149 7.357

P00367 GLUD1 0.984987 0.685172 0.798359 558 61.3592 7.796

O75348 ATP6V1G1 0.943863 118 13.74908 8.792

Q9Y230 RUVBL2 1.173264 1.353981 463 51.12456 5.643

K7EPU3 ALG1 1.189406 1.301771 0.942201 184 20.16157 9.627

Q9NP72 RAB18 0.889836 206 22.96264 5.237

E5RHG9 UQCRB 0.714886 76 9.233928 8.119

M0R0G9 SNRPA 1.075854 0.987552 87 10.07624 9.598

P07108 DBI 1.877882 87 10.03802 6.566

P10909-4 CLU 0.598794 0.528685 0.836291 416 48.77213 6.712

Q9BV81 EMC6 1.209943 110 12.00954 10.07

J3KTF4 C17orf62 0.732428 88 9.800338 9.525

C9JEL7 NDUFAF7 0.580791 111 12.41143 7.342

M0R1B0 EMC8 1.069595 100 11.72048 5.084

Q15388 TOMM20 1.41537 145 16.28765 8.602

B4DE85 PTDSS1 0.772263 1.585746 0.814046 301 34.55655 8.573

Q86SX6 GLRX5 0.514122 0.561141 157 16.61754 6.786

H3BUZ3 CAPN3 0.992297 157 17.63556 6.189

C9J931 RHEB 1.415669 79 8.668373 6.024

of 313

Ant

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Pero

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104

104

F8WDA9 GK 0.772238 79 8.6422 7.298

P43007 SLC1A4 1.097573 532 55.68763 6.252

P41250 GARS 1.534113 2.499762 1.121268 739 83.11261 7.035

H3BN94 UBE2Q2 1.136098 91 10.48005 4.221

C9J712 PFN2 1.145189 91 9.791952 9.364

Q9BYN8 MRPS26 0.918735 0.944046 205 24.19686 10.39

Q96C36 PYCR2 0.838492 320 33.61569 7.767

E5RGC7 MRPS28 0.562606 0.728144 103 11.74014 8.045

Q8NFJ5 GPRC5A 1.179067 0.938988 0.894057 357 40.22494 8.148

Q5TB21 APH1A 0.580293 150 15.84236 6.265

Q6Y1H2 PTPLB 0.832488 254 28.35014 9.554

J3KS17 APOH 0.781458 104 11.65429 6.494

Q9BVC6 TMEM109 0.837747 0.910029 0.806986 243 26.19359 10.48

K7ESE6 G6PC3 1.017857 0.998602 243 27.58953 8.924

Q14739 LBR 0.673257 615 70.65803 9.364

B4DVY1 EIF3D 1.436522 0.998114 499 58.10371 5.707

P07814 EPRS 1.67338 1.334158 1.198086 1512 170.4831 7.328

F8VZX9 METAP2 1.751555 163 18.08869 5.351

P56589 PEX3 0.689359 0.689336 373 42.11295 8.148

C9JQQ5 ATL2 1.263679 175 20.28729 7.533

Q9HD33-3 MRPL47 0.830584 1.164369 140 16.98042 10.71

P02792 FTL 0.827784 175 20.0071 5.783

P23526 AHCY 2.047492 1.426446 1.124553 432 47.68521 6.341

F8VPD4 CAD 1.289825 1.263263 1.045123 2162 235.873 6.551

Q9UGP8 SEC63 1.14793 0.97752 0.798299 760 87.94161 5.313

Q9UHA4-2 LAMTOR3 0.80316 0.751869 117 12.93295 8.133

O14949 UQCRQ 0.677723 82 9.900121 10.08

O94973 AP2A2 0.97665 0.894192 939 103.895 6.961

of 313

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105

105

B7Z4K6 DNASE2 0.844035 0.995393 0.799537 305 33.59369 8.324

Q15904 ATP6AP1 0.836096 2.193159 0.751944 470 51.9926 6.138

F5H241 GBA 0.762198 0.67644 0.702621 423 47.53423 7.284

F8WEJ5 ASNS 1.304314 401 45.597 7.093

Q8IVL5 LEPREL1 0.963144 0.645556 0.941739 708 80.93322 5.707

O43491-2 EPB41L2 1.141583 0.775995 0.84243 673 76.0062 6.961

P55809 OXCT1 0.658775 1.177417 0.862764 520 56.12193 7.459

Q13488 TCIRG1 0.975484 0.795106 830 92.90836 7.123

F5H6I7 ATL3 1.017233 1.549397 0.876098 523 58.73556 5.643

E9PNE7 SLC39A13 1.31063 321 33.75938 7.679

J3KSR8 SRSF1 0.986349 143 16.44028 11.44

Q5TCI8 LMNA 0.826178 0.74603 491 55.72859 7.02

O95168-2 NDUFB4 0.993315 120 14.01742 9.803

P04181-2 OAT 0.812678 0.52964 301 32.83215 5.326

Q9Y679-3 AUP1 1.458381 0.953911 373 41.35868 7.899

Q92847-2 GHSR 2.206096 289 32.1319 8.06

C9JC03 EHD1 1.154728 0.656458 374 42.71039 8.426

K7EK06 FARSA 1.466376 169 18.49034 5.592

A6NH27 ZWINT 1.334302 157 18.21335 7.416

C9JD65 ATG9A 0.921755 133 15.62922 8.382

O95782-2 AP2A1 1.081109 1.873053 0.967499 955 105.2947 7.665

D6RGY8 YIPF3 1.003007 109 12.28186 4.564

Q16851-2 UGP2 1.494879 497 55.64208 7.884

B4DFA2 NSF 1.065248 1.093724 0.943217 644 71.53859 6.654

H0Y750 ATP6AP2 0.756568 0.617391 243 26.61486 7.899

P49419-2 ALDH7A1 1.027341 1.12307 0.784116 511 55.33146 6.859

H0Y715 CACNA2D1 0.660242 280 32.49528 5.465

Q07960 ARHGAP1 1.645075 1.223462 439 50.40419 6.291

of 313

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106

106

P20020-5 ATP2B1 1.158381 1.066843 1171 129.0702 6.164

E9PN51 NDUFS8 0.506589 110 12.39731 9.979

E5RJH9 SQLE 0.766742 184 20.33942 6.405

K7EP23 SF3A2 1.158579 135 15.21484 9.774

H0Y9Y1 BTF3 1.669559 86 9.493752 4.996

Q15149-3 PLEC 1.022118 1.009423 0.914809 4570 517.7164 5.745

H7C1D4 TSN 1.312081 185 21.10703 7.196

A6ND22 MRPS16 0.748673 99 11.14286 9.686

Q96CT7 CCDC124 1.358862 1.115188 223 25.81956 9.54

Q9NRP0 OSTC 0.925778 1.163102 0.770044 149 16.81784 9.129

C9JA28 SSR3 0.91842 0.838837 0.914319 174 20.14854 9.437

O94925-3 GLS 0.735102 1.370408 0.492763 598 65.41791 7.884

Q9NUQ9 FAM49B 1.087859 324 36.72465 6.062

H0YJC0 PSMC6 1.198227 1.098817 262 29.63245 6.405

D6R937 AIMP1 1.134497 150 16.568 9.261

Q15599-2 SLC9A3R2 1.152308 0.88025 326 36.13141 8.207

F6SBX2 IARS2 0.556246 0.910806 0.564131 940 105.972 6.481

B4DEK4 SNX2 0.833646 0.987762 402 46.06873 7.24

D6RAE7 CCHCR1 1.432648 126 14.39542 5.681

O00754-2 MAN2B1 0.927828 1.266424 0.790621 1010 113.5443 7.284

P26599 PTBP1 0.736467 2.649674 0.992703 531 57.18564 9.173

B1AJQ6 STX12 1.070025 1.926368 215 24.56134 5.148

P14174 MIF 2.19248 2.590372 1.522282 115 12.46822 7.884

O14662-3 STX16 0.928711 115 13.00968 4.932

Q9HAV7 GRPEL1 0.757742 217 24.26392 8.119

K7ERP1 ROGDI 1.020845 230 25.33895 8.353

Q15437 SEC23B 1.305768 1.528303 1.037696 767 86.42352 6.888

E9PH05 FAM162A 0.640189 141 15.94839 9.95

of 313

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107

107

Q13492-4 PICALM 0.943702 1.707659 0.789813 551 59.88067 8.763

Q9UBM7 DHCR7 0.797564 1.126889 0.630026 475 54.45377 8.705

E9PLG2 PSMC3 1.751313 193 21.5292 5.097

H7BYN3 TFAM 0.797145 219 25.66063 9.657

Q8TCT9-5 HM13 0.848698 0.908133 0.807801 335 36.79014 6.683

Q9P0I2-2 EMC3 1.185285 219 24.89899 9.73

Q9Y320-2 TMX2 1.124285 0.908489 0.781832 258 29.62322 8.646

G5E999 TRO 1.147932 284 33.49956 9.569

P07948-2 LYN 1.062071 491 55.99746 6.494

H0YCW6 ALG9 0.952327 207 24.29349 9.422

Q96CN7 ISOC1 1.115217 298 32.21612 7.386

P10619 CTSA 0.835223 0.781734 0.877583 480 54.43112 6.61

Q96QD8 SLC38A2 1.409894 1.429413 506 55.98953 8.001

Q9BQ69 MACROD1 0.821291 325 35.48272 9.51

P07919 UQCRH 0.498351 91 10.73194 4.437

B3KVK7 MARS 1.302166 1.057521 546 61.77631 5.262

H0Y524 CPNE1 1.074103 208 21.44271 8.119

Q8WUY1 THEM6 0.945819 0.785596 208 23.84987 9.554

P61221 ABCE1 1.247269 0.949353 1.371781 599 67.27102 8.338

B4DUQ5 SLC25A32 0.907735 183 20.99708 9.583

Q9H773 DCTPP1 1.684555 170 18.66936 5.034

H0YAG8 ADH5 1.01398 262 27.529 6.202

O00526 UPK2 0.792403 184 19.42569 10.4

C9J0H3 PLSCR1 1.24945 171 19.39654 5.833

E9PGB1 CTBP1 0.819009 145 15.90726 6.367

G3V4F2 ACOT1 0.852765 0.990384 395 43.70566 6.991

R4GNE4 GPX4 1.106562 2.406508 0.853905 145 16.79655 11.17

Q8WY22 BRI3BP 1.050915 1.081041 0.939209 251 27.81784 9.437

of 313

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108

108

H7C089 TTC38 1.872607 119 12.87459 6.354

Q8NB15-2 ZNF511 1.625077 252 28.24685 7.665

Q9H9H5 MAP6D1 0.641135 199 20.99163 10.07

P28799-2 GRN 0.827023 438 46.9577 7.035

F8VNT9 CD63 0.827565 0.902124 0.847852 133 14.2554 7.591

Q13283 G3BP1 1.486912 1.217856 0.988605 466 52.13208 5.516

Q8N1N4 KRT78 1.068822 520 56.83049 6.024

B1AH87 TSPO 0.676872 107 11.88798 9.247

P20618 PSMB1 1.230592 2.060151 241 26.47237 8.133

Q6P1M0 SLC27A4 0.853427 1.015222 0.893677 643 72.01814 8.47

Q15785 TOMM34 1.013536 1.178984 309 34.53776 8.983

E7EPJ0 C10orf112 1.265377 350 38.30665 4.818

Q8TCS8 PNPT1 0.935007 0.860943 0.682558 783 85.89663 7.767

H7BYH4 SOD1 1.197198 1.617886 135 13.90083 6.113

P48960-2 CD97 1.03104 1.360822 1.037025 742 81.68971 7.049

P08574 CYC1 1.123654 0.780609 325 35.39897 8.998

P51688 SGSH 0.882958 0.979754 502 56.65945 6.947

Q3ZCQ8 TIMM50 0.500185 0.762324 0.892433 353 39.62154 8.368

P37108 SRP14 1.273184 136 14.56082 10.04

B4DGQ0 LASP1 0.741397 205 23.16723 4.945

O43837-2 IDH3B 0.658972 0.485092 383 41.86035 7.591

P17568 NDUFB7 0.864138 137 16.39127 8.924

O43242 PSMD3 1.88696 1.325435 1.688353 534 60.93949 8.441

P51991-2 HNRNPA3 1.248919 356 37.00618 8.309

P62195-2 PSMC5 2.38722 2.219372 1.043626 398 44.75569 8.177

J3KS15 ICT1 1.320623 192 21.89139 9.715

Q92575 UBXN4 1.019874 0.83535 508 56.74269 6.379

B4E1G1 DERL1 1.012082 151 17.02173 9.891

of 313

Ant

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109

109

Q14126 DSG2 1.066754 1.050857 1.090291 1118 122.2176 5.237

Q9Y3D6 FIS1 0.475392 152 16.92702 8.792

B4DR64 CTPS1 1.530362 360 41.19385 6.888

Q9Y3A5 SBDS 1.252294 250 28.74532 8.749

F8W785 GOLIM4 0.976545 0.554716 0.377185 668 78.71265 4.742

B4DKI1 ANXA8L1 1.23718 265 29.99811 5.338

P48509 CD151 1.249102 1.275855 0.984759 253 28.27631 7.474

H0YB83 RMDN1 1.3707 225 25.92103 5.503

P09497-2 CLTB 1.118839 211 23.16714 4.691

P13010 XRCC5 1.183543 0.889252 732 82.65228 5.808

H7C5Q9 PPP2R5D 0.96828 155 18.62046 7.972

B8ZZ51 MDH1 1.839668 169 18.67754 5.935

Q9Y5J5 PHLDA3 0.678766 127 13.88242 9.671

B7Z5E2 PSMC2 1.593874 0.93494 296 33.25224 8.412

P16401 HIST1H1B 1.072091 226 22.56647 10.92

D6R9H7 ATP5G1 1.180764 1.337366 99 10.18834 10.4

Q00534 CDK6 2.145621 326 36.91503 6.456

J3KSI8 MRPS7 0.902594 156 18.37262 10.13

B4E0P1 PSMB7 2.215234 142 15.31282 9.247

H0Y8D1 PRSS1 1.250055 142 15.41178 7.269

Q8WUM4 PDCD6IP 1.585894 868 95.96312 6.522

H3BUR9 CDIPT 0.915878 157 17.32359 6.654

C9JXZ0 PLOD2 0.552985 229 26.05239 8.309

B5MDQ4 RQCD1 0.96492 258 29.12136 8.031

M0QYE0 SH3GL1 1.896594 129 14.39252 7.372

B0V043 VARS 1.426902 1.444597 1264 140.3774 7.591

P53597 SUCLG1 0.711261 346 36.22685 8.792

Q9UHG3 PCYOX1 0.929033 2.924772 0.827446 505 56.60375 6.176

of 313

Ant

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110

110

F5H1I8 XRCC6 1.117477 1.123503 476 54.51675 8.954

A6NEM5 PIGK 0.839351 0.880026 332 37.76169 5.656

H7C5C8 MAATS1 1.688609 101 12.08862 10.4

Q9HA77 CARS2 0.817241 0.833524 564 62.18467 8.338

B0QZ43 ERLIN1 0.848482 275 31.05738 7.958

C9J8H1 ATP6V1E1 1.196086 1.017794 1.007808 203 23.52457 9.042

F5H342 SLC9C2 450 51.35212 7.225

J3KTK1 LPIN2 1.284922 233 25.59665 4.945

O75695 RP2 1.002286 1.705551 0.852253 350 39.61546 5.123

P49406 MRPL19 0.822931 292 33.51356 9.496

C9J719 EBP 0.820119 146 16.71063 7.005

H7C3I1 ST13 2.473939 146 16.31911 4.881

C9JGM7 DYNC1LI1 1.352286 190 21.36782 5.072

P23381-2 WARS 1.348628 1.041668 1.090538 424 48.149 6.354

P26196 DDX6 1.269469 483 54.38231 8.661

Q9Y512 SAMM50 0.765399 469 51.94332 6.903

O15121 DEGS1 1.05078 323 37.84116 7.459

Q9Y295 DRG1 1.193436 3.186811 367 40.51683 8.895

B7Z5H3 MAOB 0.323261 0.335428 0.837279 411 46.50874 8.28

Q9NSD9 FARSB 1.208562 0.808362 589 66.07355 6.844

F5H5L8 FOLR2 1.300796 1.108102 0.8732 148 16.88816 8.031

Q96S52-2 PIGS 0.86044 0.869886 547 60.96681 6.43

Q12846 STX4 1.148212 1.091465 297 34.15886 6.278

P53680-2 AP2S1 0.89416 104 12.40942 5.846

Q499Z4-2 ZNF672 0.850827 223 24.79632 8.983

F8W062 PLA2G1B 1.439988 119 13.21387 7.079

Q96L58 B3GALT6 0.944443 1.160404 329 37.1143 9.657

P08237-2 PFKM 1.527741 1.439542 1.192302 749 81.72348 7.621

of 313

Ant

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111

111

P49768-3 PSEN1 1.29948 374 42.2591 8.646

E7EP00 SEC24C 1.438154 1.454381 0.929165 975 106.5557 6.961

K7EK20 CARM1 1.10751 120 12.53511 6.756

Q16795 NDUFA9 0.566084 0.292001 377 42.48257 9.803

Q9Y3B7-2 MRPL11 0.760519 166 18.194 9.73

Q9BXW7-2 CECR5 1.023927 0.736165 393 43.56032 6.903

Q9Y6H1 CHCHD2 0.828483 151 15.5027 9.217

A8MU58 AIMP2 1.271989 1.606827 242 26.74293 8.075

G3XAN4 TRAM1 1.299262 288 33.41376 9.891

F5H843 SLC16A7 1.190195 379 41.69179 9.422

Q5W011 RBM17 1.189167 0.94415 212 24.16128 6.189

Q9Y3F4 STRAP 1.322691 1.402415 350 38.41398 5.123

Q02790 FKBP4 3.153252 1.134859 459 51.77207 5.427

Q01518-2 CAP1 1.446373 2.347952 474 51.79766 8.06

Q86UP2-2 KTN1 1.059863 0.755916 0.84917 1300 149.5189 5.707

E5RGA2 EIF3E 1.329778 352 41.33072 6.551

Q9Y2S7 POLDIP2 0.518845 368 42.00716 8.631

G3V1K1 CHCHD3 0.645291 138 15.54916 8.631

P53396-2 ACLY 1.956794 1.353749 0.965034 1091 119.6953 7.328

Q9Y6M7-11 SLC4A7 0.945963 463 52.21634 5.999

Q08379-2 GOLGA2 1.231848 620 70.42902 4.754

B4DND0 UPP1 0.902573 171 18.73872 9.73

Q02241-2 KIF23 1.363701 0.723528 1.029325 856 98.04387 8.47

P53621 COPA 1.255575 2.758402 1.17627 1224 138.2579 7.665

B4DKB2 ECE1 0.901665 0.983185 0.8194 738 83.52037 5.732

Q13423 NNT 0.745853 1.130768 0.782389 1086 113.8226 8.089

D6R9X8 ITGA3 1.069518 0.900973 142 15.21975 8.207

O14656 TOR1A 0.950648 0.628824 0.885189 332 37.78448 6.991

of 313

Ant

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112

112

E9PKA7 RCE1 1.074449 206 22.69662 7.577

F8WFB9 SH3GLB2 1.212563 127 14.47229 5.148

J3KN55 MMAB 0.714226 159 17.66105 7.796

G5E9W7 MRPS22 0.637004 0.779452 319 36.78293 6.815

O94826 TOMM70A 0.559331 0.971328 608 67.41203 7.123

B7Z5C0 DNAJA1 1.221172 240 27.52575 5.935

E7ETE2 HARS 2.197545 1.357281 0.97029 288 31.91085 5.681

R4GMY3 KIAA0368 2.097641 128 14.75896 9.071

Q6UB35 MTHFD1L 0.833667 0.672985 0.661624 978 105.7237 8.06

C9JG15 ATAD2B 1.354833 370 41.15475 9.73

P57105 SYNJ2BP 1.046476 145 15.91816 6.303

P11498 PC 0.769836 0.785721 0.68265 1178 129.5514 6.844

Q15046 KARS 1.374057 1.354475 1.141872 597 68.0046 6.354

O43776 NARS 1.611823 1.831599 548 62.90252 6.252

H0YHS6 YARS2 1.026806 291 32.16451 8.397

Q96QD5-2 DEPDC7 0.734628 0.896372 0.783459 502 57.66986 7.474

F8VZ44 AAAS 0.941853 3.431027 0.890853 422 45.60536 8.25

Q658P3-3 STEAP3 0.666776 1.300052 0.90822 487 54.43672 8.719

P08631-3 HCK 1.645563 504 57.20467 6.859

Q96AD5-2 PNPLA2 0.933287 180 19.86246 8.514

C9J8Q5 ALDH5A1 0.746859 507 53.83355 8.192

Q9UHL4 DPP7 0.709214 0.72615 0.961096 492 54.3072 6.316

E5RHD8 PTK2 1.514634 1.412668 115 12.85484 7.503

E9PBU3 ATIC 0.75035 2.229868 1.301977 591 64.48327 6.712

Q16774 GUK1 0.826706 197 21.7122 6.551

Q9UHR4 BAIAP2L1 1.377534 1.071519 511 56.84708 8.675

Q14318 FKBP8 0.550443 0.965954 412 44.53367 4.843

P30825 SLC7A1 1.099557 2.246054 0.900764 629 67.59414 5.427

of 313

Ant

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113

113

Q96L92-2 SNX27 0.834501 448 52.30108 6.367

K7EMK9 PPAP2C 0.984326 166 18.42744 8.06

Q96S66-4 CLCC1 0.835182 0.799298 366 39.81288 5.745

Q9BU61 NDUFAF3 0.451946 184 20.33742 8.221

Q9Y251-3 HPSE 0.876007 1.24858 0.734405 469 53.12712 9.408

P26639 TARS 2.209003 1.895454 1.444028 723 83.38187 6.668

M0R019 HNRNPM 1.243349 2.324147 0.865693 353 37.66014 9.027

K7EJ35 SYNGR2 0.278597 168 18.80017 4.539

B7Z589 SLC6A9 1.218745 0.77351 522 58.32185 7.02

H3BTB7 EARS2 0.835836 0.858241 506 56.78967 8.778

F5H335 EIF3A 1.417245 1.878101 1.011005 1348 162.5373 6.771

O15269 SPTLC1 0.830005 473 52.71047 6.011

Q9Y6M5 SLC30A1 1.110595 1.10251 507 55.26405 6.481

P14209-3 CD99 0.591634 169 17.1174 4.564

F5GWY0 PIGT 0.912958 1.281792 423 47.90365 8.807

B4DVJ1 DAGLB 1.62332 220 24.54937 8.148

Q9UKS6 PACSIN3 1.092926 424 48.45683 6.176

E7ERV9 ASAH1 1.016401 305 34.58179 7.767

Q16540 MRPL23 0.710094 153 17.77013 9.686

P52292 KPNA2 1.239098 1.363252 529 57.82595 5.402

Q5TBH6 GNPAT 0.852829 222 25.20905 8.69

F5H365 SEC23A 0.990387 1.417708 736 82.91563 7.459

O43674-2 NDUFB5 0.875972 137 15.65706 7.562

E7ET76 GGT1 1.185204 1.12533 463 50.02888 6.727

E9PIC0 SDHD 0.54084 120 12.60657 8.5

B1AZV3 TAP1 0.807502 808 87.12068 8.016

Q9Y676 MRPS18B 1.285966 258 29.37701 9.378

B1AH49 MPST 1.071553 224 24.96651 7.65

of 313

Ant

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114

114

Q8TBK7 TPT1 1.715824 138 15.5866 5.072

O60427 FADS1 1.038179 501 57.84873 9.481

O95373 IPO7 1.491394 1.391117 0.842853 1038 119.4399 4.818

F5H5G8 SUCLA2 0.553651 0.361274 329 36.0117 5.389

H7BZF5 C2orf80 0.98906 139 15.67411 9.833

P51114-2 FXR1 1.118303 0.881642 539 60.75436 6.392

I3L1D0 WDR45B 1.17045 0.758889 174 19.30278 7.167

E9PKJ0 WLS 0.742704 122 14.40444 9.056

H0Y5R2 CEP250 1.088816 1.100803 210 22.70323 4.386

C9JG32 TSFM 0.862646 140 15.43103 8.895

H0YGW7 ABCF1 1.316959 1.186243 596 67.61806 8.192

O00180 KCNK1 1.239537 336 38.11852 6.367

B4DDS3 CLPTM1 0.753854 1.222139 567 65.5551 5.999

P54727-2 RAD23B 0.929903 337 34.98323 4.678

B4DP17 CNBP 1.338437 160 17.67973 7.708

E9PKV2 MRPL17 0.682762 142 16.36078 10.48

Q8N387-2 MUC15 0.923146 284 30.74325 4.78

Q96D31-2 ORAI1 1.137192 231 25.32127 8.631

H7C1U8 APOO 0.899714 178 20.06728 8.617

E9PF19 TBL2 1.702768 1.030469 411 45.90616 9.481

H0YNF6 TM2D3 1.373451 161 18.17144 8.089

E5RFR9 PPP2R2A 1.274608 197 22.99205 7.254

Q9H2U2-3 PPA2 0.972971 305 34.63558 8.456

Q9H0U6 MRPL18 0.90677 180 20.56354 9.54

H0YMB1 RMDN3 1.025878 306 34.12692 4.881

F8WBJ7 TMEM245 0.706662 2.27177 0.925284 253 28.07817 8.309

P23246-2 SFPQ 1.21799 1.087693 669 72.21776 9.232

Q10713 PMPCA 0.770647 0.879338 525 58.2156 6.917

of 313

Ant

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115

115

Q13367-2 AP3B2 1.14841 145 15.80994 6.075

O43747 AP1G1 0.791782 1.272935 0.790241 822 91.29313 6.8

Q86YN1 DOLPP1 0.953196 238 27.01323 9.437

H7BZU1 EIF2S3 1.592035 183 19.81624 9.042

Q92544 TM9SF4 1.094496 1.071672 0.989709 642 74.46967 6.537

Q9UL46 PSME2 1.344532 239 27.38432 5.732

Q92692-2 PVRL2 1.325016 1.332542 479 51.32718 5.11

Q93050-1 ATP6V0A1 0.978953 0.672648 831 95.69385 6.654

G3V1K0 TXNL1 1.544625 166 18.92217 4.729

Q14050 COL9A3 0.709341 684 63.57713 7.679

P06241-3 FYN 0.792411 482 54.4791 6.227

Q9Y3C8 UFC1 0.854541 167 19.44602 7.401

P33897 ABCD1 1.18242 0.658384 1.044249 745 82.88451 8.954

P32004-3 L1CAM 1.063346 1.078946 1248 138.8208 6.214

B7Z7Q6 PRCP 0.979245 1.437204 0.792914 391 43.90565 6.303

Q14118 DAG1 1.191228 1.106221 0.913843 895 97.38067 8.558

O00519 FAAH 579 63.0252 7.665

H0Y400 DDX39B 1.741437 187 21.77609 5.123

G3XAJ6 RFTN1 1.105943 0.765607 542 58.72609 5.338

B4DJ68 TDRKH 0.241699 337 37.14301 4.488

O15382-2 BCAT2 0.960792 300 33.75464 7.723

Q04760-2 GLO1 1.41332 169 19.03059 6.049

F5H3I4 ACTR1A 0.827675 302 34.53578 6.456

Q5BKT4 ALG10 1.601853 0.904333 0.91813 473 55.569 9.291

Q5VXM9 RPF2 1.538456 3.678034 0.954767 208 24.14272 9.466

Q07817-2 BCL2L1 0.579766 170 18.88219 5.072

Q01105-3 SET 1.377528 1.014835 265 30.97422 4.234

E7ETS9 B4GALT4 0.728534 246 28.52191 9.159

of 313

Ant

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116

116

O14880 MGST3 0.898908 152 16.50557 9.378

B4DE93 NDUFV1 0.55954 363 39.43674 6.456

P30837 ALDH1B1 0.512936 0.839782 517 57.17023 6.8

Q8TCJ2 STT3B 0.878647 1.167831 0.773816 826 93.61368 8.91

Q86VP6-3 CAND1 1.969643 0.96296 403 45.50989 5.77

B7Z9I1 ACADM 0.996897 0.580065 385 42.39949 6.43

G3V126 ATP6V1H 3.668189 443 51.53683 6.227

B7Z9L2 NDUFS2 0.443102 231 26.95251 5.656

B4DS69 ARFIP1 1.008259 193 22.04122 5.821

P15144 ANPEP 1.030734 1.223168 0.659249 967 109.4709 5.478

Q9UJQ7 SCP2D1 1.519618 1.357626 156 17.6514 9.334

Q96HE7 ERO1L 1.062188 0.612081 468 54.35805 5.681

Q9NXV2 KCTD5 0.848383 234 26.07605 6.24

B3KSB1 ERMP1 0.866478 1.002318 351 39.18342 7.826

Q9H9J2 MRPL44 0.865905 0.940423 332 37.51171 8.397

Q6NUQ4-2 TMEM214 0.717787 0.75945 644 71.99378 9.261

P35221 CTNNA1 1.149036 1.194764 906 100.0085 6.291

Q96EC8 YIPF6 1.067828 236 26.2387 5.643

Q7Z777 CLPB 0.705483 315 36.15102 7.547

Q9Y4F1 FARP1 1.371267 1.269996 1.014068 1045 118.5587 8.148

Q9H0U3 MAGT1 1.000154 335 38.01141 9.627

H0YA55 ALB 1.198659 1.264774 454 51.53582 6.947

Q9UMY4-3 SNX12 1.618121 158 18.33042 7.298

P00492 HPRT1 2.147532 218 24.5636 6.683

O60260-3 PARK2 2.018586 218 23.62334 7.474

E7EWX8 MGLL 1.165629 277 30.67209 8.543

Q32P28 LEPRE1 0.735619 0.800889 736 83.34109 5.135

Q9BW60 ELOVL1 0.768996 279 32.64078 9.598

of 313

Ant

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Pero

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117

117

O15118 NPC1 0.944163 0.426973 0.604628 1278 142.0736 5.364

F5GY99 GALNT1 0.940315 0.929699 499 57.34292 7.914

P34932 HSPA4 0.929084 1.244466 1.460391 840 94.27124 5.186

H0YJE4 DHRS7 0.999921 160 17.94956 5.567

P09543-2 CNP 0.915642 0.876571 401 45.07033 8.529

P04920-2 SLC4A2 1.337605 0.957629 1227 135.5205 6.214

F5H324 ARSE 1.136729 0.919649 544 61.03771 7.035

Q00839-2 HNRNPU 1.144022 0.970876 806 88.92415 5.783

Q8TB61-3 SLC35B2 0.649797 1.490369 0.617971 383 42.09994 9.349

P09758 TACSTD2 1.231646 323 35.68662 8.866

P11171-6 EPB41 1.015031 566 63.21557 6.668

P27144 AK4 1.072258 223 25.25221 8.397

Q9BPW8 NIPSNAP1 0.848675 284 33.28884 9.305

Q9H2H9 SLC38A1 1.50668 487 54.01223 7.02

O00400 SLC33A1 0.934608 0.745285 0.904505 549 60.86977 7.328

Q9UEL6 MPZL1 1.237786 183 20.21738 8.382

C9JYN0 SYPL1 1.043696 1.519212 0.738429 224 24.76769 7.137

B4DR63 PSMC1 1.705552 1.869939 367 41.1412 5.008

B4DR94 YKT6 1.336447 1.171605 164 18.56846 7.328

Q70UQ0 IKBIP 0.914048 350 39.28496 9.173

F8WEV0 ACAD11 1.027155 433 48.9051 8.587

K7EK00 FAM210A 0.232428 268 30.27303 9.745

O76024 WFS1 0.769325 0.714525 0.913139 890 100.227 8.045

P23229-7 ITGA6 1.260589 0.893529 954 106.5103 7.665

Q9Y6K0 CEPT1 1.043597 2.717958 416 46.52275 8.207

H0Y711 WDR77 1.799978 291 31.07815 4.894

E5RJ39 RALYL 1.407383 146 16.42503 10.62

F5H3P5 ACTR3 1.21364 0.912387 356 40.7427 5.96

of 313

Ant

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118

118

H3BLU7 AKR7A2 0.999292 314 34.66225 7.181

Q15070-2 OXA1L 1.031276 419 46.66148 9.247

P42166 TMPO 0.640385 694 75.44563 7.665

Q5QPE7 MGME1 0.599338 252 28.82089 9.305

H3BSX1 SYT17 1.26127 168 19.0538 8.675

K7EPP7 DNAJC7 1.500351 253 28.68521 8.485

C9JDH9 STK25 1.148396 0.859906 148 16.35562 6.176

H0YBU8 MRPL43 0.422913 148 16.66658 6.786

J3QLE5 SNRPN 1.042236 2.600692 0.947268 169 17.53528 9.994

Q96CU9-2 FOXRED1 0.60065 0.779147 275 30.63944 6.011

C9JA35 TAPBP 0.802617 192 20.30951 6.932

Q8WVM8 SCFD1 1.228715 0.970632 642 72.33405 6.265

O75131 CPNE3 1.407907 537 60.09213 5.846

H0YJX6 PRMT5 1.139079 1.915684 279 32.2913 5.91

O95197-3 RTN3 0.893309 0.876485 236 25.5926 8.514

K7EJC1 PSMD8 0.798077 172 19.76817 6.932

Q9H936 SLC25A22 0.728863 323 34.44826 9.291

C9JMT4 PREPL 1.244231 151 17.91298 7.723

A8MQB8 FMR1 1.003434 0.714066 582 65.78121 7.621

C9JFN4 BZW1 1.194144 216 24.32856 8.338

Q8N766-4 EMC1 1.138454 1.132935 971 109.3519 7.928

H0YGG4 EIF2B1 1.13882 152 16.91546 6.903

P28072 PSMB6 2.380084 239 25.34145 4.919

Q9UKD2 MRTO4 1.257289 239 27.54291 8.294

P30566 ADSL 1.340564 1.512782 484 54.85397 7.108

G3V325 ATP5J2-PTCD1 0.714803 1.230728 0.721681 749 84.05659 8.719

Q04637-5 EIF4G1 1.8386 1.106693 1.148944 1435 158.4189 5.211

H7C1R3 IDH3G 0.890518 155 17.01277 9.481

of 313

Ant

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fer

from

this

pro

of.

119

119

H0Y8J7 EIF4E 1.244216 2.225969 155 18.45408 6.551

Q8TAE8 GADD45GIP1 0.53233 222 25.36822 10.02

H7C204 ZFYVE20 1.45217 1.102571 156 18.35461 8.368

E9PDQ8 SUCLG2 1.109183 1.318358 379 41.41251 7.723

Q9BXK5-2 BCL2L13 0.700476 201 22.59757 4.932

Q9UIW0 VAX2 2.56191 290 30.8557 9.466

J3KS22 DCXR 1.124193 224 23.94468 8.5

P00846 MT-ATP6 0.76194 1.192226 0.677092 226 24.80086 10.1

P19404 NDUFV2 1.044891 249 27.37402 8.06

P19367-4 HK1 0.961335 0.855873 905 101.0204 6.903

Q08211 DHX9 0.960707 0.79311 1270 140.8691 6.844

Q96EU7 C1GALT1C1 318 36.35797 6.844

P18084 ITGB5 1.47491 0.868759 799 87.99622 6.062

H0Y3P2 EIF4G2 1.328199 1.232863 869 98.05574 6.991

C9JZB0 INPP5K 0.922595 229 26.70651 8.309

E7EP04 DNAJC10 0.666821 275 31.3796 7.049

G5E9Z2 CLPTM1L 1.040845 369 43.2522 8.792

Q8IYJ2 C10orf67 1.574494 185 21.58016 9.613

A6NGH8 ANKRD61 1.026379 418 46.11092 8.851

H7C4H8 SLBP 0.898412 186 21.32788 10.11

Q3T7B5 TRIT1 1.675867 163 18.74679 9.422

P30086 PEBP1 1.280867 187 21.04367 7.533

Q2T9J0-2 TYSND1 0.957553 398 41.54626 7.137

Q13425 SNTB2 1.24853 540 57.91303 8.822

Q70UQ0-4 IKBIP 1.112514 377 43.05655 4.919

H3BPF7 LONP2 0.933002 0.867836 236 25.49645 8.456

Q15833-2 STXBP2 1.037587 590 66.09634 6.551

B3KQC5 MAN1B1 1.250591 402 45.99845 6.639

of 313

Ant

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dif

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120

120

P09496-5 CLTA 166 17.67666 4.64

Q8N2G8-2 GHDC 0.864977 474 51.42801 6.917

Q9UBB4 ATXN10 1.559708 475 53.45482 5.25

D6RAL1 GFM2 1.661288 1.045418 285 31.86577 7.738

P07711 CTSL1 0.553865 333 37.53967 5.453

H7BXI1 ESYT2 1.000532 0.809399 884 97.94866 8.573

H3BTZ5 CNN2 1.496845 191 20.94516 8.866

Q9HCC0-2 MCCC2 0.708254 0.467484 525 57.48243 7.708

P21283 ATP6V1C1 0.939955 382 43.91396 7.459

B4DLH2 C2orf18 0.682776 0.811431 288 31.07682 8.236

C9JVB6 TRMT10C 0.561536 1.528128 0.853825 312 36.80495 9.159

Q13444-10 ADAM15 1.11834 772 83.60999 6.392

Q8TBP6 SLC25A40 1.259051 338 38.09989 9.349

H3BP66 GALNS 0.91941 170 19.36984 8.924

P46060 RANGAP1 1.620736 587 63.50231 4.678

Q9NZZ3-2 CHMP5 1.437214 171 19.50787 6.844

Q4J6B8 SLC3A1 1.116239 391 45.34152 6.049

Q99805 TM9SF2 1.093457 1.120914 0.835604 663 75.72547 7.445

Q5JU69 TOR2A 0.915539 321 35.69148 7.972

P28062-2 PSMB8 1.490567 272 29.75029 5.821

Q9HDB5-3 NRXN3 1.210749 396 43.73906 9.247

B5MCE7 BZW2 1.396847 225 26.16552 5.554

P54577 YARS 1.594293 1.83622 528 59.1061 7.049

C9J4P8 FKBP9 1.014271 0.99304 226 24.64835 5.732

E9PF06 MRPL3 0.609086 176 19.56739 9.203

B5AK60 ABCB1 1.236142 0.998213 0.96536 1216 133.9475 8.968

C9JPE1 SLC25A20 1.08502 228 25.12304 9.408

Q9UHY8-2 FEZ2 1.005093 380 42.58602 4.678

of 313

Ant

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121

121

O95571 ETHE1 0.892524 254 27.85511 6.83

B4DGC9 DNM1L 1.322742 533 59.97143 8.807

P49588 AARS 1.528437 1.649384 968 106.7432 5.529

E9PP31 CAPRIN1 0.995353 178 19.36873 9.276

O95202 LETM1 0.836178 0.624752 739 83.30196 6.698

Q9P2B4 CTTNBP2NL 639 70.1148 8.06

Q9BR76 CORO1B 1.183583 489 54.20025 5.884

P20839-2 IMPDH1 1.951442 1.657952 489 52.56405 6.639

O14975-2 SLC27A2 1.000942 1.179552 0.76783 567 64.57429 8.485

H3BPD8 KATNB1 0.704054 208 22.75845 7.474

Q969Z0-2 TBRG4 0.636626 521 58.40581 7.035

B4E022 TKT 1.170399 576 62.83929 7.518

F5GWS8 HSPA13 0.802722 2.180864 0.747226 263 29.37337 6.537

P98082-2 DAB2 1.08965 0.683185 0.946441 552 58.82448 5.707

Q9UL68-3 MYT1L 1.464539 1.119658 184 20.60714 5.034

P10253 GAA 0.601787 0.92884 952 105.2568 5.999

G3V5X9 SNX6 0.915898 239 26.94949 5.884

P45877 PPIC 1.167603 0.565501 212 22.74885 8.397

O00534-4 VWA5A 1.218849 266 29.21665 5.135

Q9UKY7-2 CDV3 1.819937 213 22.06576 5.808

O43292-2 GPAA1 1.038494 561 61.05872 7.65

Q9H2V7-3 SPNS1 1.099477 1.009117 454 48.98191 7.752

P53701 HCCS 1.089835 268 30.58182 6.683

P11717 IGF2R 0.810536 0.739024 0.719584 2491 274.1988 5.935

E9PKK0 TNKS1BP1 1.788281 243 26.05737 9.349

C9J5V9 YBX1 1.326072 216 23.58364 10.26

Q15120 PDK3 0.797399 406 46.90907 8.368

B7Z341 NDRG3 1.552538 0.912358 271 29.70193 5.592

of 313

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122

122

Q9Y624 F11R 0.809959 0.810082 299 32.56249 7.899

E9PRM7 SLC22A18 0.849465 326 34.92975 9.657

E7EWB4 DPYSL5 1.090506 190 20.85348 6.417

O75369-5 FLNB 1.328697 0.996688 2146 230.1452 5.542

P82930 MRPS34 1.281228 218 25.63449 9.979

Q9Y678 COPG1 1.755991 2.746038 1.335984 874 97.65547 5.465

P56199 ITGA1 1.245528 1.24296 0.926973 1179 130.7647 6.291

O14980 XPO1 1.324821 2.022848 1071 123.3061 6.062

F8VX11 EIF4B 1.264867 360 41.43034 6.341

Q9BT09 CNPY3 1.064823 278 30.72865 5.491

J3KR24 IARS 1.243357 1.489168 0.966796 1152 131.6797 6.113

P23219-3 PTGS1 0.649884 537 61.88916 8.045

Q9UG63 ABCF2 1.530427 1.118926 623 71.24463 7.372

O14579-3 COPE 2.314005 256 28.7546 5.288

E9PD92 G6PD 1.952377 256 29.48397 7.167

Q99816-2 TSG101 1.052729 285 31.71218 5.326

O76031 CLPX 1.009319 633 69.18073 7.577

O14964-2 HGS 0.997025 690 76.32758 5.859

P82673-2 MRPS35 0.733322 287 32.69677 6.932

Q8IY17-5 PNPLA6 0.882457 1300 143.2608 7.738

K7EKB8 ZCCHC2 1.260929 378 39.9842 6.947

F5H248 COPS7A 1.243507 262 28.94824 5.719

Q9UH62 ARMCX3 1.033986 379 42.47387 8.368

H3BMU1 IST1 1.14299 206 23.36051 6.61

Q5VT94 GHITM 0.888661 325 35.25864 10.11

O15031 PLXNB2 0.884686 0.954203 1.197259 1838 204.9972 6.24

P15509-8 CSF2RA 1.451765 2.813744 267 31.0819 8.221

Q5TEZ5 C6orf163 1.261693 329 38.52877 6.961

of 313

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123

123

Q9NX62 IMPAD1 0.846446 359 38.65696 6.859

Q00653-4 NFKB2 0.943685 899 96.61789 6.252

Q96RD7-2 PANX1 1.215809 422 47.60378 6.011

E9PJT3 SF3B2 1.109549 273 29.11627 5.656

P06756-3 ITGAV 1.112174 2.333825 1.00193 1002 111.061 5.618

Q9UF33-2 EPHA6 1.045992 334 37.14315 8.221

P82933 MRPS9 0.931219 396 45.80576 9.51

B3KU92 LOC90826 0.755775 732 81.80457 5.275

P02765 AHSG 1.096659 0.863169 367 39.29971 5.719

Q4G0F5 VPS26B 1.102572 336 39.13017 7.357

O14657 TOR1B 0.782236 336 37.95482 8.543

P56937-3 HSD17B7 0.712584 306 34.45376 8.163

F5GY68 ANAPC5 1.516846 217 24.69819 5.148

B0QY90 EIF3L 1.221129 2.893805 466 55.12602 8.954

O00220 TNFRSF10A 1.506031 468 50.05674 7.035

F8VUA7 OSBPL8 0.918728 0.820561 695 79.16 6.888

Q5JP01 RBBP7 1.433374 285 31.48338 6.189

B7Z2A7 ACBD5 1.019595 348 38.7477 4.919

Q6WRI0-3 IGSF10 1.088677 602 66.69829 8.954

Q9Y2D0 CA5B 0.614193 317 36.4105 7.811

F8VWL0 TFCP2 1.420918 381 43.90611 6.991

E2QRH7 ELOVL5 0.779148 289 34.17938 9.481

Q96FN4 CPNE2 1.445992 548 61.15061 6.075

Q5LJB0 UCHL5 1.774012 258 29.09752 5.034

H7C0X4 ALG3 1.005136 323 36.98376 9.803

Q8IXH7-4 NELFCD 1.562668 581 65.43694 5.097

P07942 LAMB1 0.917401 1.458926 0.790964 1786 197.9086 4.945

Q8NGJ4 OR52E2 325 36.60538 8.353

of 313

Ant

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124

124

B1AMX9 TRAF2 1.020803 422 46.53609 7.079

Q08722-2 CD47 1.391991 0.931491 292 31.72203 7.21

E9PF63 ROCK2 1.186264 1.021497 1145 133.1827 5.783

Q6DKJ4-3 NXN 1.514403 327 36.84778 4.881

F5H5F3 ATP6V0A2 0.846238 0.8683 328 38.02613 6.252

H0YKM7 MAN2A2 1.078825 1.136464 330 35.84931 8.075

K7ESB6 CSNK1G2 1.22621 299 33.73248 9.437

P20042 EIF2S2 1.18826 333 38.36437 5.795

Q8TEM1-2 NUP210 1.146134 0.833643 967 105.7438 6.227

Q92783-2 STAM 0.91422 403 44.94324 4.869

F5GZJ1 NCAPD2 1.388116 1.829292 1.035389 1356 152.0786 6.698

Q9HD20-2 ATP13A1 0.814919 0.731475 0.902841 1086 121.0323 7.752

Q9NXW2 DNAJB12 0.875832 375 41.79277 8.529

F5H2A8 SYT10 342 38.94069 6.991

Q9Y4W6 AFG3L2 0.58911 0.37502 797 88.52819 8.661

Q96DV4 MRPL38 0.679954 380 44.56837 7.533

B1AKN6 NFIA 0.917064 380 42.27777 9.437

E7EQD7 DLG1 1.472285 658 71.81274 5.389

Q9UIQ6-3 LNPEP 1.084474 0.94827 1006 114.9881 5.783

Q9H553 ALG2 1.510606 416 47.0613 7.049

F5H5E2 PLBD2 0.581519 0.596116 557 61.84515 6.8

Q6YHK3-4 CD109 0.973632 1428 159.5952 5.795

Q9UMX0-2 UBQLN1 1.13587 1.020684 561 59.18281 5.097

Q6NUK1-2 SLC25A24 1.043836 458 51.32124 5.884

Q9Y6M1-5 IGF2BP2 1.235582 2.081559 493 54.68838 7.518

Q86TM6-2 SYVN1 0.74949 0.870776 565 61.69123 6.844

P29622 SERPINA4 1.238129 427 48.51116 7.752

O60313 OPA1 0.466151 0.235485 0.627159 960 111.5608 7.87

of 313

Ant

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125

125

P0C6C1 ANKRD34C 0.979708 1.036409 535 58.22031 9.027

Q9UMS4 PRPF19 1.257298 504 55.14635 6.61

Q13433 SLC39A6 755 84.99326 6.947

Q16513-3 PKN2 1.13514 1.137924 936 106.1504 6.405

Q9Y617-2 PSAT1 4.326369 324 35.16607 6.683

C9JXC1 RRM2 1.24267 289 33.76709 5.453

Q9P2B2 PTGFRN 1.333617 0.980942 879 98.4946 6.61

Q969Z3-2 MARC2 1.346595 1.462994 1.005974 257 29.0841 9.789

Q9Y266 NUDC 2.261991 331 38.21913 5.376

Q96IR7 HPDL 0.849985 371 39.36136 7.035

Q9Y399 MRPS2 0.678992 296 33.22808 9.261

Q9BXT2 CACNG6 0.841807 260 28.11081 9.173

Q9H0H5 RACGAP1 1.075148 632 70.98177 8.88

P12004 PCNA 1.18465 2.05469 261 28.75029 4.691

P15529-16 CD46 1.292519 336 36.80235 7.65

Q8TAA9-2 VANGL1 1.016921 1.379496 1.111753 522 59.71011 8.807

F5H0H1 DHCR24 1.016718 1.225041 300 34.53024 6.698

Q92616 GCN1L1 1.164114 1.495175 2671 292.5725 7.474

Q7Z2W4 ZC3HAV1 1.030651 1.021061 902 101.367 8.397

Q9H3H5-3 DPAGT1 1.023283 301 34.24724 8.089

P35237 SERPINB6 2.115173 0.967332 376 42.59406 5.275

Q9NZ53-2 PODXL2 1.070125 529 56.60054 4.323

O43464-4 HTRA2 1.103174 0.858048 377 39.88932 10.55

H0Y613 GSE1 1.828698 986 112.5705 7.123

Q969N4 TAAR8 1.432552 342 38.00349 6.815

P50552 VASP 1.153067 380 39.80509 8.939

O60942-3 RNGTT 1.188726 1.997955 1.070606 457 52.49949 8.016

Q86UL3 AGPAT6 0.81806 456 52.03721 9.188

of 313

Ant

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may

dif

fer

from

this

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of.

126

126

O00622 CYR61 2.494523 1.443355 381 41.99828 8.207

Q5JS79 CASK 1.115366 381 43.71425 6.8

Q16720-8 ATP2B3 1.386884 1115 122.6815 5.757

Q5VVW2-3 GARNL3 1.283904 1.231963 1.148944 423 48.74479 8.983

P03891 MT-ND2 0.52364 0.559293 347 38.93475 9.833

Q92900-2 UPF1 1.244204 1.978737 1118 122.958 6.683

Q9H089 LSG1 1.057141 658 75.17836 6.379

Q5VU77 UBAP2L 1.306202 1.917356 350 37.93816 6.742

P09960-3 LTA4H 508 57.26327 6.062

H7C3Z2 FLVCR1 0.933469 2.260423 354 38.15699 5.973

H3BR35 GSPT1 1.213561 475 52.90871 5.63

P30533 LRPAP1 0.564921 357 41.44091 8.778

Q9H2W6 MRPL46 0.750724 279 31.68542 7.049

E9PDM3 SLC6A6 0.974887 359 40.48957 8.192

Q9NQW1-4 SEC31B 0.492478 480 52.95023 8.485

P08581 MET 1.120399 0.958386 1390 155.4415 7.328

P43490 NAMPT 1.07257 491 55.4866 7.152

Q9NZI8 IGF2BP1 4.265769 577 63.44118 9.203

Q8N697 SLC15A4 0.700389 577 61.99343 8.998

P36551 CPOX 0.5522 454 50.11997 8.25

H0YLV8 BLM 0.991191 413 46.05255 4.97

H7C487 OSBPL10 0.957723 538 60.30767 6.859

E7EX40 RAB11FIP1 0.690324 0.836738 501 54.79899 9.012

Q5JTP4 LAMA5 0.748403 500 54.82108 7.24

B4DUC5 CSE1L 1.779767 1.741506 754 85.4181 5.478

F5H698 LARS 1.741321 1.176201 1130 129.1319 7.87

Q8WUX1-2 SLC38A5 1.169519 1.656588 421 45.88529 8.338

A6NCS6 C2orf72 0.427099 295 30.46176 8.338

of 313

Ant

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dif

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of.

127

127

Q14643-4 ITPR1 1.386526 1.019189 2695 306.578 6.291

Q9BPX3 NCAPG 1.756411 1.236768 1015 114.2621 5.592

P04066 FUCA1 0.899272 466 53.65473 6.844

C9JIG9 OXSR1 1.457147 468 51.82385 7.796

Q14247-3 CTTN 0.97738 1.562945 1.075739 513 57.43154 5.326

P43686-2 PSMC4 2.206146 1.416601 387 43.48054 5.262

Q8WVM0 TFB1M 1.429787 346 39.51799 9.261

Q8NBJ4-2 GOLM1 0.371678 391 44.24627 4.907

P08648 ITGA5 1.261205 1049 114.4647 5.77

Q6ZRP7 QSOX2 0.891353 0.631728 698 77.47962 7.723

Q14789 GOLGB1 1.210601 1.014396 1.020317 3259 375.7897 4.996

Q9NZP5 OR5AC2 1.502034 1.906181 1.133634 309 35.28065 8.939

E9PP73 COPB1 2.60955 486 55.50238 6.43

Q9UGQ3-2 SLC2A6 0.971223 445 48.00964 9.012

H0Y8B5 CADPS2 1.082887 490 56.13144 5.262

O60826 CCDC22 1.273512 627 70.7122 6.742

P25205 MCM3 1.504178 808 90.92403 5.77

P17405-4 SMPD1 0.390463 628 69.57914 7.181

O75063 FAM20B 0.760967 409 46.40282 6.874

Q96ES6 MFSD3 1.147952 412 42.66863 9.173

P09874 PARP1 0.835644 1014 113.0124 8.88

Q9C099-2 LRRCC1 1.382933 1.129748 1012 117.8571 6.24

F8W6I6 FAM178B 0.804773 647 72.80233 5.427

P02748 C9 1.295934 559 63.1327 5.592

B7Z463 NPEPPS 1.512425 0.98235 839 94.45592 5.376

O75083-3 WDR1 1.278036 1.085045 466 50.662 6.522

Q96LB3-2 IFT74 1.179131 372 42.30545 5.592

O60841 EIF5B 1.75188 1.169146 1220 138.7417 5.491

of 313

Ant

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Pero

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may

dif

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of.

128

128

Q6UWP7-3 LCLAT1 0.791503 376 44.53207 8.587

Q14117 DPYS 1.465952 519 56.5937 7.269

Q9Y666 SLC12A7 0.788691 2.13404 1083 119.0286 6.712

P16144-4 ITGB4 0.890259 0.877425 1745 194.3419 6.125

P78357 CNTNAP1 0.871558 1384 156.1671 7.049

E9PMP7 LMO7 1.490234 1.065118 1046 119.4533 5.376

O95870-2 ABHD16A 0.858908 525 59.34509 7.84

Q2VPK5-3 CTU2 428 46.49728 5.732

P55010 EIF5 1.910282 1.14816 431 49.19181 5.58

B0S7Q4 C6orf136 1.191637 433 48.11504 9.701

Q9UDT6-2 CLIP2 0.550046 1011 111.7138 6.83

Q7KZN9-2 COX15 0.67725 388 43.80714 9.642

Q6UX68 XKR5 0.384452 686 74.93379 6.683

Q96AE4 FUBP1 1.243171 0.891987 644 67.51847 7.606

Q9UNF0-2 PACSIN2 0.757589 445 51.32099 5.389

Q4KMQ2-3 ANO6 1.547572 892 103.8983 8.236

K7EPT6 TAF15 1.26435 449 48.80937 5.084

H3BRV0 EIF3C 1.712376 0.973388 903 104.036 5.63

E9PIN3 NXF1 1.020035 603 68.06475 8.895

Q9ULE4 FAM184B 1.507056 1.11878 1.110085 1060 120.9693 6.176

Q8TDN6 BRIX1 3.552663 353 41.37495 9.92

B4E321 OS9 1.050002 406 46.27345 4.843

Q7Z5H4 VN1R5 1.273724 1.829477 1.051904 357 40.75162 9.203

Q4G148-2 GXYLT1 0.833063 1.7711 409 46.76996 8.954

F6SKP1 GPNMB 1.075436 461 51.09972 6.392

B4DTG6 LSM14A 1.882094 422 46.38313 9.54

Q8IWA4 MFN1 1.061374 741 84.04712 6.252

Q9H2A2-2 ALDH8A1 1.198937 433 47.29486 6.367

of 313

Ant

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Pero

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doxi

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is a

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The

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may

dif

fer

from

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of.

129

129

Q15075 EEA1 0.719519 0.871027 1411 162.3672 5.681

O75901 RASSF9 1.49351 1.344004 435 49.98932 5.313

Q13033-2 STRN3 2.019764 0.92828 713 77.6965 5.262

A6NKB8 RNPEP 2.051127 611 68.12527 6.011

Q9NP73-4 ALG13 1.403233 954 106.7893 7.079

Q9H845 ACAD9 0.530212 621 68.71674 7.958

Q5CZ79-2 ANKRD20A8P 1.274444 395 46.62497 8.075

Q96JJ7 TMX3 1.082545 454 51.8389 4.907

Q8NEL9-3 DDHD1 1.014521 454 51.52195 6.494

B9ZVR1 MAP4 0.6509 811 85.34251 7.708

Q9Y5X3 SNX5 0.917368 404 46.78715 6.756

Q92896 GLG1 0.920041 0.803671 1179 134.4636 6.903

Q96N16-5 JAKMIP1 1.210791 646 75.69915 5.097

Q9HAR2-3 LPHN3 0.981821 707 79.2864 5.884

P98194-2 ATP2C1 0.727379 888 96.89717 6.316

P11047 LAMC1 0.695079 1.221609 1609 177.4886 5.123

F8W720 GMPS 2.432848 594 65.88747 7.474

O43865-2 AHCYL1 1.845451 483 53.71891 7.445

Q9Y2H6-2 FNDC3A 1.245853 1142 125.7414 7.079

B4DXY7 ALDH9A1 1.322077 424 46.42429 5.542

Q14573 ITPR3 0.970448 1.135529 2671 303.9121 6.481

B1AVT0 CLK2 1.06789 497 59.8379 9.657

Q14160 SCRIB 1.257709 0.943204 1630 174.7782 5.072

E7EUY0 PRKDC 1.142021 1.038889 4096 465.0889 7.167

E9PD53 SMC4 1.59362 1.458396 1263 144.3652 7.123

O60336-4 MAPKBP1 1.402236 1015 109.0875 5.846

P00395 MT-CO1 0.950341 513 57.00303 6.698

B8ZZS4 ANKZF1 1.300849 516 57.53777 9.54

of 313

Ant

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Pero

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The

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may

dif

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130

130

O00411 POLRMT 1.125978 1230 138.5319 8.983

H7BZL6 FSIP2 1.445189 1.438729 1.026572 973 109.7977 8.602

H0Y335 ADGB 1.32388 713 81.5463 8.573

Q9NR30-2 DDX21 1.012081 715 79.60742 9.378

O00222 GRM8 0.859408 908 101.6748 8.148

Q9P258 RCC2 1.224471 522 56.04921 8.778

Q5TCU6 TLN1 0.731978 1.460834 1.061228 2429 257.9205 6.494

F5GZY0 APLP2 0.721577 658 75.82961 4.767

P16066 NPR1 1.076771 1061 118.8441 6.639

Q02388-2 COL7A1 0.707121 2912 292.0904 6.227

O95239-2 KIF4A 0.916166 1127 128.3797 6.164

Q9BSW2-2 EFCAB4B 1.170936 731 83.14169 5.237

Q12770-4 SCAP 0.766007 0.798997 886 95.55569 6.189

P40222 TXLNA 1.38734 546 61.85325 6.522

Q9H987-2 SYNPO2L 1.253416 753 79.09764 9.774

E9PD78 RRM1 1.563745 695 79.16884 6.786

Q8IV36-3 HID1 0.533614 560 63.20515 7.24

P20742 PZP 1.014587 1.498878 1482 163.7596 6.379

E9PC74 EIF2B5 2.7585 705 78.29738 5.211

Q92945 KHSRP 1.127557 711 73.07003 7.298

H0YC63 MTUS1 0.798673 0.985212 505 55.13877 8.924

Q14596-2 NBR1 1.261168 937 103.7689 5.148

H0Y8U6 GPR98 0.661346 1608 176.7407 4.475

P02788-2 LTF 0.876692 666 73.11425 7.855

P45974-2 USP5 1.794846 835 93.24836 5.084

Q9BXL6 CARD14 0.603887 1004 113.1983 5.922

Q5T5P0 KIAA1217 1.090164 783 86.67605 9.188

P33176 KIF5B 1.254026 963 109.617 6.507

of 313

Ant

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Pero

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doxi

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is a

cru

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The

fin

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may

dif

fer

from

this

pro

of.

131

131

F6X344 MS4A14 1.325766 567 64.26276 5.237

F8WBH5 PSME4 1.205212 571 65.61747 7.914

P15924-2 DSP 0.934392 2272 259.9566 6.961

Q9UPT5-2 EXOC7 0.983226 653 74.66663 6.417

H0YN14 IPO4 1.295237 911 101.425 5.046

Q5JVD2 CNTRL 0.981491 828 93.84581 5.25

P29590-11 PML 834 92.50533 6.329

A1A528 ZW10 1.204654 672 76.75776 6.316

Q92973-3 TNPO1 1.397863 848 96.83798 4.932

Q9H3U1-2 UNC45A 1.596043 929 101.6108 6.062

P38435-2 GGCX 0.821136 1.707496 701 80.93728 7.577

P0C221-2 CCDC175 1.832305 1.077196 0.989715 792 93.46618 6.712

Q92888-2 ARHGEF1 1.544851 879 98.70653 5.567

B4DZI8 COPB2 1.092297 877 98.98359 5.161

D6RCT7 KIF15 1.324565 711 82.36256 6.481

Q9Y4D8-3 HECTD4 1.720814 889 98.68847 6.341

Q13443 ADAM9 0.952008 819 90.49713 7.518

Q6UVK1 CSPG4 1.26086 0.843477 2322 250.3824 5.465

H7BY50 MIA3 0.980069 1.291042 1016 114.0452 4.754

P19320-2 VCAM1 1.771415 1.27599 1.431126 647 71.20937 5.173

K7EQ71 PPL 1.860373 1115 131.2958 5.58

P55265-5 ADAR 0.598131 931 103.5764 8.661

G3V198 NUP160 1.261831 1235 140.1979 5.453

Q96M20-2 CNBD2 1.490011 572 67.03305 9.261

B7Z5Z4 CLCN4 2.018092 0.675462 666 74.29835 7.694

E9PCY5 TOP2B 0.838857 0.977699 0.846456 1150 130.3978 8.47

J3KQF5 AGBL1 1.311768 1.266288 1062 119.7863 7.313

Q99798 ACO2 1.345122 0.842871 780 85.37193 7.606

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

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Pero

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doxi

n 6

is a

cru

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fac

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in th

e in

itial

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p of

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(do

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The

fin

al p

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vers

ion

may

dif

fer

from

this

pro

of.

132

132

P07996 THBS1 1.221998 1170 129.2996 4.945

Q9UHB9-4 SRP68 1.512102 589 66.06708 7.196

Q9NV70-2 EXOC1 1.447457 879 100.219 6.595

Q5JTZ9 AARS2 0.662638 985 107.2729 6.265

P06213-2 INSR 1.134334 1370 155.0458 6.202

P51798-2 CLCN7 0.432839 781 85.97114 8.734

P49792 RANBP2 1.010454 0.962115 3224 357.9741 6.202

Q15393 SF3B3 1.074568 1217 135.4917 5.262

Q8WXE9 STON2 1.408436 1.354522 1.067901 905 101.1015 5.389

O75165 DNAJC13 0.770851 2243 254.2525 6.742

Q9NS39 ADARB2 1.199085 739 80.57113 10.17

E7ESU4 NAT10 0.849194 953 107.2289 6.991

P16383-2 GCFC2 1.376901 743 84.79424 6.202

Q1L5Z9 LONRF2 1.074615 754 83.60028 5.897

Q14686 NCOA6 2063 219.008 9.364

E7EMM2 AP3D1 1.365068 984 111.1816 8.104

Q5T1M5-2 FKBP15 1.102506 2.189178 1209 132.3853 5.173

Q7Z7L7 ZER1 1.114371 766 88.1127 5.618

J3KNL6 SEC16A 1.356974 2357 251.7375 5.795

Q92614-5 MYO18A 0.980365 1581 180.3827 5.91

H0Y547 ATP11A 0.683214 935 106.5542 6.417

E9PF10 NUP155 0.793044 0.730684 1327 147.9996 6.303

H0Y7N4 DOCK5 1.200479 1090 126.0439 7.782

Q8TDD1 DDX54 2.256169 0.802348 881 98.5342 10.02

P12882 MYH1 1939 223.0064 5.745

F5GZL7 MACF1 0.980367 0.876942 5300 605.7584 5.389

A7E2D7 EP400 1.121014 1731 188.0955 8.939

Q8TD57-3 DNAH3 1.522615 1887 215.9386 6.443

of 313

Ant

ioxi

dant

s &

Red

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Pero

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doxi

n 6

is a

cru

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fac

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itial

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(do

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The

fin

al p

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ion

may

dif

fer

from

this

pro

of.

133

133

Q9Y239 NOD1 1.012465 953 107.6223 7.108

J3QQJ5 TRAPPC8 1.410914 1381 154.8869 6.976

Q8WYK1 CNTNAP5 1.319006 1306 145.5304 6.291

Q01970-2 PLCB3 1.248443 1.07296 1.068852 1167 131.1238 5.884

F5H0N7 CLIP1 0.939677 1013 116.1837 5.148

E9PMR6 ARHGEF12 1.105344 1441 161.8084 5.656

E5RG74 BAI1 0.772566 1159 126.6066 7.899

Q9UKV0-6 HDAC9 1.465707 1025 112.381 6.24

O60292 SIPA1L3 2.122041 1781 194.4896 8.324

P41229-4 KDM5C 0.850138 1379 155.0199 5.554

H0Y8D6 ABCA2 1.134613 1441 159.86 6.727

Q15058 KIF14 0.988275 1648 186.3749 7.914

Q92621 NUP205 0.790413 2012 227.7763 6.189

Q92538 GBF1 1.972311 1859 206.3146 5.732

P08572 COL4A2 1.530736 1712 167.4486 8.661

Q96JH7 VCPIP1 0.795746 1222 134.2359 7.196

C9JTR3 RTTN 1.273629 1.038178 1593 178.8395 6.367

Q96K76-2 USP47 1.317471 1287 147.1303 5.072

F8VSZ4 PLXNA1 0.77201 1873 208.4163 6.874

Q07954 LRP1 1.106034 0.83705 4544 504.2759 5.389

Q96NW7-2 LRRC7 1.25008 1490 167.2812 6.61

Q93008-1 USP9X 1.270548 2554 290.2777 5.795

F5H2B9 UACA 1.52613 1307 150.4393 7.02

H0Y765 KMT2C 1.13645 1524 168.4316 8.265

P12259 F5 0.695973 2224 251.5455 6.049

H0Y5W0 HUWE1 1.514098 3408 374.0725 5.097

Q9Y485 DMXL1 1.683314 3027 337.6247 6.341

Q8NDH2 CCDC168 1.048706 2452 277.7779 9.305

of 313

Ant

ioxi

dant

s &

Red

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igna

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Pero

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doxi

n 6

is a

cru

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in th

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itial

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(do

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.108

9/ar

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Thi

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and

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The

fin

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ion

may

dif

fer

from

this

pro

of.

134

134

F5H7F0 UNC13C 1.348017 2212 250.5517 5.922

Q4G0P3 HYDIN 0.980242 5121 575.5277 6.062

J3QQ66 ZFHX4 1.648258 3567 393.4816 6.367

O75691 UTP20 1.140913 2785 318.1821 7.386

P42858 HTT 1.459612 1.276072 1.126057 3142 347.3828 6.202

H0Y4W2 TRRAP 0.988373 3588 405.6492 8.177

Q8NCM8 DYNC2H1 2.094258 4307 492.3115 6.537

Q9NU22 MDN1 0.937528 5596 632.4202 5.681

of 313

Ant

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dant

s &

Red

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igna

ling

Pero

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is a

cru

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(do

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9/ar

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ting

and

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f co

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tion.

The

fin

al p

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vers

ion

may

dif

fer

from

this

pro

of.

135

135

Table S2. Total proteins quantified


Q99714 HSD17B10 0.841516 1.034407 0.721248 261 26.90611 7.782

P51149 RAB7A 0.922614 1.065166 0.846551 207 23.47484 6.698

P61604 HSPE1 0.679456 0.790736 0.699603 102 10.92487 8.924

P05787 KRT8 0.675075 0.751577 0.750807 483 53.67114 5.592

P07737 PFN1 1.938756 2.252394 1.344145 140 15.04456 8.265

P04075 ALDOA 1.431453 1.24978 1.077389 364 39.39531 8.089

P62820 RAB1A 1.092382 0.88875 1.125391 205 22.66338 6.214

Q9H0U4 RAB1B 0.918566 1.065785 0.919462 201 22.15723 5.732

F8VP99 ARL1 1.157695 1.542415 0.956203 17 1.784059 8.998

P30044-2 PRDX5 0.899533 1.151113 0.875192 162 17.02001 7.24

P35232 PHB 0.763098 0.907576 0.7709 272 29.7859 5.757

P21796 VDAC1 0.900554 0.889186 0.881584 283 30.75357 8.543

P04406 GAPDH 1.458589 1.332338 1.068676 335 36.0304 8.456

P61224 RAP1B 1.16238 1.077295 1.039023 184 20.81159 5.783

P40926 MDH2 0.664156 0.837865 0.680457 338 35.48073 8.675

H7C402 PSMA2 2.176814 36 3.629869 4.462

P05388 RPLP0 1.330471 1.475431 1.056908 317 34.2518 5.973

P62805 HIST1H4A 0.955174 1.623225 0.837629 103 11.36038 11.36

P14854 COX6B1 0.757329 0.370079 0.408104 86 10.18572 7.049

P04843 RPN1 0.913799 1.010671 0.790561 607 68.52681 6.379

P12236 SLC25A6 0.70999 1.164683 0.736293 298 32.84519 9.745

J3KPX7 PHB2 0.789382 1.248585 0.888689 299 33.38196 9.803

P61106 RAB14 0.996383 1.193794 0.894419 215 23.88193 6.214

P10809 HSPD1 0.810926 0.816132 0.726478 573 61.01639 5.872

C9J4Z3 RPL37A 1.436528 1.015617 68 7.618937 10.01

of 313

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P07355 ANXA2 1.289833 1.129487 1.003301 339 38.57982 7.752

P05783 KRT18 0.799 0.85891 0.825672 430 48.02854 5.453

P45880-2 VDAC2 0.922755 0.953553 0.777764 283 30.39304 7.196

P06733 ENO1 1.914614 1.758462 1.405665 434 47.13932 7.386

P23396 RPS3 1.488376 1.290279 1.098373 243 26.67143 9.657

P11021 HSPA5 0.956886 1.019791 0.911357 654 72.28844 5.161

P30050 RPL12 1.322301 1.463871 1.083923 165 17.80754 9.422

P05187 ALPP 1.251282 1.513109 0.854797 535 57.91729 6.291

P50991-2 CCT4 1.225267 1.121238 0.973524 509 54.6851 7.826

P04083 ANXA1 2.266094 1.746823 1.194763 346 38.68998 7.02

P61204 ARF3 1.444831 1.666886 1.051078 181 20.58773 7.43

C9JPM4 ARF4 1.024415 127 14.54377 8.119

O75947-2 ATP5H 0.765966 0.744454 0.632677 137 15.76317 7.181

P05186 ALPL 1.23596 0.987719 0.873944 524 57.26863 6.668

P22392-2 NME2 2.124502 1.754569 1.124689 267 30.11763 8.924

P62937 PPIA 1.581094 1.657079 1.266474 165 18.00089 7.811

F8W181 RPL6 1.156877 1.928758 1.269758 226 25.87584 10.67

P15328 FOLR1 1.366506 1.081038 0.923879 257 29.79922 7.972

P23284 PPIB 0.898139 0.859683 0.805036 216 23.72754 9.408

P56385 ATP5I 0.656519 0.355847 0.61265 69 7.928326 9.349

I3L405 MPDU1 0.702334 1.097506 0.747594 54 5.842343 8.543

P60709 ACTB 1.24783 1.091786 1.021016 375 41.70973 5.478

Q9BQE3 TUBA1C 2.489466 1.571135 1.267975 449 49.86346 5.097

Q04837 SSBP1 0.805241 0.95227 0.876624 148 17.24903 9.598

P78371 CCT2 1.240819 1.18594 1.00711 535 57.45213 6.456

P07437 TUBB 2.198372 1.65089 1.379771 444 49.63897 4.894

P68371 TUBB4B 2.190046 1.825049 1.414922 445 49.799 4.894

G3V1A4 CFL1 1.436668 1.604942 1.119905 149 16.80082 8.353

of 313

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Q96AG4 LRRC59 0.915084 0.993629 0.812279 307 34.90888 9.569

P35268 RPL22 1.725276 0.9945 1.187181 128 14.7778 9.188

Q04695 KRT17 0.733529 0.819907 0.869358 432 48.07605 5.021

P61019 RAB2A 1.100628 1.154274 0.894823 212 23.53077 6.537

P61586 RHOA 1.254205 0.988428 0.989212 193 21.75407 6.1

B4E2V5 STOM 1.063447 1.119375 0.952542 237 25.94779 7.386

P08758 ANXA5 2.55048 2.027943 1.387868 320 35.9144 5.046

P08238 HSP90AB1 2.032999 1.859231 1.041987 724 83.21211 5.034

P25705-2 ATP5A1 0.770641 503 54.45973 8.236

F8W1R7 MYL6 1.215575 1.126743 1.032317 145 16.2798 4.653

P06576 ATP5B 0.671661 0.96268 0.673776 529 56.52461 5.402

H7BZJ3 PDIA3 1.026889 0.806688 0.896513 123 13.51076 7.298

P51148 RAB5C 0.967067 1.122958 0.802933 216 23.46779 8.412

P05141 SLC25A5 0.787078 0.722562 0.695568 298 32.83115 9.686

P11142 HSPA8 1.676814 1.507196 1.091932 646 70.85423 5.516

P21964-2 COMT 1.006936 1.232053 0.924779 221 24.43338 5.326

P07237 P4HB 0.864308 0.920657 0.801654 508 57.08068 4.869

Q15286-2 RAB35 1.233208 1.057609 1.070747 152 17.04762 6.786

P12235 SLC25A4 1.149312 298 33.04322 9.759

C9JD32 RPL23 1.186353 1.648681 1.004362 91 9.663386 11.49

P37802 TAGLN2 1.433868 1.373952 1.19946 199 22.37717 8.25

G5EA52 PDIA3 0.782183 1.237703 0.800555 485 54.92888 6.859

P02786 TFRC 0.946452 1.213344 0.810573 760 84.81795 6.61

P60174-1 TPI1 1.484075 1.743766 1.210256 249 26.65274 6.903

P14618 PKM 2.153361 2.370428 1.58462 531 57.90003 7.84

Q13162 PRDX4 0.877084 1.101935 0.887093 271 30.52081 6.291

H0YD13 CD44 1.235225 1.198431 0.977471 185 20.21538 8.265

A8MUB1 TUBA4A 2.036923 2.142278 1.476961 433 48.2976 5.008

of 313

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138

P30466 HLA-B 1.109144 362 40.25002 6.756

P62899 RPL31 1.280412 1.474387 1.010627 125 14.45393 10.54

D6RAT0 RPS3A 1.391437 2.274117 1.088799 227 25.87044 9.422

P38646 HSPA9 0.643269 0.744843 0.621853 679 73.63478 6.164

P18124 RPL7 1.358129 1.350894 0.97166 248 29.2072 10.65

P19105 MYL12A 1.245813 1.22103 1.061118 171 19.78149 4.805

P63104 YWHAZ 1.862614 2.023601 2.525793 245 27.72773 4.792

E9PKZ0 RPL8 1.479458 1.201099 1.042 205 22.37522 10.76

P25705 ATP5A1 0.810155 0.964153 553 59.7136 9.129

Q06830 PRDX1 1.785254 1.352087 1.10989 199 22.09628 8.133

B7Z254 PDIA6 0.855887 1.122926 0.795077 437 47.80807 5.084

P07195 LDHB 1.964997 1.817951 1.455855 334 36.61514 6.049

D6RAN4 RPL9 1.326622 1.204954 0.967353 182 20.86141 10.2

Q9Y5M8 SRPRB 1.050497 1.255535 0.939115 271 29.68376 9.042

P07900 HSP90AA1 1.836656 1.700895 1.059922 732 84.60669 5.021

P17987 TCP1 1.260682 1.379604 0.931344 556 60.30559 6.113

P68104 EEF1A1 1.623493 1.398227 1.146169 462 50.10911 9.012

Q15019 SEPT2 1.163427 1.163393 0.935111 361 41.46125 6.595

E9PN17 ATP5L 0.688519 0.850805 0.784382 76 8.446677 10.29

I3L397 EIF5A 1.252103 1.537274 1.130697 147 16.10798 4.996

P08195-2 SLC3A2 1.450345 1.55993 1.062157 529 57.90887 5.351

P09525 ANXA4 1.858302 1.494527 1.25553 319 35.86012 6.125

P30040 ERP29 0.940127 1.141007 0.762335 261 28.97516 7.313

P27348 YWHAQ 1.639264 1.764708 245 27.74677 4.78

P46781 RPS9 1.596054 1.646443 1.137516 194 22.57756 10.65

P39019 RPS19 1.41885 2.247615 1.038056 145 16.05054 10.32

P61026 RAB10 1.023099 1.368584 0.851934 200 22.52659 8.382

P62906 RPL10A 1.426027 1.112273 1.122081 217 24.81554 9.935

of 313

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P09211 GSTP1 2.264256 1.306028 1.773251 210 23.34102 5.643

F8W7C6 RPL10 1.204563 1.269058 163 18.57973 9.95

Q9UBI6 GNG12 1.043246 1.20671 0.704077 72 8.00117 8.968

Q9Y2Q5 LAMTOR2 0.980146 1.111427 0.77696 125 13.49885 5.402

Q15293 RCN1 0.990571 0.964389 0.872109 331 38.86617 4.996

P49411 TUFM 0.807198 0.801759 0.780787 452 49.51018 7.606

P50454 SERPINH1 0.947646 1.159278 0.839949 418 46.41118 8.69

P00387-2 CYB5R3 0.845523 0.670345 0.888954 278 31.60836 7.577

D6RB85 CANX 0.446045 144 15.99796 4.742

P13639 EEF2 1.692874 2.529139 1.184579 858 95.27695 6.83

P05387 RPLP2 1.395322 1.271484 1.097447 115 11.65785 4.539

P04899 GNAI2 1.21145 1.10679 0.796403 355 40.42506 5.542

Q9H3K6 BOLA2 1.005165 1.066989 86 10.11018 6.522

Q14697 GANAB 0.928261 0.940956 0.819932 944 106.8067 6.138

H0YIC4 CS 0.721654 123 14.11442 9.569

C9J9K3 RPSA 1.484789 2.096834 0.965794 264 29.487 5.25

H3BRU6 PCBP2 1.303973 2.759481 1.020001 301 31.69025 8.441

P31327 CPS1 0.738376 0.773863 0.620871 1500 164.8348 6.742

P84095 RHOG 1.043651 0.825372 191 21.29493 8.119

P27797 CALR 0.84085 0.960863 0.770204 417 48.11183 4.437

P35613-4 BSG 1.399049 1.07799 0.949404 205 22.7502 5.465

P62277 RPS13 1.678969 1.478867 1.078018 151 17.21167 10.54

P62979 RPS27A 1.440632 0.943459 1.152788 156 17.95349 9.642

C9JXB8 RPL24 1.199513 1.607222 0.984919 121 14.35982 11.31

Q99832 CCT7 1.253512 1.025571 0.931442 543 59.32893 7.65

F5H897 TRAP1 0.694887 0.819808 0.765467 651 74.22066 7.87

Q15907 RAB11B 0.944864 1.163245 0.742528 218 24.47349 5.935

P11233 RALA 1.101317 1.210924 0.908307 206 23.55197 7.108

of 313

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140

P14625 HSP90B1 0.892788 0.951019 0.830767 803 92.41135 4.843

P00558 PGK1 1.471019 1.379579 1.293939 417 44.58613 8.104

P62834 RAP1A 1.131845 184 20.97371 6.668

F5H867 SLC3A2 1.151961 135 14.74766 5.96

P06899 HIST1H2BJ 1.33263 126 13.89558 10.32

O60814 HIST1H2BK 1.189797 126 13.88156 10.32

P48047 ATP5O 0.633851 1.24605 0.808641 213 23.26266 9.964

F8W1N5 NACA 1.270608 2.333095 71 7.808271 9.627

P15880 RPS2 1.664077 1.47961 1.113606 293 31.3046 10.24

P00966 ASS1 1.839589 1.676893 1.362175 412 46.50097 8.016

P08754 GNAI3 1.175651 0.804725 1.039917 354 40.50627 5.694

B4DUR8 CCT3 1.22739 1.151447 0.915537 500 55.6387 5.643

J3KPE3 GNB2L1 1.484859 1.549646 0.982292 273 30.08503 7.65

P62701 RPS4X 1.302232 2.454188 0.93498 263 29.57906 10.15

K7EJW7 RAB34 1.16037 0.794762 51 5.83202 9.378

P13667 PDIA4 0.930947 0.925643 0.89519 645 72.88698 5.072

P60953 CDC42 1.431487 1.57275 0.920497 191 21.24502 6.551

P62241 RPS8 1.47423 1.177438 1.187905 208 24.19016 10.32

B4DP11 PTGES3 1.681728 2.155438 1.223253 139 16.46559 4.805

P62081 RPS7 1.354286 1.2582 1.16434 194 22.11326 10.1

P10599-2 TXN 1.730395 1.578375 1.437973 85 9.445685 6.037

E7EPB3 RPL14 1.301225 1.305218 1.102775 124 14.5486 10.21

E9PJD9 RPL27A 1.364131 1.230209 0.96926 91 10.1206 10.21

P27635 RPL10 1.362447 214 24.58787 10.08

Q9NS69 TOMM22 0.681845 0.776688 142 15.51179 4.335

Q13011 ECH1 0.768997 0.747662 0.814573 328 35.79338 8.001

P62826 RAN 1.649783 1.16876 1.196289 216 24.40762 7.489

O43852 CALU 0.757461 0.647413 0.615452 315 37.08354 4.64

of 313

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141

P30519 HMOX2 1.01223 0.847264 0.881484 316 36.00983 5.415

P09923 ALPI 1.094579 1.315935 0.881478 528 56.77642 5.859

F8W1A4 AK2 0.895767 0.521958 0.570225 232 25.61431 7.826

F8VSD4 UBE2N 1.798173 1.165616 105 11.97532 9.115

O15260-2 SURF4 0.965792 1.794887 0.832768 159 17.95813 6.049

Q00325-2 SLC25A3 0.750895 0.864622 0.675982 361 39.93264 9.364

Q96QV6 HIST1H2AA 0.903956 131 14.22491 10.86

Q8WXC6 MYEOV2 3.511982 57 6.206755 3.828

P26038 MSN 0.997356 0.961161 0.841568 577 67.77779 6.405

Q9Y4L1 HYOU1 0.945504 1.059093 0.930768 999 111.2662 5.224

B4DT77 ANXA7 1.799431 2.522988 1.392255 336 37.78092 7.181

P20340 RAB6A 0.976054 1.189046 0.893356 208 23.57792 5.542

Q07065 CKAP4 0.828617 1.04363 0.862488 602 65.98273 5.922

O75396 SEC22B 0.901232 0.960989 0.94581 215 24.57753 6.917

P62873 GNB1 1.277162 1.015888 0.94075 340 37.35301 5.999

P62879 GNB2 1.315584 1.060956 0.898893 340 37.30706 5.999

P14314-2 PRKCSH 0.91234 1.048005 1.041739 525 59.1407 4.424

P80723-2 BASP1 1.166233 1.056561 0.901991 173 17.65361 4.767

J3KRB3 RPL17 1.489923 2.946832 0.995291 106 12.18533 10.33

Q7Z7H5-3 TMED4 1.342651 1.19789 0.815333 186 20.76759 6.874

Q15365 PCBP1 1.261067 2.948268 0.9692 356 37.47395 7.093

P08133-2 ANXA6 1.403662 1.436018 1.034728 641 72.37795 5.605

P34897-3 SHMT2 0.685224 0.741831 0.678145 483 53.4214 8.148

P62258 YWHAE 1.992235 1.280401 1.494461 255 29.15542 4.742

Q5TGZ0-2 MINOS1 0.800924 1.149823 0.884853 24 2.807374 5.021

P42704 LRPPRC 0.690941 0.910268 0.672625 1394 157.8051 6.125

Q15836 VAMP3 0.998247 0.865657 100 11.30195 8.792

P62269 RPS18 1.346863 1.626686 1.028083 152 17.70786 10.99

of 313

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dif

fer

from

this

pro

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142

142

H0YJW7 SLIRP 0.71013 0.971971 0.865119 76 8.686431 9.056

P08729 KRT7 1.062605 1.561058 0.950673 469 51.35431 5.478

P51151 RAB9A 0.791237 1.072214 0.935898 201 22.82317 5.465

Q96KK5 HIST1H2AH 0.735924 1.673838 0.56306 128 13.89783 10.89

P62851 RPS25 1.40709 1.856292 1.141014 125 13.7337 10.11

P06753-2 TPM3 1.33755 1.366747 248 29.01475 4.78

P55145 MANF 0.926633 0.909981 0.846526 182 20.68681 8.69

Q9Y277 VDAC3 0.760055 1.266825 0.695581 283 30.63929 8.661

H3BSJ9 UQCRC2 0.833404 1.259801 0.853102 336 36.36685 9.056

D6R9Z7 COX7C 0.626331 0.848862 56 6.378306 9.833

P49755 TMED10 0.944925 0.898659 0.864641 219 24.96002 7.445

P51659 HSD17B4 0.912127 1.142433 0.907175 736 79.63631 8.836

M0R3D6 RPL18A 1.374033 1.25685 0.974152 141 16.70379 10.77

P07954-2 FH 0.75616 0.821024 0.77492 467 50.18071 7.401

P61006 RAB8A 0.901174 1.246924 0.836144 207 23.65319 9.071

P18077 RPL35A 1.477323 1.059888 1.092934 110 12.52977 11.06

O00264 PGRMC1 0.896808 1.252782 0.816996 195 21.65776 4.704

P48643 CCT5 1.237512 1.01463 1.005196 541 59.63281 5.656

P00338 LDHA 1.812565 2.760047 1.429861 332 36.66536 8.265

C9J0K6 SRI 2.289808 155 17.59351 5.605

P27824 CANX 0.925213 0.986537 0.774761 592 67.52585 4.602

E9PI90 TMEM126A 0.972535 1.250469 0.866371 95 10.5577 9.349

E9PIE4 MTCH2 0.568568 0.880562 0.724825 263 28.64363 7.606

O43707 ACTN4 1.262195 1.082558 0.9702 911 104.7885 5.44

O60493-4 SNX3 1.267295 0.705719 0.97026 140 16.30543 6.8

H7BYD0 NDUFA5 0.473911 0.506902 112 13.08984 5.148

H0YNX5 SEC11A 1.109807 1.068807 0.796946 106 11.9784 8.573

P08708 RPS17 1.448131 1.01641 135 15.54039 9.847

of 313

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143

143

P40227-2 CCT6A 1.192214 0.996239 0.919703 486 53.25512 7.269

E9PPQ4 FTH1 0.622898 0.799481 0.801175 58 6.659315 5.833

P62280 RPS11 1.662973 1.502607 1.097377 158 18.41899 10.3

P36578 RPL4 1.35429 1.903045 0.988733 427 47.66743 11.06

Q9NZM1-6 MYOF 1.037945 1.021888 0.808942 2048 233.3291 6.214

P13073 COX4I1 0.483846 0.765167 0.556132 169 19.56405 9.51

Q09666 AHNAK 1.396628 1.078414 1.085748 5890 628.6994 6.151

O00299 CLIC1 1.488679 1.783422 1.075934 241 26.90575 5.173

O75340-2 PDCD6 1.339131 2.016605 0.873893 189 21.6507 5.402

Q9BVK6 TMED9 1.089255 1.206477 1.029899 235 27.26019 8.016

B0YJC4 VIM 1.04978 0.95151 0.834099 431 49.62311 5.25

P16435 POR 1.075094 1.406985 0.862966 677 76.64125 5.58

P62857 RPS28 1.611754 1.450764 1.260379 69 7.836202 10.7

E9PH29 PRDX3 1.032865 1.063725 0.964449 238 25.82229 7.459

F8VWC5 RPL18 1.362265 1.227657 1.081671 159 18.08001 11.84

E7EP42 TIMM23B 0.773211 123 12.69314 5.059

B4DJV2 CS 0.738233 0.967624 0.528491 453 50.39972 7.899

G5E9G0 RPL3 1.270871 1.237766 1.026216 351 40.24159 10.01

P62136 PPP1CA 1.343226 1.108105 1.095776 330 37.48781 6.329

P31930 UQCRC1 0.774534 0.886231 0.935639 480 52.61243 6.367

P05023-3 ATP1A1 1.294006 0.992424 1.007667 992 109.4801 5.313

P30041 PRDX6 2.172555 2.201779 1.531302 224 25.01919 6.379

E9PE17 MRPS17 0.737873 0.985275 129 14.36487 9.847

P56381 ATP5E 0.520223 0.661011 51 5.776108 9.92

P49748-2 ACADVL 0.856184 0.941784 0.884746 633 68.01516 8.558

P24752 ACAT1 0.638064 0.687537 0.508238 427 45.17065 8.851

P62847-2 RPS24 1.28488 1.502636 1.211886 130 15.05924 10.89

J3QRU4 VAMP2 1.035579 0.87911 0.88375 113 12.24347 6.698

of 313

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144

144

P38117 ETFB 0.638357 0.914762 0.756683 255 27.82615 8.104

P50990 CCT8 1.308838 1.110844 1.013766 548 59.58251 5.605

B4DJA5 RAB5A 1.106414 201 22.16413 8.822

H3BLV0 CD55 1.328456 1.063833 0.912351 326 35.78247 5.542

K7EK18 SEPT9 1.098243 2.065827 0.89968 195 22.20265 9.364

M0R210 RPS16 1.69377 1.999538 1.206613 129 14.40996 10.23

H7C131 ACAA1 1.048769 1.409101 0.869312 290 30.31385 8.631

Q9Y3U8 RPL36 1.31536 1.586732 1.003242 105 12.24591 11.59

P63173 RPL38 1.294342 1.106003 0.869385 70 8.212732 10.1

P35579 MYH9 1.302687 1.086399 1.071008 1960 226.3916 5.605

P14923 JUP 1.086031 1.9394 0.870796 745 81.69273 6.138

E7EPK1 SEPT7 1.093627 0.907592 0.935756 436 50.53491 8.631

P60981-2 DSTN 1.581098 1.011045 1.184857 148 16.60962 8.338

P49207 RPL34 1.395191 1.314732 0.995061 117 13.28447 11.47

P62158 CALM1 1.168528 0.976215 1.043359 149 16.82684 4.221

B0V0C2 HLA-C 1.174925 1.450967 1.015708 355 39.9159 6.252

P61020 RAB5B 0.95207 1.502444 215 23.6919 8.133

P62424 RPL7A 1.271624 1.253347 1.056754 266 29.97703 10.61

P32119 PRDX2 1.699211 1.093831 1.077377 198 21.87824 5.973

E9PNW4 CD59 1.27023 1.074834 108 11.97652 5.745

P14406 COX7A2 1.049713 0.36366 83 9.390106 9.759

P56378 MP68 0.57071 1.525767 0.537005 58 6.657592 10.08

E7EQV9 RPL15 1.487834 1.212723 1.172524 174 20.4971 11.28

P26373 RPL13 1.341332 1.017938 1.180794 211 24.24653 11.65

P04264 KRT1 0.85955 0.950506 1.147848 644 65.999 8.119

P07339 CTSD 0.787297 1.54094 0.754058 412 44.52363 6.537

Q96BM9 ARL8A 0.693297 186 21.40204 7.767

O95881 TXNDC12 0.767286 1.351947 0.708736 172 19.19358 5.402

of 313

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P08107-2 HSPA1A 1.451974 1.304211 1.128996 586 63.89795 5.707

P46777 RPL5 1.4141 1.415486 0.956259 297 34.3407 9.715

P46783 RPS10 1.235944 2.429152 1.195446 165 18.88587 10.15

B8ZZT4 VAMP8 0.981127 0.644367 99 11.18456 5.034

P63000 RAC1 0.949096 1.149969 0.843695 192 21.43624 8.5

P31946-2 YWHAB 1.6004 244 27.83274 4.831

P15311 EZR 1.044674 1.131245 0.844371 586 69.36974 6.265

Q9H3R2 MUC13 0.978161 1.009123 0.874289 511 54.4823 5.072

P67936 TPM4 1.082235 248 28.50449 4.691

P51153 RAB13 0.987342 0.880775 203 22.75974 9.188

P04844-2 RPN2 0.865835 1.515186 0.790879 615 67.68143 6.062

P22626-2 HNRNPA2B1 1.46531 1.472787 1.080379 341 35.98387 8.646

Q9NVJ2 ARL8B 1.056423 186 21.52514 8.426

Q07021 C1QBP 0.539476 0.617432 0.63902 282 31.34261 4.843

B0QYW5 SLC25A17 0.80683 1.515895 0.830338 225 25.70527 10.33

P40939 HADHA 0.854214 0.933591 0.693905 763 82.94688 9.042

P18859 ATP5J 0.606499 0.905095 108 12.5796 9.525

Q8NBS9-2 TXNDC5 0.859163 1.032573 0.891072 324 36.15501 5.465

Q9NZ45 CISD1 1.052653 108 12.19121 9.085

R4GN98 S100A6 1.80781 1.242526 85 9.675063 5.453

P60842 EIF4A1 1.965905 2.235364 1.377883 406 46.12456 5.478

P04792 HSPB1 1.745388 1.579063 1.377766 205 22.76849 6.405

P00505 GOT2 0.74356 1.11953 0.835989 430 47.48732 9.012

A6NNI4 CD9 1.162542 1.471833 0.875901 159 17.75198 6.291

J3KTJ8 RPL26 1.253158 1.097186 0.952303 97 11.59029 10.9

P46940 IQGAP1 1.311338 1.179563 1.051245 1657 189.1338 6.481

Q5SQT8 SAR1A 1.342855 1.036644 1.046629 121 13.65307 7.035

A2A2D0 STMN1 1.436459 1.078793 86 9.858311 7.416

of 313

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146

146

E5RJ48 LYPLA1 0.974708 90 9.613937 4.894

I3L1N9 CISD2 0.948726 47 5.140685 8.587

P01891 HLA-A 1.141704 1.080213 0.870519 365 40.88311 6.698

R4GMU8 LAMTOR5 1.802162 1.58376 79 8.210105 5.681

M0R213 NAPA 1.380978 0.797603 83 9.850914 5.059

O00116 AGPS 0.916199 1.008498 0.881695 658 72.86575 7.342

O60869-2 EDF1 1.474209 139 15.47123 9.774

P36542 ATP5C1 0.794469 1.137386 0.851877 298 32.97527 9.217

Q8TBQ9 TMEM167A 0.969974 72 8.054331 8.954

Q9P0J0 NDUFA13 0.945637 1.150368 144 16.6876 8.426

P62745 RHOB 1.735407 196 22.10913 5.237

P62750 RPL23A 1.612112 1.035822 1.037671 156 17.68414 10.45

P42677 RPS27 1.229176 1.262495 1.039197 84 9.454836 9.452

F8WBT9 APOD 1.859735 108 11.78589 7.562

H0YLW1 SPG21 1.172061 1.030744 72 8.198275 8.163

P68032 ACTC1 1.34282 1.013944 1.055046 377 41.99188 5.389

P46779 RPL28 1.626481 1.301392 1.045187 137 15.73767 12.02

O00571-2 DDX3X 1.312787 1.984043 1.036829 646 71.31093 6.625

P00533 EGFR 1.313611 1.150044 0.967401 1210 134.1903 6.683

O00483 NDUFA4 0.523392 0.706709 0.775773 81 9.363911 9.378

A1L0T0 ILVBL 0.939325 1.132552 0.986583 632 67.82475 8.148

Q9BS26 ERP44 1.071049 0.980132 0.906419 406 46.9414 5.262

P39656 DDOST 0.870036 1.214033 0.817799 456 50.76897 6.551

E5RI99 RPL30 1.335092 1.112029 1.043232 114 12.64765 9.554

P50416 CPT1A 0.78061 0.995421 0.755873 773 88.31074 8.646

H0YJ63 AHSA1 1.229447 1.349447 1.208246 90 10.13504 7.035

Q9Y5U9 IER3IP1 1.275533 82 8.962939 8.221

F8W031 2 0.947739 0.875083 0.923028 263 29.20588 7.005

of 313

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147

P47813 EIF1AX 1.885051 1.752925 1.039483 144 16.45023 5.237

P16615 ATP2A2 0.916231 0.957004 0.913417 1042 114.6826 5.338

P25398 RPS12 1.659114 1.104536 1.065406 132 14.50548 7.21

P54886-2 ALDH18A1 0.695204 1.022175 0.785468 793 87.03444 7.123

P50897 PPT1 0.765644 0.910308 306 34.17125 6.522

H0YJ10 4 1.021539 1.300787 0.811753 91 10.72949 8.192

P12277 CKB 1.649735 3.416205 1.579158 381 42.61732 5.592

G3V5B2 LGMN 0.883774 58 6.428232 6.932

Q96D15 RCN3 0.761235 0.664588 0.875835 328 37.47 4.894

P61978-3 HNRNPK 1.293792 1.262426 1.041703 440 48.53217 5.542

Q9UJZ1 STOML2 0.938409 0.635069 0.93784 356 38.5102 7.386

Q9NUP9 LIN7C 1.20256 1.122703 197 21.82047 8.426

Q969X5-2 ERGIC1 1.119816 0.901479 0.66877 198 22.14624 9.159

C9IZG4 CUTA 0.988956 1.690078 1.10773 135 14.39131 5.453

F8WB87 CCDC66 0.945362 38 4.209334 7.24

Q9H9B4 SFXN1 0.877179 0.76235 322 35.59635 9.071

Q9BW72 HIGD2A 0.560691 106 11.52112 10.2

Q8WVC2 RPS21 2.174773 1.079974 81 8.844458 8.5

E9PK01 EEF1D 1.302939 1.516644 1.004283 261 28.8036 5.021

Q9UBQ0-2 VPS29 1.041183 0.601188 0.878376 186 20.9139 7.049

P08559 PDHA1 0.60855 0.708728 0.778748 390 43.26761 8.06

K7ES20 CDKN2A 1.387355 2.537661 1.194942 104 11.0686 6.062

Q7KZF4 SND1 1.045645 1.052682 0.894108 910 101.9335 7.167

O00159-2 MYO1C 1.090572 1.879908 0.932649 1028 117.8338 9.408

Q05639 EEF1A2 1.264052 1.278046 463 50.43831 9.027

P13797 PLS3 1.278969 1.281915 0.894728 630 70.76621 5.605

Q71UI9-2 H2AFV 1.022639 0.894296 114 12.13865 10.46

P51809 VAMP7 0.593834 1.216902 0.666516 220 24.91897 8.602

of 313

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148

H0YHC3 NAP1L1 1.749507 1.215395 1.242297 198 23.40282 4.805

H0YK49 ETFA 0.808242 0.650196 0.816799 229 24.14479 8.661

P55072 VCP 1.356492 1.053145 1.115978 806 89.26572 5.262

P40429 RPL13A 1.465869 1.290089 1.005122 203 23.56238 10.93

C9JTY3 TFG 1.535206 128 14.74983 5.364

Q9Y2Q3 GSTK1 0.827654 1.67774 0.733029 226 25.4803 8.412

Q15738 NSDHL 0.85239 1.055136 0.852621 373 41.87357 8.06

E5RFR7 TPD52 1.234298 111 12.38146 4.678

Q96AY3 FKBP10 0.996141 1.329693 0.892073 582 64.20419 5.618

M0R0F0 RPS5 1.166646 2.470449 1.0889 200 22.37678 9.554

P62753 RPS6 1.397225 1.387364 1.065198 249 28.66299 10.84

E9PNM1 FDFT1 0.895386 0.707255 0.816685 410 47.25481 6.537

P26641 EEF1G 1.415485 1.530083 1.06643 437 50.08714 6.668

B8ZZQ6 PTMA 5.213533 1.279016 107 11.75182 3.815

H7BXT7 BET1L 1.055968 58 6.461192 4.881

H3BN98 4 1.438958 1.477913 1.126454 237 27.15036 9.554

P21333-2 FLNA 1.379542 1.316975 1.06758 2639 279.8435 6.049

P09972 ALDOC 1.14555 0.929752 364 39.43124 6.874

Q9BTV4 TMEM43 0.780347 1.962667 0.746693 400 44.8472 8.133

Q9NQC3-2 RTN4 1.054777 1.248568 0.896947 373 40.29295 4.78

P05198 EIF2S1 1.355816 1.614618 1.018009 315 36.08938 5.084

F8WBD0 SELT 1.090135 45 4.854753 11.06

O75394-2 MRPL33 1.602748 54 5.961127 9.129

P05362 ICAM1 1.305694 1.302605 0.922945 532 57.78895 7.987

Q14257 RCN2 0.96242 0.623272 0.879469 317 36.85364 4.399

P50151 GNG10 1.012014 68 7.200677 7.855

B4DVE7 ANXA11 1.313376 1.152581 1.024236 472 51.20963 7.665

Q96CG1 ETF1 1.291047 1.189461 0.911591 404 45.43428 5.567

of 313

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The

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may

dif

fer

from

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149

149

H7C342 DDT 1.587367 50 5.696016 8.734

P63092-3 GNAS 1.24904 0.974517 0.876229 379 44.15129 6.291

P06748-2 NPM1 1.232216 1.080336 265 29.44624 4.615

P60468 SEC61B 0.969906 0.935849 0.82461 96 9.968098 11.56

P28288-2 ABCD3 0.788009 0.999881 0.771997 549 62.68583 9.232

Q8NE86-3 MCU 0.419177 1.259917 0.395554 302 35.13636 7.489

P35610 SOAT1 0.95731 1.141503 0.792908 550 64.69228 8.939

E9PJK1 CD81 0.86806 1.22258 0.922512 165 17.95093 4.996

H3BPJ9 NDUFB10 0.77567 161 19.24561 8.705

Q9Y5J9 TIMM8B 0.796617 0.872531 83 9.337537 5.123

F8VZ49 HNRNPA1 1.457102 1.12016 0.929332 231 25.67093 8.265

H7BYV1 IFITM2 0.942264 1.110098 1.041262 74 8.191374 9.554

O75955 FLOT1 0.959809 1.219525 0.894697 427 47.32562 7.489

E5RIX8 TBCA 1.739399 1.326092 79 9.390927 5.376

Q9H7Z7 PTGES2 0.708644 1.222006 0.767571 377 41.91667 9.159

Q9BX68 HINT2 0.971993 1.052643 163 17.15124 9.159

K7ERU1 PTPN2 1.112802 0.919441 42 5.149685 6.494

P20674 COX5A 0.642662 0.823961 0.797611 150 16.75169 6.786

K7ELW0 PARK7 1.709521 1.716847 169 17.89849 7.87

P21291 CSRP1 1.305284 1.28095 0.904117 193 20.55376 8.573

H0YJC4 PSMA6 0.875222 85 9.33469 4.412

E9PRJ5 NDUFC2 1.275935 71 8.260498 9.876

Q9NVI7-3 ATAD3A 0.736017 0.95477 0.758229 507 57.91198 9.247

O60506-4 SYNCRIP 1.439233 1.325961 1.109899 527 58.69934 7.562

P43121-2 MCAM 0.888794 527 57.56921 5.516

Q00610-2 CLTC 1.264943 1.277724 1.081325 1639 187.7708 5.694

D6RG34 SLC35B1 0.745193 76 8.437234 8.573

P11940-2 PABPC1 1.51283 1.56743 0.845456 547 61.14204 9.071

of 313

Ant

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dif

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150

150

P52907 CAPZA1 1.176207 2.293021 1.045937 286 32.90233 5.694

P47755 CAPZA2 1.297423 0.592928 286 32.92861 5.846

P62266 RPS23 1.216428 2.655464 1.01516 143 15.79772 10.49

O14745 SLC9A3R1 1.260811 1.01792 1.042626 358 38.84461 5.77

P62854 RPS26 1.351794 0.788218 115 13.00708 11

O95816 BAG2 1.272411 1.042008 1.089469 211 23.75721 6.698

B1AK87 CAPZB 1.603968 1.278082 260 29.27683 6.917

Q15758 SLC1A5 1.308418 1.492866 1.055568 541 56.56225 5.478

P00403 MT-CO2 0.70371 1.021196 0.80279 227 25.54821 4.818

P08240-2 SRPR 0.957363 1.306896 0.943597 610 66.5166 9.042

P20338 RAB4A 1.124238 218 24.37422 6.075

P31040 SDHA 0.710747 0.800021 0.515262 664 72.64529 7.386

P46778 RPL21 1.327984 160 18.55306 10.49

J3QRD1 ALDH3A2 0.739254 0.922268 0.81764 393 44.61966 5.529

Q9P2E9-2 RRBP1 0.963369 0.97999 0.774962 1407 152.0976 8.661

P61353 RPL27 1.418572 1.185726 1.319388 136 15.78775 10.56

O60568 PLOD3 0.984509 0.966926 0.997824 738 84.73148 6.049

Q7Z451 AP2B1 1.095112 1.00145 880 98.05567 5.237

P21266 GSTM3 1.957089 0.908341 225 26.54214 5.542

P43121 MCAM 1.271354 1.833761 0.94972 646 71.5626 5.757

P28066 PSMA5 1.174746 1.323802 241 26.39421 4.792

Q99720-3 SIGMAR1 0.907501 1.012009 192 21.46903 5.986

H0YDT8 EMC7 0.745164 0.727399 0.818959 192 20.98168 9.364

C9JKI3 CAV1 0.962885 0.926635 138 15.91812 5.25

Q96C01 FAM136A 1.339867 138 15.63066 7.606

Q8N5N7 MRPL50 0.873347 1.175161 0.730664 158 18.31337 7.884

Q9UDT1 WUGSC:H_RG122E10.2a 0.955392 79 8.374288 7.87

Q96A33 CCDC47 0.925467 1.238405 0.965277 483 55.83831 4.869

of 313

Ant

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151

151

O43175 PHGDH 1.747724 2.068921 1.496959 533 56.61441 6.712

H7C463 IMMT 0.877231 0.809576 0.904617 613 68.13328 6.062

P09669 COX6C 0.728532 75 8.77569 10.39

K7ESJ4 PDCD5 0.907409 0.995335 65 7.463784 8.25

P07686 HEXB 0.741613 0.992336 0.75352 556 63.07118 6.756

Q9BUF5 TUBB6 1.672282 2.65095 1.110157 446 49.825 4.881

P32322-2 PYCR1 0.845045 0.642088 0.695944 316 33.3195 6.8

Q14344 GNA13 1.227688 0.797547 377 44.02167 8.001

Q53GQ0 HSD17B12 0.970736 0.911635 312 34.30219 9.32

K7EPV6 SLC44A2 1.068303 0.984311 146 16.72829 8.661

O75915 ARL6IP5 0.964027 1.020583 1.120619 188 21.60041 9.774

B4DLN1 SLC25A10 0.858637 0.915177 0.867875 442 48.06871 9.525

E9PP23 ACP2 0.827875 1.245691 0.514516 305 35.13374 7.606

P51571 SSR4 0.914168 1.083905 0.770754 173 18.98661 6.151

H0YID2 AK1 1.369342 51 5.828051 5.313

P15941-7 MUC1 1.044978 2.078388 0.85959 255 27.54883 6.379

P07099 EPHX1 0.999873 1.231505 0.831531 455 52.91497 7.254

P49720 PSMB3 1.0479 1.238449 0.807103 205 22.93345 6.551

I3L294 ABHD12 0.977071 159 18.02189 5.948

P63096 GNAI1 1.312397 1.01678 354 40.33523 5.973

P20645 M6PR 0.989309 0.783721 0.824571 277 30.97338 5.833

J3KTD9 ALDH3A2 1.14157 62 7.077955 5.719

P60866 RPS20 1.455372 1.259972 1.211516 119 13.36431 9.935

P30084 ECHS1 0.883418 1.356612 0.867611 290 31.36713 8.075

K7EJN0 ZNF383 1.612734 114 13.15237 4.539

Q9UBS4 DNAJB11 0.972224 1.029518 358 40.48862 6.176

P07203 GPX1 1.062831 203 22.07511 6.551

P04040 CAT 0.850883 0.954433 0.938398 527 59.71876 7.386

of 313

Ant

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152

152

P62070 RRAS2 1.266491 1.827886 1.19924 204 23.38472 6.011

O95295 SNAPIN 0.956505 0.88864 0.963864 136 14.86489 9.305

P60059 SEC61G 0.944746 68 7.736173 9.994

Q9BWM7 SFXN3 0.531569 1.297676 0.717848 325 35.95574 9.085

D6RFH4 CYB5B 1.229277 1.121125 0.872535 131 14.83656 6.189

Q9H488-2 POFUT1 1.008152 0.897625 0.79064 194 22.32318 8.763

P31949 S100A11 2.030099 1.585923 1.773105 105 11.73283 7.123

P26885 FKBP2 1.060719 0.988314 0.97951 142 15.63932 9.129

J3QL14 ATP6V0D1 0.866587 0.826526 0.729162 232 26.79831 4.945

E3W990 SQSTM1 1.018551 190 20.92407 6.507

Q96B49 TOMM6 1.217067 0.519094 74 7.997054 4.894

G3V1U5 GOLT1B 1.450358 74 8.208504 10.26

P07602 PSAP 0.683775 0.629512 0.706638 524 58.07385 5.173

P54136-2 RARS 1.198519 1.2051 1.051643 588 67.09754 6.551

P35241 RDX 1.144341 0.789788 0.79542 583 68.52139 6.367

Q05682-5 CALD1 1.137854 0.959064 532 61.17615 6.712

Q7Z7F7 MRPL55 0.786156 0.729764 128 15.11912 11.15

H7C5U3 MFSD1 0.754188 0.65536 64 6.817588 4.831

K7EMN2 PGD 2.315309 0.984759 160 17.28195 8.441

Q9NYU2-2 UGGT1 0.966708 1.082893 0.827887 1531 174.867 5.605

Q49AN9 SNRPG 1.06565 64 7.096674 7.181

H3BTL1 MAP1LC3B 1.202473 1.328199 0.978317 75 9.005942 9.818

Q16143 SNCB 0.609864 134 14.27902 4.412

Q9Y3B3-2 TMED7 1.068593 188 21.21938 6.202

B4E241 SFRS3 1.073649 124 14.19419 10.08

P01111 NRAS 1.312077 1.099683 1.02401 189 21.21552 5.173

P11177-2 PDHB 0.801466 0.826505 0.686171 341 37.17589 5.897

O95573 ACSL3 1.005102 0.842287 0.750326 720 80.3683 8.382

of 313

Ant

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153

153

Q5QNZ2 ATP5F1 1.016849 0.861305 0.934918 195 22.26079 9.261

F5H895 DAD1 0.941767 1.090094 0.921763 65 7.283816 6.507

Q04941 PLP2 1.11339 1.166644 0.873699 152 16.6797 7.24

Q15363 TMED2 1.129736 0.691615 0.857814 201 22.74638 5.173

Q9Y3D7 PAM16 0.499786 125 13.81625 9.701

H0YAL7 EEF1E1 0.983966 136 15.32889 8.397

Q8NBJ5 COLGALT1 1.034208 1.152908 0.94246 622 71.59049 7.313

P16403 HIST1H1C 1.104125 0.964902 213 21.35175 10.93

P21912 SDHB 0.78746 0.688895 0.585378 280 31.60884 8.763

Q99735-2 MGST2 1.108131 77 8.353378 9.452

Q99643-5 SDHC 1.05488 116 12.46562 8.983

Q8NI22-2 MCFD2 0.873529 94 10.71107 4.412

D3YTB1 RPL32 1.46215 1.225551 1.090284 133 15.60672 11.44

P68036-2 UBE2L3 1.29082 122 14.1123 8.924

A8MXH2 NAP1L4 1.024651 156 18.14119 5.097

P54709 ATP1B3 0.862547 1.39039 0.692303 279 31.4921 8.353

Q6PIU2 NCEH1 0.983177 1.03137 0.951544 408 45.77873 7.225

P10301 RRAS 0.982982 218 23.46589 6.932

F5GX33 SLC25A13 0.957621 0.688932 0.827212 567 62.20553 9.012

P05556 ITGB1 1.158754 1.035265 0.917412 798 88.35701 5.389

Q10589 BST2 1.017301 0.804819 0.929134 180 19.75632 5.605

O14717-6 TRDMT1 1.173837 1.692801 0.93187 107 12.07936 9.408

F2Z388 RPL35 1.250751 1.521157 1.170053 96 10.63799 10.29

P25789 PSMA4 1.638164 1.269063 261 29.46518 7.723

J3QR09 RPL19 1.070284 0.939773 1.179406 193 23.12009 11.47

P60903 S100A10 1.135403 0.850453 1.076286 97 11.19551 7.372

Q15006 EMC2 0.863007 0.726281 0.875542 297 34.81137 6.566

Q9GZY8-4 MFF 0.739802 0.53782 0.695619 218 25.05105 5.58

of 313

Ant

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The

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dif

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from

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154

154

Q9P035 PTPLAD1 0.877567 1.337144 0.857696 362 43.13156 8.939

Q96QK1 VPS35 1.003638 1.242269 0.838696 796 91.64894 5.491

O60762 DPM1 0.851512 0.83312 0.902944 260 29.61578 9.569

P05534 HLA-A 1.27307 0.891351 365 40.66303 6.341

P06280 GLA 0.884287 0.768463 0.781778 429 48.73487 5.605

P07951 TPM2 0.820195 284 32.83057 4.704

Q8WUH6 C12orf23 0.815821 116 11.7411 9.32

Q96IX5 USMG5 1.416234 1.690851 58 6.453373 9.759

F8VZL6 SLC11A2 0.841982 87 9.529282 6.507

P17931 LGALS3 1.461607 1.151114 0.995674 250 26.13605 8.558

P07741-2 APRT 1.912567 1.645471 134 14.54781 7.342

H0YAG0 OSCP1 0.904197 94 10.27113 4.488

Q9UII2 ATPIF1 0.999876 0.587263 0.953559 106 12.24131 9.349

H0YCU8 ZFPL1 1.030018 53 6.09175 4.145

P62861 FAU 1.083569 2.505195 1.002681 59 6.643817 12.15

Q9Y3L5 RAP2C 1.022952 2.862522 183 20.7314 4.945

P22314 UBA1 1.679951 1.436978 1.088012 1058 117.7743 5.757

Q12974-3 PTP4A2 1.853871 136 15.6589 8.485

F5H7F6 MGST1 1.09648 0.754375 77 8.880476 8.792

B4DLR8 NQO1 1.86144 2.576048 1.108224 202 22.7789 8.5

O15400-2 STX7 1.134266 1.059861 239 27.38366 5.123

M0R1C0 SARS2 1.048859 90 10.26025 9.525

H3BRM6 GSTM1 1.831089 102 11.97895 5.262

B7Z9S8 ATP1B1 0.987011 1.162697 0.775269 247 28.60945 7.591

Q9HBH0 RHOF 0.955615 211 23.61022 8.646

E5RHW4 ERLIN2 1.075576 1.673551 0.91896 338 37.70141 5.618

Q15067 ACOX1 0.820907 0.853837 0.80665 660 74.37619 8.163

Q8NF37 LPCAT1 0.968721 0.940151 0.824247 534 59.11339 6.024

of 313

Ant

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from

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155

155

B3KUK2 SOD2 0.983114 1.068819 0.875183 176 19.718 8.031

Q9NP58-4 ABCB6 0.866446 0.735973 0.921757 796 88.54343 8.69

P53007 SLC25A1 0.657693 0.838483 0.552905 311 33.991 9.891

C9JDI6 ARHGEF7 1.054952 61 7.059381 5.237

I3L2F4 EDC4 1.135017 135 14.88059 8.88

Q02818 NUCB1 0.746638 0.571069 0.704151 461 53.84633 5.25

P34931 HSPA1L 1.29594 641 70.33133 6.024

Q9Y3E5 PTRH2 1.195788 0.669064 0.835644 179 19.18096 8.734

B7Z371 SEPT10 1.00586 0.998061 321 37.86738 8.104

P57088 TMEM33 0.828436 1.442192 0.868994 247 27.95981 9.701

Q6IAA8 LAMTOR1 1.24942 0.816071 0.786799 161 17.73383 5.148

Q9NR28-2 DIABLO 0.635184 186 21.2195 4.805

P59998 ARPC4 1.341496 1.09597 1.045125 168 19.6543 8.426

I3L0U2 PRSS21 0.691442 0.583658 0.82809 218 24.80035 8.309

B4E2W0 HADHB 0.850703 0.886421 0.451736 452 48.84822 9.173

Q16836 HADH 0.792688 0.742475 0.744782 314 34.27194 8.851

P13645 KRT10 1.28587 0.939907 0.591393 584 58.7917 5.211

J3KNT0 FSCN1 1.29256 1.174877 0.981105 472 52.22991 7.445

B4DJP7 SNRPD3 1.222577 2.00277 0.961715 120 13.28287 8.91

O96008-2 TOMM40 1.011459 0.843353 0.925812 329 34.41926 7.24

P09493-2 TPM1 1.324331 0.743304 228 26.66351 4.818

P53999 SUB1 1.527801 1.221018 127 14.38641 9.598

Q92820 GGH 0.839025 1.22591 0.82501 318 35.94117 7.108

P60891 PRPS1 2.22903 1.813701 1.35476 318 34.81193 6.976

J3KNJ2 EIF3M 1.620833 2.034655 1.076182 191 21.67855 7.767

Q96GS4 C17orf59 0.854628 0.76674 357 37.20361 5.757

B4DL37 AKR1C3 0.987396 2.243348 1.180967 204 23.34887 7.987

F5H780 TXNRD1 1.297551 1.226029 459 50.63389 6.625

of 313

Ant

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Pero

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dif

fer

from

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156

156

Q969V3-2 NCLN 0.894773 0.958908 0.953311 562 62.80652 6.888

Q96AP7 ESAM 1.027231 1.020602 390 41.15057 9.32

C9JT62 HDLBP 0.96782 96 10.62135 5.415

Q96HY6 DDRGK1 0.986476 1.127326 314 35.5895 5.123

O43399-2 TPD52L2 1.061307 1.272973 0.957152 186 19.8891 5.478

Q01650 SLC7A5 1.431562 1.133416 1.266765 507 54.97428 7.723

H7C0D5 YIPF4 0.89801 58 6.443188 4.424

P21281 ATP6V1B2 0.917239 1.985412 0.827157 511 56.46488 5.808

P30153 PPP2R1A 1.46472 1.401303 589 65.26692 5.11

O14818-4 PSMA7 1.652808 149 16.12523 8.016

E5RJR5 SKP1 0.83808 163 18.7083 4.704

D6RAW0 UBE2D3 1.458593 72 8.208111 8.88

Q9UBV2-2 SEL1L 0.957267 0.94284 301 33.50934 4.831

P22307-4 SCP2 0.926588 0.997557 0.801347 466 50.30939 7.02

P33316-2 DUT 1.286103 1.06712 164 17.73693 6.566

P62263 RPS14 1.753372 1.312114 1.238416 151 16.26253 10.05

K7EMV3 H3F3B 1.138243 92 10.32783 11.82

P12814-2 ACTN1 1.286 1.051952 887 102.6444 5.503

E9PN68 EPS8L2 1.150686 79 8.599192 8.016

O60664-4 PLIN3 1.365876 0.982602 1.202173 422 45.77523 5.427

F5H587 TM7SF3 0.930398 66 7.269389 3.98

P62306 SNRPF 2.06344 86 9.718777 4.666

P42765 ACAA2 0.664527 0.989564 0.733337 397 41.89765 8.089

P49257 LMAN1 1.063775 0.783376 0.907985 510 57.51298 6.771

P83881 RPL36A 1.429071 106 12.43281 10.58

O00560-3 SDCBP 1.00285 1.337478 0.9725 292 31.74152 7.533

Q14108 SCARB2 0.91485 0.796744 478 54.25546 5.135

P15291-2 B4GALT1 0.852987 0.735356 385 42.51059 8.5

of 313

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157

157

P51572 BCAP31 0.946674 1.001908 0.936711 246 27.97401 8.441

E9PQW0 PEX16 0.739747 60 6.828543 8.69

Q9H4G0-4 EPB41L1 1.079995 0.94112 0.691207 701 78.78222 7.093

Q5TB53 TM9SF3 1.044122 1.176811 1.01852 254 29.91872 5.821

Q96E11-2 MRRF 1.006137 0.813755 201 22.43575 9.715

B4DSN5 PTPN1 0.975514 1.198382 1.02545 362 41.23352 5.973

Q13740-2 ALCAM 1.304214 1.065807 1.040666 570 63.62447 7.298

Q9HDC9 APMAP 1.059751 1.719589 0.767649 416 46.45085 6.164

C9JFR7 CYCS 0.500598 0.686837 0.429284 101 11.32596 9.657

P09382 LGALS1 1.711321 2.920376 135 14.7062 5.503

P60201 PLP1 0.911351 277 30.0571 8.353

Q9Y5L4 TIMM13 1.143695 1.50709 0.927134 95 10.493 8.177

P10606 COX5B 0.823219 0.631925 0.835023 129 13.68694 8.807

K7EJ78 RPS15 0.925059 129 14.72883 10.24

C9IZ01 GFM1 0.587804 0.935326 0.620201 591 65.9928 8.06

P06744 GPI 1.348222 1.828248 1.178758 558 63.10725 8.324

Q9UL25 RAB21 1.085956 225 24.33226 7.943

G8JLQ3 BLOC1S1 1.164209 75 8.562332 5.973

O95831-3 AIFM1 0.940237 0.661734 1.070264 609 66.25356 8.939

A6NLH6 CNIH4 0.526879 1.017896 137 15.75993 6.961

Q9BSJ8 ESYT1 0.941908 0.91924 0.810372 1104 122.78 5.833

P61981 YWHAG 1.142905 247 28.28491 4.894

P18669 PGAM1 3.402846 2.572908 1.775781 254 28.78584 7.181

P06865 HEXA 0.741061 1.292861 0.744929 529 60.66428 5.161

Q9Y2T3-2 GDA 1.566466 380 42.41842 5.478

C9J388 GALNT3 1.545813 90 10.78688 10.37

P43487 RANBP1 1.57851 2.930969 2.310803 201 23.29557 5.288

H3BNE1 SNAP23 1.377626 97 11.13347 4.945

of 313

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158

158

J3QQY2 TMCO1 0.474765 104 11.36482 9.657

K7EQB1 STX8 0.998855 125 14.15518 4.526

B3KP87 MDS025 1.39529 153 17.80015 6.049

Q92599-3 SEPT8 1.120498 369 43.49215 6.341

P61769 B2M 1.401427 119 13.70591 6.522

G3V576 HNRNPC 1.169722 2.128537 0.967671 231 25.24106 9.818

D6R9X5 G3BP2 1.120781 56 6.446252 9.129

H0Y2L7 HMGCL 1.296851 182 19.0678 8.558

F8W8K9 AP1S3 0.807881 63 7.753411 10.55

Q5BJF2 TMEM97 0.875928 0.795105 0.757884 176 20.83417 9.378

B4DHW1 TMEM165 0.974704 1.003516 0.941358 261 28.41395 6.537

O95716 RAB3D 0.760676 219 24.25181 4.932

P11279 LAMP1 0.608898 1.120847 0.706852 417 44.85382 8.749

D6RFY5 PIN4 0.694351 106 11.91329 9.217

Q8IVT2 MISP 1.199723 0.98305 1.110681 679 75.31095 6.83

Q9BQB6-3 VKORC1 0.876945 92 9.868119 8.397

Q562R1 ACTBL2 0.9542 376 41.97597 5.592

G3V1I3 FAM9C 0.945348 128 14.75897 4.412

P05386 RPLP1 1.205217 2.053789 0.964117 114 11.50669 4.323

E9PPH5 ANP32E 1.637476 114 13.12044 4.221

O75489 NDUFS3 0.592567 0.923178 264 30.22271 7.503

C9JNK6 MTX2 0.767573 207 23.62804 6.786

P13284 IFI30 0.963744 0.568155 0.601458 250 27.94501 4.881

O95292 VAPB 1.125427 0.969664 243 27.21109 7.298

O75439 PMPCB 0.659306 0.939695 0.498041 489 54.3315 6.83

O15173 PGRMC2 0.827862 1.932896 0.829608 223 23.80373 4.881

Q6YN16 HSDL2 0.823101 0.762803 418 45.36552 7.987

Q13637 RAB32 1.051914 1.252506 0.905242 225 24.98169 6.537

of 313

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159

159

P16278-3 GLB1 0.840196 0.913291 0.761187 647 72.70454 6.252

Q99536 VAT1 1.187142 0.901623 1.084757 393 41.89342 6.291

Q8N4H5 TOMM5 0.591459 51 6.031371 9.701

Q96HS1-2 PGAM5 0.454368 1.187436 255 28.00246 7.254

P31947 SFN 3.446891 248 27.75669 4.742

Q96CS3 FAF2 1.089111 1.28199 0.972315 445 52.59055 5.618

Q7Z650 MTHFD2 0.605882 0.492332 1.147144 248 26.83225 7.181

F5H1S8 MLEC 0.980032 1.037988 146 16.71859 5.567

P30049 ATP5D 0.934173 0.710515 168 17.47919 5.491

C9JP16 CRTAP 1.000826 1.113831 358 41.40646 5.872

P48449-2 LSS 0.915827 1.416043 0.777651 652 74.16963 6.456

K7EP16 EIF3G 1.661915 118 13.20375 9.349

Q16850 CYP51A1 0.662896 0.698398 0.722726 503 56.76947 8.529

O75531 BANF1 0.762528 89 10.05202 6.087

O75844 ZMPSTE24 0.86299 0.817096 0.784706 475 54.77753 7.489

Q86UE4 MTDH 0.907267 0.715012 0.654347 582 63.79881 9.32

F8W6E4 GPD2 0.899309 0.75753 0.803208 500 55.72346 6.252

D6RA82 ANXA3 2.968576 2.210312 1.509352 284 32.09853 5.935

Q9Y3D5 MRPS18C 0.82206 142 15.83928 9.554

Q12965 MYO1E 1.157812 1.586147 0.860113 1108 126.982 8.924

E9PCY7 HNRNPH1 1.363449 1.306548 1.101049 429 47.05745 6.341

E9PI87 HTATIP2 0.865647 0.838961 196 21.96233 7.401

P00167-2 CYB5A 0.906793 98 11.26149 5.135

P63218 GNG5 1.272266 68 7.313805 9.847

P61619 SEC61A1 0.879768 0.896405 0.827963 476 52.23052 8.06

H3BRS6 ADPGK 0.893255 204 21.90121 5.542

P13489 RNH1 1.652398 1.238122 461 49.94109 4.818

O95167 NDUFA3 1.14379 84 9.272854 8.456

of 313

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160

160

B1AK63 MEAF6 1.387248 169 19.15251 9.071

H0YGH6 A2M 0.730294 200 21.88479 6.164

P62913-2 RPL11 1.272692 1.258457 0.902436 177 20.11158 9.598

F8WE40 PPP1R21 1.686818 54 5.996114 8.148

Q9UM22 EPDR1 1.020808 1.082312 0.768408 224 25.42059 6.595

Q9HCU5 PREB 1.062268 1.629471 0.735926 417 45.43967 7.884

C9J4I9 PXDN 0.821855 224 25.55339 9.071

Q9UQ80 PA2G4 1.590945 1.198977 1.160384 394 43.75919 6.551

Q14974 KPNB1 1.22989 1.503563 1.088321 876 97.10802 4.78

P24534 EEF1B2 1.585491 1.279222 1.094085 225 24.74826 4.666

Q12797-10 ASPH 1.043348 1.189876 0.813744 729 83.21622 4.919

J3QLD9 FLOT2 1.032759 1.570063 0.976805 428 47.11269 5.313

I3L1P8 SLC25A11 1.077713 0.696175 296 32.16176 9.774

C9J3L8 SSR1 0.93948 1.461099 0.808455 265 29.55479 4.297

Q7L2E3-3 DHX30 0.849954 0.940023 0.934964 1155 129.3572 8.529

Q16401-2 PSMD5 1.194932 1.623917 461 51.27975 5.44

C9JAG1 EPT1 0.751895 180 20.54343 6.507

P47985 UQCRFS1 0.652977 274 29.64937 8.324

Q9Y281-3 CFL2 1.417396 1.240597 149 16.90597 8.617

Q9BQC6 MRP63 0.859636 102 12.25851 11.44

Q68CR9 DKFZp781B11202 1.19292 0.795632 0.839561 401 45.7421 5.707

P22234 PAICS 1.702885 425 47.04914 7.225

O15427 SLC16A3 1.232511 1.776773 0.928498 465 49.43689 7.958

O00410 IPO5 1.463066 1.30058 0.90374 1097 123.5499 4.945

H3BNK3 NDUFAB1 0.729937 1.041921 111 12.20118 4.627

K7EKI4 MRPL4 0.721064 127 14.04731 7.401

O43752 STX6 0.887754 255 29.15782 4.932

H0Y4R1 IMPDH2 1.902177 1.154282 1.101765 470 51.03521 8.177

of 313

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161

161

Q8TF09 DYNLRB2 1.842978 0.831149 96 10.84772 7.503

H7C3P4 GNS 0.696256 0.943496 0.683875 496 56.33784 7.914

P25788-2 PSMA3 2.155845 248 27.62974 5.326

H0YD64 SLC43A3 0.840539 0.847195 137 15.77293 9.042

P13674-3 P4HA1 0.892033 0.747971 0.914487 516 58.92102 6.024

O14828 SCAMP3 0.890442 0.891977 347 38.26233 7.635

O43615 TIMM44 0.861854 0.602304 452 51.32346 8.324

Q5T0M2 SFTPD 1.430391 218 20.98747 9.334

H0YA96 HNRNPD 0.899992 2.609714 0.891389 210 23.90618 9.583

Q5T7C0 HMGB1 1.619916 97 11.34476 9.891

O94874-2 UFL1 1.047756 1.340076 0.869645 729 82.04688 6.961

O00186 STXBP3 1.092524 1.366247 0.949951 592 67.72085 7.796

H0YD18 NUCB2 0.551343 0.921066 0.543678 73 8.61033 5.034

O00303 EIF3F 1.370267 1.308429 0.918465 357 37.54015 5.453

B4DXI5 HACL1 1.011871 0.775829 0.904438 496 54.68875 7.386

O14908-2 GIPC1 0.833121 0.748431 236 26.0554 5.567

J3QT77 PON2 0.861767 0.894472 0.683039 342 37.95661 5.719

P31942-6 HNRNPH3 1.127698 139 15.40311 6.405

P31948 STIP1 1.849264 0.868017 543 62.59941 6.8

C9JH92 CRYZ 1.182705 0.995488 206 21.91846 8.763

Q9NTJ5 SACM1L 0.965358 0.756503 0.77892 587 66.92401 7.123

Q12907 LMAN2 0.983969 1.472574 0.593896 356 40.2031 6.947

H0YL72 IDH3A 0.749484 331 35.76304 6.443

Q9NVX0-2 HAUS2 0.648186 141 16.52282 8.441

E9PK34 ARCN1 1.916516 83 9.096853 9.496

Q8IV08 PLD3 0.73999 0.772273 0.894603 490 54.67051 6.468

P61225 RAP2B 1.225306 183 20.49121 4.805

C9J151 CLASP1 1.95138 1.10518 150 16.47028 5.681

of 313

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162

162

E5RFI3 PPP2CB 0.856556 125 14.48235 5.846

Q13813-3 SPTAN1 1.139287 1.219372 1.1031 2452 282.108 5.338

K7EJE8 LONP1 0.829917 1.016024 0.519841 829 93.23797 6.494

Q9UNE7 STUB1 1.148392 0.866995 303 34.83425 5.872

Q3ZAQ7 VMA21 0.810308 1.110932 101 11.34687 7.24

Q5RI15 COX20 1.256363 0.797828 118 13.2828 8.763

O95832 CLDN1 1.142394 0.875745 211 22.72858 8.089

Q53GA4 PHLDA2 0.940372 0.863586 152 17.08185 9.173

E7EPW2 MRPS25 0.661211 0.804902 110 12.93769 9.745

H7C1H2 PSMD2 1.011241 2.326836 203 22.42748 6.888

P25786 PSMA1 2.193811 263 29.53686 6.61

Q9H3N1 TMX1 0.844979 2.043181 280 31.7708 4.983

B4DJ81 NDUFS1 0.974395 0.790292 0.38251 611 66.87901 5.376

Q12805-2 EFEMP1 0.801188 1.250061 0.854084 485 53.6867 5.021

B4DDG7 AP1M1 0.933933 1.013888 0.758721 351 40.22886 7.196

E5RIU6 CDK1 1.693136 1.248107 189 21.7245 8.514

Q96N66-3 MBOAT7 0.846529 1.232302 0.640309 344 38.44495 8.866

Q5T8R5 SLC16A1 1.263313 2.216101 456 49.18659 9.159

P27449 ATP6V0C 0.967412 1.412399 0.842574 155 15.72546 8.441

G3V5Q1 APEX1 1.136659 1.255624 0.974198 242 27.10788 8.763

Q02809 PLOD1 0.877053 0.822037 0.784821 727 83.49739 6.947

G3V2B8 MTHFD1 1.347932 1.357394 1.207432 935 101.4673 7.298

A8MUF7 HBE1 0.656514 2.016002 87 9.463879 9.129

P51398-2 DAP3 0.575503 0.867781 357 41.01839 8.983

Q5HY57 EMD 0.857364 0.682404 219 24.92288 5.021

P10109 FDX1 0.806776 184 19.38062 5.833

B7Z6A8 ABHD10 0.814569 149 16.89883 6.727

P35527 KRT9 0.97582 623 62.02682 5.237

of 313

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163

163

Q9ULV4 CORO1C 0.991697 0.92873 474 53.21506 7.079

Q8NC51-4 SERBP1 1.738228 1.416782 1.265482 387 42.40128 8.441

B7Z3G9 RASA3 1.17287 132 15.40668 8.763

O60220 TIMM8A 0.68574 1.020334 0.682477 97 10.9913 5.161

Q9Y305-2 ACOT9 1.137077 0.758182 406 46.32453 7.972

Q9BZ62 FKSG61 0.770369 124 13.83909 9.203

P19338 NCL 1.040359 1.025532 0.933224 710 76.56836 4.704

R4GN43 NDUFA6 0.668874 1.001193 71 8.50446 9.466

Q9P0L0 VAPA 1.398465 1.527194 0.837129 249 27.87521 8.617

Q5SQT6 PPA1 1.184002 178 19.96892 5.25

H7C4G5 RUVBL1 1.037621 1.736831 267 30.00456 5.554

Q15043-2 SLC39A14 1.264436 1.01454 1.024396 481 52.80448 5.77

Q8NBP7-2 PCSK9 0.88743 0.750024 196 20.81377 8.397

Q99584 S100A13 1.212684 98 11.46409 6.164

Q01813-2 PFKP 1.616762 1.886669 1.278092 776 85.26146 8.587

Q27J81-2 INF2 1.445221 1.514672 0.958636 1240 134.5334 5.529

P38919 EIF4A3 1.32645 411 46.84118 6.727

Q8NBX0 SCCPDH 0.817882 1.056136 429 47.12145 9.144

J3QLR8 MRPS23 0.789258 152 17.50639 9.627

B7Z1R5 ATP6V1A 1.237055 584 64.69478 5.656

J3KNB5 GPX8 1.291884 0.919668 90 10.06874 10.24

Q10567-4 AP1B1 0.791809 919 101.2835 5.11

Q96CW1-2 AP2M1 1.102053 1.818434 0.835605 433 49.35791 9.54

P49327 FASN 1.882644 1.564007 1.401742 2511 273.2543 6.443

Q9BTU6 PI4K2A 0.652547 1.177311 0.596076 479 53.98861 8.294

B4DT69 DLD 0.743285 0.989039 0.76888 461 49.25137 7.679

B1ANR0 PABPC4 1.481386 615 67.92792 9.452

Q9UMX5 NENF 1.037892 1.048986 1.05816 172 18.84479 5.694

of 313

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B4DLW8 DDX5 1.271055 1.583436 1.034134 535 60.52538 9.071

O00592-2 PODXL 1.223322 1.00787 0.985307 526 55.35142 5.58

R4GN99 PPIF 0.734405 0.925852 145 15.34077 9.247

Q92520 FAM3C 0.858676 1.058761 227 24.66458 8.294

O60701-2 UGDH 1.486766 2.369461 0.754955 427 47.57231 5.922

F5H7M3 DLAT 0.802293 0.975184 0.665679 418 44.6336 6.443

K7EIN4 TMED1 0.97612 82 9.629161 8.968

Q92598-2 HSPH1 1.486035 1.487949 1.475798 814 92.05745 5.554

Q9UNN8 PROCR 0.910456 2.103759 0.758776 238 26.65458 7.181

O75414-2 NME6 0.605335 119 13.50185 5.783

P07858 CTSB 0.86307 339 37.79684 6.303

B7Z5W8 DLST 0.903802 1.609263 0.387486 367 39.52787 9.554

H3BPA9 NUP93 1.363568 0.839605 230 26.39812 5.922

H7C531 PSMD6 1.37871 138 15.95713 6.138

A1L3A6 NUFIP2 1.511288 120 14.63392 8.075

F5H826 NOMO3 1.048414 0.90546 0.948643 1100 121.943 5.694

P46977 STT3A 0.920142 1.377587 0.849084 705 80.47685 8.075

F8WEV7 SUMF2 0.955361 102 10.86275 10.15

D6RC06 HINT1 3.252862 65 7.318954 9.408

H7C0D9 POLR1B 1.155853 308 34.42123 6.417

M0QXF7 C19orf10 0.808628 1.538965 0.684605 84 9.663568 4.996

Q9BRQ8-2 AIFM2 1.285245 1.03152 0.868966 336 36.49731 9.261

D6RH20 MRPS27 0.929614 1.810816 0.631838 299 34.43659 5.58

Q14696 MESDC2 1.137482 0.851096 0.685203 234 26.06031 7.782

Q9UBR2 CTSZ 0.757963 0.79509 0.796878 303 33.84622 7.108

Q6PI48 DARS2 0.843445 1.476624 0.729804 645 73.5161 8.016

Q03519 TAP2 0.946329 1.038205 0.874849 686 75.61581 8.016

Q15800-2 MSMO1 0.780947 162 19.45783 7.708

of 313

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165

O43795-2 MYO1B 1.190268 1.057615 1078 124.8719 9.203

B4E2S7 LAMP2 0.649824 0.942853 0.612689 363 39.78684 5.668

P49721 PSMB2 1.719065 201 22.82168 7.02

E7ENA9 NCSTN 1.006023 1.166959 0.903849 451 50.22973 5.643

P82932 MRPS6 0.694656 125 14.21759 9.261

Q9H4A6 GOLPH3 0.47583 0.894545 298 33.7895 6.443

H3BRV3 MAN2C1 1.181813 77 8.696426 8.573

Q7Z7H8 MRPL10 0.901762 1.028103 261 29.26368 9.583

K7EJ83 CDK3 1.328211 213 24.42697 8.016

G3V1S6 GALNT2 1.260822 0.94241 1.033844 533 60.75543 7.65

P29992 GNA11 1.031481 0.880584 359 42.09652 5.694

P62330 ARF6 1.008838 175 20.06944 8.954

I3L1H3 LITAF 0.874305 68 7.367382 7.445

P28074 PSMB5 1.580678 263 28.46221 6.917

Q01082-3 SPTBN1 1.179103 1.175346 0.976195 2155 251.2412 5.529

Q99653 CHP1 0.576249 195 22.44234 5.097

Q2TB90 HKDC1 0.676628 0.573985 917 102.4785 7.123

P82675 MRPS5 1.022344 0.662661 430 47.9761 9.92

C9JJ54 WDFY1 0.892774 0.759744 215 24.24417 7.796

Q96TA1-2 FAM129B 1.326602 1.318136 1.052594 733 82.63093 6.151

Q5SZE1 CERS2 0.896112 0.877504 0.681865 324 38.49522 9.144

O60716-32 CTNND1 1.107563 1.054132 0.918675 589 65.60001 8.133

F2Z3J9 PTGR1 1.458885 118 13.43588 5.554

H7BZ72 NOP58 0.92172 187 21.20553 5.148

E9PNW8 FAR1 0.922818 1.628174 0.887954 335 37.45766 6.917

O15270 SPTLC2 0.755711 0.816155 1.022249 562 62.88386 7.782

P60602 ROMO1 1.114651 79 8.176862 9.334

O60831 PRAF2 0.940022 0.997831 0.994865 178 19.24552 9.188

of 313

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166

Q5T1M3 SLC31A1 1.538724 188 20.99112 7.152

Q9HB71 CACYBP 1.536034 228 26.19365 8.25

Q16864 ATP6V1F 1.926234 119 13.36195 5.516

Q9NZ01 TECR 0.768905 2.079845 0.833769 308 36.01078 9.452

M0R1L7 CHMP2A 1.126957 1.16744 159 18.7266 9.481

Q00765 REEP5 0.877974 0.83712 189 21.47904 8.104

H0YD97 PDHX 0.797406 189 20.65991 7.342

Q9Y3A6 TMED5 1.077755 1.190711 0.91123 229 25.98819 4.843

P18206-2 VCL 1.768811 1.923924 0.879547 1066 116.6493 6.087

F5GZY7 GABARAPL1 1.129263 70 8.571752 9.95

K7ES82 CAPNS1 1.699408 0.745452 100 11.39149 5.415

O14773-2 TPP1 1.130555 320 34.44196 6.087

B4DWJ2 QARS 1.23714 1.016419 0.882057 764 86.52421 7.049

E9PFD2 UMPS 1.726265 0.985496 342 37.61611 8.089

Q9BV43 PDIA5 0.924283 1.824159 0.774782 262 30.10461 8.924

J3QSF2 SLC12A4 0.840389 91 9.81709 8.719

P78310-2 CXADR 1.268586 0.901349 0.987165 344 38.09933 7.547

P35908 KRT2 1.019978 0.856203 0.984704 639 65.39322 8.001

Q13724-2 MOGS 1.044736 1.298356 0.884982 731 80.65263 7.108

H0YFP4 GPR89C 1.276886 122 13.67608 9.92

H7BXQ8 ARMC10 0.901244 193 20.85772 7.84

P42126-2 ECI1 0.792812 0.673548 285 30.87627 8.895

E7EQS5 DMD 1.264136 2.239666 1.017674 1225 141.3109 6.024

E9PEF9 AKR1B1 1.352448 102 10.99773 6.756

Q14204 DYNC1H1 1.372133 1.438188 1.102725 4646 532.0719 6.405

B1AXG2 RPS6KA3 1.568099 133 15.25818 8.836

P17813-2 ENG 1.124942 1.066038 625 67.49872 6.566

D6RDM7 UBE2K 1.087814 123 14.02619 7.181

of 313

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167

F5H801 OGDH 0.736426 0.751363 0.683379 974 110.5408 6.844

O75521-2 ECI2 1.254443 359 39.58436 8.646

O15127 SCAMP2 1.231236 0.734023 329 36.62534 6.1

F5H702 MRPL48 0.875202 113 12.76165 5.237

Q8WTV0-4 SCARB1 0.981031 1.959415 0.775127 474 53.54381 7.254

O15258 RER1 0.752135 196 22.94286 9.54

I3L3Z1 SHCBP1 1.165636 155 17.6855 4.627

Q15056-2 EIF4H 1.523391 1.372811 228 25.18452 8.089

Q96JB5-3 CDK5RAP3 0.843484 0.955776 281 31.18103 4.513

Q8NFQ8 TOR1AIP2 0.9361 470 51.23215 4.958

Q9BWD1 ACAT2 2.192211 1.162535 397 41.32439 6.917

P49591 SARS 1.651656 1.390755 514 58.74005 6.43

Q13217 DNAJC3 1.106552 1.231576 0.930653 504 57.54417 6.151

Q5R3B4 MPC2 0.37012 0.799854 105 11.67318 10.2

H0YE35 RIC8A 1.29523 147 16.24857 4.615

P50395-2 GDI2 1.413569 400 45.59022 6.24

Q8WUK0-2 PTPMT1 1.248374 137 15.67942 9.847

H0YMJ5 IGF1R 1.086405 190 21.24445 5.11

Q9BSD7 NTPCR 1.008314 190 20.70011 9.54

D6R9X9 RPL37 1.470178 74 8.474352 10.35

Q9Y2R0 COA3 0.623199 0.654097 106 11.72413 9.598

M0R2T8 HOMER3 1.432533 85 9.530911 10.43

H7BZ81 RETSAT 0.919355 0.936578 320 35.15895 8.06

P11166 SLC2A1 1.158881 2.739135 1.030393 492 54.04854 8.719

P55884 EIF3B 1.63804 1.291677 814 92.42382 4.996

O15144 ARPC2 1.214495 1.441681 1.216683 300 34.31149 7.357

P00367 GLUD1 0.984987 0.685172 0.798359 558 61.3592 7.796

O75348 ATP6V1G1 0.943863 118 13.74908 8.792

of 313

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168

168

Q9Y230 RUVBL2 1.173264 1.353981 463 51.12456 5.643

K7EPU3 ALG1 1.189406 1.301771 0.942201 184 20.16157 9.627

Q9NP72 RAB18 0.889836 206 22.96264 5.237

E5RHG9 UQCRB 0.714886 76 9.233928 8.119

M0R0G9 SNRPA 1.075854 0.987552 87 10.07624 9.598

P07108 DBI 1.877882 87 10.03802 6.566

P10909-4 CLU 0.598794 0.528685 0.836291 416 48.77213 6.712

Q9BV81 EMC6 1.209943 110 12.00954 10.07

J3KTF4 C17orf62 0.732428 88 9.800338 9.525

C9JEL7 NDUFAF7 0.580791 111 12.41143 7.342

M0R1B0 EMC8 1.069595 100 11.72048 5.084

Q15388 TOMM20 1.41537 145 16.28765 8.602

B4DE85 PTDSS1 0.772263 1.585746 0.814046 301 34.55655 8.573

Q86SX6 GLRX5 0.514122 0.561141 157 16.61754 6.786

H3BUZ3 CAPN3 0.992297 157 17.63556 6.189

C9J931 RHEB 1.415669 79 8.668373 6.024

F8WDA9 GK 0.772238 79 8.6422 7.298

P43007 SLC1A4 1.097573 532 55.68763 6.252

P41250 GARS 1.534113 2.499762 1.121268 739 83.11261 7.035

H3BN94 UBE2Q2 1.136098 91 10.48005 4.221

C9J712 PFN2 1.145189 91 9.791952 9.364

Q9BYN8 MRPS26 0.918735 0.944046 205 24.19686 10.39

Q96C36 PYCR2 0.838492 320 33.61569 7.767

E5RGC7 MRPS28 0.562606 0.728144 103 11.74014 8.045

Q8NFJ5 GPRC5A 1.179067 0.938988 0.894057 357 40.22494 8.148

Q5TB21 APH1A 0.580293 150 15.84236 6.265

Q6Y1H2 PTPLB 0.832488 254 28.35014 9.554

J3KS17 APOH 0.781458 104 11.65429 6.494

of 313

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169

169

Q9BVC6 TMEM109 0.837747 0.910029 0.806986 243 26.19359 10.48

K7ESE6 G6PC3 1.017857 0.998602 243 27.58953 8.924

Q14739 LBR 0.673257 615 70.65803 9.364

B4DVY1 EIF3D 1.436522 0.998114 499 58.10371 5.707

P07814 EPRS 1.67338 1.334158 1.198086 1512 170.4831 7.328

F8VZX9 METAP2 1.751555 163 18.08869 5.351

P56589 PEX3 0.689359 0.689336 373 42.11295 8.148

C9JQQ5 ATL2 1.263679 175 20.28729 7.533

Q9HD33-3 MRPL47 0.830584 1.164369 140 16.98042 10.71

P02792 FTL 0.827784 175 20.0071 5.783

P23526 AHCY 2.047492 1.426446 1.124553 432 47.68521 6.341

F8VPD4 CAD 1.289825 1.263263 1.045123 2162 235.873 6.551

Q9UGP8 SEC63 1.14793 0.97752 0.798299 760 87.94161 5.313

Q9UHA4-2 LAMTOR3 0.80316 0.751869 117 12.93295 8.133

O14949 UQCRQ 0.677723 82 9.900121 10.08

O94973 AP2A2 0.97665 0.894192 939 103.895 6.961

B7Z4K6 DNASE2 0.844035 0.995393 0.799537 305 33.59369 8.324

Q15904 ATP6AP1 0.836096 2.193159 0.751944 470 51.9926 6.138

F5H241 GBA 0.762198 0.67644 0.702621 423 47.53423 7.284

F8WEJ5 ASNS 1.304314 401 45.597 7.093

Q8IVL5 LEPREL1 0.963144 0.645556 0.941739 708 80.93322 5.707

O43491-2 EPB41L2 1.141583 0.775995 0.84243 673 76.0062 6.961

P55809 OXCT1 0.658775 1.177417 0.862764 520 56.12193 7.459

Q13488 TCIRG1 0.975484 0.795106 830 92.90836 7.123

F5H6I7 ATL3 1.017233 1.549397 0.876098 523 58.73556 5.643

E9PNE7 SLC39A13 1.31063 321 33.75938 7.679

J3KSR8 SRSF1 0.986349 143 16.44028 11.44

Q5TCI8 LMNA 0.826178 0.74603 491 55.72859 7.02

of 313

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170

170

O95168-2 NDUFB4 0.993315 120 14.01742 9.803

P04181-2 OAT 0.812678 0.52964 301 32.83215 5.326

Q9Y679-3 AUP1 1.458381 0.953911 373 41.35868 7.899

Q92847-2 GHSR 2.206096 289 32.1319 8.06

C9JC03 EHD1 1.154728 0.656458 374 42.71039 8.426

K7EK06 FARSA 1.466376 169 18.49034 5.592

A6NH27 ZWINT 1.334302 157 18.21335 7.416

C9JD65 ATG9A 0.921755 133 15.62922 8.382

O95782-2 AP2A1 1.081109 1.873053 0.967499 955 105.2947 7.665

D6RGY8 YIPF3 1.003007 109 12.28186 4.564

Q16851-2 UGP2 1.494879 497 55.64208 7.884

B4DFA2 NSF 1.065248 1.093724 0.943217 644 71.53859 6.654

H0Y750 ATP6AP2 0.756568 0.617391 243 26.61486 7.899

P49419-2 ALDH7A1 1.027341 1.12307 0.784116 511 55.33146 6.859

H0Y715 CACNA2D1 0.660242 280 32.49528 5.465

Q07960 ARHGAP1 1.645075 1.223462 439 50.40419 6.291

P20020-5 ATP2B1 1.158381 1.066843 1171 129.0702 6.164

E9PN51 NDUFS8 0.506589 110 12.39731 9.979

E5RJH9 SQLE 0.766742 184 20.33942 6.405

K7EP23 SF3A2 1.158579 135 15.21484 9.774

H0Y9Y1 BTF3 1.669559 86 9.493752 4.996

Q15149-3 PLEC 1.022118 1.009423 0.914809 4570 517.7164 5.745

H7C1D4 TSN 1.312081 185 21.10703 7.196

A6ND22 MRPS16 0.748673 99 11.14286 9.686

Q96CT7 CCDC124 1.358862 1.115188 223 25.81956 9.54

Q9NRP0 OSTC 0.925778 1.163102 0.770044 149 16.81784 9.129

C9JA28 SSR3 0.91842 0.838837 0.914319 174 20.14854 9.437

O94925-3 GLS 0.735102 1.370408 0.492763 598 65.41791 7.884

of 313

Ant

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Pero

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doxi

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The

fin

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may

dif

fer

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171

171

Q9NUQ9 FAM49B 1.087859 324 36.72465 6.062

H0YJC0 PSMC6 1.198227 1.098817 262 29.63245 6.405

D6R937 AIMP1 1.134497 150 16.568 9.261

Q15599-2 SLC9A3R2 1.152308 0.88025 326 36.13141 8.207

F6SBX2 IARS2 0.556246 0.910806 0.564131 940 105.972 6.481

B4DEK4 SNX2 0.833646 0.987762 402 46.06873 7.24

D6RAE7 CCHCR1 1.432648 126 14.39542 5.681

O00754-2 MAN2B1 0.927828 1.266424 0.790621 1010 113.5443 7.284

P26599 PTBP1 0.736467 2.649674 0.992703 531 57.18564 9.173

B1AJQ6 STX12 1.070025 1.926368 215 24.56134 5.148

P14174 MIF 2.19248 2.590372 1.522282 115 12.46822 7.884

O14662-3 STX16 0.928711 115 13.00968 4.932

Q9HAV7 GRPEL1 0.757742 217 24.26392 8.119

K7ERP1 ROGDI 1.020845 230 25.33895 8.353

Q15437 SEC23B 1.305768 1.528303 1.037696 767 86.42352 6.888

E9PH05 FAM162A 0.640189 141 15.94839 9.95

Q13492-4 PICALM 0.943702 1.707659 0.789813 551 59.88067 8.763

Q9UBM7 DHCR7 0.797564 1.126889 0.630026 475 54.45377 8.705

E9PLG2 PSMC3 1.751313 193 21.5292 5.097

H7BYN3 TFAM 0.797145 219 25.66063 9.657

Q8TCT9-5 HM13 0.848698 0.908133 0.807801 335 36.79014 6.683

Q9P0I2-2 EMC3 1.185285 219 24.89899 9.73

Q9Y320-2 TMX2 1.124285 0.908489 0.781832 258 29.62322 8.646

G5E999 TRO 1.147932 284 33.49956 9.569

P07948-2 LYN 1.062071 491 55.99746 6.494

H0YCW6 ALG9 0.952327 207 24.29349 9.422

Q96CN7 ISOC1 1.115217 298 32.21612 7.386

P10619 CTSA 0.835223 0.781734 0.877583 480 54.43112 6.61

of 313

Ant

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172

172

Q96QD8 SLC38A2 1.409894 1.429413 506 55.98953 8.001

Q9BQ69 MACROD1 0.821291 325 35.48272 9.51

P07919 UQCRH 0.498351 91 10.73194 4.437

B3KVK7 MARS 1.302166 1.057521 546 61.77631 5.262

H0Y524 CPNE1 1.074103 208 21.44271 8.119

Q8WUY1 THEM6 0.945819 0.785596 208 23.84987 9.554

P61221 ABCE1 1.247269 0.949353 1.371781 599 67.27102 8.338

B4DUQ5 SLC25A32 0.907735 183 20.99708 9.583

Q9H773 DCTPP1 1.684555 170 18.66936 5.034

H0YAG8 ADH5 1.01398 262 27.529 6.202

O00526 UPK2 0.792403 184 19.42569 10.4

C9J0H3 PLSCR1 1.24945 171 19.39654 5.833

E9PGB1 CTBP1 0.819009 145 15.90726 6.367

G3V4F2 ACOT1 0.852765 0.990384 395 43.70566 6.991

R4GNE4 GPX4 1.106562 2.406508 0.853905 145 16.79655 11.17

Q8WY22 BRI3BP 1.050915 1.081041 0.939209 251 27.81784 9.437

H7C089 TTC38 1.872607 119 12.87459 6.354

Q8NB15-2 ZNF511 1.625077 252 28.24685 7.665

Q9H9H5 MAP6D1 0.641135 199 20.99163 10.07

P28799-2 GRN 0.827023 438 46.9577 7.035

F8VNT9 CD63 0.827565 0.902124 0.847852 133 14.2554 7.591

Q13283 G3BP1 1.486912 1.217856 0.988605 466 52.13208 5.516

Q8N1N4 KRT78 1.068822 520 56.83049 6.024

B1AH87 TSPO 0.676872 107 11.88798 9.247

P20618 PSMB1 1.230592 2.060151 241 26.47237 8.133

Q6P1M0 SLC27A4 0.853427 1.015222 0.893677 643 72.01814 8.47

Q15785 TOMM34 1.013536 1.178984 309 34.53776 8.983

E7EPJ0 C10orf112 1.265377 350 38.30665 4.818

of 313

Ant

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173

173

Q8TCS8 PNPT1 0.935007 0.860943 0.682558 783 85.89663 7.767

H7BYH4 SOD1 1.197198 1.617886 135 13.90083 6.113

P48960-2 CD97 1.03104 1.360822 1.037025 742 81.68971 7.049

P08574 CYC1 1.123654 0.780609 325 35.39897 8.998

P51688 SGSH 0.882958 0.979754 502 56.65945 6.947

Q3ZCQ8 TIMM50 0.500185 0.762324 0.892433 353 39.62154 8.368

P37108 SRP14 1.273184 136 14.56082 10.04

B4DGQ0 LASP1 0.741397 205 23.16723 4.945

O43837-2 IDH3B 0.658972 0.485092 383 41.86035 7.591

P17568 NDUFB7 0.864138 137 16.39127 8.924

O43242 PSMD3 1.88696 1.325435 1.688353 534 60.93949 8.441

P51991-2 HNRNPA3 1.248919 356 37.00618 8.309

P62195-2 PSMC5 2.38722 2.219372 1.043626 398 44.75569 8.177

J3KS15 ICT1 1.320623 192 21.89139 9.715

Q92575 UBXN4 1.019874 0.83535 508 56.74269 6.379

B4E1G1 DERL1 1.012082 151 17.02173 9.891

Q14126 DSG2 1.066754 1.050857 1.090291 1118 122.2176 5.237

Q9Y3D6 FIS1 0.475392 152 16.92702 8.792

B4DR64 CTPS1 1.530362 360 41.19385 6.888

Q9Y3A5 SBDS 1.252294 250 28.74532 8.749

F8W785 GOLIM4 0.976545 0.554716 0.377185 668 78.71265 4.742

B4DKI1 ANXA8L1 1.23718 265 29.99811 5.338

P48509 CD151 1.249102 1.275855 0.984759 253 28.27631 7.474

H0YB83 RMDN1 1.3707 225 25.92103 5.503

P09497-2 CLTB 1.118839 211 23.16714 4.691

P13010 XRCC5 1.183543 0.889252 732 82.65228 5.808

H7C5Q9 PPP2R5D 0.96828 155 18.62046 7.972

B8ZZ51 MDH1 1.839668 169 18.67754 5.935

of 313

Ant

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174

174

Q9Y5J5 PHLDA3 0.678766 127 13.88242 9.671

B7Z5E2 PSMC2 1.593874 0.93494 296 33.25224 8.412

P16401 HIST1H1B 1.072091 226 22.56647 10.92

D6R9H7 ATP5G1 1.180764 1.337366 99 10.18834 10.4

Q00534 CDK6 2.145621 326 36.91503 6.456

J3KSI8 MRPS7 0.902594 156 18.37262 10.13

B4E0P1 PSMB7 2.215234 142 15.31282 9.247

H0Y8D1 PRSS1 1.250055 142 15.41178 7.269

Q8WUM4 PDCD6IP 1.585894 868 95.96312 6.522

H3BUR9 CDIPT 0.915878 157 17.32359 6.654

C9JXZ0 PLOD2 0.552985 229 26.05239 8.309

B5MDQ4 RQCD1 0.96492 258 29.12136 8.031

M0QYE0 SH3GL1 1.896594 129 14.39252 7.372

B0V043 VARS 1.426902 1.444597 1264 140.3774 7.591

P53597 SUCLG1 0.711261 346 36.22685 8.792

Q9UHG3 PCYOX1 0.929033 2.924772 0.827446 505 56.60375 6.176

F5H1I8 XRCC6 1.117477 1.123503 476 54.51675 8.954

A6NEM5 PIGK 0.839351 0.880026 332 37.76169 5.656

H7C5C8 MAATS1 1.688609 101 12.08862 10.4

Q9HA77 CARS2 0.817241 0.833524 564 62.18467 8.338

B0QZ43 ERLIN1 0.848482 275 31.05738 7.958

C9J8H1 ATP6V1E1 1.196086 1.017794 1.007808 203 23.52457 9.042

J3KTK1 LPIN2 1.284922 233 25.59665 4.945

O75695 RP2 1.002286 1.705551 0.852253 350 39.61546 5.123

P49406 MRPL19 0.822931 292 33.51356 9.496

C9J719 EBP 0.820119 146 16.71063 7.005

H7C3I1 ST13 2.473939 146 16.31911 4.881

C9JGM7 DYNC1LI1 1.352286 190 21.36782 5.072

of 313

Ant

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175

175

P23381-2 WARS 1.348628 1.041668 1.090538 424 48.149 6.354

P26196 DDX6 1.269469 483 54.38231 8.661

Q9Y512 SAMM50 0.765399 469 51.94332 6.903

O15121 DEGS1 1.05078 323 37.84116 7.459

Q9Y295 DRG1 1.193436 3.186811 367 40.51683 8.895

B7Z5H3 MAOB 0.323261 0.335428 0.837279 411 46.50874 8.28

Q9NSD9 FARSB 1.208562 0.808362 589 66.07355 6.844

F5H5L8 FOLR2 1.300796 1.108102 0.8732 148 16.88816 8.031

Q96S52-2 PIGS 0.86044 0.869886 547 60.96681 6.43

Q12846 STX4 1.148212 1.091465 297 34.15886 6.278

P53680-2 AP2S1 0.89416 104 12.40942 5.846

Q499Z4-2 ZNF672 0.850827 223 24.79632 8.983

F8W062 PLA2G1B 1.439988 119 13.21387 7.079

Q96L58 B3GALT6 0.944443 1.160404 329 37.1143 9.657

P08237-2 PFKM 1.527741 1.439542 1.192302 749 81.72348 7.621

P49768-3 PSEN1 1.29948 374 42.2591 8.646

E7EP00 SEC24C 1.438154 1.454381 0.929165 975 106.5557 6.961

K7EK20 CARM1 1.10751 120 12.53511 6.756

Q16795 NDUFA9 0.566084 0.292001 377 42.48257 9.803

Q9Y3B7-2 MRPL11 0.760519 166 18.194 9.73

Q9BXW7-2 CECR5 1.023927 0.736165 393 43.56032 6.903

Q9Y6H1 CHCHD2 0.828483 151 15.5027 9.217

A8MU58 AIMP2 1.271989 1.606827 242 26.74293 8.075

G3XAN4 TRAM1 1.299262 288 33.41376 9.891

F5H843 SLC16A7 1.190195 379 41.69179 9.422

Q5W011 RBM17 1.189167 0.94415 212 24.16128 6.189

Q9Y3F4 STRAP 1.322691 1.402415 350 38.41398 5.123

Q02790 FKBP4 3.153252 1.134859 459 51.77207 5.427

of 313

Ant

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Pero

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176

176

Q01518-2 CAP1 1.446373 2.347952 474 51.79766 8.06

Q86UP2-2 KTN1 1.059863 0.755916 0.84917 1300 149.5189 5.707

E5RGA2 EIF3E 1.329778 352 41.33072 6.551

Q9Y2S7 POLDIP2 0.518845 368 42.00716 8.631

G3V1K1 CHCHD3 0.645291 138 15.54916 8.631

P53396-2 ACLY 1.956794 1.353749 0.965034 1091 119.6953 7.328

Q9Y6M7-11 SLC4A7 0.945963 463 52.21634 5.999

Q08379-2 GOLGA2 1.231848 620 70.42902 4.754

B4DND0 UPP1 0.902573 171 18.73872 9.73

Q02241-2 KIF23 1.363701 0.723528 1.029325 856 98.04387 8.47

P53621 COPA 1.255575 2.758402 1.17627 1224 138.2579 7.665

B4DKB2 ECE1 0.901665 0.983185 0.8194 738 83.52037 5.732

Q13423 NNT 0.745853 1.130768 0.782389 1086 113.8226 8.089

D6R9X8 ITGA3 1.069518 0.900973 142 15.21975 8.207

O14656 TOR1A 0.950648 0.628824 0.885189 332 37.78448 6.991

E9PKA7 RCE1 1.074449 206 22.69662 7.577

F8WFB9 SH3GLB2 1.212563 127 14.47229 5.148

J3KN55 MMAB 0.714226 159 17.66105 7.796

G5E9W7 MRPS22 0.637004 0.779452 319 36.78293 6.815

O94826 TOMM70A 0.559331 0.971328 608 67.41203 7.123

B7Z5C0 DNAJA1 1.221172 240 27.52575 5.935

E7ETE2 HARS 2.197545 1.357281 0.97029 288 31.91085 5.681

R4GMY3 KIAA0368 2.097641 128 14.75896 9.071

Q6UB35 MTHFD1L 0.833667 0.672985 0.661624 978 105.7237 8.06

C9JG15 ATAD2B 1.354833 370 41.15475 9.73

P57105 SYNJ2BP 1.046476 145 15.91816 6.303

P11498 PC 0.769836 0.785721 0.68265 1178 129.5514 6.844

Q15046 KARS 1.374057 1.354475 1.141872 597 68.0046 6.354

of 313

Ant

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177

177

O43776 NARS 1.611823 1.831599 548 62.90252 6.252

H0YHS6 YARS2 1.026806 291 32.16451 8.397

Q96QD5-2 DEPDC7 0.734628 0.896372 0.783459 502 57.66986 7.474

F8VZ44 AAAS 0.941853 3.431027 0.890853 422 45.60536 8.25

Q658P3-3 STEAP3 0.666776 1.300052 0.90822 487 54.43672 8.719

P08631-3 HCK 1.645563 504 57.20467 6.859

Q96AD5-2 PNPLA2 0.933287 180 19.86246 8.514

C9J8Q5 ALDH5A1 0.746859 507 53.83355 8.192

Q9UHL4 DPP7 0.709214 0.72615 0.961096 492 54.3072 6.316

E5RHD8 PTK2 1.514634 1.412668 115 12.85484 7.503

E9PBU3 ATIC 0.75035 2.229868 1.301977 591 64.48327 6.712

Q16774 GUK1 0.826706 197 21.7122 6.551

Q9UHR4 BAIAP2L1 1.377534 1.071519 511 56.84708 8.675

Q14318 FKBP8 0.550443 0.965954 412 44.53367 4.843

P30825 SLC7A1 1.099557 2.246054 0.900764 629 67.59414 5.427

Q96L92-2 SNX27 0.834501 448 52.30108 6.367

K7EMK9 PPAP2C 0.984326 166 18.42744 8.06

Q96S66-4 CLCC1 0.835182 0.799298 366 39.81288 5.745

Q9BU61 NDUFAF3 0.451946 184 20.33742 8.221

Q9Y251-3 HPSE 0.876007 1.24858 0.734405 469 53.12712 9.408

P26639 TARS 2.209003 1.895454 1.444028 723 83.38187 6.668

M0R019 HNRNPM 1.243349 2.324147 0.865693 353 37.66014 9.027

K7EJ35 SYNGR2 0.278597 168 18.80017 4.539

B7Z589 SLC6A9 1.218745 0.77351 522 58.32185 7.02

H3BTB7 EARS2 0.835836 0.858241 506 56.78967 8.778

F5H335 EIF3A 1.417245 1.878101 1.011005 1348 162.5373 6.771

O15269 SPTLC1 0.830005 473 52.71047 6.011

Q9Y6M5 SLC30A1 1.110595 1.10251 507 55.26405 6.481

of 313

Ant

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from

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178

178

P14209-3 CD99 0.591634 169 17.1174 4.564

F5GWY0 PIGT 0.912958 1.281792 423 47.90365 8.807

B4DVJ1 DAGLB 1.62332 220 24.54937 8.148

Q9UKS6 PACSIN3 1.092926 424 48.45683 6.176

E7ERV9 ASAH1 1.016401 305 34.58179 7.767

Q16540 MRPL23 0.710094 153 17.77013 9.686

P52292 KPNA2 1.239098 1.363252 529 57.82595 5.402

Q5TBH6 GNPAT 0.852829 222 25.20905 8.69

F5H365 SEC23A 0.990387 1.417708 736 82.91563 7.459

O43674-2 NDUFB5 0.875972 137 15.65706 7.562

E7ET76 GGT1 1.185204 1.12533 463 50.02888 6.727

E9PIC0 SDHD 0.54084 120 12.60657 8.5

B1AZV3 TAP1 0.807502 808 87.12068 8.016

Q9Y676 MRPS18B 1.285966 258 29.37701 9.378

B1AH49 MPST 1.071553 224 24.96651 7.65

Q8TBK7 TPT1 1.715824 138 15.5866 5.072

O60427 FADS1 1.038179 501 57.84873 9.481

O95373 IPO7 1.491394 1.391117 0.842853 1038 119.4399 4.818

F5H5G8 SUCLA2 0.553651 0.361274 329 36.0117 5.389

H7BZF5 C2orf80 0.98906 139 15.67411 9.833

P51114-2 FXR1 1.118303 0.881642 539 60.75436 6.392

I3L1D0 WDR45B 1.17045 0.758889 174 19.30278 7.167

E9PKJ0 WLS 0.742704 122 14.40444 9.056

H0Y5R2 CEP250 1.088816 1.100803 210 22.70323 4.386

C9JG32 TSFM 0.862646 140 15.43103 8.895

H0YGW7 ABCF1 1.316959 1.186243 596 67.61806 8.192

O00180 KCNK1 1.239537 336 38.11852 6.367

B4DDS3 CLPTM1 0.753854 1.222139 567 65.5551 5.999

of 313

Ant

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179

179

P54727-2 RAD23B 0.929903 337 34.98323 4.678

B4DP17 CNBP 1.338437 160 17.67973 7.708

E9PKV2 MRPL17 0.682762 142 16.36078 10.48

Q8N387-2 MUC15 0.923146 284 30.74325 4.78

Q96D31-2 ORAI1 1.137192 231 25.32127 8.631

H7C1U8 APOO 0.899714 178 20.06728 8.617

E9PF19 TBL2 1.702768 1.030469 411 45.90616 9.481

H0YNF6 TM2D3 1.373451 161 18.17144 8.089

E5RFR9 PPP2R2A 1.274608 197 22.99205 7.254

Q9H2U2-3 PPA2 0.972971 305 34.63558 8.456

Q9H0U6 MRPL18 0.90677 180 20.56354 9.54

H0YMB1 RMDN3 1.025878 306 34.12692 4.881

F8WBJ7 TMEM245 0.706662 2.27177 0.925284 253 28.07817 8.309

P23246-2 SFPQ 1.21799 1.087693 669 72.21776 9.232

Q10713 PMPCA 0.770647 0.879338 525 58.2156 6.917

Q13367-2 AP3B2 1.14841 145 15.80994 6.075

O43747 AP1G1 0.791782 1.272935 0.790241 822 91.29313 6.8

Q86YN1 DOLPP1 0.953196 238 27.01323 9.437

H7BZU1 EIF2S3 1.592035 183 19.81624 9.042

Q92544 TM9SF4 1.094496 1.071672 0.989709 642 74.46967 6.537

Q9UL46 PSME2 1.344532 239 27.38432 5.732

Q92692-2 PVRL2 1.325016 1.332542 479 51.32718 5.11

Q93050-1 ATP6V0A1 0.978953 0.672648 831 95.69385 6.654

G3V1K0 TXNL1 1.544625 166 18.92217 4.729

Q14050 COL9A3 0.709341 684 63.57713 7.679

P06241-3 FYN 0.792411 482 54.4791 6.227

Q9Y3C8 UFC1 0.854541 167 19.44602 7.401

P33897 ABCD1 1.18242 0.658384 1.044249 745 82.88451 8.954

of 313

Ant

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180

180

P32004-3 L1CAM 1.063346 1.078946 1248 138.8208 6.214

B7Z7Q6 PRCP 0.979245 1.437204 0.792914 391 43.90565 6.303

Q14118 DAG1 1.191228 1.106221 0.913843 895 97.38067 8.558

H0Y400 DDX39B 1.741437 187 21.77609 5.123

G3XAJ6 RFTN1 1.105943 0.765607 542 58.72609 5.338

B4DJ68 TDRKH 0.241699 337 37.14301 4.488

O15382-2 BCAT2 0.960792 300 33.75464 7.723

Q04760-2 GLO1 1.41332 169 19.03059 6.049

F5H3I4 ACTR1A 0.827675 302 34.53578 6.456

Q5BKT4 ALG10 1.601853 0.904333 0.91813 473 55.569 9.291

Q5VXM9 RPF2 1.538456 3.678034 0.954767 208 24.14272 9.466

Q07817-2 BCL2L1 0.579766 170 18.88219 5.072

Q01105-3 SET 1.377528 1.014835 265 30.97422 4.234

E7ETS9 B4GALT4 0.728534 246 28.52191 9.159

O14880 MGST3 0.898908 152 16.50557 9.378

B4DE93 NDUFV1 0.55954 363 39.43674 6.456

P30837 ALDH1B1 0.512936 0.839782 517 57.17023 6.8

Q8TCJ2 STT3B 0.878647 1.167831 0.773816 826 93.61368 8.91

Q86VP6-3 CAND1 1.969643 0.96296 403 45.50989 5.77

B7Z9I1 ACADM 0.996897 0.580065 385 42.39949 6.43

G3V126 ATP6V1H 3.668189 443 51.53683 6.227

B7Z9L2 NDUFS2 0.443102 231 26.95251 5.656

B4DS69 ARFIP1 1.008259 193 22.04122 5.821

P15144 ANPEP 1.030734 1.223168 0.659249 967 109.4709 5.478

Q9UJQ7 SCP2D1 1.519618 1.357626 156 17.6514 9.334

Q96HE7 ERO1L 1.062188 0.612081 468 54.35805 5.681

Q9NXV2 KCTD5 0.848383 234 26.07605 6.24

B3KSB1 ERMP1 0.866478 1.002318 351 39.18342 7.826

of 313

Ant

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181

181

Q9H9J2 MRPL44 0.865905 0.940423 332 37.51171 8.397

Q6NUQ4-2 TMEM214 0.717787 0.75945 644 71.99378 9.261

P35221 CTNNA1 1.149036 1.194764 906 100.0085 6.291

Q96EC8 YIPF6 1.067828 236 26.2387 5.643

Q7Z777 CLPB 0.705483 315 36.15102 7.547

Q9Y4F1 FARP1 1.371267 1.269996 1.014068 1045 118.5587 8.148

Q9H0U3 MAGT1 1.000154 335 38.01141 9.627

H0YA55 ALB 1.198659 1.264774 454 51.53582 6.947

Q9UMY4-3 SNX12 1.618121 158 18.33042 7.298

P00492 HPRT1 2.147532 218 24.5636 6.683

O60260-3 PARK2 2.018586 218 23.62334 7.474

E7EWX8 MGLL 1.165629 277 30.67209 8.543

Q32P28 LEPRE1 0.735619 0.800889 736 83.34109 5.135

Q9BW60 ELOVL1 0.768996 279 32.64078 9.598

O15118 NPC1 0.944163 0.426973 0.604628 1278 142.0736 5.364

F5GY99 GALNT1 0.940315 0.929699 499 57.34292 7.914

P34932 HSPA4 0.929084 1.244466 1.460391 840 94.27124 5.186

H0YJE4 DHRS7 0.999921 160 17.94956 5.567

P09543-2 CNP 0.915642 0.876571 401 45.07033 8.529

P04920-2 SLC4A2 1.337605 0.957629 1227 135.5205 6.214

F5H324 ARSE 1.136729 0.919649 544 61.03771 7.035

Q00839-2 HNRNPU 1.144022 0.970876 806 88.92415 5.783

Q8TB61-3 SLC35B2 0.649797 1.490369 0.617971 383 42.09994 9.349

P09758 TACSTD2 1.231646 323 35.68662 8.866

P11171-6 EPB41 1.015031 566 63.21557 6.668

P27144 AK4 1.072258 223 25.25221 8.397

Q9BPW8 NIPSNAP1 0.848675 284 33.28884 9.305

Q9H2H9 SLC38A1 1.50668 487 54.01223 7.02

of 313

Ant

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182

182

O00400 SLC33A1 0.934608 0.745285 0.904505 549 60.86977 7.328

Q9UEL6 MPZL1 1.237786 183 20.21738 8.382

C9JYN0 SYPL1 1.043696 1.519212 0.738429 224 24.76769 7.137

B4DR63 PSMC1 1.705552 1.869939 367 41.1412 5.008

B4DR94 YKT6 1.336447 1.171605 164 18.56846 7.328

Q70UQ0 IKBIP 0.914048 350 39.28496 9.173

F8WEV0 ACAD11 1.027155 433 48.9051 8.587

K7EK00 FAM210A 0.232428 268 30.27303 9.745

O76024 WFS1 0.769325 0.714525 0.913139 890 100.227 8.045

P23229-7 ITGA6 1.260589 0.893529 954 106.5103 7.665

Q9Y6K0 CEPT1 1.043597 2.717958 416 46.52275 8.207

H0Y711 WDR77 1.799978 291 31.07815 4.894

E5RJ39 RALYL 1.407383 146 16.42503 10.62

F5H3P5 ACTR3 1.21364 0.912387 356 40.7427 5.96

H3BLU7 AKR7A2 0.999292 314 34.66225 7.181

Q15070-2 OXA1L 1.031276 419 46.66148 9.247

P42166 TMPO 0.640385 694 75.44563 7.665

Q5QPE7 MGME1 0.599338 252 28.82089 9.305

H3BSX1 SYT17 1.26127 168 19.0538 8.675

K7EPP7 DNAJC7 1.500351 253 28.68521 8.485

C9JDH9 STK25 1.148396 0.859906 148 16.35562 6.176

H0YBU8 MRPL43 0.422913 148 16.66658 6.786

J3QLE5 SNRPN 1.042236 2.600692 0.947268 169 17.53528 9.994

Q96CU9-2 FOXRED1 0.60065 0.779147 275 30.63944 6.011

C9JA35 TAPBP 0.802617 192 20.30951 6.932

Q8WVM8 SCFD1 1.228715 0.970632 642 72.33405 6.265

O75131 CPNE3 1.407907 537 60.09213 5.846

H0YJX6 PRMT5 1.139079 1.915684 279 32.2913 5.91

of 313

Ant

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183

183

O95197-3 RTN3 0.893309 0.876485 236 25.5926 8.514

K7EJC1 PSMD8 0.798077 172 19.76817 6.932

Q9H936 SLC25A22 0.728863 323 34.44826 9.291

C9JMT4 PREPL 1.244231 151 17.91298 7.723

A8MQB8 FMR1 1.003434 0.714066 582 65.78121 7.621

C9JFN4 BZW1 1.194144 216 24.32856 8.338

Q8N766-4 EMC1 1.138454 1.132935 971 109.3519 7.928

H0YGG4 EIF2B1 1.13882 152 16.91546 6.903

P28072 PSMB6 2.380084 239 25.34145 4.919

Q9UKD2 MRTO4 1.257289 239 27.54291 8.294

P30566 ADSL 1.340564 1.512782 484 54.85397 7.108

G3V325 ATP5J2-PTCD1 0.714803 1.230728 0.721681 749 84.05659 8.719

Q04637-5 EIF4G1 1.8386 1.106693 1.148944 1435 158.4189 5.211

H7C1R3 IDH3G 0.890518 155 17.01277 9.481

H0Y8J7 EIF4E 1.244216 2.225969 155 18.45408 6.551

Q8TAE8 GADD45GIP1 0.53233 222 25.36822 10.02

H7C204 ZFYVE20 1.45217 1.102571 156 18.35461 8.368

E9PDQ8 SUCLG2 1.109183 1.318358 379 41.41251 7.723

Q9BXK5-2 BCL2L13 0.700476 201 22.59757 4.932

Q9UIW0 VAX2 2.56191 290 30.8557 9.466

J3KS22 DCXR 1.124193 224 23.94468 8.5

P00846 MT-ATP6 0.76194 1.192226 0.677092 226 24.80086 10.1

P19404 NDUFV2 1.044891 249 27.37402 8.06

P19367-4 HK1 0.961335 0.855873 905 101.0204 6.903

Q08211 DHX9 0.960707 0.79311 1270 140.8691 6.844

P18084 ITGB5 1.47491 0.868759 799 87.99622 6.062

H0Y3P2 EIF4G2 1.328199 1.232863 869 98.05574 6.991

C9JZB0 INPP5K 0.922595 229 26.70651 8.309

of 313

Ant

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184

184

E7EP04 DNAJC10 0.666821 275 31.3796 7.049

G5E9Z2 CLPTM1L 1.040845 369 43.2522 8.792

Q8IYJ2 C10orf67 1.574494 185 21.58016 9.613

A6NGH8 ANKRD61 1.026379 418 46.11092 8.851

H7C4H8 SLBP 0.898412 186 21.32788 10.11

Q3T7B5 TRIT1 1.675867 163 18.74679 9.422

P30086 PEBP1 1.280867 187 21.04367 7.533

Q2T9J0-2 TYSND1 0.957553 398 41.54626 7.137

Q13425 SNTB2 1.24853 540 57.91303 8.822

Q70UQ0-4 IKBIP 1.112514 377 43.05655 4.919

H3BPF7 LONP2 0.933002 0.867836 236 25.49645 8.456

Q15833-2 STXBP2 1.037587 590 66.09634 6.551

B3KQC5 MAN1B1 1.250591 402 45.99845 6.639

Q8N2G8-2 GHDC 0.864977 474 51.42801 6.917

Q9UBB4 ATXN10 1.559708 475 53.45482 5.25

D6RAL1 GFM2 1.661288 1.045418 285 31.86577 7.738

P07711 CTSL1 0.553865 333 37.53967 5.453

H7BXI1 ESYT2 1.000532 0.809399 884 97.94866 8.573

H3BTZ5 CNN2 1.496845 191 20.94516 8.866

Q9HCC0-2 MCCC2 0.708254 0.467484 525 57.48243 7.708

P21283 ATP6V1C1 0.939955 382 43.91396 7.459

B4DLH2 C2orf18 0.682776 0.811431 288 31.07682 8.236

C9JVB6 TRMT10C 0.561536 1.528128 0.853825 312 36.80495 9.159

Q13444-10 ADAM15 1.11834 772 83.60999 6.392

Q8TBP6 SLC25A40 1.259051 338 38.09989 9.349

H3BP66 GALNS 0.91941 170 19.36984 8.924

P46060 RANGAP1 1.620736 587 63.50231 4.678

Q9NZZ3-2 CHMP5 1.437214 171 19.50787 6.844

of 313

Ant

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from

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185

185

Q4J6B8 SLC3A1 1.116239 391 45.34152 6.049

Q99805 TM9SF2 1.093457 1.120914 0.835604 663 75.72547 7.445

Q5JU69 TOR2A 0.915539 321 35.69148 7.972

P28062-2 PSMB8 1.490567 272 29.75029 5.821

Q9HDB5-3 NRXN3 1.210749 396 43.73906 9.247

B5MCE7 BZW2 1.396847 225 26.16552 5.554

P54577 YARS 1.594293 1.83622 528 59.1061 7.049

C9J4P8 FKBP9 1.014271 0.99304 226 24.64835 5.732

E9PF06 MRPL3 0.609086 176 19.56739 9.203

B5AK60 ABCB1 1.236142 0.998213 0.96536 1216 133.9475 8.968

C9JPE1 SLC25A20 1.08502 228 25.12304 9.408

Q9UHY8-2 FEZ2 1.005093 380 42.58602 4.678

O95571 ETHE1 0.892524 254 27.85511 6.83

B4DGC9 DNM1L 1.322742 533 59.97143 8.807

P49588 AARS 1.528437 1.649384 968 106.7432 5.529

E9PP31 CAPRIN1 0.995353 178 19.36873 9.276

O95202 LETM1 0.836178 0.624752 739 83.30196 6.698

Q9BR76 CORO1B 1.183583 489 54.20025 5.884

P20839-2 IMPDH1 1.951442 1.657952 489 52.56405 6.639

O14975-2 SLC27A2 1.000942 1.179552 0.76783 567 64.57429 8.485

H3BPD8 KATNB1 0.704054 208 22.75845 7.474

Q969Z0-2 TBRG4 0.636626 521 58.40581 7.035

B4E022 TKT 1.170399 576 62.83929 7.518

F5GWS8 HSPA13 0.802722 2.180864 0.747226 263 29.37337 6.537

P98082-2 DAB2 1.08965 0.683185 0.946441 552 58.82448 5.707

Q9UL68-3 MYT1L 1.464539 1.119658 184 20.60714 5.034

P10253 GAA 0.601787 0.92884 952 105.2568 5.999

G3V5X9 SNX6 0.915898 239 26.94949 5.884

of 313

Ant

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Pero

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186

186

P45877 PPIC 1.167603 0.565501 212 22.74885 8.397

O00534-4 VWA5A 1.218849 266 29.21665 5.135

Q9UKY7-2 CDV3 1.819937 213 22.06576 5.808

O43292-2 GPAA1 1.038494 561 61.05872 7.65

Q9H2V7-3 SPNS1 1.099477 1.009117 454 48.98191 7.752

P53701 HCCS 1.089835 268 30.58182 6.683

P11717 IGF2R 0.810536 0.739024 0.719584 2491 274.1988 5.935

E9PKK0 TNKS1BP1 1.788281 243 26.05737 9.349

C9J5V9 YBX1 1.326072 216 23.58364 10.26

Q15120 PDK3 0.797399 406 46.90907 8.368

B7Z341 NDRG3 1.552538 0.912358 271 29.70193 5.592

Q9Y624 F11R 0.809959 0.810082 299 32.56249 7.899

E9PRM7 SLC22A18 0.849465 326 34.92975 9.657

E7EWB4 DPYSL5 1.090506 190 20.85348 6.417

O75369-5 FLNB 1.328697 0.996688 2146 230.1452 5.542

P82930 MRPS34 1.281228 218 25.63449 9.979

Q9Y678 COPG1 1.755991 2.746038 1.335984 874 97.65547 5.465

P56199 ITGA1 1.245528 1.24296 0.926973 1179 130.7647 6.291

O14980 XPO1 1.324821 2.022848 1071 123.3061 6.062

F8VX11 EIF4B 1.264867 360 41.43034 6.341

Q9BT09 CNPY3 1.064823 278 30.72865 5.491

J3KR24 IARS 1.243357 1.489168 0.966796 1152 131.6797 6.113

P23219-3 PTGS1 0.649884 537 61.88916 8.045

Q9UG63 ABCF2 1.530427 1.118926 623 71.24463 7.372

O14579-3 COPE 2.314005 256 28.7546 5.288

E9PD92 G6PD 1.952377 256 29.48397 7.167

Q99816-2 TSG101 1.052729 285 31.71218 5.326

O76031 CLPX 1.009319 633 69.18073 7.577

of 313

Ant

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187

187

O14964-2 HGS 0.997025 690 76.32758 5.859

P82673-2 MRPS35 0.733322 287 32.69677 6.932

Q8IY17-5 PNPLA6 0.882457 1300 143.2608 7.738

K7EKB8 ZCCHC2 1.260929 378 39.9842 6.947

F5H248 COPS7A 1.243507 262 28.94824 5.719

Q9UH62 ARMCX3 1.033986 379 42.47387 8.368

H3BMU1 IST1 1.14299 206 23.36051 6.61

Q5VT94 GHITM 0.888661 325 35.25864 10.11

O15031 PLXNB2 0.884686 0.954203 1.197259 1838 204.9972 6.24

P15509-8 CSF2RA 1.451765 2.813744 267 31.0819 8.221

Q5TEZ5 C6orf163 1.261693 329 38.52877 6.961

Q9NX62 IMPAD1 0.846446 359 38.65696 6.859

Q00653-4 NFKB2 0.943685 899 96.61789 6.252

Q96RD7-2 PANX1 1.215809 422 47.60378 6.011

E9PJT3 SF3B2 1.109549 273 29.11627 5.656

P06756-3 ITGAV 1.112174 2.333825 1.00193 1002 111.061 5.618

Q9UF33-2 EPHA6 1.045992 334 37.14315 8.221

P82933 MRPS9 0.931219 396 45.80576 9.51

B3KU92 LOC90826 0.755775 732 81.80457 5.275

P02765 AHSG 1.096659 0.863169 367 39.29971 5.719

Q4G0F5 VPS26B 1.102572 336 39.13017 7.357

O14657 TOR1B 0.782236 336 37.95482 8.543

P56937-3 HSD17B7 0.712584 306 34.45376 8.163

F5GY68 ANAPC5 1.516846 217 24.69819 5.148

B0QY90 EIF3L 1.221129 2.893805 466 55.12602 8.954

O00220 TNFRSF10A 1.506031 468 50.05674 7.035

F8VUA7 OSBPL8 0.918728 0.820561 695 79.16 6.888

Q5JP01 RBBP7 1.433374 285 31.48338 6.189

of 313

Ant

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188

188

B7Z2A7 ACBD5 1.019595 348 38.7477 4.919

Q6WRI0-3 IGSF10 1.088677 602 66.69829 8.954

Q9Y2D0 CA5B 0.614193 317 36.4105 7.811

F8VWL0 TFCP2 1.420918 381 43.90611 6.991

E2QRH7 ELOVL5 0.779148 289 34.17938 9.481

Q96FN4 CPNE2 1.445992 548 61.15061 6.075

Q5LJB0 UCHL5 1.774012 258 29.09752 5.034

H7C0X4 ALG3 1.005136 323 36.98376 9.803

Q8IXH7-4 NELFCD 1.562668 581 65.43694 5.097

P07942 LAMB1 0.917401 1.458926 0.790964 1786 197.9086 4.945

B1AMX9 TRAF2 1.020803 422 46.53609 7.079

Q08722-2 CD47 1.391991 0.931491 292 31.72203 7.21

E9PF63 ROCK2 1.186264 1.021497 1145 133.1827 5.783

Q6DKJ4-3 NXN 1.514403 327 36.84778 4.881

F5H5F3 ATP6V0A2 0.846238 0.8683 328 38.02613 6.252

H0YKM7 MAN2A2 1.078825 1.136464 330 35.84931 8.075

K7ESB6 CSNK1G2 1.22621 299 33.73248 9.437

P20042 EIF2S2 1.18826 333 38.36437 5.795

Q8TEM1-2 NUP210 1.146134 0.833643 967 105.7438 6.227

Q92783-2 STAM 0.91422 403 44.94324 4.869

F5GZJ1 NCAPD2 1.388116 1.829292 1.035389 1356 152.0786 6.698

Q9HD20-2 ATP13A1 0.814919 0.731475 0.902841 1086 121.0323 7.752

Q9NXW2 DNAJB12 0.875832 375 41.79277 8.529

Q9Y4W6 AFG3L2 0.58911 0.37502 797 88.52819 8.661

Q96DV4 MRPL38 0.679954 380 44.56837 7.533

B1AKN6 NFIA 0.917064 380 42.27777 9.437

E7EQD7 DLG1 1.472285 658 71.81274 5.389

Q9UIQ6-3 LNPEP 1.084474 0.94827 1006 114.9881 5.783

of 313

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189

189

Q9H553 ALG2 1.510606 416 47.0613 7.049

F5H5E2 PLBD2 0.581519 0.596116 557 61.84515 6.8

Q6YHK3-4 CD109 0.973632 1428 159.5952 5.795

Q9UMX0-2 UBQLN1 1.13587 1.020684 561 59.18281 5.097

Q6NUK1-2 SLC25A24 1.043836 458 51.32124 5.884

Q9Y6M1-5 IGF2BP2 1.235582 2.081559 493 54.68838 7.518

Q86TM6-2 SYVN1 0.74949 0.870776 565 61.69123 6.844

P29622 SERPINA4 1.238129 427 48.51116 7.752

O60313 OPA1 0.466151 0.235485 0.627159 960 111.5608 7.87

P0C6C1 ANKRD34C 0.979708 1.036409 535 58.22031 9.027

Q9UMS4 PRPF19 1.257298 504 55.14635 6.61

Q16513-3 PKN2 1.13514 1.137924 936 106.1504 6.405

Q9Y617-2 PSAT1 4.326369 324 35.16607 6.683

C9JXC1 RRM2 1.24267 289 33.76709 5.453

Q9P2B2 PTGFRN 1.333617 0.980942 879 98.4946 6.61

Q969Z3-2 MARC2 1.346595 1.462994 1.005974 257 29.0841 9.789

Q9Y266 NUDC 2.261991 331 38.21913 5.376

Q96IR7 HPDL 0.849985 371 39.36136 7.035

Q9Y399 MRPS2 0.678992 296 33.22808 9.261

Q9BXT2 CACNG6 0.841807 260 28.11081 9.173

Q9H0H5 RACGAP1 1.075148 632 70.98177 8.88

P12004 PCNA 1.18465 2.05469 261 28.75029 4.691

P15529-16 CD46 1.292519 336 36.80235 7.65

Q8TAA9-2 VANGL1 1.016921 1.379496 1.111753 522 59.71011 8.807

F5H0H1 DHCR24 1.016718 1.225041 300 34.53024 6.698

Q92616 GCN1L1 1.164114 1.495175 2671 292.5725 7.474

Q7Z2W4 ZC3HAV1 1.030651 1.021061 902 101.367 8.397

Q9H3H5-3 DPAGT1 1.023283 301 34.24724 8.089

of 313

Ant

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190

190

P35237 SERPINB6 2.115173 0.967332 376 42.59406 5.275

Q9NZ53-2 PODXL2 1.070125 529 56.60054 4.323

O43464-4 HTRA2 1.103174 0.858048 377 39.88932 10.55

H0Y613 GSE1 1.828698 986 112.5705 7.123

Q969N4 TAAR8 1.432552 342 38.00349 6.815

P50552 VASP 1.153067 380 39.80509 8.939

O60942-3 RNGTT 1.188726 1.997955 1.070606 457 52.49949 8.016

Q86UL3 AGPAT6 0.81806 456 52.03721 9.188

O00622 CYR61 2.494523 1.443355 381 41.99828 8.207

Q5JS79 CASK 1.115366 381 43.71425 6.8

Q16720-8 ATP2B3 1.386884 1115 122.6815 5.757

Q5VVW2-3 GARNL3 1.283904 1.231963 1.148944 423 48.74479 8.983

P03891 MT-ND2 0.52364 0.559293 347 38.93475 9.833

Q92900-2 UPF1 1.244204 1.978737 1118 122.958 6.683

Q9H089 LSG1 1.057141 658 75.17836 6.379

Q5VU77 UBAP2L 1.306202 1.917356 350 37.93816 6.742

H7C3Z2 FLVCR1 0.933469 2.260423 354 38.15699 5.973

H3BR35 GSPT1 1.213561 475 52.90871 5.63

P30533 LRPAP1 0.564921 357 41.44091 8.778

Q9H2W6 MRPL46 0.750724 279 31.68542 7.049

E9PDM3 SLC6A6 0.974887 359 40.48957 8.192

Q9NQW1-4 SEC31B 0.492478 480 52.95023 8.485

P08581 MET 1.120399 0.958386 1390 155.4415 7.328

P43490 NAMPT 1.07257 491 55.4866 7.152

Q9NZI8 IGF2BP1 4.265769 577 63.44118 9.203

Q8N697 SLC15A4 0.700389 577 61.99343 8.998

P36551 CPOX 0.5522 454 50.11997 8.25

H0YLV8 BLM 0.991191 413 46.05255 4.97

of 313

Ant

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191

191

H7C487 OSBPL10 0.957723 538 60.30767 6.859

E7EX40 RAB11FIP1 0.690324 0.836738 501 54.79899 9.012

Q5JTP4 LAMA5 0.748403 500 54.82108 7.24

B4DUC5 CSE1L 1.779767 1.741506 754 85.4181 5.478

F5H698 LARS 1.741321 1.176201 1130 129.1319 7.87

Q8WUX1-2 SLC38A5 1.169519 1.656588 421 45.88529 8.338

A6NCS6 C2orf72 0.427099 295 30.46176 8.338

Q14643-4 ITPR1 1.386526 1.019189 2695 306.578 6.291

Q9BPX3 NCAPG 1.756411 1.236768 1015 114.2621 5.592

P04066 FUCA1 0.899272 466 53.65473 6.844

C9JIG9 OXSR1 1.457147 468 51.82385 7.796

Q14247-3 CTTN 0.97738 1.562945 1.075739 513 57.43154 5.326

P43686-2 PSMC4 2.206146 1.416601 387 43.48054 5.262

Q8WVM0 TFB1M 1.429787 346 39.51799 9.261

Q8NBJ4-2 GOLM1 0.371678 391 44.24627 4.907

P08648 ITGA5 1.261205 1049 114.4647 5.77

Q6ZRP7 QSOX2 0.891353 0.631728 698 77.47962 7.723

Q14789 GOLGB1 1.210601 1.014396 1.020317 3259 375.7897 4.996

Q9NZP5 OR5AC2 1.502034 1.906181 1.133634 309 35.28065 8.939

E9PP73 COPB1 2.60955 486 55.50238 6.43

Q9UGQ3-2 SLC2A6 0.971223 445 48.00964 9.012

H0Y8B5 CADPS2 1.082887 490 56.13144 5.262

O60826 CCDC22 1.273512 627 70.7122 6.742

P25205 MCM3 1.504178 808 90.92403 5.77

P17405-4 SMPD1 0.390463 628 69.57914 7.181

O75063 FAM20B 0.760967 409 46.40282 6.874

Q96ES6 MFSD3 1.147952 412 42.66863 9.173

P09874 PARP1 0.835644 1014 113.0124 8.88

of 313

Ant

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192

192

Q9C099-2 LRRCC1 1.382933 1.129748 1012 117.8571 6.24

F8W6I6 FAM178B 0.804773 647 72.80233 5.427

P02748 C9 1.295934 559 63.1327 5.592

B7Z463 NPEPPS 1.512425 0.98235 839 94.45592 5.376

O75083-3 WDR1 1.278036 1.085045 466 50.662 6.522

Q96LB3-2 IFT74 1.179131 372 42.30545 5.592

O60841 EIF5B 1.75188 1.169146 1220 138.7417 5.491

Q6UWP7-3 LCLAT1 0.791503 376 44.53207 8.587

Q14117 DPYS 1.465952 519 56.5937 7.269

Q9Y666 SLC12A7 0.788691 2.13404 1083 119.0286 6.712

P16144-4 ITGB4 0.890259 0.877425 1745 194.3419 6.125

P78357 CNTNAP1 0.871558 1384 156.1671 7.049

E9PMP7 LMO7 1.490234 1.065118 1046 119.4533 5.376

O95870-2 ABHD16A 0.858908 525 59.34509 7.84

P55010 EIF5 1.910282 1.14816 431 49.19181 5.58

B0S7Q4 C6orf136 1.191637 433 48.11504 9.701

Q9UDT6-2 CLIP2 0.550046 1011 111.7138 6.83

Q7KZN9-2 COX15 0.67725 388 43.80714 9.642

Q6UX68 XKR5 0.384452 686 74.93379 6.683

Q96AE4 FUBP1 1.243171 0.891987 644 67.51847 7.606

Q9UNF0-2 PACSIN2 0.757589 445 51.32099 5.389

Q4KMQ2-3 ANO6 1.547572 892 103.8983 8.236

K7EPT6 TAF15 1.26435 449 48.80937 5.084

H3BRV0 EIF3C 1.712376 0.973388 903 104.036 5.63

E9PIN3 NXF1 1.020035 603 68.06475 8.895

Q9ULE4 FAM184B 1.507056 1.11878 1.110085 1060 120.9693 6.176

Q8TDN6 BRIX1 3.552663 353 41.37495 9.92

B4E321 OS9 1.050002 406 46.27345 4.843

of 313

Ant

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193

193

Q7Z5H4 VN1R5 1.273724 1.829477 1.051904 357 40.75162 9.203

Q4G148-2 GXYLT1 0.833063 1.7711 409 46.76996 8.954

F6SKP1 GPNMB 1.075436 461 51.09972 6.392

B4DTG6 LSM14A 1.882094 422 46.38313 9.54

Q8IWA4 MFN1 1.061374 741 84.04712 6.252

Q9H2A2-2 ALDH8A1 1.198937 433 47.29486 6.367

Q15075 EEA1 0.719519 0.871027 1411 162.3672 5.681

O75901 RASSF9 1.49351 1.344004 435 49.98932 5.313

Q13033-2 STRN3 2.019764 0.92828 713 77.6965 5.262

A6NKB8 RNPEP 2.051127 611 68.12527 6.011

Q9NP73-4 ALG13 1.403233 954 106.7893 7.079

Q9H845 ACAD9 0.530212 621 68.71674 7.958

Q5CZ79-2 ANKRD20A8P 1.274444 395 46.62497 8.075

Q96JJ7 TMX3 1.082545 454 51.8389 4.907

Q8NEL9-3 DDHD1 1.014521 454 51.52195 6.494

B9ZVR1 MAP4 0.6509 811 85.34251 7.708

Q9Y5X3 SNX5 0.917368 404 46.78715 6.756

Q92896 GLG1 0.920041 0.803671 1179 134.4636 6.903

Q96N16-5 JAKMIP1 1.210791 646 75.69915 5.097

Q9HAR2-3 LPHN3 0.981821 707 79.2864 5.884

P98194-2 ATP2C1 0.727379 888 96.89717 6.316

P11047 LAMC1 0.695079 1.221609 1609 177.4886 5.123

F8W720 GMPS 2.432848 594 65.88747 7.474

O43865-2 AHCYL1 1.845451 483 53.71891 7.445

Q9Y2H6-2 FNDC3A 1.245853 1142 125.7414 7.079

B4DXY7 ALDH9A1 1.322077 424 46.42429 5.542

Q14573 ITPR3 0.970448 1.135529 2671 303.9121 6.481

B1AVT0 CLK2 1.06789 497 59.8379 9.657

of 313

Ant

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194

194

Q14160 SCRIB 1.257709 0.943204 1630 174.7782 5.072

E7EUY0 PRKDC 1.142021 1.038889 4096 465.0889 7.167

E9PD53 SMC4 1.59362 1.458396 1263 144.3652 7.123

O60336-4 MAPKBP1 1.402236 1015 109.0875 5.846

P00395 MT-CO1 0.950341 513 57.00303 6.698

B8ZZS4 ANKZF1 1.300849 516 57.53777 9.54

O00411 POLRMT 1.125978 1230 138.5319 8.983

H7BZL6 FSIP2 1.445189 1.438729 1.026572 973 109.7977 8.602

H0Y335 ADGB 1.32388 713 81.5463 8.573

Q9NR30-2 DDX21 1.012081 715 79.60742 9.378

O00222 GRM8 0.859408 908 101.6748 8.148

Q9P258 RCC2 1.224471 522 56.04921 8.778

Q5TCU6 TLN1 0.731978 1.460834 1.061228 2429 257.9205 6.494

F5GZY0 APLP2 0.721577 658 75.82961 4.767

P16066 NPR1 1.076771 1061 118.8441 6.639

Q02388-2 COL7A1 0.707121 2912 292.0904 6.227

O95239-2 KIF4A 0.916166 1127 128.3797 6.164

Q9BSW2-2 EFCAB4B 1.170936 731 83.14169 5.237

Q12770-4 SCAP 0.766007 0.798997 886 95.55569 6.189

P40222 TXLNA 1.38734 546 61.85325 6.522

Q9H987-2 SYNPO2L 1.253416 753 79.09764 9.774

E9PD78 RRM1 1.563745 695 79.16884 6.786

Q8IV36-3 HID1 0.533614 560 63.20515 7.24

P20742 PZP 1.014587 1.498878 1482 163.7596 6.379

E9PC74 EIF2B5 2.7585 705 78.29738 5.211

Q92945 KHSRP 1.127557 711 73.07003 7.298

H0YC63 MTUS1 0.798673 0.985212 505 55.13877 8.924

Q14596-2 NBR1 1.261168 937 103.7689 5.148

of 313

Ant

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Pero

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195

195

H0Y8U6 GPR98 0.661346 1608 176.7407 4.475

P02788-2 LTF 0.876692 666 73.11425 7.855

P45974-2 USP5 1.794846 835 93.24836 5.084

Q9BXL6 CARD14 0.603887 1004 113.1983 5.922

Q5T5P0 KIAA1217 1.090164 783 86.67605 9.188

P33176 KIF5B 1.254026 963 109.617 6.507

F6X344 MS4A14 1.325766 567 64.26276 5.237

F8WBH5 PSME4 1.205212 571 65.61747 7.914

P15924-2 DSP 0.934392 2272 259.9566 6.961

Q9UPT5-2 EXOC7 0.983226 653 74.66663 6.417

H0YN14 IPO4 1.295237 911 101.425 5.046

Q5JVD2 CNTRL 0.981491 828 93.84581 5.25

A1A528 ZW10 1.204654 672 76.75776 6.316

Q92973-3 TNPO1 1.397863 848 96.83798 4.932

Q9H3U1-2 UNC45A 1.596043 929 101.6108 6.062

P38435-2 GGCX 0.821136 1.707496 701 80.93728 7.577

P0C221-2 CCDC175 1.832305 1.077196 0.989715 792 93.46618 6.712

Q92888-2 ARHGEF1 1.544851 879 98.70653 5.567

B4DZI8 COPB2 1.092297 877 98.98359 5.161

D6RCT7 KIF15 1.324565 711 82.36256 6.481

Q9Y4D8-3 HECTD4 1.720814 889 98.68847 6.341

Q13443 ADAM9 0.952008 819 90.49713 7.518

Q6UVK1 CSPG4 1.26086 0.843477 2322 250.3824 5.465

H7BY50 MIA3 0.980069 1.291042 1016 114.0452 4.754

P19320-2 VCAM1 1.771415 1.27599 1.431126 647 71.20937 5.173

K7EQ71 PPL 1.860373 1115 131.2958 5.58

P55265-5 ADAR 0.598131 931 103.5764 8.661

G3V198 NUP160 1.261831 1235 140.1979 5.453

of 313

Ant

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Pero

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196

196

Q96M20-2 CNBD2 1.490011 572 67.03305 9.261

B7Z5Z4 CLCN4 2.018092 0.675462 666 74.29835 7.694

E9PCY5 TOP2B 0.838857 0.977699 0.846456 1150 130.3978 8.47

J3KQF5 AGBL1 1.311768 1.266288 1062 119.7863 7.313

Q99798 ACO2 1.345122 0.842871 780 85.37193 7.606

P07996 THBS1 1.221998 1170 129.2996 4.945

Q9UHB9-4 SRP68 1.512102 589 66.06708 7.196

Q9NV70-2 EXOC1 1.447457 879 100.219 6.595

Q5JTZ9 AARS2 0.662638 985 107.2729 6.265

P06213-2 INSR 1.134334 1370 155.0458 6.202

P51798-2 CLCN7 0.432839 781 85.97114 8.734

P49792 RANBP2 1.010454 0.962115 3224 357.9741 6.202

Q15393 SF3B3 1.074568 1217 135.4917 5.262

Q8WXE9 STON2 1.408436 1.354522 1.067901 905 101.1015 5.389

O75165 DNAJC13 0.770851 2243 254.2525 6.742

Q9NS39 ADARB2 1.199085 739 80.57113 10.17

E7ESU4 NAT10 0.849194 953 107.2289 6.991

P16383-2 GCFC2 1.376901 743 84.79424 6.202

Q1L5Z9 LONRF2 1.074615 754 83.60028 5.897

E7EMM2 AP3D1 1.365068 984 111.1816 8.104

Q5T1M5-2 FKBP15 1.102506 2.189178 1209 132.3853 5.173

Q7Z7L7 ZER1 1.114371 766 88.1127 5.618

J3KNL6 SEC16A 1.356974 2357 251.7375 5.795

Q92614-5 MYO18A 0.980365 1581 180.3827 5.91

H0Y547 ATP11A 0.683214 935 106.5542 6.417

E9PF10 NUP155 0.793044 0.730684 1327 147.9996 6.303

H0Y7N4 DOCK5 1.200479 1090 126.0439 7.782

Q8TDD1 DDX54 2.256169 0.802348 881 98.5342 10.02

of 313

Ant

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197

197

F5GZL7 MACF1 0.980367 0.876942 5300 605.7584 5.389

A7E2D7 EP400 1.121014 1731 188.0955 8.939

Q8TD57-3 DNAH3 1.522615 1887 215.9386 6.443

Q9Y239 NOD1 1.012465 953 107.6223 7.108

J3QQJ5 TRAPPC8 1.410914 1381 154.8869 6.976

Q8WYK1 CNTNAP5 1.319006 1306 145.5304 6.291

Q01970-2 PLCB3 1.248443 1.07296 1.068852 1167 131.1238 5.884

F5H0N7 CLIP1 0.939677 1013 116.1837 5.148

E9PMR6 ARHGEF12 1.105344 1441 161.8084 5.656

E5RG74 BAI1 0.772566 1159 126.6066 7.899

Q9UKV0-6 HDAC9 1.465707 1025 112.381 6.24

O60292 SIPA1L3 2.122041 1781 194.4896 8.324

P41229-4 KDM5C 0.850138 1379 155.0199 5.554

H0Y8D6 ABCA2 1.134613 1441 159.86 6.727

Q15058 KIF14 0.988275 1648 186.3749 7.914

Q92621 NUP205 0.790413 2012 227.7763 6.189

Q92538 GBF1 1.972311 1859 206.3146 5.732

P08572 COL4A2 1.530736 1712 167.4486 8.661

Q96JH7 VCPIP1 0.795746 1222 134.2359 7.196

C9JTR3 RTTN 1.273629 1.038178 1593 178.8395 6.367

Q96K76-2 USP47 1.317471 1287 147.1303 5.072

F8VSZ4 PLXNA1 0.77201 1873 208.4163 6.874

Q07954 LRP1 1.106034 0.83705 4544 504.2759 5.389

Q96NW7-2 LRRC7 1.25008 1490 167.2812 6.61

Q93008-1 USP9X 1.270548 2554 290.2777 5.795

F5H2B9 UACA 1.52613 1307 150.4393 7.02

H0Y765 KMT2C 1.13645 1524 168.4316 8.265

P12259 F5 0.695973 2224 251.5455 6.049

of 313

Ant

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Pero

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198

198

H0Y5W0 HUWE1 1.514098 3408 374.0725 5.097

Q9Y485 DMXL1 1.683314 3027 337.6247 6.341

Q8NDH2 CCDC168 1.048706 2452 277.7779 9.305

F5H7F0 UNC13C 1.348017 2212 250.5517 5.922

Q4G0P3 HYDIN 0.980242 5121 575.5277 6.062

J3QQ66 ZFHX4 1.648258 3567 393.4816 6.367

O75691 UTP20 1.140913 2785 318.1821 7.386

P42858 HTT 1.459612 1.276072 1.126057 3142 347.3828 6.202

H0Y4W2 TRRAP 0.988373 3588 405.6492 8.177

Q8NCM8 DYNC2H1 2.094258 4307 492.3115 6.537

Q9NU22 MDN1 0.937528 5596 632.4202 5.681

of 313

Ant

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from

this

pro

of.

199

199

Table S3. Reproducibly identified proteins


Q99714 HSD17B10 0.841516 1.034407 0.721248 261 26.90611 7.782

P51149 RAB7A 0.922614 1.065166 0.846551 207 23.47484 6.698

P51149 HSPE1 0.679456 0.790736 0.699603 102 10.92487 8.924

P05787 KRT8 0.675075 0.751577 0.750807 483 53.67114 5.592

P07737 PFN1 1.938756 2.252394 1.344145 140 15.04456 8.265

P04075 ALDOA 1.431453 1.24978 1.077389 364 39.39531 8.089

P62820 RAB1A 1.092382 0.88875 1.125391 205 22.66338 6.214

Q9H0U4 RAB1B 0.918566 1.065785 0.919462 201 22.15723 5.732

F8VP99 ARL1 1.157695 1.542415 0.956203 17 1.784059 8.998

P30044-2 PRDX5 0.899533 1.151113 0.875192 162 17.02001 7.24

P35232 PHB 0.763098 0.907576 0.7709 272 29.7859 5.757

P21796 VDAC1 0.900554 0.889186 0.881584 283 30.75357 8.543

P04406 GAPDH 1.458589 1.332338 1.068676 335 36.0304 8.456

P61224 RAP1B 1.16238 1.077295 1.039023 184 20.81159 5.783

P40926 MDH2 0.664156 0.837865 0.680457 338 35.48073 8.675

P05388 RPLP0 1.330471 1.475431 1.056908 317 34.2518 5.973

P62805 HIST1H4A 0.955174 1.623225 0.837629 103 11.36038 11.36

P14854 COX6B1 0.757329 0.370079 0.408104 86 10.18572 7.049

P04843 RPN1 0.913799 1.010671 0.790561 607 68.52681 6.379

P12236 SLC25A6 0.70999 1.164683 0.736293 298 32.84519 9.745

J3KPX7 PHB2 0.789382 1.248585 0.888689 299 33.38196 9.803

P61106 RAB14 0.996383 1.193794 0.894419 215 23.88193 6.214

P10809 HSPD1 0.810926 0.816132 0.726478 573 61.01639 5.872

C9J4Z3 RPL37A 1.436528 1.015617 68 7.618937 10.01

P07355 ANXA2 1.289833 1.129487 1.003301 339 38.57982 7.752

of 313

Ant

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200

200

P05783 KRT18 0.799 0.85891 0.825672 430 48.02854 5.453

P45880-2 VDAC2 0.922755 0.953553 0.777764 283 30.39304 7.196

P06733 ENO1 1.914614 1.758462 1.405665 434 47.13932 7.386

P23396 RPS3 1.488376 1.290279 1.098373 243 26.67143 9.657

P11021 HSPA5 0.956886 1.019791 0.911357 654 72.28844 5.161

P30050 RPL12 1.322301 1.463871 1.083923 165 17.80754 9.422

P05187 ALPP 1.251282 1.513109 0.854797 535 57.91729 6.291

P50991-2 CCT4 1.225267 1.121238 0.973524 509 54.6851 7.826

P04083 ANXA1 2.266094 1.746823 1.194763 346 38.68998 7.02

P61204 ARF3 1.444831 1.666886 1.051078 181 20.58773 7.43

O75947-2 ATP5H 0.765966 0.744454 0.632677 137 15.76317 7.181

P05186 ALPL 1.23596 0.987719 0.873944 524 57.26863 6.668

P22392-2 NME2 2.124502 1.754569 1.124689 267 30.11763 8.924

P62937 PPIA 1.581094 1.657079 1.266474 165 18.00089 7.811

F8W181 RPL6 1.156877 1.928758 1.269758 226 25.87584 10.67

P15328 FOLR1 1.366506 1.081038 0.923879 257 29.79922 7.972

P23284 PPIB 0.898139 0.859683 0.805036 216 23.72754 9.408

P56385 ATP5I 0.656519 0.355847 0.61265 69 7.928326 9.349

I3L405 MPDU1 0.702334 1.097506 0.747594 54 5.842343 8.543

P60709 ACTB 1.24783 1.091786 1.021016 375 41.70973 5.478

Q9BQE3 TUBA1C 2.489466 1.571135 1.267975 449 49.86346 5.097

Q04837 SSBP1 0.805241 0.95227 0.876624 148 17.24903 9.598

P78371 CCT2 1.240819 1.18594 1.00711 535 57.45213 6.456

P07437 TUBB 2.198372 1.65089 1.379771 444 49.63897 4.894

P68371 TUBB4B 2.190046 1.825049 1.414922 445 49.799 4.894

G3V1A4 CFL1 1.436668 1.604942 1.119905 149 16.80082 8.353

Q96AG4 LRRC59 0.915084 0.993629 0.812279 307 34.90888 9.569

P35268 RPL22 1.725276 0.9945 1.187181 128 14.7778 9.188

of 313

Ant

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Pero

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The

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201

201

Q04695 KRT17 0.733529 0.819907 0.869358 432 48.07605 5.021

P61019 RAB2A 1.100628 1.154274 0.894823 212 23.53077 6.537

P61586 RHOA 1.254205 0.988428 0.989212 193 21.75407 6.1

B4E2V5 STOM 1.063447 1.119375 0.952542 237 25.94779 7.386

P08758 ANXA5 2.55048 2.027943 1.387868 320 35.9144 5.046

P08238 HSP90AB1 2.032999 1.859231 1.041987 724 83.21211 5.034

F8W1R7 MYL6 1.215575 1.126743 1.032317 145 16.2798 4.653

P06576 ATP5B 0.671661 0.96268 0.673776 529 56.52461 5.402

H7BZJ3 PDIA3 1.026889 0.806688 0.896513 123 13.51076 7.298

P51148 RAB5C 0.967067 1.122958 0.802933 216 23.46779 8.412

P05141 SLC25A5 0.787078 0.722562 0.695568 298 32.83115 9.686

P11142 HSPA8 1.676814 1.507196 1.091932 646 70.85423 5.516

P21964-2 COMT 1.006936 1.232053 0.924779 221 24.43338 5.326

P07237 P4HB 0.864308 0.920657 0.801654 508 57.08068 4.869

Q15286-2 RAB35 1.233208 1.057609 1.070747 152 17.04762 6.786

C9JD32 RPL23 1.186353 1.648681 1.004362 91 9.663386 11.49

P37802 TAGLN2 1.433868 1.373952 1.19946 199 22.37717 8.25

G5EA52 PDIA3 0.782183 1.237703 0.800555 485 54.92888 6.859

P02786 TFRC 0.946452 1.213344 0.810573 760 84.81795 6.61

P60174-1 TPI1 1.484075 1.743766 1.210256 249 26.65274 6.903

P14618 PKM 2.153361 2.370428 1.58462 531 57.90003 7.84

Q13162 PRDX4 0.877084 1.101935 0.887093 271 30.52081 6.291

H0YD13 CD44 1.235225 1.198431 0.977471 185 20.21538 8.265

A8MUB1 TUBA4A 2.036923 2.142278 1.476961 433 48.2976 5.008

P62899 RPL31 1.280412 1.474387 1.010627 125 14.45393 10.54

D6RAT0 RPS3A 1.391437 2.274117 1.088799 227 25.87044 9.422

P38646 HSPA9 0.643269 0.744843 0.621853 679 73.63478 6.164

P18124 RPL7 1.358129 1.350894 0.97166 248 29.2072 10.65

of 313

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P19105 MYL12A 1.245813 1.22103 1.061118 171 19.78149 4.805

P63104 YWHAZ 1.862614 2.023601 2.525793 245 27.72773 4.792

E9PKZ0 RPL8 1.479458 1.201099 1.042 205 22.37522 10.76

P25705 ATP5A1 0.810155 0.964153 553 59.7136 9.129

Q06830 PRDX1 1.785254 1.352087 1.10989 199 22.09628 8.133

B7Z254 PDIA6 0.855887 1.122926 0.795077 437 47.80807 5.084

P07195 LDHB 1.964997 1.817951 1.455855 334 36.61514 6.049

D6RAN4 RPL9 1.326622 1.204954 0.967353 182 20.86141 10.2

Q9Y5M8 SRPRB 1.050497 1.255535 0.939115 271 29.68376 9.042

P07900 HSP90AA1 1.836656 1.700895 1.059922 732 84.60669 5.021

P17987 TCP1 1.260682 1.379604 0.931344 556 60.30559 6.113

P68104 EEF1A1 1.623493 1.398227 1.146169 462 50.10911 9.012

Q15019 SEPT2 1.163427 1.163393 0.935111 361 41.46125 6.595

E9PN17 ATP5L 0.688519 0.850805 0.784382 76 8.446677 10.29

I3L397 EIF5A 1.252103 1.537274 1.130697 147 16.10798 4.996

P08195-2 SLC3A2 1.450345 1.55993 1.062157 529 57.90887 5.351

P09525 ANXA4 1.858302 1.494527 1.25553 319 35.86012 6.125

P30040 ERP29 0.940127 1.141007 0.762335 261 28.97516 7.313

P27348 YWHAQ 1.639264 1.764708 245 27.74677 4.78

P46781 RPS9 1.596054 1.646443 1.137516 194 22.57756 10.65

P39019 RPS19 1.41885 2.247615 1.038056 145 16.05054 10.32

P61026 RAB10 1.023099 1.368584 0.851934 200 22.52659 8.382

P62906 RPL10A 1.426027 1.112273 1.122081 217 24.81554 9.935

P09211 GSTP1 2.264256 1.306028 1.773251 210 23.34102 5.643

F8W7C6 RPL10 1.204563 1.269058 163 18.57973 9.95

Q9UBI6 GNG12 1.043246 1.20671 0.704077 72 8.00117 8.968

Q9Y2Q5 LAMTOR2 0.980146 1.111427 0.77696 125 13.49885 5.402

Q15293 RCN1 0.990571 0.964389 0.872109 331 38.86617 4.996

of 313

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P49411 TUFM 0.807198 0.801759 0.780787 452 49.51018 7.606

P50454 SERPINH1 0.947646 1.159278 0.839949 418 46.41118 8.69

P00387-2 CYB5R3 0.845523 0.670345 0.888954 278 31.60836 7.577

P13639 EEF2 1.692874 2.529139 1.184579 858 95.27695 6.83

P05387 RPLP2 1.395322 1.271484 1.097447 115 11.65785 4.539

P04899 GNAI2 1.21145 1.10679 0.796403 355 40.42506 5.542

Q9H3K6 BOLA2 1.005165 1.066989 86 10.11018 6.522

Q14697 GANAB 0.928261 0.940956 0.819932 944 106.8067 6.138

C9J9K3 RPSA 1.484789 2.096834 0.965794 264 29.487 5.25

H3BRU6 PCBP2 1.303973 2.759481 1.020001 301 31.69025 8.441

P31327 CPS1 0.738376 0.773863 0.620871 1500 164.8348 6.742

P84095 RHOG 1.043651 0.825372 191 21.29493 8.119

P27797 CALR 0.84085 0.960863 0.770204 417 48.11183 4.437

P35613-4 BSG 1.399049 1.07799 0.949404 205 22.7502 5.465

P62277 RPS13 1.678969 1.478867 1.078018 151 17.21167 10.54

P62979 RPS27A 1.440632 0.943459 1.152788 156 17.95349 9.642

C9JXB8 RPL24 1.199513 1.607222 0.984919 121 14.35982 11.31

Q99832 CCT7 1.253512 1.025571 0.931442 543 59.32893 7.65

F5H897 TRAP1 0.694887 0.819808 0.765467 651 74.22066 7.87

Q15907 RAB11B 0.944864 1.163245 0.742528 218 24.47349 5.935

P11233 RALA 1.101317 1.210924 0.908307 206 23.55197 7.108

P14625 HSP90B1 0.892788 0.951019 0.830767 803 92.41135 4.843

P00558 PGK1 1.471019 1.379579 1.293939 417 44.58613 8.104

P48047 ATP5O 0.633851 1.24605 0.808641 213 23.26266 9.964

F8W1N5 NACA 1.270608 2.333095 71 7.808271 9.627

P15880 RPS2 1.664077 1.47961 1.113606 293 31.3046 10.24

P00966 ASS1 1.839589 1.676893 1.362175 412 46.50097 8.016

P08754 GNAI3 1.175651 0.804725 1.039917 354 40.50627 5.694

of 313

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204

B4DUR8 CCT3 1.22739 1.151447 0.915537 500 55.6387 5.643

J3KPE3 GNB2L1 1.484859 1.549646 0.982292 273 30.08503 7.65

P62701 RPS4X 1.302232 2.454188 0.93498 263 29.57906 10.15

K7EJW7 RAB34 1.16037 0.794762 51 5.83202 9.378

P13667 PDIA4 0.930947 0.925643 0.89519 645 72.88698 5.072

P60953 CDC42 1.431487 1.57275 0.920497 191 21.24502 6.551

P62241 RPS8 1.47423 1.177438 1.187905 208 24.19016 10.32

B4DP11 PTGES3 1.681728 2.155438 1.223253 139 16.46559 4.805

P62081 RPS7 1.354286 1.2582 1.16434 194 22.11326 10.1

P10599-2 TXN 1.730395 1.578375 1.437973 85 9.445685 6.037

E7EPB3 RPL14 1.301225 1.305218 1.102775 124 14.5486 10.21

E9PJD9 RPL27A 1.364131 1.230209 0.96926 91 10.1206 10.21

Q9NS69 TOMM22 0.681845 0.776688 142 15.51179 4.335

Q13011 ECH1 0.768997 0.747662 0.814573 328 35.79338 8.001

P62826 RAN 1.649783 1.16876 1.196289 216 24.40762 7.489

O43852 CALU 0.757461 0.647413 0.615452 315 37.08354 4.64

P30519 HMOX2 1.01223 0.847264 0.881484 316 36.00983 5.415

P09923 ALPI 1.094579 1.315935 0.881478 528 56.77642 5.859

F8W1A4 AK2 0.895767 0.521958 0.570225 232 25.61431 7.826

F8VSD4 UBE2N 1.798173 1.165616 105 11.97532 9.115

O15260-2 SURF4 0.965792 1.794887 0.832768 159 17.95813 6.049

Q00325-2 SLC25A3 0.750895 0.864622 0.675982 361 39.93264 9.364

P26038 MSN 0.997356 0.961161 0.841568 577 67.77779 6.405

Q9Y4L1 HYOU1 0.945504 1.059093 0.930768 999 111.2662 5.224

B4DT77 ANXA7 1.799431 2.522988 1.392255 336 37.78092 7.181

P20340 RAB6A 0.976054 1.189046 0.893356 208 23.57792 5.542

Q07065 CKAP4 0.828617 1.04363 0.862488 602 65.98273 5.922

O75396 SEC22B 0.901232 0.960989 0.94581 215 24.57753 6.917

of 313

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P62873 GNB1 1.277162 1.015888 0.94075 340 37.35301 5.999

P62879 GNB2 1.315584 1.060956 0.898893 340 37.30706 5.999

P14314-2 PRKCSH 0.91234 1.048005 1.041739 525 59.1407 4.424

P80723-2 BASP1 1.166233 1.056561 0.901991 173 17.65361 4.767

J3KRB3 RPL17 1.489923 2.946832 0.995291 106 12.18533 10.33

Q7Z7H5-3 TMED4 1.342651 1.19789 0.815333 186 20.76759 6.874

Q15365 PCBP1 1.261067 2.948268 0.9692 356 37.47395 7.093

P08133-2 ANXA6 1.403662 1.436018 1.034728 641 72.37795 5.605

P34897-3 SHMT2 0.685224 0.741831 0.678145 483 53.4214 8.148

P62258 YWHAE 1.992235 1.280401 1.494461 255 29.15542 4.742

Q5TGZ0-2 MINOS1 0.800924 1.149823 0.884853 24 2.807374 5.021

P42704 LRPPRC 0.690941 0.910268 0.672625 1394 157.8051 6.125

Q15836 VAMP3 0.998247 0.865657 100 11.30195 8.792

P62269 RPS18 1.346863 1.626686 1.028083 152 17.70786 10.99

H0YJW7 SLIRP 0.71013 0.971971 0.865119 76 8.686431 9.056

P08729 KRT7 1.062605 1.561058 0.950673 469 51.35431 5.478

P51151 RAB9A 0.791237 1.072214 0.935898 201 22.82317 5.465

Q96KK5 HIST1H2AH 0.735924 1.673838 0.56306 128 13.89783 10.89

P62851 RPS25 1.40709 1.856292 1.141014 125 13.7337 10.11

P06753-2 TPM3 1.33755 1.366747 248 29.01475 4.78

P55145 MANF 0.926633 0.909981 0.846526 182 20.68681 8.69

Q9Y277 VDAC3 0.760055 1.266825 0.695581 283 30.63929 8.661

H3BSJ9 UQCRC2 0.833404 1.259801 0.853102 336 36.36685 9.056

D6R9Z7 COX7C 0.626331 0.848862 56 6.378306 9.833

P49755 TMED10 0.944925 0.898659 0.864641 219 24.96002 7.445

P51659 HSD17B4 0.912127 1.142433 0.907175 736 79.63631 8.836

M0R3D6 RPL18A 1.374033 1.25685 0.974152 141 16.70379 10.77

P07954-2 FH 0.75616 0.821024 0.77492 467 50.18071 7.401

of 313

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206

206

P61006 RAB8A 0.901174 1.246924 0.836144 207 23.65319 9.071

P18077 RPL35A 1.477323 1.059888 1.092934 110 12.52977 11.06

O00264 PGRMC1 0.896808 1.252782 0.816996 195 21.65776 4.704

P48643 CCT5 1.237512 1.01463 1.005196 541 59.63281 5.656

P00338 LDHA 1.812565 2.760047 1.429861 332 36.66536 8.265

P27824 CANX 0.925213 0.986537 0.774761 592 67.52585 4.602

E9PI90 TMEM126A 0.972535 1.250469 0.866371 95 10.5577 9.349

E9PIE4 MTCH2 0.568568 0.880562 0.724825 263 28.64363 7.606

O43707 ACTN4 1.262195 1.082558 0.9702 911 104.7885 5.44

O60493-4 SNX3 1.267295 0.705719 0.97026 140 16.30543 6.8

H7BYD0 NDUFA5 0.473911 0.506902 112 13.08984 5.148

H0YNX5 SEC11A 1.109807 1.068807 0.796946 106 11.9784 8.573

P08708 RPS17 1.448131 1.01641 135 15.54039 9.847

P40227-2 CCT6A 1.192214 0.996239 0.919703 486 53.25512 7.269

E9PPQ4 FTH1 0.622898 0.799481 0.801175 58 6.659315 5.833

P62280 RPS11 1.662973 1.502607 1.097377 158 18.41899 10.3

P36578 RPL4 1.35429 1.903045 0.988733 427 47.66743 11.06

Q9NZM1-6 MYOF 1.037945 1.021888 0.808942 2048 233.3291 6.214

P13073 COX4I1 0.483846 0.765167 0.556132 169 19.56405 9.51

Q09666 AHNAK 1.396628 1.078414 1.085748 5890 628.6994 6.151

O00299 CLIC1 1.488679 1.783422 1.075934 241 26.90575 5.173

O75340-2 PDCD6 1.339131 2.016605 0.873893 189 21.6507 5.402

Q9BVK6 TMED9 1.089255 1.206477 1.029899 235 27.26019 8.016

B0YJC4 VIM 1.04978 0.95151 0.834099 431 49.62311 5.25

P16435 POR 1.075094 1.406985 0.862966 677 76.64125 5.58

P62857 RPS28 1.611754 1.450764 1.260379 69 7.836202 10.7

E9PH29 PRDX3 1.032865 1.063725 0.964449 238 25.82229 7.459

F8VWC5 RPL18 1.362265 1.227657 1.081671 159 18.08001 11.84

of 313

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207

207

B4DJV2 CS 0.738233 0.967624 0.528491 453 50.39972 7.899

G5E9G0 RPL3 1.270871 1.237766 1.026216 351 40.24159 10.01

P62136 PPP1CA 1.343226 1.108105 1.095776 330 37.48781 6.329

P31930 UQCRC1 0.774534 0.886231 0.935639 480 52.61243 6.367

P05023-3 ATP1A1 1.294006 0.992424 1.007667 992 109.4801 5.313

P30041 PRDX6 2.172555 2.201779 1.531302 224 25.01919 6.379

E9PE17 MRPS17 0.737873 0.985275 129 14.36487 9.847

P56381 ATP5E 0.520223 0.661011 51 5.776108 9.92

P49748-2 ACADVL 0.856184 0.941784 0.884746 633 68.01516 8.558

P24752 ACAT1 0.638064 0.687537 0.508238 427 45.17065 8.851

P62847-2 RPS24 1.28488 1.502636 1.211886 130 15.05924 10.89

J3QRU4 VAMP2 1.035579 0.87911 0.88375 113 12.24347 6.698

P38117 ETFB 0.638357 0.914762 0.756683 255 27.82615 8.104

P50990 CCT8 1.308838 1.110844 1.013766 548 59.58251 5.605

H3BLV0 CD55 1.328456 1.063833 0.912351 326 35.78247 5.542

K7EK18 SEPT9 1.098243 2.065827 0.89968 195 22.20265 9.364

M0R210 RPS16 1.69377 1.999538 1.206613 129 14.40996 10.23

H7C131 ACAA1 1.048769 1.409101 0.869312 290 30.31385 8.631

Q9Y3U8 RPL36 1.31536 1.586732 1.003242 105 12.24591 11.59

P63173 RPL38 1.294342 1.106003 0.869385 70 8.212732 10.1

P35579 MYH9 1.302687 1.086399 1.071008 1960 226.3916 5.605

P14923 JUP 1.086031 1.9394 0.870796 745 81.69273 6.138

E7EPK1 SEPT7 1.093627 0.907592 0.935756 436 50.53491 8.631

P60981-2 DSTN 1.581098 1.011045 1.184857 148 16.60962 8.338

P49207 RPL34 1.395191 1.314732 0.995061 117 13.28447 11.47

P62158 CALM1 1.168528 0.976215 1.043359 149 16.82684 4.221

B0V0C2 HLA-C 1.174925 1.450967 1.015708 355 39.9159 6.252

P61020 RAB5B 0.95207 1.502444 215 23.6919 8.133

of 313

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208

208

P62424 RPL7A 1.271624 1.253347 1.056754 266 29.97703 10.61

P32119 PRDX2 1.699211 1.093831 1.077377 198 21.87824 5.973

E9PNW4 CD59 1.27023 1.074834 108 11.97652 5.745

P14406 COX7A2 1.049713 0.36366 83 9.390106 9.759

P56378 MP68 0.57071 1.525767 0.537005 58 6.657592 10.08

E7EQV9 RPL15 1.487834 1.212723 1.172524 174 20.4971 11.28

P26373 RPL13 1.341332 1.017938 1.180794 211 24.24653 11.65

P04264 KRT1 0.85955 0.950506 1.147848 644 65.999 8.119

P07339 CTSD 0.787297 1.54094 0.754058 412 44.52363 6.537

O95881 TXNDC12 0.767286 1.351947 0.708736 172 19.19358 5.402

P08107-2 HSPA1A 1.451974 1.304211 1.128996 586 63.89795 5.707

P46777 RPL5 1.4141 1.415486 0.956259 297 34.3407 9.715

P46783 RPS10 1.235944 2.429152 1.195446 165 18.88587 10.15

B8ZZT4 VAMP8 0.981127 0.644367 99 11.18456 5.034

P63000 RAC1 0.949096 1.149969 0.843695 192 21.43624 8.5

P15311 EZR 1.044674 1.131245 0.844371 586 69.36974 6.265

Q9H3R2 MUC13 0.978161 1.009123 0.874289 511 54.4823 5.072

P51153 RAB13 0.987342 0.880775 203 22.75974 9.188

P04844-2 RPN2 0.865835 1.515186 0.790879 615 67.68143 6.062

P22626-2 HNRNPA2B1 1.46531 1.472787 1.080379 341 35.98387 8.646

Q07021 C1QBP 0.539476 0.617432 0.63902 282 31.34261 4.843

B0QYW5 SLC25A17 0.80683 1.515895 0.830338 225 25.70527 10.33

P40939 HADHA 0.854214 0.933591 0.693905 763 82.94688 9.042

P18859 ATP5J 0.606499 0.905095 108 12.5796 9.525

Q8NBS9-2 TXNDC5 0.859163 1.032573 0.891072 324 36.15501 5.465

R4GN98 S100A6 1.80781 1.242526 85 9.675063 5.453

P60842 EIF4A1 1.965905 2.235364 1.377883 406 46.12456 5.478

P04792 HSPB1 1.745388 1.579063 1.377766 205 22.76849 6.405

of 313

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209

209

P00505 GOT2 0.74356 1.11953 0.835989 430 47.48732 9.012

A6NNI4 CD9 1.162542 1.471833 0.875901 159 17.75198 6.291

J3KTJ8 RPL26 1.253158 1.097186 0.952303 97 11.59029 10.9

P46940 IQGAP1 1.311338 1.179563 1.051245 1657 189.1338 6.481

Q5SQT8 SAR1A 1.342855 1.036644 1.046629 121 13.65307 7.035

A2A2D0 STMN1 1.436459 1.078793 86 9.858311 7.416

P01891 HLA-A 1.141704 1.080213 0.870519 365 40.88311 6.698

R4GMU8 LAMTOR5 1.802162 1.58376 79 8.210105 5.681

M0R213 NAPA 1.380978 0.797603 83 9.850914 5.059

O00116 AGPS 0.916199 1.008498 0.881695 658 72.86575 7.342

P36542 ATP5C1 0.794469 1.137386 0.851877 298 32.97527 9.217

Q9P0J0 NDUFA13 0.945637 1.150368 144 16.6876 8.426

P62750 RPL23A 1.612112 1.035822 1.037671 156 17.68414 10.45

P42677 RPS27 1.229176 1.262495 1.039197 84 9.454836 9.452

H0YLW1 SPG21 1.172061 1.030744 72 8.198275 8.163

P68032 ACTC1 1.34282 1.013944 1.055046 377 41.99188 5.389

P46779 RPL28 1.626481 1.301392 1.045187 137 15.73767 12.02

O00571-2 DDX3X 1.312787 1.984043 1.036829 646 71.31093 6.625

P00533 EGFR 1.313611 1.150044 0.967401 1210 134.1903 6.683

O00483 NDUFA4 0.523392 0.706709 0.775773 81 9.363911 9.378

A1L0T0 ILVBL 0.939325 1.132552 0.986583 632 67.82475 8.148

Q9BS26 ERP44 1.071049 0.980132 0.906419 406 46.9414 5.262

P39656 DDOST 0.870036 1.214033 0.817799 456 50.76897 6.551

E5RI99 RPL30 1.335092 1.112029 1.043232 114 12.64765 9.554

P50416 CPT1A 0.78061 0.995421 0.755873 773 88.31074 8.646

H0YJ63 AHSA1 1.229447 1.349447 1.208246 90 10.13504 7.035

F8W031 2 0.947739 0.875083 0.923028 263 29.20588 7.005

P47813 EIF1AX 1.885051 1.752925 1.039483 144 16.45023 5.237

of 313

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210

210

P16615 ATP2A2 0.916231 0.957004 0.913417 1042 114.6826 5.338

P25398 RPS12 1.659114 1.104536 1.065406 132 14.50548 7.21

P54886-2 ALDH18A1 0.695204 1.022175 0.785468 793 87.03444 7.123

P50897 PPT1 0.765644 0.910308 306 34.17125 6.522

H0YJ10 4 1.021539 1.300787 0.811753 91 10.72949 8.192

P12277 CKB 1.649735 3.416205 1.579158 381 42.61732 5.592

Q96D15 RCN3 0.761235 0.664588 0.875835 328 37.47 4.894

P61978-3 HNRNPK 1.293792 1.262426 1.041703 440 48.53217 5.542

Q9UJZ1 STOML2 0.938409 0.635069 0.93784 356 38.5102 7.386

Q9NUP9 LIN7C 1.20256 1.122703 197 21.82047 8.426

Q969X5-2 ERGIC1 1.119816 0.901479 0.66877 198 22.14624 9.159

C9IZG4 CUTA 0.988956 1.690078 1.10773 135 14.39131 5.453

Q9H9B4 SFXN1 0.877179 0.76235 322 35.59635 9.071

Q8WVC2 RPS21 2.174773 1.079974 81 8.844458 8.5

E9PK01 EEF1D 1.302939 1.516644 1.004283 261 28.8036 5.021

Q9UBQ0-2 VPS29 1.041183 0.601188 0.878376 186 20.9139 7.049

P08559 PDHA1 0.60855 0.708728 0.778748 390 43.26761 8.06

K7ES20 CDKN2A 1.387355 2.537661 1.194942 104 11.0686 6.062

Q7KZF4 SND1 1.045645 1.052682 0.894108 910 101.9335 7.167

O00159-2 MYO1C 1.090572 1.879908 0.932649 1028 117.8338 9.408

Q05639 EEF1A2 1.264052 1.278046 463 50.43831 9.027

P13797 PLS3 1.278969 1.281915 0.894728 630 70.76621 5.605

Q71UI9-2 H2AFV 1.022639 0.894296 114 12.13865 10.46

P51809 VAMP7 0.593834 1.216902 0.666516 220 24.91897 8.602

H0YHC3 NAP1L1 1.749507 1.215395 1.242297 198 23.40282 4.805

H0YK49 ETFA 0.808242 0.650196 0.816799 229 24.14479 8.661

P55072 VCP 1.356492 1.053145 1.115978 806 89.26572 5.262

P40429 RPL13A 1.465869 1.290089 1.005122 203 23.56238 10.93

of 313

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211

211

Q9Y2Q3 GSTK1 0.827654 1.67774 0.733029 226 25.4803 8.412

Q15738 NSDHL 0.85239 1.055136 0.852621 373 41.87357 8.06

Q96AY3 FKBP10 0.996141 1.329693 0.892073 582 64.20419 5.618

M0R0F0 RPS5 1.166646 2.470449 1.0889 200 22.37678 9.554

P62753 RPS6 1.397225 1.387364 1.065198 249 28.66299 10.84

E9PNM1 FDFT1 0.895386 0.707255 0.816685 410 47.25481 6.537

P26641 EEF1G 1.415485 1.530083 1.06643 437 50.08714 6.668

B8ZZQ6 PTMA 5.213533 1.279016 107 11.75182 3.815

H3BN98 4 1.438958 1.477913 1.126454 237 27.15036 9.554

P21333-2 FLNA 1.379542 1.316975 1.06758 2639 279.8435 6.049

P09972 ALDOC 1.14555 0.929752 364 39.43124 6.874

Q9BTV4 TMEM43 0.780347 1.962667 0.746693 400 44.8472 8.133

Q9NQC3-2 RTN4 1.054777 1.248568 0.896947 373 40.29295 4.78

P05198 EIF2S1 1.355816 1.614618 1.018009 315 36.08938 5.084

P05362 ICAM1 1.305694 1.302605 0.922945 532 57.78895 7.987

Q14257 RCN2 0.96242 0.623272 0.879469 317 36.85364 4.399

B4DVE7 ANXA11 1.313376 1.152581 1.024236 472 51.20963 7.665

Q96CG1 ETF1 1.291047 1.189461 0.911591 404 45.43428 5.567

P63092-3 GNAS 1.24904 0.974517 0.876229 379 44.15129 6.291

P06748-2 NPM1 1.232216 1.080336 265 29.44624 4.615

P60468 SEC61B 0.969906 0.935849 0.82461 96 9.968098 11.56

P28288-2 ABCD3 0.788009 0.999881 0.771997 549 62.68583 9.232

Q8NE86-3 MCU 0.419177 1.259917 0.395554 302 35.13636 7.489

P35610 SOAT1 0.95731 1.141503 0.792908 550 64.69228 8.939

E9PJK1 CD81 0.86806 1.22258 0.922512 165 17.95093 4.996

Q9Y5J9 TIMM8B 0.796617 0.872531 83 9.337537 5.123

F8VZ49 HNRNPA1 1.457102 1.12016 0.929332 231 25.67093 8.265

H7BYV1 IFITM2 0.942264 1.110098 1.041262 74 8.191374 9.554

of 313

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212

212

O75955 FLOT1 0.959809 1.219525 0.894697 427 47.32562 7.489

E5RIX8 TBCA 1.739399 1.326092 79 9.390927 5.376

Q9H7Z7 PTGES2 0.708644 1.222006 0.767571 377 41.91667 9.159

Q9BX68 HINT2 0.971993 1.052643 163 17.15124 9.159

K7ERU1 PTPN2 1.112802 0.919441 42 5.149685 6.494

P20674 COX5A 0.642662 0.823961 0.797611 150 16.75169 6.786

K7ELW0 PARK7 1.709521 1.716847 169 17.89849 7.87

P21291 CSRP1 1.305284 1.28095 0.904117 193 20.55376 8.573

Q9NVI7-3 ATAD3A 0.736017 0.95477 0.758229 507 57.91198 9.247

O60506-4 SYNCRIP 1.439233 1.325961 1.109899 527 58.69934 7.562

Q00610-2 CLTC 1.264943 1.277724 1.081325 1639 187.7708 5.694

P11940-2 PABPC1 1.51283 1.56743 0.845456 547 61.14204 9.071

P52907 CAPZA1 1.176207 2.293021 1.045937 286 32.90233 5.694

P47755 CAPZA2 1.297423 0.592928 286 32.92861 5.846

P62266 RPS23 1.216428 2.655464 1.01516 143 15.79772 10.49

O14745 SLC9A3R1 1.260811 1.01792 1.042626 358 38.84461 5.77

P62854 RPS26 1.351794 0.788218 115 13.00708 11

O95816 BAG2 1.272411 1.042008 1.089469 211 23.75721 6.698

B1AK87 CAPZB 1.603968 1.278082 260 29.27683 6.917

Q15758 SLC1A5 1.308418 1.492866 1.055568 541 56.56225 5.478

P00403 MT-CO2 0.70371 1.021196 0.80279 227 25.54821 4.818

P08240-2 SRPR 0.957363 1.306896 0.943597 610 66.5166 9.042

P31040 SDHA 0.710747 0.800021 0.515262 664 72.64529 7.386

J3QRD1 ALDH3A2 0.739254 0.922268 0.81764 393 44.61966 5.529

Q9P2E9-2 RRBP1 0.963369 0.97999 0.774962 1407 152.0976 8.661

P61353 RPL27 1.418572 1.185726 1.319388 136 15.78775 10.56

O60568 PLOD3 0.984509 0.966926 0.997824 738 84.73148 6.049

Q7Z451 AP2B1 1.095112 1.00145 880 98.05567 5.237

of 313

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213

213

P21266 GSTM3 1.957089 0.908341 225 26.54214 5.542

P43121 MCAM 1.271354 1.833761 0.94972 646 71.5626 5.757

P28066 PSMA5 1.174746 1.323802 241 26.39421 4.792

Q99720-3 SIGMAR1 0.907501 1.012009 192 21.46903 5.986

H0YDT8 EMC7 0.745164 0.727399 0.818959 192 20.98168 9.364

C9JKI3 CAV1 0.962885 0.926635 138 15.91812 5.25

Q8N5N7 MRPL50 0.873347 1.175161 0.730664 158 18.31337 7.884

Q96A33 CCDC47 0.925467 1.238405 0.965277 483 55.83831 4.869

O43175 PHGDH 1.747724 2.068921 1.496959 533 56.61441 6.712

H7C463 IMMT 0.877231 0.809576 0.904617 613 68.13328 6.062

K7ESJ4 PDCD5 0.907409 0.995335 65 7.463784 8.25

P07686 HEXB 0.741613 0.992336 0.75352 556 63.07118 6.756

Q9BUF5 TUBB6 1.672282 2.65095 1.110157 446 49.825 4.881

P32322-2 PYCR1 0.845045 0.642088 0.695944 316 33.3195 6.8

Q14344 GNA13 1.227688 0.797547 377 44.02167 8.001

Q53GQ0 HSD17B12 0.970736 0.911635 312 34.30219 9.32

K7EPV6 SLC44A2 1.068303 0.984311 146 16.72829 8.661

O75915 ARL6IP5 0.964027 1.020583 1.120619 188 21.60041 9.774

B4DLN1 SLC25A10 0.858637 0.915177 0.867875 442 48.06871 9.525

E9PP23 ACP2 0.827875 1.245691 0.514516 305 35.13374 7.606

P51571 SSR4 0.914168 1.083905 0.770754 173 18.98661 6.151

P15941-7 MUC1 1.044978 2.078388 0.85959 255 27.54883 6.379

P07099 EPHX1 0.999873 1.231505 0.831531 455 52.91497 7.254

P49720 PSMB3 1.0479 1.238449 0.807103 205 22.93345 6.551

P63096 GNAI1 1.312397 1.01678 354 40.33523 5.973

P20645 M6PR 0.989309 0.783721 0.824571 277 30.97338 5.833

P60866 RPS20 1.455372 1.259972 1.211516 119 13.36431 9.935

P30084 ECHS1 0.883418 1.356612 0.867611 290 31.36713 8.075

of 313

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214

214

Q9UBS4 DNAJB11 0.972224 1.029518 358 40.48862 6.176

P04040 CAT 0.850883 0.954433 0.938398 527 59.71876 7.386

P62070 RRAS2 1.266491 1.827886 1.19924 204 23.38472 6.011

O95295 SNAPIN 0.956505 0.88864 0.963864 136 14.86489 9.305

Q9BWM7 SFXN3 0.531569 1.297676 0.717848 325 35.95574 9.085

D6RFH4 CYB5B 1.229277 1.121125 0.872535 131 14.83656 6.189

Q9H488-2 POFUT1 1.008152 0.897625 0.79064 194 22.32318 8.763

P31949 S100A11 2.030099 1.585923 1.773105 105 11.73283 7.123

P26885 FKBP2 1.060719 0.988314 0.97951 142 15.63932 9.129

J3QL14 ATP6V0D1 0.866587 0.826526 0.729162 232 26.79831 4.945

Q96B49 TOMM6 1.217067 0.519094 74 7.997054 4.894

P07602 PSAP 0.683775 0.629512 0.706638 524 58.07385 5.173

P54136-2 RARS 1.198519 1.2051 1.051643 588 67.09754 6.551

P35241 RDX 1.144341 0.789788 0.79542 583 68.52139 6.367

Q05682-5 CALD1 1.137854 0.959064 532 61.17615 6.712

Q7Z7F7 MRPL55 0.786156 0.729764 128 15.11912 11.15

H7C5U3 MFSD1 0.754188 0.65536 64 6.817588 4.831

K7EMN2 PGD 2.315309 0.984759 160 17.28195 8.441

Q9NYU2-2 UGGT1 0.966708 1.082893 0.827887 1531 174.867 5.605

H3BTL1 MAP1LC3B 1.202473 1.328199 0.978317 75 9.005942 9.818

P01111 NRAS 1.312077 1.099683 1.02401 189 21.21552 5.173

P11177-2 PDHB 0.801466 0.826505 0.686171 341 37.17589 5.897

O95573 ACSL3 1.005102 0.842287 0.750326 720 80.3683 8.382

Q5QNZ2 ATP5F1 1.016849 0.861305 0.934918 195 22.26079 9.261

F5H895 DAD1 0.941767 1.090094 0.921763 65 7.283816 6.507

Q04941 PLP2 1.11339 1.166644 0.873699 152 16.6797 7.24

Q15363 TMED2 1.129736 0.691615 0.857814 201 22.74638 5.173

Q8NBJ5 COLGALT1 1.034208 1.152908 0.94246 622 71.59049 7.313

of 313

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215

215

P16403 HIST1H1C 1.104125 0.964902 213 21.35175 10.93

P21912 SDHB 0.78746 0.688895 0.585378 280 31.60884 8.763

D3YTB1 RPL32 1.46215 1.225551 1.090284 133 15.60672 11.44

P54709 ATP1B3 0.862547 1.39039 0.692303 279 31.4921 8.353

Q6PIU2 NCEH1 0.983177 1.03137 0.951544 408 45.77873 7.225

F5GX33 SLC25A13 0.957621 0.688932 0.827212 567 62.20553 9.012

P05556 ITGB1 1.158754 1.035265 0.917412 798 88.35701 5.389

Q10589 BST2 1.017301 0.804819 0.929134 180 19.75632 5.605

O14717-6 TRDMT1 1.173837 1.692801 0.93187 107 12.07936 9.408

F2Z388 RPL35 1.250751 1.521157 1.170053 96 10.63799 10.29

P25789 PSMA4 1.638164 1.269063 261 29.46518 7.723

J3QR09 RPL19 1.070284 0.939773 1.179406 193 23.12009 11.47

P60903 S100A10 1.135403 0.850453 1.076286 97 11.19551 7.372

Q15006 EMC2 0.863007 0.726281 0.875542 297 34.81137 6.566

Q9GZY8-4 MFF 0.739802 0.53782 0.695619 218 25.05105 5.58

Q9P035 PTPLAD1 0.877567 1.337144 0.857696 362 43.13156 8.939

Q96QK1 VPS35 1.003638 1.242269 0.838696 796 91.64894 5.491

O60762 DPM1 0.851512 0.83312 0.902944 260 29.61578 9.569

P05534 HLA-A 1.27307 0.891351 365 40.66303 6.341

P06280 GLA 0.884287 0.768463 0.781778 429 48.73487 5.605

Q96IX5 USMG5 1.416234 1.690851 58 6.453373 9.759

P17931 LGALS3 1.461607 1.151114 0.995674 250 26.13605 8.558

P07741-2 APRT 1.912567 1.645471 134 14.54781 7.342

Q9UII2 ATPIF1 0.999876 0.587263 0.953559 106 12.24131 9.349

P62861 FAU 1.083569 2.505195 1.002681 59 6.643817 12.15

Q9Y3L5 RAP2C 1.022952 2.862522 183 20.7314 4.945

P22314 UBA1 1.679951 1.436978 1.088012 1058 117.7743 5.757

F5H7F6 MGST1 1.09648 0.754375 77 8.880476 8.792

of 313

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216

216

B4DLR8 NQO1 1.86144 2.576048 1.108224 202 22.7789 8.5

O15400-2 STX7 1.134266 1.059861 239 27.38366 5.123

B7Z9S8 ATP1B1 0.987011 1.162697 0.775269 247 28.60945 7.591

E5RHW4 ERLIN2 1.075576 1.673551 0.91896 338 37.70141 5.618

Q15067 ACOX1 0.820907 0.853837 0.80665 660 74.37619 8.163

Q8NF37 LPCAT1 0.968721 0.940151 0.824247 534 59.11339 6.024

B3KUK2 SOD2 0.983114 1.068819 0.875183 176 19.718 8.031

Q9NP58-4 ABCB6 0.866446 0.735973 0.921757 796 88.54343 8.69

P53007 SLC25A1 0.657693 0.838483 0.552905 311 33.991 9.891

Q02818 NUCB1 0.746638 0.571069 0.704151 461 53.84633 5.25

Q9Y3E5 PTRH2 1.195788 0.669064 0.835644 179 19.18096 8.734

B7Z371 SEPT10 1.00586 0.998061 321 37.86738 8.104

P57088 TMEM33 0.828436 1.442192 0.868994 247 27.95981 9.701

Q6IAA8 LAMTOR1 1.24942 0.816071 0.786799 161 17.73383 5.148

P59998 ARPC4 1.341496 1.09597 1.045125 168 19.6543 8.426

I3L0U2 PRSS21 0.691442 0.583658 0.82809 218 24.80035 8.309

B4E2W0 HADHB 0.850703 0.886421 0.451736 452 48.84822 9.173

Q16836 HADH 0.792688 0.742475 0.744782 314 34.27194 8.851

P13645 KRT10 1.28587 0.939907 0.591393 584 58.7917 5.211

J3KNT0 FSCN1 1.29256 1.174877 0.981105 472 52.22991 7.445

B4DJP7 SNRPD3 1.222577 2.00277 0.961715 120 13.28287 8.91

O96008-2 TOMM40 1.011459 0.843353 0.925812 329 34.41926 7.24

P09493-2 TPM1 1.324331 0.743304 228 26.66351 4.818

P53999 SUB1 1.527801 1.221018 127 14.38641 9.598

Q92820 GGH 0.839025 1.22591 0.82501 318 35.94117 7.108

P60891 PRPS1 2.22903 1.813701 1.35476 318 34.81193 6.976

J3KNJ2 EIF3M 1.620833 2.034655 1.076182 191 21.67855 7.767

Q96GS4 C17orf59 0.854628 0.76674 357 37.20361 5.757

of 313

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217

217

B4DL37 AKR1C3 0.987396 2.243348 1.180967 204 23.34887 7.987

F5H780 TXNRD1 1.297551 1.226029 459 50.63389 6.625

Q969V3-2 NCLN 0.894773 0.958908 0.953311 562 62.80652 6.888

Q96AP7 ESAM 1.027231 1.020602 390 41.15057 9.32

Q96HY6 DDRGK1 0.986476 1.127326 314 35.5895 5.123

O43399-2 TPD52L2 1.061307 1.272973 0.957152 186 19.8891 5.478

Q01650 SLC7A5 1.431562 1.133416 1.266765 507 54.97428 7.723

P21281 ATP6V1B2 0.917239 1.985412 0.827157 511 56.46488 5.808

P30153 PPP2R1A 1.46472 1.401303 589 65.26692 5.11

Q9UBV2-2 SEL1L 0.957267 0.94284 301 33.50934 4.831

P22307-4 SCP2 0.926588 0.997557 0.801347 466 50.30939 7.02

P33316-2 DUT 1.286103 1.06712 164 17.73693 6.566

P62263 RPS14 1.753372 1.312114 1.238416 151 16.26253 10.05

P12814-2 ACTN1 1.286 1.051952 887 102.6444 5.503

O60664-4 PLIN3 1.365876 0.982602 1.202173 422 45.77523 5.427

P42765 ACAA2 0.664527 0.989564 0.733337 397 41.89765 8.089

P49257 LMAN1 1.063775 0.783376 0.907985 510 57.51298 6.771

O00560-3 SDCBP 1.00285 1.337478 0.9725 292 31.74152 7.533

Q14108 SCARB2 0.91485 0.796744 478 54.25546 5.135

P15291-2 B4GALT1 0.852987 0.735356 385 42.51059 8.5

P51572 BCAP31 0.946674 1.001908 0.936711 246 27.97401 8.441

Q9H4G0-4 EPB41L1 1.079995 0.94112 0.691207 701 78.78222 7.093

Q5TB53 TM9SF3 1.044122 1.176811 1.01852 254 29.91872 5.821

Q96E11-2 MRRF 1.006137 0.813755 201 22.43575 9.715

B4DSN5 PTPN1 0.975514 1.198382 1.02545 362 41.23352 5.973

Q13740-2 ALCAM 1.304214 1.065807 1.040666 570 63.62447 7.298

Q9HDC9 APMAP 1.059751 1.719589 0.767649 416 46.45085 6.164

C9JFR7 CYCS 0.500598 0.686837 0.429284 101 11.32596 9.657

of 313

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218

218

P09382 LGALS1 1.711321 2.920376 135 14.7062 5.503

Q9Y5L4 TIMM13 1.143695 1.50709 0.927134 95 10.493 8.177

P10606 COX5B 0.823219 0.631925 0.835023 129 13.68694 8.807

C9IZ01 GFM1 0.587804 0.935326 0.620201 591 65.9928 8.06

P06744 GPI 1.348222 1.828248 1.178758 558 63.10725 8.324

O95831-3 AIFM1 0.940237 0.661734 1.070264 609 66.25356 8.939

A6NLH6 CNIH4 0.526879 1.017896 137 15.75993 6.961

Q9BSJ8 ESYT1 0.941908 0.91924 0.810372 1104 122.78 5.833

P18669 PGAM1 3.402846 2.572908 1.775781 254 28.78584 7.181

P06865 HEXA 0.741061 1.292861 0.744929 529 60.66428 5.161

P43487 RANBP1 1.57851 2.930969 2.310803 201 23.29557 5.288

G3V576 HNRNPC 1.169722 2.128537 0.967671 231 25.24106 9.818

Q5BJF2 TMEM97 0.875928 0.795105 0.757884 176 20.83417 9.378

B4DHW1 TMEM165 0.974704 1.003516 0.941358 261 28.41395 6.537

P11279 LAMP1 0.608898 1.120847 0.706852 417 44.85382 8.749

Q8IVT2 MISP 1.199723 0.98305 1.110681 679 75.31095 6.83

P05386 RPLP1 1.205217 2.053789 0.964117 114 11.50669 4.323

O75489 NDUFS3 0.592567 0.923178 264 30.22271 7.503

P13284 IFI30 0.963744 0.568155 0.601458 250 27.94501 4.881

O95292 VAPB 1.125427 0.969664 243 27.21109 7.298

O75439 PMPCB 0.659306 0.939695 0.498041 489 54.3315 6.83

O15173 PGRMC2 0.827862 1.932896 0.829608 223 23.80373 4.881

Q6YN16 HSDL2 0.823101 0.762803 418 45.36552 7.987

Q13637 RAB32 1.051914 1.252506 0.905242 225 24.98169 6.537

P16278-3 GLB1 0.840196 0.913291 0.761187 647 72.70454 6.252

Q99536 VAT1 1.187142 0.901623 1.084757 393 41.89342 6.291

Q96HS1-2 PGAM5 0.454368 1.187436 255 28.00246 7.254

Q96CS3 FAF2 1.089111 1.28199 0.972315 445 52.59055 5.618

of 313

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219

Q7Z650 MTHFD2 0.605882 0.492332 1.147144 248 26.83225 7.181

F5H1S8 MLEC 0.980032 1.037988 146 16.71859 5.567

P30049 ATP5D 0.934173 0.710515 168 17.47919 5.491

C9JP16 CRTAP 1.000826 1.113831 358 41.40646 5.872

P48449-2 LSS 0.915827 1.416043 0.777651 652 74.16963 6.456

Q16850 CYP51A1 0.662896 0.698398 0.722726 503 56.76947 8.529

O75844 ZMPSTE24 0.86299 0.817096 0.784706 475 54.77753 7.489

Q86UE4 MTDH 0.907267 0.715012 0.654347 582 63.79881 9.32

F8W6E4 GPD2 0.899309 0.75753 0.803208 500 55.72346 6.252

D6RA82 ANXA3 2.968576 2.210312 1.509352 284 32.09853 5.935

Q12965 MYO1E 1.157812 1.586147 0.860113 1108 126.982 8.924

E9PCY7 HNRNPH1 1.363449 1.306548 1.101049 429 47.05745 6.341

E9PI87 HTATIP2 0.865647 0.838961 196 21.96233 7.401

P61619 SEC61A1 0.879768 0.896405 0.827963 476 52.23052 8.06

P13489 RNH1 1.652398 1.238122 461 49.94109 4.818

P62913-2 RPL11 1.272692 1.258457 0.902436 177 20.11158 9.598

Q9UM22 EPDR1 1.020808 1.082312 0.768408 224 25.42059 6.595

Q9HCU5 PREB 1.062268 1.629471 0.735926 417 45.43967 7.884

Q9UQ80 PA2G4 1.590945 1.198977 1.160384 394 43.75919 6.551

Q14974 KPNB1 1.22989 1.503563 1.088321 876 97.10802 4.78

P24534 EEF1B2 1.585491 1.279222 1.094085 225 24.74826 4.666

Q12797-10 ASPH 1.043348 1.189876 0.813744 729 83.21622 4.919

J3QLD9 FLOT2 1.032759 1.570063 0.976805 428 47.11269 5.313

I3L1P8 SLC25A11 1.077713 0.696175 296 32.16176 9.774

C9J3L8 SSR1 0.93948 1.461099 0.808455 265 29.55479 4.297

Q7L2E3-3 DHX30 0.849954 0.940023 0.934964 1155 129.3572 8.529

Q16401-2 PSMD5 1.194932 1.623917 461 51.27975 5.44

Q9Y281-3 CFL2 1.417396 1.240597 149 16.90597 8.617

of 313

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220

Q68CR9 DKFZp781B11202 1.19292 0.795632 0.839561 401 45.7421 5.707

O15427 SLC16A3 1.232511 1.776773 0.928498 465 49.43689 7.958

O00410 IPO5 1.463066 1.30058 0.90374 1097 123.5499 4.945

H3BNK3 NDUFAB1 0.729937 1.041921 111 12.20118 4.627

H0Y4R1 IMPDH2 1.902177 1.154282 1.101765 470 51.03521 8.177

Q8TF09 DYNLRB2 1.842978 0.831149 96 10.84772 7.503

H7C3P4 GNS 0.696256 0.943496 0.683875 496 56.33784 7.914

H0YD64 SLC43A3 0.840539 0.847195 137 15.77293 9.042

P13674-3 P4HA1 0.892033 0.747971 0.914487 516 58.92102 6.024

O14828 SCAMP3 0.890442 0.891977 347 38.26233 7.635

O43615 TIMM44 0.861854 0.602304 452 51.32346 8.324

H0YA96 HNRNPD 0.899992 2.609714 0.891389 210 23.90618 9.583

O94874-2 UFL1 1.047756 1.340076 0.869645 729 82.04688 6.961

O00186 STXBP3 1.092524 1.366247 0.949951 592 67.72085 7.796

H0YD18 NUCB2 0.551343 0.921066 0.543678 73 8.61033 5.034

O00303 EIF3F 1.370267 1.308429 0.918465 357 37.54015 5.453

B4DXI5 HACL1 1.011871 0.775829 0.904438 496 54.68875 7.386

O14908-2 GIPC1 0.833121 0.748431 236 26.0554 5.567

J3QT77 PON2 0.861767 0.894472 0.683039 342 37.95661 5.719

P31948 STIP1 1.849264 0.868017 543 62.59941 6.8

C9JH92 CRYZ 1.182705 0.995488 206 21.91846 8.763

Q9NTJ5 SACM1L 0.965358 0.756503 0.77892 587 66.92401 7.123

Q12907 LMAN2 0.983969 1.472574 0.593896 356 40.2031 6.947

Q8IV08 PLD3 0.73999 0.772273 0.894603 490 54.67051 6.468

C9J151 CLASP1 1.95138 1.10518 150 16.47028 5.681

Q13813-3 SPTAN1 1.139287 1.219372 1.1031 2452 282.108 5.338

K7EJE8 LONP1 0.829917 1.016024 0.519841 829 93.23797 6.494

Q9UNE7 STUB1 1.148392 0.866995 303 34.83425 5.872

of 313

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221

221

Q3ZAQ7 VMA21 0.810308 1.110932 101 11.34687 7.24

Q5RI15 COX20 1.256363 0.797828 118 13.2828 8.763

O95832 CLDN1 1.142394 0.875745 211 22.72858 8.089

Q53GA4 PHLDA2 0.940372 0.863586 152 17.08185 9.173

E7EPW2 MRPS25 0.661211 0.804902 110 12.93769 9.745

H7C1H2 PSMD2 1.011241 2.326836 203 22.42748 6.888

Q9H3N1 TMX1 0.844979 2.043181 280 31.7708 4.983

B4DJ81 NDUFS1 0.974395 0.790292 0.38251 611 66.87901 5.376

Q12805-2 EFEMP1 0.801188 1.250061 0.854084 485 53.6867 5.021

B4DDG7 AP1M1 0.933933 1.013888 0.758721 351 40.22886 7.196

E5RIU6 CDK1 1.693136 1.248107 189 21.7245 8.514

Q96N66-3 MBOAT7 0.846529 1.232302 0.640309 344 38.44495 8.866

Q5T8R5 SLC16A1 1.263313 2.216101 456 49.18659 9.159

P27449 ATP6V0C 0.967412 1.412399 0.842574 155 15.72546 8.441

G3V5Q1 APEX1 1.136659 1.255624 0.974198 242 27.10788 8.763

Q02809 PLOD1 0.877053 0.822037 0.784821 727 83.49739 6.947

G3V2B8 MTHFD1 1.347932 1.357394 1.207432 935 101.4673 7.298

A8MUF7 HBE1 0.656514 2.016002 87 9.463879 9.129

P51398-2 DAP3 0.575503 0.867781 357 41.01839 8.983

Q5HY57 EMD 0.857364 0.682404 219 24.92288 5.021

Q9ULV4 CORO1C 0.991697 0.92873 474 53.21506 7.079

Q8NC51-4 SERBP1 1.738228 1.416782 1.265482 387 42.40128 8.441

O60220 TIMM8A 0.68574 1.020334 0.682477 97 10.9913 5.161

Q9Y305-2 ACOT9 1.137077 0.758182 406 46.32453 7.972

P19338 NCL 1.040359 1.025532 0.933224 710 76.56836 4.704

R4GN43 NDUFA6 0.668874 1.001193 71 8.50446 9.466

Q9P0L0 VAPA 1.398465 1.527194 0.837129 249 27.87521 8.617

H7C4G5 RUVBL1 1.037621 1.736831 267 30.00456 5.554

of 313

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Q15043-2 SLC39A14 1.264436 1.01454 1.024396 481 52.80448 5.77

Q8NBP7-2 PCSK9 0.88743 0.750024 196 20.81377 8.397

Q01813-2 PFKP 1.616762 1.886669 1.278092 776 85.26146 8.587

Q27J81-2 INF2 1.445221 1.514672 0.958636 1240 134.5334 5.529

Q8NBX0 SCCPDH 0.817882 1.056136 429 47.12145 9.144

J3KNB5 GPX8 1.291884 0.919668 90 10.06874 10.24

Q96CW1-2 AP2M1 1.102053 1.818434 0.835605 433 49.35791 9.54

P49327 FASN 1.882644 1.564007 1.401742 2511 273.2543 6.443

Q9BTU6 PI4K2A 0.652547 1.177311 0.596076 479 53.98861 8.294

B4DT69 DLD 0.743285 0.989039 0.76888 461 49.25137 7.679

Q9UMX5 NENF 1.037892 1.048986 1.05816 172 18.84479 5.694

B4DLW8 DDX5 1.271055 1.583436 1.034134 535 60.52538 9.071

O00592-2 PODXL 1.223322 1.00787 0.985307 526 55.35142 5.58

R4GN99 PPIF 0.734405 0.925852 145 15.34077 9.247

Q92520 FAM3C 0.858676 1.058761 227 24.66458 8.294

O60701-2 UGDH 1.486766 2.369461 0.754955 427 47.57231 5.922

F5H7M3 DLAT 0.802293 0.975184 0.665679 418 44.6336 6.443

Q92598-2 HSPH1 1.486035 1.487949 1.475798 814 92.05745 5.554

Q9UNN8 PROCR 0.910456 2.103759 0.758776 238 26.65458 7.181

B7Z5W8 DLST 0.903802 1.609263 0.387486 367 39.52787 9.554

H3BPA9 NUP93 1.363568 0.839605 230 26.39812 5.922

F5H826 NOMO3 1.048414 0.90546 0.948643 1100 121.943 5.694

P46977 STT3A 0.920142 1.377587 0.849084 705 80.47685 8.075

M0QXF7 C19orf10 0.808628 1.538965 0.684605 84 9.663568 4.996

Q9BRQ8-2 AIFM2 1.285245 1.03152 0.868966 336 36.49731 9.261

D6RH20 MRPS27 0.929614 1.810816 0.631838 299 34.43659 5.58

Q14696 MESDC2 1.137482 0.851096 0.685203 234 26.06031 7.782

Q9UBR2 CTSZ 0.757963 0.79509 0.796878 303 33.84622 7.108

of 313

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223

223

Q6PI48 DARS2 0.843445 1.476624 0.729804 645 73.5161 8.016

Q03519 TAP2 0.946329 1.038205 0.874849 686 75.61581 8.016

O43795-2 MYO1B 1.190268 1.057615 1078 124.8719 9.203

B4E2S7 LAMP2 0.649824 0.942853 0.612689 363 39.78684 5.668

E7ENA9 NCSTN 1.006023 1.166959 0.903849 451 50.22973 5.643

Q9H4A6 GOLPH3 0.47583 0.894545 298 33.7895 6.443

Q7Z7H8 MRPL10 0.901762 1.028103 261 29.26368 9.583

G3V1S6 GALNT2 1.260822 0.94241 1.033844 533 60.75543 7.65

P29992 GNA11 1.031481 0.880584 359 42.09652 5.694

Q01082-3 SPTBN1 1.179103 1.175346 0.976195 2155 251.2412 5.529

Q2TB90 HKDC1 0.676628 0.573985 917 102.4785 7.123

P82675 MRPS5 1.022344 0.662661 430 47.9761 9.92

C9JJ54 WDFY1 0.892774 0.759744 215 24.24417 7.796

Q96TA1-2 FAM129B 1.326602 1.318136 1.052594 733 82.63093 6.151

Q5SZE1 CERS2 0.896112 0.877504 0.681865 324 38.49522 9.144

O60716-32 CTNND1 1.107563 1.054132 0.918675 589 65.60001 8.133

E9PNW8 FAR1 0.922818 1.628174 0.887954 335 37.45766 6.917

O15270 SPTLC2 0.755711 0.816155 1.022249 562 62.88386 7.782

O60831 PRAF2 0.940022 0.997831 0.994865 178 19.24552 9.188

Q9NZ01 TECR 0.768905 2.079845 0.833769 308 36.01078 9.452

M0R1L7 CHMP2A 1.126957 1.16744 159 18.7266 9.481

Q00765 REEP5 0.877974 0.83712 189 21.47904 8.104

Q9Y3A6 TMED5 1.077755 1.190711 0.91123 229 25.98819 4.843

P18206-2 VCL 1.768811 1.923924 0.879547 1066 116.6493 6.087

K7ES82 CAPNS1 1.699408 0.745452 100 11.39149 5.415

B4DWJ2 QARS 1.23714 1.016419 0.882057 764 86.52421 7.049

E9PFD2 UMPS 1.726265 0.985496 342 37.61611 8.089

Q9BV43 PDIA5 0.924283 1.824159 0.774782 262 30.10461 8.924

of 313

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224

P78310-2 CXADR 1.268586 0.901349 0.987165 344 38.09933 7.547

P35908 KRT2 1.019978 0.856203 0.984704 639 65.39322 8.001

Q13724-2 MOGS 1.044736 1.298356 0.884982 731 80.65263 7.108

P42126-2 ECI1 0.792812 0.673548 285 30.87627 8.895

E7EQS5 DMD 1.264136 2.239666 1.017674 1225 141.3109 6.024

Q14204 DYNC1H1 1.372133 1.438188 1.102725 4646 532.0719 6.405

P17813-2 ENG 1.124942 1.066038 625 67.49872 6.566

F5H801 OGDH 0.736426 0.751363 0.683379 974 110.5408 6.844

O15127 SCAMP2 1.231236 0.734023 329 36.62534 6.1

Q8WTV0-4 SCARB1 0.981031 1.959415 0.775127 474 53.54381 7.254

Q15056-2 EIF4H 1.523391 1.372811 228 25.18452 8.089

Q96JB5-3 CDK5RAP3 0.843484 0.955776 281 31.18103 4.513

Q9BWD1 ACAT2 2.192211 1.162535 397 41.32439 6.917

P49591 SARS 1.651656 1.390755 514 58.74005 6.43

Q13217 DNAJC3 1.106552 1.231576 0.930653 504 57.54417 6.151

Q5R3B4 MPC2 0.37012 0.799854 105 11.67318 10.2

Q9Y2R0 COA3 0.623199 0.654097 106 11.72413 9.598

H7BZ81 RETSAT 0.919355 0.936578 320 35.15895 8.06

P11166 SLC2A1 1.158881 2.739135 1.030393 492 54.04854 8.719

P55884 EIF3B 1.63804 1.291677 814 92.42382 4.996

O15144 ARPC2 1.214495 1.441681 1.216683 300 34.31149 7.357

P00367 GLUD1 0.984987 0.685172 0.798359 558 61.3592 7.796

Q9Y230 RUVBL2 1.173264 1.353981 463 51.12456 5.643

K7EPU3 ALG1 1.189406 1.301771 0.942201 184 20.16157 9.627

M0R0G9 SNRPA 1.075854 0.987552 87 10.07624 9.598

P10909-4 CLU 0.598794 0.528685 0.836291 416 48.77213 6.712

B4DE85 PTDSS1 0.772263 1.585746 0.814046 301 34.55655 8.573

Q86SX6 GLRX5 0.514122 0.561141 157 16.61754 6.786

of 313

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P41250 GARS 1.534113 2.499762 1.121268 739 83.11261 7.035

Q9BYN8 MRPS26 0.918735 0.944046 205 24.19686 10.39

E5RGC7 MRPS28 0.562606 0.728144 103 11.74014 8.045

Q8NFJ5 GPRC5A 1.179067 0.938988 0.894057 357 40.22494 8.148

Q9BVC6 TMEM109 0.837747 0.910029 0.806986 243 26.19359 10.48

K7ESE6 G6PC3 1.017857 0.998602 243 27.58953 8.924

B4DVY1 EIF3D 1.436522 0.998114 499 58.10371 5.707

P07814 EPRS 1.67338 1.334158 1.198086 1512 170.4831 7.328

P56589 PEX3 0.689359 0.689336 373 42.11295 8.148

Q9HD33-3 MRPL47 0.830584 1.164369 140 16.98042 10.71

P23526 AHCY 2.047492 1.426446 1.124553 432 47.68521 6.341

F8VPD4 CAD 1.289825 1.263263 1.045123 2162 235.873 6.551

Q9UGP8 SEC63 1.14793 0.97752 0.798299 760 87.94161 5.313

Q9UHA4-2 LAMTOR3 0.80316 0.751869 117 12.93295 8.133

O94973 AP2A2 0.97665 0.894192 939 103.895 6.961

B7Z4K6 DNASE2 0.844035 0.995393 0.799537 305 33.59369 8.324

Q15904 ATP6AP1 0.836096 2.193159 0.751944 470 51.9926 6.138

F5H241 GBA 0.762198 0.67644 0.702621 423 47.53423 7.284

Q8IVL5 LEPREL1 0.963144 0.645556 0.941739 708 80.93322 5.707

O43491-2 EPB41L2 1.141583 0.775995 0.84243 673 76.0062 6.961

P55809 OXCT1 0.658775 1.177417 0.862764 520 56.12193 7.459

Q13488 TCIRG1 0.975484 0.795106 830 92.90836 7.123

F5H6I7 ATL3 1.017233 1.549397 0.876098 523 58.73556 5.643

Q5TCI8 LMNA 0.826178 0.74603 491 55.72859 7.02

P04181-2 OAT 0.812678 0.52964 301 32.83215 5.326

Q9Y679-3 AUP1 1.458381 0.953911 373 41.35868 7.899

C9JC03 EHD1 1.154728 0.656458 374 42.71039 8.426

O95782-2 AP2A1 1.081109 1.873053 0.967499 955 105.2947 7.665

of 313

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226

B4DFA2 NSF 1.065248 1.093724 0.943217 644 71.53859 6.654

H0Y750 ATP6AP2 0.756568 0.617391 243 26.61486 7.899

P49419-2 ALDH7A1 1.027341 1.12307 0.784116 511 55.33146 6.859

Q07960 ARHGAP1 1.645075 1.223462 439 50.40419 6.291

P20020-5 ATP2B1 1.158381 1.066843 1171 129.0702 6.164

Q15149-3 PLEC 1.022118 1.009423 0.914809 4570 517.7164 5.745

Q96CT7 CCDC124 1.358862 1.115188 223 25.81956 9.54

Q9NRP0 OSTC 0.925778 1.163102 0.770044 149 16.81784 9.129

C9JA28 SSR3 0.91842 0.838837 0.914319 174 20.14854 9.437

O94925-3 GLS 0.735102 1.370408 0.492763 598 65.41791 7.884

H0YJC0 PSMC6 1.198227 1.098817 262 29.63245 6.405

Q15599-2 SLC9A3R2 1.152308 0.88025 326 36.13141 8.207

F6SBX2 IARS2 0.556246 0.910806 0.564131 940 105.972 6.481

B4DEK4 SNX2 0.833646 0.987762 402 46.06873 7.24

O00754-2 MAN2B1 0.927828 1.266424 0.790621 1010 113.5443 7.284

P26599 PTBP1 0.736467 2.649674 0.992703 531 57.18564 9.173

B1AJQ6 STX12 1.070025 1.926368 215 24.56134 5.148

P14174 MIF 2.19248 2.590372 1.522282 115 12.46822 7.884

Q15437 SEC23B 1.305768 1.528303 1.037696 767 86.42352 6.888

Q13492-4 PICALM 0.943702 1.707659 0.789813 551 59.88067 8.763

Q9UBM7 DHCR7 0.797564 1.126889 0.630026 475 54.45377 8.705

Q8TCT9-5 HM13 0.848698 0.908133 0.807801 335 36.79014 6.683

Q9Y320-2 TMX2 1.124285 0.908489 0.781832 258 29.62322 8.646

P10619 CTSA 0.835223 0.781734 0.877583 480 54.43112 6.61

Q96QD8 SLC38A2 1.409894 1.429413 506 55.98953 8.001

B3KVK7 MARS 1.302166 1.057521 546 61.77631 5.262

Q8WUY1 THEM6 0.945819 0.785596 208 23.84987 9.554

P61221 ABCE1 1.247269 0.949353 1.371781 599 67.27102 8.338

of 313

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227

G3V4F2 ACOT1 0.852765 0.990384 395 43.70566 6.991

R4GNE4 GPX4 1.106562 2.406508 0.853905 145 16.79655 11.17

Q8WY22 BRI3BP 1.050915 1.081041 0.939209 251 27.81784 9.437

F8VNT9 CD63 0.827565 0.902124 0.847852 133 14.2554 7.591

Q13283 G3BP1 1.486912 1.217856 0.988605 466 52.13208 5.516

P20618 PSMB1 1.230592 2.060151 241 26.47237 8.133

Q6P1M0 SLC27A4 0.853427 1.015222 0.893677 643 72.01814 8.47

Q15785 TOMM34 1.013536 1.178984 309 34.53776 8.983

Q8TCS8 PNPT1 0.935007 0.860943 0.682558 783 85.89663 7.767

H7BYH4 SOD1 1.197198 1.617886 135 13.90083 6.113

P48960-2 CD97 1.03104 1.360822 1.037025 742 81.68971 7.049

P08574 CYC1 1.123654 0.780609 325 35.39897 8.998

P51688 SGSH 0.882958 0.979754 502 56.65945 6.947

Q3ZCQ8 TIMM50 0.500185 0.762324 0.892433 353 39.62154 8.368

O43837-2 IDH3B 0.658972 0.485092 383 41.86035 7.591

O43242 PSMD3 1.88696 1.325435 1.688353 534 60.93949 8.441

P62195-2 PSMC5 2.38722 2.219372 1.043626 398 44.75569 8.177

Q92575 UBXN4 1.019874 0.83535 508 56.74269 6.379

Q14126 DSG2 1.066754 1.050857 1.090291 1118 122.2176 5.237

F8W785 GOLIM4 0.976545 0.554716 0.377185 668 78.71265 4.742

P48509 CD151 1.249102 1.275855 0.984759 253 28.27631 7.474

P13010 XRCC5 1.183543 0.889252 732 82.65228 5.808

B7Z5E2 PSMC2 1.593874 0.93494 296 33.25224 8.412

D6R9H7 ATP5G1 1.180764 1.337366 99 10.18834 10.4

B0V043 VARS 1.426902 1.444597 1264 140.3774 7.591

Q9UHG3 PCYOX1 0.929033 2.924772 0.827446 505 56.60375 6.176

F5H1I8 XRCC6 1.117477 1.123503 476 54.51675 8.954

A6NEM5 PIGK 0.839351 0.880026 332 37.76169 5.656

of 313

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228

Q9HA77 CARS2 0.817241 0.833524 564 62.18467 8.338

C9J8H1 ATP6V1E1 1.196086 1.017794 1.007808 203 23.52457 9.042

O75695 RP2 1.002286 1.705551 0.852253 350 39.61546 5.123

P23381-2 WARS 1.348628 1.041668 1.090538 424 48.149 6.354

Q9Y295 DRG1 1.193436 3.186811 367 40.51683 8.895

B7Z5H3 MAOB 0.323261 0.335428 0.837279 411 46.50874 8.28

Q9NSD9 FARSB 1.208562 0.808362 589 66.07355 6.844

F5H5L8 FOLR2 1.300796 1.108102 0.8732 148 16.88816 8.031

Q96S52-2 PIGS 0.86044 0.869886 547 60.96681 6.43

Q12846 STX4 1.148212 1.091465 297 34.15886 6.278

Q96L58 B3GALT6 0.944443 1.160404 329 37.1143 9.657

P08237-2 PFKM 1.527741 1.439542 1.192302 749 81.72348 7.621

E7EP00 SEC24C 1.438154 1.454381 0.929165 975 106.5557 6.961

Q16795 NDUFA9 0.566084 0.292001 377 42.48257 9.803

Q9BXW7-2 CECR5 1.023927 0.736165 393 43.56032 6.903

A8MU58 AIMP2 1.271989 1.606827 242 26.74293 8.075

Q5W011 RBM17 1.189167 0.94415 212 24.16128 6.189

Q9Y3F4 STRAP 1.322691 1.402415 350 38.41398 5.123

Q02790 FKBP4 3.153252 1.134859 459 51.77207 5.427

Q01518-2 CAP1 1.446373 2.347952 474 51.79766 8.06

Q86UP2-2 KTN1 1.059863 0.755916 0.84917 1300 149.5189 5.707

P53396-2 ACLY 1.956794 1.353749 0.965034 1091 119.6953 7.328

Q02241-2 KIF23 1.363701 0.723528 1.029325 856 98.04387 8.47

P53621 COPA 1.255575 2.758402 1.17627 1224 138.2579 7.665

B4DKB2 ECE1 0.901665 0.983185 0.8194 738 83.52037 5.732

Q13423 NNT 0.745853 1.130768 0.782389 1086 113.8226 8.089

D6R9X8 ITGA3 1.069518 0.900973 142 15.21975 8.207

O14656 TOR1A 0.950648 0.628824 0.885189 332 37.78448 6.991

of 313

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229

229

G5E9W7 MRPS22 0.637004 0.779452 319 36.78293 6.815

O94826 TOMM70A 0.559331 0.971328 608 67.41203 7.123

E7ETE2 HARS 2.197545 1.357281 0.97029 288 31.91085 5.681

Q6UB35 MTHFD1L 0.833667 0.672985 0.661624 978 105.7237 8.06

P11498 PC 0.769836 0.785721 0.68265 1178 129.5514 6.844

Q15046 KARS 1.374057 1.354475 1.141872 597 68.0046 6.354

O43776 NARS 1.611823 1.831599 548 62.90252 6.252

Q96QD5-2 DEPDC7 0.734628 0.896372 0.783459 502 57.66986 7.474

F8VZ44 AAAS 0.941853 3.431027 0.890853 422 45.60536 8.25

Q658P3-3 STEAP3 0.666776 1.300052 0.90822 487 54.43672 8.719

Q9UHL4 DPP7 0.709214 0.72615 0.961096 492 54.3072 6.316

E5RHD8 PTK2 1.514634 1.412668 115 12.85484 7.503

E9PBU3 ATIC 0.75035 2.229868 1.301977 591 64.48327 6.712

Q9UHR4 BAIAP2L1 1.377534 1.071519 511 56.84708 8.675

Q14318 FKBP8 0.550443 0.965954 412 44.53367 4.843

P30825 SLC7A1 1.099557 2.246054 0.900764 629 67.59414 5.427

Q96S66-4 CLCC1 0.835182 0.799298 366 39.81288 5.745

Q9Y251-3 HPSE 0.876007 1.24858 0.734405 469 53.12712 9.408

P26639 TARS 2.209003 1.895454 1.444028 723 83.38187 6.668

M0R019 HNRNPM 1.243349 2.324147 0.865693 353 37.66014 9.027

B7Z589 SLC6A9 1.218745 0.77351 522 58.32185 7.02

H3BTB7 EARS2 0.835836 0.858241 506 56.78967 8.778

F5H335 EIF3A 1.417245 1.878101 1.011005 1348 162.5373 6.771

Q9Y6M5 SLC30A1 1.110595 1.10251 507 55.26405 6.481

F5GWY0 PIGT 0.912958 1.281792 423 47.90365 8.807

P52292 KPNA2 1.239098 1.363252 529 57.82595 5.402

F5H365 SEC23A 0.990387 1.417708 736 82.91563 7.459

E7ET76 GGT1 1.185204 1.12533 463 50.02888 6.727

of 313

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230

230

O95373 IPO7 1.491394 1.391117 0.842853 1038 119.4399 4.818

F5H5G8 SUCLA2 0.553651 0.361274 329 36.0117 5.389

P51114-2 FXR1 1.118303 0.881642 539 60.75436 6.392

I3L1D0 WDR45B 1.17045 0.758889 174 19.30278 7.167

H0Y5R2 CEP250 1.088816 1.100803 210 22.70323 4.386

H0YGW7 ABCF1 1.316959 1.186243 596 67.61806 8.192

B4DDS3 CLPTM1 0.753854 1.222139 567 65.5551 5.999

E9PF19 TBL2 1.702768 1.030469 411 45.90616 9.481

F8WBJ7 TMEM245 0.706662 2.27177 0.925284 253 28.07817 8.309

P23246-2 SFPQ 1.21799 1.087693 669 72.21776 9.232

Q10713 PMPCA 0.770647 0.879338 525 58.2156 6.917

O43747 AP1G1 0.791782 1.272935 0.790241 822 91.29313 6.8

Q92544 TM9SF4 1.094496 1.071672 0.989709 642 74.46967 6.537

Q92692-2 PVRL2 1.325016 1.332542 479 51.32718 5.11

Q93050-1 ATP6V0A1 0.978953 0.672648 831 95.69385 6.654

P33897 ABCD1 1.18242 0.658384 1.044249 745 82.88451 8.954

P32004-3 L1CAM 1.063346 1.078946 1248 138.8208 6.214

B7Z7Q6 PRCP 0.979245 1.437204 0.792914 391 43.90565 6.303

Q14118 DAG1 1.191228 1.106221 0.913843 895 97.38067 8.558

G3XAJ6 RFTN1 1.105943 0.765607 542 58.72609 5.338

Q5BKT4 ALG10 1.601853 0.904333 0.91813 473 55.569 9.291

Q5VXM9 RPF2 1.538456 3.678034 0.954767 208 24.14272 9.466

Q01105-3 SET 1.377528 1.014835 265 30.97422 4.234

P30837 ALDH1B1 0.512936 0.839782 517 57.17023 6.8

Q8TCJ2 STT3B 0.878647 1.167831 0.773816 826 93.61368 8.91

Q86VP6-3 CAND1 1.969643 0.96296 403 45.50989 5.77

B7Z9I1 ACADM 0.996897 0.580065 385 42.39949 6.43

P15144 ANPEP 1.030734 1.223168 0.659249 967 109.4709 5.478

of 313

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231

Q9UJQ7 SCP2D1 1.519618 1.357626 156 17.6514 9.334

Q96HE7 ERO1L 1.062188 0.612081 468 54.35805 5.681

B3KSB1 ERMP1 0.866478 1.002318 351 39.18342 7.826

Q9H9J2 MRPL44 0.865905 0.940423 332 37.51171 8.397

Q6NUQ4-2 TMEM214 0.717787 0.75945 644 71.99378 9.261

P35221 CTNNA1 1.149036 1.194764 906 100.0085 6.291

Q9Y4F1 FARP1 1.371267 1.269996 1.014068 1045 118.5587 8.148

H0YA55 ALB 1.198659 1.264774 454 51.53582 6.947

Q32P28 LEPRE1 0.735619 0.800889 736 83.34109 5.135

O15118 NPC1 0.944163 0.426973 0.604628 1278 142.0736 5.364

F5GY99 GALNT1 0.940315 0.929699 499 57.34292 7.914

P34932 HSPA4 0.929084 1.244466 1.460391 840 94.27124 5.186

P09543-2 CNP 0.915642 0.876571 401 45.07033 8.529

P04920-2 SLC4A2 1.337605 0.957629 1227 135.5205 6.214

F5H324 ARSE 1.136729 0.919649 544 61.03771 7.035

Q00839-2 HNRNPU 1.144022 0.970876 806 88.92415 5.783

Q8TB61-3 SLC35B2 0.649797 1.490369 0.617971 383 42.09994 9.349

O00400 SLC33A1 0.934608 0.745285 0.904505 549 60.86977 7.328

C9JYN0 SYPL1 1.043696 1.519212 0.738429 224 24.76769 7.137

B4DR63 PSMC1 1.705552 1.869939 367 41.1412 5.008

B4DR94 YKT6 1.336447 1.171605 164 18.56846 7.328

O76024 WFS1 0.769325 0.714525 0.913139 890 100.227 8.045

P23229-7 ITGA6 1.260589 0.893529 954 106.5103 7.665

Q9Y6K0 CEPT1 1.043597 2.717958 416 46.52275 8.207

F5H3P5 ACTR3 1.21364 0.912387 356 40.7427 5.96

C9JDH9 STK25 1.148396 0.859906 148 16.35562 6.176

J3QLE5 SNRPN 1.042236 2.600692 0.947268 169 17.53528 9.994

Q96CU9-2 FOXRED1 0.60065 0.779147 275 30.63944 6.011

of 313

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232

Q8WVM8 SCFD1 1.228715 0.970632 642 72.33405 6.265

H0YJX6 PRMT5 1.139079 1.915684 279 32.2913 5.91

O95197-3 RTN3 0.893309 0.876485 236 25.5926 8.514

A8MQB8 FMR1 1.003434 0.714066 582 65.78121 7.621

Q8N766-4 EMC1 1.138454 1.132935 971 109.3519 7.928

P30566 ADSL 1.340564 1.512782 484 54.85397 7.108

G3V325 ATP5J2-PTCD1 0.714803 1.230728 0.721681 749 84.05659 8.719

Q04637-5 EIF4G1 1.8386 1.106693 1.148944 1435 158.4189 5.211

H0Y8J7 EIF4E 1.244216 2.225969 155 18.45408 6.551

H7C204 ZFYVE20 1.45217 1.102571 156 18.35461 8.368

E9PDQ8 SUCLG2 1.109183 1.318358 379 41.41251 7.723

P00846 MT-ATP6 0.76194 1.192226 0.677092 226 24.80086 10.1

P19367-4 HK1 0.961335 0.855873 905 101.0204 6.903

Q08211 DHX9 0.960707 0.79311 1270 140.8691 6.844

P18084 ITGB5 1.47491 0.868759 799 87.99622 6.062

H0Y3P2 EIF4G2 1.328199 1.232863 869 98.05574 6.991

H3BPF7 LONP2 0.933002 0.867836 236 25.49645 8.456

D6RAL1 GFM2 1.661288 1.045418 285 31.86577 7.738

H7BXI1 ESYT2 1.000532 0.809399 884 97.94866 8.573

Q9HCC0-2 MCCC2 0.708254 0.467484 525 57.48243 7.708

B4DLH2 C2orf18 0.682776 0.811431 288 31.07682 8.236

C9JVB6 TRMT10C 0.561536 1.528128 0.853825 312 36.80495 9.159

Q99805 TM9SF2 1.093457 1.120914 0.835604 663 75.72547 7.445

P54577 YARS 1.594293 1.83622 528 59.1061 7.049

C9J4P8 FKBP9 1.014271 0.99304 226 24.64835 5.732

B5AK60 ABCB1 1.236142 0.998213 0.96536 1216 133.9475 8.968

P49588 AARS 1.528437 1.649384 968 106.7432 5.529

O95202 LETM1 0.836178 0.624752 739 83.30196 6.698

of 313

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233

233

P20839-2 IMPDH1 1.951442 1.657952 489 52.56405 6.639

O14975-2 SLC27A2 1.000942 1.179552 0.76783 567 64.57429 8.485

F5GWS8 HSPA13 0.802722 2.180864 0.747226 263 29.37337 6.537

P98082-2 DAB2 1.08965 0.683185 0.946441 552 58.82448 5.707

Q9UL68-3 MYT1L 1.464539 1.119658 184 20.60714 5.034

P10253 GAA 0.601787 0.92884 952 105.2568 5.999

P45877 PPIC 1.167603 0.565501 212 22.74885 8.397

Q9H2V7-3 SPNS1 1.099477 1.009117 454 48.98191 7.752

P11717 IGF2R 0.810536 0.739024 0.719584 2491 274.1988 5.935

B7Z341 NDRG3 1.552538 0.912358 271 29.70193 5.592

Q9Y624 F11R 0.809959 0.810082 299 32.56249 7.899

O75369-5 FLNB 1.328697 0.996688 2146 230.1452 5.542

Q9Y678 COPG1 1.755991 2.746038 1.335984 874 97.65547 5.465

P56199 ITGA1 1.245528 1.24296 0.926973 1179 130.7647 6.291

O14980 XPO1 1.324821 2.022848 1071 123.3061 6.062

J3KR24 IARS 1.243357 1.489168 0.966796 1152 131.6797 6.113

Q9UG63 ABCF2 1.530427 1.118926 623 71.24463 7.372

O15031 PLXNB2 0.884686 0.954203 1.197259 1838 204.9972 6.24

P15509-8 CSF2RA 1.451765 2.813744 267 31.0819 8.221

P06756-3 ITGAV 1.112174 2.333825 1.00193 1002 111.061 5.618

P02765 AHSG 1.096659 0.863169 367 39.29971 5.719

B0QY90 EIF3L 1.221129 2.893805 466 55.12602 8.954

F8VUA7 OSBPL8 0.918728 0.820561 695 79.16 6.888

P07942 LAMB1 0.917401 1.458926 0.790964 1786 197.9086 4.945

Q08722-2 CD47 1.391991 0.931491 292 31.72203 7.21

E9PF63 ROCK2 1.186264 1.021497 1145 133.1827 5.783

F5H5F3 ATP6V0A2 0.846238 0.8683 328 38.02613 6.252

H0YKM7 MAN2A2 1.078825 1.136464 330 35.84931 8.075

of 313

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234

234

Q8TEM1-2 NUP210 1.146134 0.833643 967 105.7438 6.227

F5GZJ1 NCAPD2 1.388116 1.829292 1.035389 1356 152.0786 6.698

Q9HD20-2 ATP13A1 0.814919 0.731475 0.902841 1086 121.0323 7.752

Q9Y4W6 AFG3L2 0.58911 0.37502 797 88.52819 8.661

Q9UIQ6-3 LNPEP 1.084474 0.94827 1006 114.9881 5.783

F5H5E2 PLBD2 0.581519 0.596116 557 61.84515 6.8

Q9UMX0-2 UBQLN1 1.13587 1.020684 561 59.18281 5.097

Q9Y6M1-5 IGF2BP2 1.235582 2.081559 493 54.68838 7.518

Q86TM6-2 SYVN1 0.74949 0.870776 565 61.69123 6.844

O60313 OPA1 0.466151 0.235485 0.627159 960 111.5608 7.87

P0C6C1 ANKRD34C 0.979708 1.036409 535 58.22031 9.027

Q16513-3 PKN2 1.13514 1.137924 936 106.1504 6.405

Q9P2B2 PTGFRN 1.333617 0.980942 879 98.4946 6.61

Q969Z3-2 MARC2 1.346595 1.462994 1.005974 257 29.0841 9.789

P12004 PCNA 1.18465 2.05469 261 28.75029 4.691

Q8TAA9-2 VANGL1 1.016921 1.379496 1.111753 522 59.71011 8.807

F5H0H1 DHCR24 1.016718 1.225041 300 34.53024 6.698

Q92616 GCN1L1 1.164114 1.495175 2671 292.5725 7.474

Q7Z2W4 ZC3HAV1 1.030651 1.021061 902 101.367 8.397

P35237 SERPINB6 2.115173 0.967332 376 42.59406 5.275

O43464-4 HTRA2 1.103174 0.858048 377 39.88932 10.55

O60942-3 RNGTT 1.188726 1.997955 1.070606 457 52.49949 8.016

O00622 CYR61 2.494523 1.443355 381 41.99828 8.207

Q5VVW2-3 GARNL3 1.283904 1.231963 1.148944 423 48.74479 8.983

P03891 MT-ND2 0.52364 0.559293 347 38.93475 9.833

Q92900-2 UPF1 1.244204 1.978737 1118 122.958 6.683

Q5VU77 UBAP2L 1.306202 1.917356 350 37.93816 6.742

H7C3Z2 FLVCR1 0.933469 2.260423 354 38.15699 5.973

of 313

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235

235

P08581 MET 1.120399 0.958386 1390 155.4415 7.328

E7EX40 RAB11FIP1 0.690324 0.836738 501 54.79899 9.012

B4DUC5 CSE1L 1.779767 1.741506 754 85.4181 5.478

F5H698 LARS 1.741321 1.176201 1130 129.1319 7.87

Q8WUX1-2 SLC38A5 1.169519 1.656588 421 45.88529 8.338

Q14643-4 ITPR1 1.386526 1.019189 2695 306.578 6.291

Q9BPX3 NCAPG 1.756411 1.236768 1015 114.2621 5.592

Q14247-3 CTTN 0.97738 1.562945 1.075739 513 57.43154 5.326

P43686-2 PSMC4 2.206146 1.416601 387 43.48054 5.262

Q6ZRP7 QSOX2 0.891353 0.631728 698 77.47962 7.723

Q14789 GOLGB1 1.210601 1.014396 1.020317 3259 375.7897 4.996

Q9NZP5 OR5AC2 1.502034 1.906181 1.133634 309 35.28065 8.939

Q9C099-2 LRRCC1 1.382933 1.129748 1012 117.8571 6.24

B7Z463 NPEPPS 1.512425 0.98235 839 94.45592 5.376

O75083-3 WDR1 1.278036 1.085045 466 50.662 6.522

O60841 EIF5B 1.75188 1.169146 1220 138.7417 5.491

Q9Y666 SLC12A7 0.788691 2.13404 1083 119.0286 6.712

P16144-4 ITGB4 0.890259 0.877425 1745 194.3419 6.125

E9PMP7 LMO7 1.490234 1.065118 1046 119.4533 5.376

P55010 EIF5 1.910282 1.14816 431 49.19181 5.58

Q96AE4 FUBP1 1.243171 0.891987 644 67.51847 7.606

H3BRV0 EIF3C 1.712376 0.973388 903 104.036 5.63

Q9ULE4 FAM184B 1.507056 1.11878 1.110085 1060 120.9693 6.176

Q7Z5H4 VN1R5 1.273724 1.829477 1.051904 357 40.75162 9.203

Q4G148-2 GXYLT1 0.833063 1.7711 409 46.76996 8.954

Q15075 EEA1 0.719519 0.871027 1411 162.3672 5.681

O75901 RASSF9 1.49351 1.344004 435 49.98932 5.313

Q13033-2 STRN3 2.019764 0.92828 713 77.6965 5.262

of 313

Ant

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The

fin

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may

dif

fer

from

this

pro

of.

236

236

Q92896 GLG1 0.920041 0.803671 1179 134.4636 6.903

P11047 LAMC1 0.695079 1.221609 1609 177.4886 5.123

Q14573 ITPR3 0.970448 1.135529 2671 303.9121 6.481

Q14160 SCRIB 1.257709 0.943204 1630 174.7782 5.072

E7EUY0 PRKDC 1.142021 1.038889 4096 465.0889 7.167

E9PD53 SMC4 1.59362 1.458396 1263 144.3652 7.123

H7BZL6 FSIP2 1.445189 1.438729 1.026572 973 109.7977 8.602

Q5TCU6 TLN1 0.731978 1.460834 1.061228 2429 257.9205 6.494

Q12770-4 SCAP 0.766007 0.798997 886 95.55569 6.189

P20742 PZP 1.014587 1.498878 1482 163.7596 6.379

H0YC63 MTUS1 0.798673 0.985212 505 55.13877 8.924

P38435-2 GGCX 0.821136 1.707496 701 80.93728 7.577

P0C221-2 CCDC175 1.832305 1.077196 0.989715 792 93.46618 6.712

Q6UVK1 CSPG4 1.26086 0.843477 2322 250.3824 5.465

H7BY50 MIA3 0.980069 1.291042 1016 114.0452 4.754

P19320-2 VCAM1 1.771415 1.27599 1.431126 647 71.20937 5.173

B7Z5Z4 CLCN4 2.018092 0.675462 666 74.29835 7.694

E9PCY5 TOP2B 0.838857 0.977699 0.846456 1150 130.3978 8.47

J3KQF5 AGBL1 1.311768 1.266288 1062 119.7863 7.313

Q99798 ACO2 1.345122 0.842871 780 85.37193 7.606

P49792 RANBP2 1.010454 0.962115 3224 357.9741 6.202

Q8WXE9 STON2 1.408436 1.354522 1.067901 905 101.1015 5.389

Q5T1M5-2 FKBP15 1.102506 2.189178 1209 132.3853 5.173

E9PF10 NUP155 0.793044 0.730684 1327 147.9996 6.303

Q8TDD1 DDX54 2.256169 0.802348 881 98.5342 10.02

F5GZL7 MACF1 0.980367 0.876942 5300 605.7584 5.389

Q01970-2 PLCB3 1.248443 1.07296 1.068852 1167 131.1238 5.884

C9JTR3 RTTN 1.273629 1.038178 1593 178.8395 6.367

of 313

Ant

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237

Q07954 LRP1 1.106034 0.83705 4544 504.2759 5.389

P42858 HTT 1.459612 1.276072 1.126057 3142 347.3828 6.202

of 313

Ant

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238

238

Table S4. Proteins identified three times


Q99714 HSD17B10 0.841516 1.034407 0.721248 261 26.90611 7.782

P51149 RAB7A 0.922614 1.065166 0.846551 207 23.47484 6.698

P61604 HSPE1 0.679456 0.790736 0.699603 102 10.92487 8.924

P05787 KRT8 0.675075 0.751577 0.750807 483 53.67114 5.592

P07737 PFN1 1.938756 2.252394 1.344145 140 15.04456 8.265

P04075 ALDOA 1.431453 1.24978 1.077389 364 39.39531 8.089

P62820 RAB1A 1.092382 0.88875 1.125391 205 22.66338 6.214

Q9H0U4 RAB1B 0.918566 1.065785 0.919462 201 22.15723 5.732

F8VP99 ARL1 1.157695 1.542415 0.956203 17 1.784059 8.998

P30044-2 PRDX5 0.899533 1.151113 0.875192 162 17.02001 7.24

P35232 PHB 0.763098 0.907576 0.7709 272 29.7859 5.757

P21796 VDAC1 0.900554 0.889186 0.881584 283 30.75357 8.543

P04406 GAPDH 1.458589 1.332338 1.068676 335 36.0304 8.456

P61224 RAP1B 1.16238 1.077295 1.039023 184 20.81159 5.783

P40926 MDH2 0.664156 0.837865 0.680457 338 35.48073 8.675

P05388 RPLP0 1.330471 1.475431 1.056908 317 34.2518 5.973

P62805 HIST1H4A 0.955174 1.623225 0.837629 103 11.36038 11.36

P14854 COX6B1 0.757329 0.370079 0.408104 86 10.18572 7.049

P04843 RPN1 0.913799 1.010671 0.790561 607 68.52681 6.379

P12236 SLC25A6 0.70999 1.164683 0.736293 298 32.84519 9.745

J3KPX7 PHB2 0.789382 1.248585 0.888689 299 33.38196 9.803

P61106 RAB14 0.996383 1.193794 0.894419 215 23.88193 6.214

P10809 HSPD1 0.810926 0.816132 0.726478 573 61.01639 5.872

P07355 ANXA2 1.289833 1.129487 1.003301 339 38.57982 7.752

P05783 KRT18 0.799 0.85891 0.825672 430 48.02854 5.453

of 313

Ant

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239

P45880-2 VDAC2 0.922755 0.953553 0.777764 283 30.39304 7.196

P06733 ENO1 1.914614 1.758462 1.405665 434 47.13932 7.386

P23396 RPS3 1.488376 1.290279 1.098373 243 26.67143 9.657

P11021 HSPA5 0.956886 1.019791 0.911357 654 72.28844 5.161

P30050 RPL12 1.322301 1.463871 1.083923 165 17.80754 9.422

P05187 ALPP 1.251282 1.513109 0.854797 535 57.91729 6.291

P50991-2 CCT4 1.225267 1.121238 0.973524 509 54.6851 7.826

P04083 ANXA1 2.266094 1.746823 1.194763 346 38.68998 7.02

P61204 ARF3 1.444831 1.666886 1.051078 181 20.58773 7.43

O75947-2 ATP5H 0.765966 0.744454 0.632677 137 15.76317 7.181

P05186 ALPL 1.23596 0.987719 0.873944 524 57.26863 6.668

P22392-2 NME2 2.124502 1.754569 1.124689 267 30.11763 8.924

P62937 PPIA 1.581094 1.657079 1.266474 165 18.00089 7.811

F8W181 RPL6 1.156877 1.928758 1.269758 226 25.87584 10.67

P15328 FOLR1 1.366506 1.081038 0.923879 257 29.79922 7.972

P23284 PPIB 0.898139 0.859683 0.805036 216 23.72754 9.408

P56385 ATP5I 0.656519 0.355847 0.61265 69 7.928326 9.349

I3L405 MPDU1 0.702334 1.097506 0.747594 54 5.842343 8.543

P60709 ACTB 1.24783 1.091786 1.021016 375 41.70973 5.478

Q9BQE3 TUBA1C 2.489466 1.571135 1.267975 449 49.86346 5.097

Q04837 SSBP1 0.805241 0.95227 0.876624 148 17.24903 9.598

P78371 CCT2 1.240819 1.18594 1.00711 535 57.45213 6.456

P07437 TUBB 2.198372 1.65089 1.379771 444 49.63897 4.894

P68371 TUBB4B 2.190046 1.825049 1.414922 445 49.799 4.894

G3V1A4 CFL1 1.436668 1.604942 1.119905 149 16.80082 8.353

Q96AG4 LRRC59 0.915084 0.993629 0.812279 307 34.90888 9.569

P35268 RPL22 1.725276 0.9945 1.187181 128 14.7778 9.188

Q04695 KRT17 0.733529 0.819907 0.869358 432 48.07605 5.021

of 313

Ant

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Pero

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dif

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240

240

P61019 RAB2A 1.100628 1.154274 0.894823 212 23.53077 6.537

P61586 RHOA 1.254205 0.988428 0.989212 193 21.75407 6.1

B4E2V5 STOM 1.063447 1.119375 0.952542 237 25.94779 7.386

P08758 ANXA5 2.55048 2.027943 1.387868 320 35.9144 5.046

P08238 HSP90AB1 2.032999 1.859231 1.041987 724 83.21211 5.034

F8W1R7 MYL6 1.215575 1.126743 1.032317 145 16.2798 4.653

P06576 ATP5B 0.671661 0.96268 0.673776 529 56.52461 5.402

H7BZJ3 PDIA3 1.026889 0.806688 0.896513 123 13.51076 7.298

P51148 RAB5C 0.967067 1.122958 0.802933 216 23.46779 8.412

P05141 SLC25A5 0.787078 0.722562 0.695568 298 32.83115 9.686

P11142 HSPA8 1.676814 1.507196 1.091932 646 70.85423 5.516

P21964-2 COMT 1.006936 1.232053 0.924779 221 24.43338 5.326

P07237 P4HB 0.864308 0.920657 0.801654 508 57.08068 4.869

Q15286-2 RAB35 1.233208 1.057609 1.070747 152 17.04762 6.786

C9JD32 RPL23 1.186353 1.648681 1.004362 91 9.663386 11.49

P37802 TAGLN2 1.433868 1.373952 1.19946 199 22.37717 8.25

G5EA52 PDIA3 0.782183 1.237703 0.800555 485 54.92888 6.859

P02786 TFRC 0.946452 1.213344 0.810573 760 84.81795 6.61

P60174-1 TPI1 1.484075 1.743766 1.210256 249 26.65274 6.903

P14618 PKM 2.153361 2.370428 1.58462 531 57.90003 7.84

Q13162 PRDX4 0.877084 1.101935 0.887093 271 30.52081 6.291

H0YD13 CD44 1.235225 1.198431 0.977471 185 20.21538 8.265

A8MUB1 TUBA4A 2.036923 2.142278 1.476961 433 48.2976 5.008

P62899 RPL31 1.280412 1.474387 1.010627 125 14.45393 10.54

D6RAT0 RPS3A 1.391437 2.274117 1.088799 227 25.87044 9.422

P38646 HSPA9 0.643269 0.744843 0.621853 679 73.63478 6.164

P18124 RPL7 1.358129 1.350894 0.97166 248 29.2072 10.65

P19105 MYL12A 1.245813 1.22103 1.061118 171 19.78149 4.805

of 313

Ant

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Pero

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241

241

P63104 YWHAZ 1.862614 2.023601 2.525793 245 27.72773 4.792

E9PKZ0 RPL8 1.479458 1.201099 1.042 205 22.37522 10.76

Q06830 PRDX1 1.785254 1.352087 1.10989 199 22.09628 8.133

B7Z254 PDIA6 0.855887 1.122926 0.795077 437 47.80807 5.084

P07195 LDHB 1.964997 1.817951 1.455855 334 36.61514 6.049

D6RAN4 RPL9 1.326622 1.204954 0.967353 182 20.86141 10.2

Q9Y5M8 SRPRB 1.050497 1.255535 0.939115 271 29.68376 9.042

P07900 HSP90AA1 1.836656 1.700895 1.059922 732 84.60669 5.021

P17987 TCP1 1.260682 1.379604 0.931344 556 60.30559 6.113

P68104 EEF1A1 1.623493 1.398227 1.146169 462 50.10911 9.012

Q15019 SEPT2 1.163427 1.163393 0.935111 361 41.46125 6.595

E9PN17 ATP5L 0.688519 0.850805 0.784382 76 8.446677 10.29

I3L397 EIF5A 1.252103 1.537274 1.130697 147 16.10798 4.996

P08195-2 SLC3A2 1.450345 1.55993 1.062157 529 57.90887 5.351

P09525 ANXA4 1.858302 1.494527 1.25553 319 35.86012 6.125

P30040 ERP29 0.940127 1.141007 0.762335 261 28.97516 7.313

P46781 RPS9 1.596054 1.646443 1.137516 194 22.57756 10.65

P39019 RPS19 1.41885 2.247615 1.038056 145 16.05054 10.32

P61026 RAB10 1.023099 1.368584 0.851934 200 22.52659 8.382

P62906 RPL10A 1.426027 1.112273 1.122081 217 24.81554 9.935

P09211 GSTP1 2.264256 1.306028 1.773251 210 23.34102 5.643

Q9UBI6 GNG12 1.043246 1.20671 0.704077 72 8.00117 8.968

Q9Y2Q5 LAMTOR2 0.980146 1.111427 0.77696 125 13.49885 5.402

Q15293 RCN1 0.990571 0.964389 0.872109 331 38.86617 4.996

P49411 TUFM 0.807198 0.801759 0.780787 452 49.51018 7.606

P50454 SERPINH1 0.947646 1.159278 0.839949 418 46.41118 8.69

P00387-2 CYB5R3 0.845523 0.670345 0.888954 278 31.60836 7.577

P13639 EEF2 1.692874 2.529139 1.184579 858 95.27695 6.83

of 313

Ant

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Pero

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The

fin

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ion

may

dif

fer

from

this

pro

of.

242

242

P05387 RPLP2 1.395322 1.271484 1.097447 115 11.65785 4.539

P04899 GNAI2 1.21145 1.10679 0.796403 355 40.42506 5.542

Q14697 GANAB 0.928261 0.940956 0.819932 944 106.8067 6.138

C9J9K3 RPSA 1.484789 2.096834 0.965794 264 29.487 5.25

H3BRU6 PCBP2 1.303973 2.759481 1.020001 301 31.69025 8.441

P31327 CPS1 0.738376 0.773863 0.620871 1500 164.8348 6.742

P27797 CALR 0.84085 0.960863 0.770204 417 48.11183 4.437

P35613-4 BSG 1.399049 1.07799 0.949404 205 22.7502 5.465

P62277 RPS13 1.678969 1.478867 1.078018 151 17.21167 10.54

P62979 RPS27A 1.440632 0.943459 1.152788 156 17.95349 9.642

C9JXB8 RPL24 1.199513 1.607222 0.984919 121 14.35982 11.31

Q99832 CCT7 1.253512 1.025571 0.931442 543 59.32893 7.65

F5H897 TRAP1 0.694887 0.819808 0.765467 651 74.22066 7.87

Q15907 RAB11B 0.944864 1.163245 0.742528 218 24.47349 5.935

P11233 RALA 1.101317 1.210924 0.908307 206 23.55197 7.108

P14625 HSP90B1 0.892788 0.951019 0.830767 803 92.41135 4.843

P00558 PGK1 1.471019 1.379579 1.293939 417 44.58613 8.104

P48047 ATP5O 0.633851 1.24605 0.808641 213 23.26266 9.964

P15880 RPS2 1.664077 1.47961 1.113606 293 31.3046 10.24

P00966 ASS1 1.839589 1.676893 1.362175 412 46.50097 8.016

P08754 GNAI3 1.175651 0.804725 1.039917 354 40.50627 5.694

B4DUR8 CCT3 1.22739 1.151447 0.915537 500 55.6387 5.643

J3KPE3 GNB2L1 1.484859 1.549646 0.982292 273 30.08503 7.65

P62701 RPS4X 1.302232 2.454188 0.93498 263 29.57906 10.15

P13667 PDIA4 0.930947 0.925643 0.89519 645 72.88698 5.072

P60953 CDC42 1.431487 1.57275 0.920497 191 21.24502 6.551

P62241 RPS8 1.47423 1.177438 1.187905 208 24.19016 10.32

B4DP11 PTGES3 1.681728 2.155438 1.223253 139 16.46559 4.805

of 313

Ant

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Pero

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The

fin

al p

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ion

may

dif

fer

from

this

pro

of.

243

243

P62081 RPS7 1.354286 1.2582 1.16434 194 22.11326 10.1

P10599-2 TXN 1.730395 1.578375 1.437973 85 9.445685 6.037

E7EPB3 RPL14 1.301225 1.305218 1.102775 124 14.5486 10.21

E9PJD9 RPL27A 1.364131 1.230209 0.96926 91 10.1206 10.21

Q13011 ECH1 0.768997 0.747662 0.814573 328 35.79338 8.001

P62826 RAN 1.649783 1.16876 1.196289 216 24.40762 7.489

O43852 CALU 0.757461 0.647413 0.615452 315 37.08354 4.64

P30519 HMOX2 1.01223 0.847264 0.881484 316 36.00983 5.415

P09923 ALPI 1.094579 1.315935 0.881478 528 56.77642 5.859

F8W1A4 AK2 0.895767 0.521958 0.570225 232 25.61431 7.826

O15260-2 SURF4 0.965792 1.794887 0.832768 159 17.95813 6.049

Q00325-2 SLC25A3 0.750895 0.864622 0.675982 361 39.93264 9.364

P26038 MSN 0.997356 0.961161 0.841568 577 67.77779 6.405

Q9Y4L1 HYOU1 0.945504 1.059093 0.930768 999 111.2662 5.224

B4DT77 ANXA7 1.799431 2.522988 1.392255 336 37.78092 7.181

P20340 RAB6A 0.976054 1.189046 0.893356 208 23.57792 5.542

Q07065 CKAP4 0.828617 1.04363 0.862488 602 65.98273 5.922

O75396 SEC22B 0.901232 0.960989 0.94581 215 24.57753 6.917

P62873 GNB1 1.277162 1.015888 0.94075 340 37.35301 5.999

P62879 GNB2 1.315584 1.060956 0.898893 340 37.30706 5.999

P14314-2 PRKCSH 0.91234 1.048005 1.041739 525 59.1407 4.424

P80723-2 BASP1 1.166233 1.056561 0.901991 173 17.65361 4.767

J3KRB3 RPL17 1.489923 2.946832 0.995291 106 12.18533 10.33

Q7Z7H5-3 TMED4 1.342651 1.19789 0.815333 186 20.76759 6.874

Q15365 PCBP1 1.261067 2.948268 0.9692 356 37.47395 7.093

P08133-2 ANXA6 1.403662 1.436018 1.034728 641 72.37795 5.605

P34897-3 SHMT2 0.685224 0.741831 0.678145 483 53.4214 8.148

P62258 YWHAE 1.992235 1.280401 1.494461 255 29.15542 4.742

of 313

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Q5TGZ0-2 MINOS1 0.800924 1.149823 0.884853 24 2.807374 5.021

P42704 LRPPRC 0.690941 0.910268 0.672625 1394 157.8051 6.125

P62269 RPS18 1.346863 1.626686 1.028083 152 17.70786 10.99

H0YJW7 SLIRP 0.71013 0.971971 0.865119 76 8.686431 9.056

P08729 KRT7 1.062605 1.561058 0.950673 469 51.35431 5.478

P51151 RAB9A 0.791237 1.072214 0.935898 201 22.82317 5.465

Q96KK5 HIST1H2AH 0.735924 1.673838 0.56306 128 13.89783 10.89

P62851 RPS25 1.40709 1.856292 1.141014 125 13.7337 10.11

P55145 MANF 0.926633 0.909981 0.846526 182 20.68681 8.69

Q9Y277 VDAC3 0.760055 1.266825 0.695581 283 30.63929 8.661

H3BSJ9 UQCRC2 0.833404 1.259801 0.853102 336 36.36685 9.056

P49755 TMED10 0.944925 0.898659 0.864641 219 24.96002 7.445

P51659 HSD17B4 0.912127 1.142433 0.907175 736 79.63631 8.836

M0R3D6 RPL18A 1.374033 1.25685 0.974152 141 16.70379 10.77

P07954-2 FH 0.75616 0.821024 0.77492 467 50.18071 7.401

P61006 RAB8A 0.901174 1.246924 0.836144 207 23.65319 9.071

P18077 RPL35A 1.477323 1.059888 1.092934 110 12.52977 11.06

O00264 PGRMC1 0.896808 1.252782 0.816996 195 21.65776 4.704

P48643 CCT5 1.237512 1.01463 1.005196 541 59.63281 5.656

P00338 LDHA 1.812565 2.760047 1.429861 332 36.66536 8.265

P27824 CANX 0.925213 0.986537 0.774761 592 67.52585 4.602

E9PI90 TMEM126A 0.972535 1.250469 0.866371 95 10.5577 9.349

E9PIE4 MTCH2 0.568568 0.880562 0.724825 263 28.64363 7.606

O43707 ACTN4 1.262195 1.082558 0.9702 911 104.7885 5.44

O60493-4 SNX3 1.267295 0.705719 0.97026 140 16.30543 6.8

H0YNX5 SEC11A 1.109807 1.068807 0.796946 106 11.9784 8.573

P40227-2 CCT6A 1.192214 0.996239 0.919703 486 53.25512 7.269

E9PPQ4 FTH1 0.622898 0.799481 0.801175 58 6.659315 5.833

of 313

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P62280 RPS11 1.662973 1.502607 1.097377 158 18.41899 10.3

P36578 RPL4 1.35429 1.903045 0.988733 427 47.66743 11.06

Q9NZM1-6 MYOF 1.037945 1.021888 0.808942 2048 233.3291 6.214

P13073 COX4I1 0.483846 0.765167 0.556132 169 19.56405 9.51

Q09666 AHNAK 1.396628 1.078414 1.085748 5890 628.6994 6.151

O00299 CLIC1 1.488679 1.783422 1.075934 241 26.90575 5.173

O75340-2 PDCD6 1.339131 2.016605 0.873893 189 21.6507 5.402

Q9BVK6 TMED9 1.089255 1.206477 1.029899 235 27.26019 8.016

B0YJC4 VIM 1.04978 0.95151 0.834099 431 49.62311 5.25

P16435 POR 1.075094 1.406985 0.862966 677 76.64125 5.58

P62857 RPS28 1.611754 1.450764 1.260379 69 7.836202 10.7

E9PH29 PRDX3 1.032865 1.063725 0.964449 238 25.82229 7.459

F8VWC5 RPL18 1.362265 1.227657 1.081671 159 18.08001 11.84

B4DJV2 CS 0.738233 0.967624 0.528491 453 50.39972 7.899

G5E9G0 RPL3 1.270871 1.237766 1.026216 351 40.24159 10.01

P62136 PPP1CA 1.343226 1.108105 1.095776 330 37.48781 6.329

P31930 UQCRC1 0.774534 0.886231 0.935639 480 52.61243 6.367

P05023-3 ATP1A1 1.294006 0.992424 1.007667 992 109.4801 5.313

P30041 PRDX6 2.172555 2.201779 1.531302 224 25.01919 6.379

P49748-2 ACADVL 0.856184 0.941784 0.884746 633 68.01516 8.558

P24752 ACAT1 0.638064 0.687537 0.508238 427 45.17065 8.851

P62847-2 RPS24 1.28488 1.502636 1.211886 130 15.05924 10.89

J3QRU4 VAMP2 1.035579 0.87911 0.88375 113 12.24347 6.698

P38117 ETFB 0.638357 0.914762 0.756683 255 27.82615 8.104

P50990 CCT8 1.308838 1.110844 1.013766 548 59.58251 5.605

H3BLV0 CD55 1.328456 1.063833 0.912351 326 35.78247 5.542

K7EK18 SEPT9 1.098243 2.065827 0.89968 195 22.20265 9.364

M0R210 RPS16 1.69377 1.999538 1.206613 129 14.40996 10.23

of 313

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H7C131 ACAA1 1.048769 1.409101 0.869312 290 30.31385 8.631

Q9Y3U8 RPL36 1.31536 1.586732 1.003242 105 12.24591 11.59

P63173 RPL38 1.294342 1.106003 0.869385 70 8.212732 10.1

P35579 MYH9 1.302687 1.086399 1.071008 1960 226.3916 5.605

P14923 JUP 1.086031 1.9394 0.870796 745 81.69273 6.138

E7EPK1 SEPT7 1.093627 0.907592 0.935756 436 50.53491 8.631

P60981-2 DSTN 1.581098 1.011045 1.184857 148 16.60962 8.338

P49207 RPL34 1.395191 1.314732 0.995061 117 13.28447 11.47

P62158 CALM1 1.168528 0.976215 1.043359 149 16.82684 4.221

B0V0C2 HLA-C 1.174925 1.450967 1.015708 355 39.9159 6.252

P62424 RPL7A 1.271624 1.253347 1.056754 266 29.97703 10.61

P32119 PRDX2 1.699211 1.093831 1.077377 198 21.87824 5.973

P56378 MP68 0.57071 1.525767 0.537005 58 6.657592 10.08

E7EQV9 RPL15 1.487834 1.212723 1.172524 174 20.4971 11.28

P26373 RPL13 1.341332 1.017938 1.180794 211 24.24653 11.65

P04264 KRT1 0.85955 0.950506 1.147848 644 65.999 8.119

P07339 CTSD 0.787297 1.54094 0.754058 412 44.52363 6.537

O95881 TXNDC12 0.767286 1.351947 0.708736 172 19.19358 5.402

P08107-2 HSPA1A 1.451974 1.304211 1.128996 586 63.89795 5.707

P46777 RPL5 1.4141 1.415486 0.956259 297 34.3407 9.715

P46783 RPS10 1.235944 2.429152 1.195446 165 18.88587 10.15

P63000 RAC1 0.949096 1.149969 0.843695 192 21.43624 8.5

P15311 EZR 1.044674 1.131245 0.844371 586 69.36974 6.265

Q9H3R2 MUC13 0.978161 1.009123 0.874289 511 54.4823 5.072

P04844-2 RPN2 0.865835 1.515186 0.790879 615 67.68143 6.062

P22626-2 HNRNPA2B1 1.46531 1.472787 1.080379 341 35.98387 8.646

Q07021 C1QBP 0.539476 0.617432 0.63902 282 31.34261 4.843

B0QYW5 SLC25A17 0.80683 1.515895 0.830338 225 25.70527 10.33

of 313

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P40939 HADHA 0.854214 0.933591 0.693905 763 82.94688 9.042

Q8NBS9-2 TXNDC5 0.859163 1.032573 0.891072 324 36.15501 5.465

P60842 EIF4A1 1.965905 2.235364 1.377883 406 46.12456 5.478

P04792 HSPB1 1.745388 1.579063 1.377766 205 22.76849 6.405

P00505 GOT2 0.74356 1.11953 0.835989 430 47.48732 9.012

A6NNI4 CD9 1.162542 1.471833 0.875901 159 17.75198 6.291

J3KTJ8 RPL26 1.253158 1.097186 0.952303 97 11.59029 10.9

P46940 IQGAP1 1.311338 1.179563 1.051245 1657 189.1338 6.481

Q5SQT8 SAR1A 1.342855 1.036644 1.046629 121 13.65307 7.035

P01891 HLA-A 1.141704 1.080213 0.870519 365 40.88311 6.698

O00116 AGPS 0.916199 1.008498 0.881695 658 72.86575 7.342

P36542 ATP5C1 0.794469 1.137386 0.851877 298 32.97527 9.217

P62750 RPL23A 1.612112 1.035822 1.037671 156 17.68414 10.45

P42677 RPS27 1.229176 1.262495 1.039197 84 9.454836 9.452

P68032 ACTC1 1.34282 1.013944 1.055046 377 41.99188 5.389

P46779 RPL28 1.626481 1.301392 1.045187 137 15.73767 12.02

O00571-2 DDX3X 1.312787 1.984043 1.036829 646 71.31093 6.625

P00533 EGFR 1.313611 1.150044 0.967401 1210 134.1903 6.683

O00483 NDUFA4 0.523392 0.706709 0.775773 81 9.363911 9.378

A1L0T0 ILVBL 0.939325 1.132552 0.986583 632 67.82475 8.148

Q9BS26 ERP44 1.071049 0.980132 0.906419 406 46.9414 5.262

P39656 DDOST 0.870036 1.214033 0.817799 456 50.76897 6.551

E5RI99 RPL30 1.335092 1.112029 1.043232 114 12.64765 9.554

P50416 CPT1A 0.78061 0.995421 0.755873 773 88.31074 8.646

H0YJ63 AHSA1 1.229447 1.349447 1.208246 90 10.13504 7.035

F8W031 2 0.947739 0.875083 0.923028 263 29.20588 7.005

P47813 EIF1AX 1.885051 1.752925 1.039483 144 16.45023 5.237

P16615 ATP2A2 0.916231 0.957004 0.913417 1042 114.6826 5.338

of 313

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P25398 RPS12 1.659114 1.104536 1.065406 132 14.50548 7.21

P54886-2 ALDH18A1 0.695204 1.022175 0.785468 793 87.03444 7.123

H0YJ10 4 1.021539 1.300787 0.811753 91 10.72949 8.192

P12277 CKB 1.649735 3.416205 1.579158 381 42.61732 5.592

Q96D15 RCN3 0.761235 0.664588 0.875835 328 37.47 4.894

P61978-3 HNRNPK 1.293792 1.262426 1.041703 440 48.53217 5.542

Q9UJZ1 STOML2 0.938409 0.635069 0.93784 356 38.5102 7.386

Q969X5-2 ERGIC1 1.119816 0.901479 0.66877 198 22.14624 9.159

C9IZG4 CUTA 0.988956 1.690078 1.10773 135 14.39131 5.453

E9PK01 EEF1D 1.302939 1.516644 1.004283 261 28.8036 5.021

Q9UBQ0-2 VPS29 1.041183 0.601188 0.878376 186 20.9139 7.049

P08559 PDHA1 0.60855 0.708728 0.778748 390 43.26761 8.06

K7ES20 CDKN2A 1.387355 2.537661 1.194942 104 11.0686 6.062

Q7KZF4 SND1 1.045645 1.052682 0.894108 910 101.9335 7.167

O00159-2 MYO1C 1.090572 1.879908 0.932649 1028 117.8338 9.408

P13797 PLS3 1.278969 1.281915 0.894728 630 70.76621 5.605

P51809 VAMP7 0.593834 1.216902 0.666516 220 24.91897 8.602

H0YHC3 NAP1L1 1.749507 1.215395 1.242297 198 23.40282 4.805

H0YK49 ETFA 0.808242 0.650196 0.816799 229 24.14479 8.661

P55072 VCP 1.356492 1.053145 1.115978 806 89.26572 5.262

P40429 RPL13A 1.465869 1.290089 1.005122 203 23.56238 10.93

Q9Y2Q3 GSTK1 0.827654 1.67774 0.733029 226 25.4803 8.412

Q15738 NSDHL 0.85239 1.055136 0.852621 373 41.87357 8.06

Q96AY3 FKBP10 0.996141 1.329693 0.892073 582 64.20419 5.618

M0R0F0 RPS5 1.166646 2.470449 1.0889 200 22.37678 9.554

P62753 RPS6 1.397225 1.387364 1.065198 249 28.66299 10.84

E9PNM1 FDFT1 0.895386 0.707255 0.816685 410 47.25481 6.537

P26641 EEF1G 1.415485 1.530083 1.06643 437 50.08714 6.668

of 313

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H3BN98 4 1.438958 1.477913 1.126454 237 27.15036 9.554

P21333-2 FLNA 1.379542 1.316975 1.06758 2639 279.8435 6.049

Q9BTV4 TMEM43 0.780347 1.962667 0.746693 400 44.8472 8.133

Q9NQC3-2 RTN4 1.054777 1.248568 0.896947 373 40.29295 4.78

P05198 EIF2S1 1.355816 1.614618 1.018009 315 36.08938 5.084

P05362 ICAM1 1.305694 1.302605 0.922945 532 57.78895 7.987

Q14257 RCN2 0.96242 0.623272 0.879469 317 36.85364 4.399

B4DVE7 ANXA11 1.313376 1.152581 1.024236 472 51.20963 7.665

Q96CG1 ETF1 1.291047 1.189461 0.911591 404 45.43428 5.567

P63092-3 GNAS 1.24904 0.974517 0.876229 379 44.15129 6.291

P60468 SEC61B 0.969906 0.935849 0.82461 96 9.968098 11.56

P28288-2 ABCD3 0.788009 0.999881 0.771997 549 62.68583 9.232

Q8NE86-3 MCU 0.419177 1.259917 0.395554 302 35.13636 7.489

P35610 SOAT1 0.95731 1.141503 0.792908 550 64.69228 8.939

E9PJK1 CD81 0.86806 1.22258 0.922512 165 17.95093 4.996

F8VZ49 HNRNPA1 1.457102 1.12016 0.929332 231 25.67093 8.265

H7BYV1 IFITM2 0.942264 1.110098 1.041262 74 8.191374 9.554

O75955 FLOT1 0.959809 1.219525 0.894697 427 47.32562 7.489

Q9H7Z7 PTGES2 0.708644 1.222006 0.767571 377 41.91667 9.159

P20674 COX5A 0.642662 0.823961 0.797611 150 16.75169 6.786

P21291 CSRP1 1.305284 1.28095 0.904117 193 20.55376 8.573

Q9NVI7-3 ATAD3A 0.736017 0.95477 0.758229 507 57.91198 9.247

O60506-4 SYNCRIP 1.439233 1.325961 1.109899 527 58.69934 7.562

Q00610-2 CLTC 1.264943 1.277724 1.081325 1639 187.7708 5.694

P11940-2 PABPC1 1.51283 1.56743 0.845456 547 61.14204 9.071

P52907 CAPZA1 1.176207 2.293021 1.045937 286 32.90233 5.694

P62266 RPS23 1.216428 2.655464 1.01516 143 15.79772 10.49

O14745 SLC9A3R1 1.260811 1.01792 1.042626 358 38.84461 5.77

of 313

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O95816 BAG2 1.272411 1.042008 1.089469 211 23.75721 6.698

Q15758 SLC1A5 1.308418 1.492866 1.055568 541 56.56225 5.478

P00403 MT-CO2 0.70371 1.021196 0.80279 227 25.54821 4.818

P08240-2 SRPR 0.957363 1.306896 0.943597 610 66.5166 9.042

P31040 SDHA 0.710747 0.800021 0.515262 664 72.64529 7.386

J3QRD1 ALDH3A2 0.739254 0.922268 0.81764 393 44.61966 5.529

Q9P2E9-2 RRBP1 0.963369 0.97999 0.774962 1407 152.0976 8.661

P61353 RPL27 1.418572 1.185726 1.319388 136 15.78775 10.56

O60568 PLOD3 0.984509 0.966926 0.997824 738 84.73148 6.049

P43121 MCAM 1.271354 1.833761 0.94972 646 71.5626 5.757

H0YDT8 EMC7 0.745164 0.727399 0.818959 192 20.98168 9.364

Q8N5N7 MRPL50 0.873347 1.175161 0.730664 158 18.31337 7.884

Q96A33 CCDC47 0.925467 1.238405 0.965277 483 55.83831 4.869

O43175 PHGDH 1.747724 2.068921 1.496959 533 56.61441 6.712

H7C463 IMMT 0.877231 0.809576 0.904617 613 68.13328 6.062

P07686 HEXB 0.741613 0.992336 0.75352 556 63.07118 6.756

Q9BUF5 TUBB6 1.672282 2.65095 1.110157 446 49.825 4.881

P32322-2 PYCR1 0.845045 0.642088 0.695944 316 33.3195 6.8

O75915 ARL6IP5 0.964027 1.020583 1.120619 188 21.60041 9.774

B4DLN1 SLC25A10 0.858637 0.915177 0.867875 442 48.06871 9.525

E9PP23 ACP2 0.827875 1.245691 0.514516 305 35.13374 7.606

P51571 SSR4 0.914168 1.083905 0.770754 173 18.98661 6.151

P15941-7 MUC1 1.044978 2.078388 0.85959 255 27.54883 6.379

P07099 EPHX1 0.999873 1.231505 0.831531 455 52.91497 7.254

P49720 PSMB3 1.0479 1.238449 0.807103 205 22.93345 6.551

P20645 M6PR 0.989309 0.783721 0.824571 277 30.97338 5.833

P60866 RPS20 1.455372 1.259972 1.211516 119 13.36431 9.935

P30084 ECHS1 0.883418 1.356612 0.867611 290 31.36713 8.075

of 313

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P04040 CAT 0.850883 0.954433 0.938398 527 59.71876 7.386

P62070 RRAS2 1.266491 1.827886 1.19924 204 23.38472 6.011

O95295 SNAPIN 0.956505 0.88864 0.963864 136 14.86489 9.305

Q9BWM7 SFXN3 0.531569 1.297676 0.717848 325 35.95574 9.085

D6RFH4 CYB5B 1.229277 1.121125 0.872535 131 14.83656 6.189

Q9H488-2 POFUT1 1.008152 0.897625 0.79064 194 22.32318 8.763

P31949 S100A11 2.030099 1.585923 1.773105 105 11.73283 7.123

P26885 FKBP2 1.060719 0.988314 0.97951 142 15.63932 9.129

J3QL14 ATP6V0D1 0.866587 0.826526 0.729162 232 26.79831 4.945

P07602 PSAP 0.683775 0.629512 0.706638 524 58.07385 5.173

P54136-2 RARS 1.198519 1.2051 1.051643 588 67.09754 6.551

P35241 RDX 1.144341 0.789788 0.79542 583 68.52139 6.367

Q9NYU2-2 UGGT1 0.966708 1.082893 0.827887 1531 174.867 5.605

H3BTL1 MAP1LC3B 1.202473 1.328199 0.978317 75 9.005942 9.818

P01111 NRAS 1.312077 1.099683 1.02401 189 21.21552 5.173

P11177-2 PDHB 0.801466 0.826505 0.686171 341 37.17589 5.897

O95573 ACSL3 1.005102 0.842287 0.750326 720 80.3683 8.382

Q5QNZ2 ATP5F1 1.016849 0.861305 0.934918 195 22.26079 9.261

F5H895 DAD1 0.941767 1.090094 0.921763 65 7.283816 6.507

Q04941 PLP2 1.11339 1.166644 0.873699 152 16.6797 7.24

Q15363 TMED2 1.129736 0.691615 0.857814 201 22.74638 5.173

Q8NBJ5 COLGALT1 1.034208 1.152908 0.94246 622 71.59049 7.313

P21912 SDHB 0.78746 0.688895 0.585378 280 31.60884 8.763

D3YTB1 RPL32 1.46215 1.225551 1.090284 133 15.60672 11.44

P54709 ATP1B3 0.862547 1.39039 0.692303 279 31.4921 8.353

Q6PIU2 NCEH1 0.983177 1.03137 0.951544 408 45.77873 7.225

F5GX33 SLC25A13 0.957621 0.688932 0.827212 567 62.20553 9.012

P05556 ITGB1 1.158754 1.035265 0.917412 798 88.35701 5.389

of 313

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Q10589 BST2 1.017301 0.804819 0.929134 180 19.75632 5.605

O14717-6 TRDMT1 1.173837 1.692801 0.93187 107 12.07936 9.408

F2Z388 RPL35 1.250751 1.521157 1.170053 96 10.63799 10.29

J3QR09 RPL19 1.070284 0.939773 1.179406 193 23.12009 11.47

P60903 S100A10 1.135403 0.850453 1.076286 97 11.19551 7.372

Q15006 EMC2 0.863007 0.726281 0.875542 297 34.81137 6.566

Q9GZY8-4 MFF 0.739802 0.53782 0.695619 218 25.05105 5.58

Q9P035 PTPLAD1 0.877567 1.337144 0.857696 362 43.13156 8.939

Q96QK1 VPS35 1.003638 1.242269 0.838696 796 91.64894 5.491

O60762 DPM1 0.851512 0.83312 0.902944 260 29.61578 9.569

P06280 GLA 0.884287 0.768463 0.781778 429 48.73487 5.605

P17931 LGALS3 1.461607 1.151114 0.995674 250 26.13605 8.558

Q9UII2 ATPIF1 0.999876 0.587263 0.953559 106 12.24131 9.349

P62861 FAU 1.083569 2.505195 1.002681 59 6.643817 12.15

P22314 UBA1 1.679951 1.436978 1.088012 1058 117.7743 5.757

B4DLR8 NQO1 1.86144 2.576048 1.108224 202 22.7789 8.5

B7Z9S8 ATP1B1 0.987011 1.162697 0.775269 247 28.60945 7.591

E5RHW4 ERLIN2 1.075576 1.673551 0.91896 338 37.70141 5.618

Q15067 ACOX1 0.820907 0.853837 0.80665 660 74.37619 8.163

Q8NF37 LPCAT1 0.968721 0.940151 0.824247 534 59.11339 6.024

B3KUK2 SOD2 0.983114 1.068819 0.875183 176 19.718 8.031

Q9NP58-4 ABCB6 0.866446 0.735973 0.921757 796 88.54343 8.69

P53007 SLC25A1 0.657693 0.838483 0.552905 311 33.991 9.891

Q02818 NUCB1 0.746638 0.571069 0.704151 461 53.84633 5.25

Q9Y3E5 PTRH2 1.195788 0.669064 0.835644 179 19.18096 8.734

P57088 TMEM33 0.828436 1.442192 0.868994 247 27.95981 9.701

Q6IAA8 LAMTOR1 1.24942 0.816071 0.786799 161 17.73383 5.148

P59998 ARPC4 1.341496 1.09597 1.045125 168 19.6543 8.426

of 313

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I3L0U2 PRSS21 0.691442 0.583658 0.82809 218 24.80035 8.309

B4E2W0 HADHB 0.850703 0.886421 0.451736 452 48.84822 9.173

Q16836 HADH 0.792688 0.742475 0.744782 314 34.27194 8.851

P13645 KRT10 1.28587 0.939907 0.591393 584 58.7917 5.211

J3KNT0 FSCN1 1.29256 1.174877 0.981105 472 52.22991 7.445

B4DJP7 SNRPD3 1.222577 2.00277 0.961715 120 13.28287 8.91

O96008-2 TOMM40 1.011459 0.843353 0.925812 329 34.41926 7.24

Q92820 GGH 0.839025 1.22591 0.82501 318 35.94117 7.108

P60891 PRPS1 2.22903 1.813701 1.35476 318 34.81193 6.976

J3KNJ2 EIF3M 1.620833 2.034655 1.076182 191 21.67855 7.767

B4DL37 AKR1C3 0.987396 2.243348 1.180967 204 23.34887 7.987

Q969V3-2 NCLN 0.894773 0.958908 0.953311 562 62.80652 6.888

O43399-2 TPD52L2 1.061307 1.272973 0.957152 186 19.8891 5.478

Q01650 SLC7A5 1.431562 1.133416 1.266765 507 54.97428 7.723

P21281 ATP6V1B2 0.917239 1.985412 0.827157 511 56.46488 5.808

P22307-4 SCP2 0.926588 0.997557 0.801347 466 50.30939 7.02

P62263 RPS14 1.753372 1.312114 1.238416 151 16.26253 10.05

O60664-4 PLIN3 1.365876 0.982602 1.202173 422 45.77523 5.427

P42765 ACAA2 0.664527 0.989564 0.733337 397 41.89765 8.089

P49257 LMAN1 1.063775 0.783376 0.907985 510 57.51298 6.771

O00560-3 SDCBP 1.00285 1.337478 0.9725 292 31.74152 7.533

P51572 BCAP31 0.946674 1.001908 0.936711 246 27.97401 8.441

Q9H4G0-4 EPB41L1 1.079995 0.94112 0.691207 701 78.78222 7.093

Q5TB53 TM9SF3 1.044122 1.176811 1.01852 254 29.91872 5.821

B4DSN5 PTPN1 0.975514 1.198382 1.02545 362 41.23352 5.973

Q13740-2 ALCAM 1.304214 1.065807 1.040666 570 63.62447 7.298

Q9HDC9 APMAP 1.059751 1.719589 0.767649 416 46.45085 6.164

C9JFR7 CYCS 0.500598 0.686837 0.429284 101 11.32596 9.657

of 313

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254

Q9Y5L4 TIMM13 1.143695 1.50709 0.927134 95 10.493 8.177

P10606 COX5B 0.823219 0.631925 0.835023 129 13.68694 8.807

C9IZ01 GFM1 0.587804 0.935326 0.620201 591 65.9928 8.06

P06744 GPI 1.348222 1.828248 1.178758 558 63.10725 8.324

O95831-3 AIFM1 0.940237 0.661734 1.070264 609 66.25356 8.939

Q9BSJ8 ESYT1 0.941908 0.91924 0.810372 1104 122.78 5.833

P18669 PGAM1 3.402846 2.572908 1.775781 254 28.78584 7.181

P06865 HEXA 0.741061 1.292861 0.744929 529 60.66428 5.161

P43487 RANBP1 1.57851 2.930969 2.310803 201 23.29557 5.288

G3V576 HNRNPC 1.169722 2.128537 0.967671 231 25.24106 9.818

Q5BJF2 TMEM97 0.875928 0.795105 0.757884 176 20.83417 9.378

B4DHW1 TMEM165 0.974704 1.003516 0.941358 261 28.41395 6.537

P11279 LAMP1 0.608898 1.120847 0.706852 417 44.85382 8.749

Q8IVT2 MISP 1.199723 0.98305 1.110681 679 75.31095 6.83

P05386 RPLP1 1.205217 2.053789 0.964117 114 11.50669 4.323

P13284 IFI30 0.963744 0.568155 0.601458 250 27.94501 4.881

O75439 PMPCB 0.659306 0.939695 0.498041 489 54.3315 6.83

O15173 PGRMC2 0.827862 1.932896 0.829608 223 23.80373 4.881

Q13637 RAB32 1.051914 1.252506 0.905242 225 24.98169 6.537

P16278-3 GLB1 0.840196 0.913291 0.761187 647 72.70454 6.252

Q99536 VAT1 1.187142 0.901623 1.084757 393 41.89342 6.291

Q96CS3 FAF2 1.089111 1.28199 0.972315 445 52.59055 5.618

Q7Z650 MTHFD2 0.605882 0.492332 1.147144 248 26.83225 7.181

P48449-2 LSS 0.915827 1.416043 0.777651 652 74.16963 6.456

Q16850 CYP51A1 0.662896 0.698398 0.722726 503 56.76947 8.529

O75844 ZMPSTE24 0.86299 0.817096 0.784706 475 54.77753 7.489

Q86UE4 MTDH 0.907267 0.715012 0.654347 582 63.79881 9.32

F8W6E4 GPD2 0.899309 0.75753 0.803208 500 55.72346 6.252

of 313

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255

D6RA82 ANXA3 2.968576 2.210312 1.509352 284 32.09853 5.935

Q12965 MYO1E 1.157812 1.586147 0.860113 1108 126.982 8.924

E9PCY7 HNRNPH1 1.363449 1.306548 1.101049 429 47.05745 6.341

P61619 SEC61A1 0.879768 0.896405 0.827963 476 52.23052 8.06

P62913-2 RPL11 1.272692 1.258457 0.902436 177 20.11158 9.598

Q9UM22 EPDR1 1.020808 1.082312 0.768408 224 25.42059 6.595

Q9HCU5 PREB 1.062268 1.629471 0.735926 417 45.43967 7.884

Q9UQ80 PA2G4 1.590945 1.198977 1.160384 394 43.75919 6.551

Q14974 KPNB1 1.22989 1.503563 1.088321 876 97.10802 4.78

P24534 EEF1B2 1.585491 1.279222 1.094085 225 24.74826 4.666

Q12797-10 ASPH 1.043348 1.189876 0.813744 729 83.21622 4.919

J3QLD9 FLOT2 1.032759 1.570063 0.976805 428 47.11269 5.313

C9J3L8 SSR1 0.93948 1.461099 0.808455 265 29.55479 4.297

Q7L2E3-3 DHX30 0.849954 0.940023 0.934964 1155 129.3572 8.529

Q68CR9 DKFZp781B11202 1.19292 0.795632 0.839561 401 45.7421 5.707

O15427 SLC16A3 1.232511 1.776773 0.928498 465 49.43689 7.958

O00410 IPO5 1.463066 1.30058 0.90374 1097 123.5499 4.945

H0Y4R1 IMPDH2 1.902177 1.154282 1.101765 470 51.03521 8.177

H7C3P4 GNS 0.696256 0.943496 0.683875 496 56.33784 7.914

P13674-3 P4HA1 0.892033 0.747971 0.914487 516 58.92102 6.024

H0YA96 HNRNPD 0.899992 2.609714 0.891389 210 23.90618 9.583

O94874-2 UFL1 1.047756 1.340076 0.869645 729 82.04688 6.961

O00186 STXBP3 1.092524 1.366247 0.949951 592 67.72085 7.796

H0YD18 NUCB2 0.551343 0.921066 0.543678 73 8.61033 5.034

O00303 EIF3F 1.370267 1.308429 0.918465 357 37.54015 5.453

B4DXI5 HACL1 1.011871 0.775829 0.904438 496 54.68875 7.386

J3QT77 PON2 0.861767 0.894472 0.683039 342 37.95661 5.719

Q9NTJ5 SACM1L 0.965358 0.756503 0.77892 587 66.92401 7.123

of 313

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256

256

Q12907 LMAN2 0.983969 1.472574 0.593896 356 40.2031 6.947

Q8IV08 PLD3 0.73999 0.772273 0.894603 490 54.67051 6.468

Q13813-3 SPTAN1 1.139287 1.219372 1.1031 2452 282.108 5.338

K7EJE8 LONP1 0.829917 1.016024 0.519841 829 93.23797 6.494

B4DJ81 NDUFS1 0.974395 0.790292 0.38251 611 66.87901 5.376

Q12805-2 EFEMP1 0.801188 1.250061 0.854084 485 53.6867 5.021

B4DDG7 AP1M1 0.933933 1.013888 0.758721 351 40.22886 7.196

Q96N66-3 MBOAT7 0.846529 1.232302 0.640309 344 38.44495 8.866

P27449 ATP6V0C 0.967412 1.412399 0.842574 155 15.72546 8.441

G3V5Q1 APEX1 1.136659 1.255624 0.974198 242 27.10788 8.763

Q02809 PLOD1 0.877053 0.822037 0.784821 727 83.49739 6.947

G3V2B8 MTHFD1 1.347932 1.357394 1.207432 935 101.4673 7.298

Q8NC51-4 SERBP1 1.738228 1.416782 1.265482 387 42.40128 8.441

O60220 TIMM8A 0.68574 1.020334 0.682477 97 10.9913 5.161

P19338 NCL 1.040359 1.025532 0.933224 710 76.56836 4.704

Q9P0L0 VAPA 1.398465 1.527194 0.837129 249 27.87521 8.617

Q15043-2 SLC39A14 1.264436 1.01454 1.024396 481 52.80448 5.77

Q01813-2 PFKP 1.616762 1.886669 1.278092 776 85.26146 8.587

Q27J81-2 INF2 1.445221 1.514672 0.958636 1240 134.5334 5.529

Q96CW1-2 AP2M1 1.102053 1.818434 0.835605 433 49.35791 9.54

P49327 FASN 1.882644 1.564007 1.401742 2511 273.2543 6.443

Q9BTU6 PI4K2A 0.652547 1.177311 0.596076 479 53.98861 8.294

B4DT69 DLD 0.743285 0.989039 0.76888 461 49.25137 7.679

Q9UMX5 NENF 1.037892 1.048986 1.05816 172 18.84479 5.694

B4DLW8 DDX5 1.271055 1.583436 1.034134 535 60.52538 9.071

O00592-2 PODXL 1.223322 1.00787 0.985307 526 55.35142 5.58

O60701-2 UGDH 1.486766 2.369461 0.754955 427 47.57231 5.922

F5H7M3 DLAT 0.802293 0.975184 0.665679 418 44.6336 6.443

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257

257

Q92598-2 HSPH1 1.486035 1.487949 1.475798 814 92.05745 5.554

Q9UNN8 PROCR 0.910456 2.103759 0.758776 238 26.65458 7.181

B7Z5W8 DLST 0.903802 1.609263 0.387486 367 39.52787 9.554

F5H826 NOMO3 1.048414 0.90546 0.948643 1100 121.943 5.694

P46977 STT3A 0.920142 1.377587 0.849084 705 80.47685 8.075

M0QXF7 C19orf10 0.808628 1.538965 0.684605 84 9.663568 4.996

Q9BRQ8-2 AIFM2 1.285245 1.03152 0.868966 336 36.49731 9.261

D6RH20 MRPS27 0.929614 1.810816 0.631838 299 34.43659 5.58

Q14696 MESDC2 1.137482 0.851096 0.685203 234 26.06031 7.782

Q9UBR2 CTSZ 0.757963 0.79509 0.796878 303 33.84622 7.108

Q6PI48 DARS2 0.843445 1.476624 0.729804 645 73.5161 8.016

Q03519 TAP2 0.946329 1.038205 0.874849 686 75.61581 8.016

B4E2S7 LAMP2 0.649824 0.942853 0.612689 363 39.78684 5.668

E7ENA9 NCSTN 1.006023 1.166959 0.903849 451 50.22973 5.643

G3V1S6 GALNT2 1.260822 0.94241 1.033844 533 60.75543 7.65

Q01082-3 SPTBN1 1.179103 1.175346 0.976195 2155 251.2412 5.529

Q96TA1-2 FAM129B 1.326602 1.318136 1.052594 733 82.63093 6.151

Q5SZE1 CERS2 0.896112 0.877504 0.681865 324 38.49522 9.144

O60716-32 CTNND1 1.107563 1.054132 0.918675 589 65.60001 8.133

E9PNW8 FAR1 0.922818 1.628174 0.887954 335 37.45766 6.917

O15270 SPTLC2 0.755711 0.816155 1.022249 562 62.88386 7.782

O60831 PRAF2 0.940022 0.997831 0.994865 178 19.24552 9.188

Q9NZ01 TECR 0.768905 2.079845 0.833769 308 36.01078 9.452

Q9Y3A6 TMED5 1.077755 1.190711 0.91123 229 25.98819 4.843

P18206-2 VCL 1.768811 1.923924 0.879547 1066 116.6493 6.087

B4DWJ2 QARS 1.23714 1.016419 0.882057 764 86.52421 7.049

Q9BV43 PDIA5 0.924283 1.824159 0.774782 262 30.10461 8.924

P78310-2 CXADR 1.268586 0.901349 0.987165 344 38.09933 7.547

of 313

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258

P35908 KRT2 1.019978 0.856203 0.984704 639 65.39322 8.001

Q13724-2 MOGS 1.044736 1.298356 0.884982 731 80.65263 7.108

E7EQS5 DMD 1.264136 2.239666 1.017674 1225 141.3109 6.024

Q14204 DYNC1H1 1.372133 1.438188 1.102725 4646 532.0719 6.405

F5H801 OGDH 0.736426 0.751363 0.683379 974 110.5408 6.844

Q8WTV0-4 SCARB1 0.981031 1.959415 0.775127 474 53.54381 7.254

Q13217 DNAJC3 1.106552 1.231576 0.930653 504 57.54417 6.151

P11166 SLC2A1 1.158881 2.739135 1.030393 492 54.04854 8.719

O15144 ARPC2 1.214495 1.441681 1.216683 300 34.31149 7.357

P00367 GLUD1 0.984987 0.685172 0.798359 558 61.3592 7.796

K7EPU3 ALG1 1.189406 1.301771 0.942201 184 20.16157 9.627

P10909-4 CLU 0.598794 0.528685 0.836291 416 48.77213 6.712

B4DE85 PTDSS1 0.772263 1.585746 0.814046 301 34.55655 8.573

P41250 GARS 1.534113 2.499762 1.121268 739 83.11261 7.035

Q8NFJ5 GPRC5A 1.179067 0.938988 0.894057 357 40.22494 8.148

Q9BVC6 TMEM109 0.837747 0.910029 0.806986 243 26.19359 10.48

P07814 EPRS 1.67338 1.334158 1.198086 1512 170.4831 7.328

P23526 AHCY 2.047492 1.426446 1.124553 432 47.68521 6.341

F8VPD4 CAD 1.289825 1.263263 1.045123 2162 235.873 6.551

Q9UGP8 SEC63 1.14793 0.97752 0.798299 760 87.94161 5.313

B7Z4K6 DNASE2 0.844035 0.995393 0.799537 305 33.59369 8.324

Q15904 ATP6AP1 0.836096 2.193159 0.751944 470 51.9926 6.138

F5H241 GBA 0.762198 0.67644 0.702621 423 47.53423 7.284

Q8IVL5 LEPREL1 0.963144 0.645556 0.941739 708 80.93322 5.707

O43491-2 EPB41L2 1.141583 0.775995 0.84243 673 76.0062 6.961

P55809 OXCT1 0.658775 1.177417 0.862764 520 56.12193 7.459

F5H6I7 ATL3 1.017233 1.549397 0.876098 523 58.73556 5.643

O95782-2 AP2A1 1.081109 1.873053 0.967499 955 105.2947 7.665

of 313

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259

259

B4DFA2 NSF 1.065248 1.093724 0.943217 644 71.53859 6.654

P49419-2 ALDH7A1 1.027341 1.12307 0.784116 511 55.33146 6.859

Q15149-3 PLEC 1.022118 1.009423 0.914809 4570 517.7164 5.745

Q9NRP0 OSTC 0.925778 1.163102 0.770044 149 16.81784 9.129

C9JA28 SSR3 0.91842 0.838837 0.914319 174 20.14854 9.437

O94925-3 GLS 0.735102 1.370408 0.492763 598 65.41791 7.884

F6SBX2 IARS2 0.556246 0.910806 0.564131 940 105.972 6.481

O00754-2 MAN2B1 0.927828 1.266424 0.790621 1010 113.5443 7.284

P26599 PTBP1 0.736467 2.649674 0.992703 531 57.18564 9.173

P14174 MIF 2.19248 2.590372 1.522282 115 12.46822 7.884

Q15437 SEC23B 1.305768 1.528303 1.037696 767 86.42352 6.888

Q13492-4 PICALM 0.943702 1.707659 0.789813 551 59.88067 8.763

Q9UBM7 DHCR7 0.797564 1.126889 0.630026 475 54.45377 8.705

Q8TCT9-5 HM13 0.848698 0.908133 0.807801 335 36.79014 6.683

Q9Y320-2 TMX2 1.124285 0.908489 0.781832 258 29.62322 8.646

P10619 CTSA 0.835223 0.781734 0.877583 480 54.43112 6.61

P61221 ABCE1 1.247269 0.949353 1.371781 599 67.27102 8.338

R4GNE4 GPX4 1.106562 2.406508 0.853905 145 16.79655 11.17

Q8WY22 BRI3BP 1.050915 1.081041 0.939209 251 27.81784 9.437

F8VNT9 CD63 0.827565 0.902124 0.847852 133 14.2554 7.591

Q13283 G3BP1 1.486912 1.217856 0.988605 466 52.13208 5.516

Q6P1M0 SLC27A4 0.853427 1.015222 0.893677 643 72.01814 8.47

Q8TCS8 PNPT1 0.935007 0.860943 0.682558 783 85.89663 7.767

P48960-2 CD97 1.03104 1.360822 1.037025 742 81.68971 7.049

Q3ZCQ8 TIMM50 0.500185 0.762324 0.892433 353 39.62154 8.368

O43242 PSMD3 1.88696 1.325435 1.688353 534 60.93949 8.441

P62195-2 PSMC5 2.38722 2.219372 1.043626 398 44.75569 8.177

Q14126 DSG2 1.066754 1.050857 1.090291 1118 122.2176 5.237

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F8W785 GOLIM4 0.976545 0.554716 0.377185 668 78.71265 4.742

P48509 CD151 1.249102 1.275855 0.984759 253 28.27631 7.474

Q9UHG3 PCYOX1 0.929033 2.924772 0.827446 505 56.60375 6.176

C9J8H1 ATP6V1E1 1.196086 1.017794 1.007808 203 23.52457 9.042

O75695 RP2 1.002286 1.705551 0.852253 350 39.61546 5.123

P23381-2 WARS 1.348628 1.041668 1.090538 424 48.149 6.354

B7Z5H3 MAOB 0.323261 0.335428 0.837279 411 46.50874 8.28

F5H5L8 FOLR2 1.300796 1.108102 0.8732 148 16.88816 8.031

P08237-2 PFKM 1.527741 1.439542 1.192302 749 81.72348 7.621

E7EP00 SEC24C 1.438154 1.454381 0.929165 975 106.5557 6.961

Q86UP2-2 KTN1 1.059863 0.755916 0.84917 1300 149.5189 5.707

P53396-2 ACLY 1.956794 1.353749 0.965034 1091 119.6953 7.328

Q02241-2 KIF23 1.363701 0.723528 1.029325 856 98.04387 8.47

P53621 COPA 1.255575 2.758402 1.17627 1224 138.2579 7.665

B4DKB2 ECE1 0.901665 0.983185 0.8194 738 83.52037 5.732

Q13423 NNT 0.745853 1.130768 0.782389 1086 113.8226 8.089

O14656 TOR1A 0.950648 0.628824 0.885189 332 37.78448 6.991

E7ETE2 HARS 2.197545 1.357281 0.97029 288 31.91085 5.681

Q6UB35 MTHFD1L 0.833667 0.672985 0.661624 978 105.7237 8.06

P11498 PC 0.769836 0.785721 0.68265 1178 129.5514 6.844

Q15046 KARS 1.374057 1.354475 1.141872 597 68.0046 6.354

Q96QD5-2 DEPDC7 0.734628 0.896372 0.783459 502 57.66986 7.474

F8VZ44 AAAS 0.941853 3.431027 0.890853 422 45.60536 8.25

Q658P3-3 STEAP3 0.666776 1.300052 0.90822 487 54.43672 8.719

Q9UHL4 DPP7 0.709214 0.72615 0.961096 492 54.3072 6.316

E9PBU3 ATIC 0.75035 2.229868 1.301977 591 64.48327 6.712

P30825 SLC7A1 1.099557 2.246054 0.900764 629 67.59414 5.427

Q9Y251-3 HPSE 0.876007 1.24858 0.734405 469 53.12712 9.408

of 313

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261

261

P26639 TARS 2.209003 1.895454 1.444028 723 83.38187 6.668

M0R019 HNRNPM 1.243349 2.324147 0.865693 353 37.66014 9.027

F5H335 EIF3A 1.417245 1.878101 1.011005 1348 162.5373 6.771

O95373 IPO7 1.491394 1.391117 0.842853 1038 119.4399 4.818

F8WBJ7 TMEM245 0.706662 2.27177 0.925284 253 28.07817 8.309

O43747 AP1G1 0.791782 1.272935 0.790241 822 91.29313 6.8

Q92544 TM9SF4 1.094496 1.071672 0.989709 642 74.46967 6.537

P33897 ABCD1 1.18242 0.658384 1.044249 745 82.88451 8.954

B7Z7Q6 PRCP 0.979245 1.437204 0.792914 391 43.90565 6.303

Q14118 DAG1 1.191228 1.106221 0.913843 895 97.38067 8.558

Q5BKT4 ALG10 1.601853 0.904333 0.91813 473 55.569 9.291

Q5VXM9 RPF2 1.538456 3.678034 0.954767 208 24.14272 9.466

Q8TCJ2 STT3B 0.878647 1.167831 0.773816 826 93.61368 8.91

P15144 ANPEP 1.030734 1.223168 0.659249 967 109.4709 5.478

Q9Y4F1 FARP1 1.371267 1.269996 1.014068 1045 118.5587 8.148

O15118 NPC1 0.944163 0.426973 0.604628 1278 142.0736 5.364

P34932 HSPA4 0.929084 1.244466 1.460391 840 94.27124 5.186

Q8TB61-3 SLC35B2 0.649797 1.490369 0.617971 383 42.09994 9.349

O00400 SLC33A1 0.934608 0.745285 0.904505 549 60.86977 7.328

C9JYN0 SYPL1 1.043696 1.519212 0.738429 224 24.76769 7.137

O76024 WFS1 0.769325 0.714525 0.913139 890 100.227 8.045

J3QLE5 SNRPN 1.042236 2.600692 0.947268 169 17.53528 9.994

G3V325 ATP5J2-PTCD1 0.714803 1.230728 0.721681 749 84.05659 8.719

Q04637-5 EIF4G1 1.8386 1.106693 1.148944 1435 158.4189 5.211

P00846 MT-ATP6 0.76194 1.192226 0.677092 226 24.80086 10.1

C9JVB6 TRMT10C 0.561536 1.528128 0.853825 312 36.80495 9.159

Q99805 TM9SF2 1.093457 1.120914 0.835604 663 75.72547 7.445

B5AK60 ABCB1 1.236142 0.998213 0.96536 1216 133.9475 8.968

of 313

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262

O14975-2 SLC27A2 1.000942 1.179552 0.76783 567 64.57429 8.485

F5GWS8 HSPA13 0.802722 2.180864 0.747226 263 29.37337 6.537

P98082-2 DAB2 1.08965 0.683185 0.946441 552 58.82448 5.707

P11717 IGF2R 0.810536 0.739024 0.719584 2491 274.1988 5.935

Q9Y678 COPG1 1.755991 2.746038 1.335984 874 97.65547 5.465

P56199 ITGA1 1.245528 1.24296 0.926973 1179 130.7647 6.291

J3KR24 IARS 1.243357 1.489168 0.966796 1152 131.6797 6.113

O15031 PLXNB2 0.884686 0.954203 1.197259 1838 204.9972 6.24

P06756-3 ITGAV 1.112174 2.333825 1.00193 1002 111.061 5.618

P07942 LAMB1 0.917401 1.458926 0.790964 1786 197.9086 4.945

F5GZJ1 NCAPD2 1.388116 1.829292 1.035389 1356 152.0786 6.698

Q9HD20-2 ATP13A1 0.814919 0.731475 0.902841 1086 121.0323 7.752

O60313 OPA1 0.466151 0.235485 0.627159 960 111.5608 7.87

Q969Z3-2 MARC2 1.346595 1.462994 1.005974 257 29.0841 9.789

Q8TAA9-2 VANGL1 1.016921 1.379496 1.111753 522 59.71011 8.807

O60942-3 RNGTT 1.188726 1.997955 1.070606 457 52.49949 8.016

Q5VVW2-3 GARNL3 1.283904 1.231963 1.148944 423 48.74479 8.983

Q14247-3 CTTN 0.97738 1.562945 1.075739 513 57.43154 5.326

Q14789 GOLGB1 1.210601 1.014396 1.020317 3259 375.7897 4.996

Q9NZP5 OR5AC2 1.502034 1.906181 1.133634 309 35.28065 8.939

Q9ULE4 FAM184B 1.507056 1.11878 1.110085 1060 120.9693 6.176

Q7Z5H4 VN1R5 1.273724 1.829477 1.051904 357 40.75162 9.203

H7BZL6 FSIP2 1.445189 1.438729 1.026572 973 109.7977 8.602

Q5TCU6 TLN1 0.731978 1.460834 1.061228 2429 257.9205 6.494

P0C221-2 CCDC175 1.832305 1.077196 0.989715 792 93.46618 6.712

P19320-2 VCAM1 1.771415 1.27599 1.431126 647 71.20937 5.173

E9PCY5 TOP2B 0.838857 0.977699 0.846456 1150 130.3978 8.47

Q8WXE9 STON2 1.408436 1.354522 1.067901 905 101.1015 5.389

of 313

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263

263

Q01970-2 PLCB3 1.248443 1.07296 1.068852 1167 131.1238 5.884

P42858 HTT 1.459612 1.276072 1.126057 3142 347.3828 6.202

of 313

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Table S5. Differentially abundant proteins

Increased Proteins

Accession Gene Name A: 131/128 B: 131/128 C: 131/128 average AAs MW [kDa] calc. pI

P07737 PFN1 1.938756 2.252394 1.344145 1.845098 140 15.04456 8.265

P06733 ENO1 1.914614 1.758462 1.405665 1.692913 434 47.13932 7.386

P04083 ANXA1 2.266094 1.746823 1.194763 1.735893 346 38.68998 7.02

P22392-2 NME2 2.124502 1.754569 1.124689 1.66792 267 30.11763 8.924

P62937 PPIA 1.581094 1.657079 1.266474 1.501549 165 18.00089 7.811

Q9BQE3 TUBA1C 2.489466 1.571135 1.267975 1.776192 449 49.86346 5.097

P07437 TUBB 2.198372 1.65089 1.379771 1.743011 444 49.63897 4.894

P68371 TUBB4B 2.190046 1.825049 1.414922 1.810006 445 49.799 4.894

P08758 ANXA5 2.55048 2.027943 1.387868 1.988763 320 35.9144 5.046

P08238 HSP90AB1 2.032999 1.859231 1.041987 1.644739 724 83.21211 5.034

P11142 HSPA8 1.676814 1.507196 1.091932 1.425314 646 70.85423 5.516

P14618 PKM 2.153361 2.370428 1.58462 2.036136 531 57.90003 7.84

A8MUB1 TUBA4A 2.036923 2.142278 1.476961 1.885387 433 48.2976 5.008

P63104 YWHAZ 1.862614 2.023601 2.525793 2.137336 245 27.72773 4.792

P07195 LDHB 1.964997 1.817951 1.455855 1.746268 334 36.61514 4.792

P07900 HSP90AA1 1.836656 1.700895 1.059922 1.532491 732 84.60669 5.021

P27348 YWHAQ 1.639264 1.764708 1.701986 245 27.74677 4.78

P46781 RPS9 1.596054 1.646443 1.137516 1.460004 194 22.57756 10.65

P09211 GSTP1 2.264256 1.306028 1.773251 1.781178 210 23.34102 5.643

P13639 EEF2 1.692874 2.529139 1.184579 1.802197 858 95.27695 6.83

P00966 ASS1 1.839589 1.676893 1.362175 1.626219 412 46.50097 8.016

B4DP11 PTGES3 1.681728 2.155438 1.223253 1.686806 139 16.46559 4.805

P10599-2 TXN 1.730395 1.578375 1.437973 1.582248 85 9.445685 6.037

B4DT77 ANXA7 1.799431 2.522988 1.392255 1.904891 336 37.78092 7.181

of 313

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P00338 LDHA 1.812565 2.760047 1.429861 2.000824 332 36.66536 8.265

P62280 RPS11 1.662973 1.502607 1.097377 1.420985 158 18.41899 10.3

P30041 PRDX6 2.172555 2.201779 1.531302 1.968545 224 25.01919 6.379

M0R210 RPS16 1.69377 1.999538 1.206613 1.633307 129 14.40996 10.23

P60842 EIF4A1 1.965905 2.235364 1.377883 1.859717 406 46.12456 5.478

P04792 HSPB1 1.745388 1.579063 1.377766 1.567406 205 22.76849 6.405

R4GMU8 LAMTOR5 1.802162 1.58376 1.692961 79 8.210105 5.681

P47813 EIF1AX 1.885051 1.752925 1.039483 1.559153 144 16.45023 5.237

P12277 CKB 1.649735 3.416205 1.579158 2.215033 381 42.61732 5.592

K7ELW0 PARK7 1.709521 1.716847 1.713184 169 17.89849 7.87

P11940-2 PABPC1 1.51283 1.56743 0.845456 1.308572 547 61.14204 9.071

O43175 PHGDH 1.747724 2.068921 1.496959 1.771201 533 56.61441 6.712

Q9BUF5 TUBB6 1.672282 2.65095 1.110157 1.81113 446 49.825 4.881

P31949 S100A11 2.030099 1.585923 1.773105 1.796376 105 11.73283 7.123

P07741-2 APRT 1.912567 1.645471 1.779019 134 14.54781 7.342

B4DLR8 NQO1 1.86144 2.576048 1.108224 1.848571 202 22.7789 8.5

P60891 PRPS1 2.22903 1.813701 1.35476 1.799164 318 34.81193 6.976

J3KNJ2 EIF3M 1.620833 2.034655 1.076182 1.577224 191 21.67855 7.767

P09382 LGALS1 1.711321 2.920376 2.315849 135 14.7062 5.503

P18669 PGAM1 3.402846 2.572908 1.775781 2.583845 254 28.78584 7.181

P43487 RANBP1 1.57851 2.930969 2.310803 2.273427 201 23.29557 5.288

D6RA82 ANXA3 2.968576 2.210312 1.509352 2.229413 284 32.09853 5.935

Q01813-2 PFKP 1.616762 1.886669 1.278092 1.593841 776 85.26146 8.587

P49327 FASN 1.882644 1.564007 1.401742 1.616131 2511 273.2543 6.443

P18206-2 VCL 1.768811 1.923924 0.879547 1.524094 1066 116.6493 6.087

P41250 GARS 1.534113 2.499762 1.121268 1.718381 739 83.11261 7.035

P14174 MIF 2.19248 2.590372 1.522282 2.101711 115 12.46822 7.884

O43242 PSMD3 1.88696 1.325435 1.688353 1.633583 534 60.93949 8.441

of 313

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P62195-2 PSMC5 2.38722 2.219372 1.043626 1.883406 398 44.75569 8.177

O43776 NARS 1.611823 1.831599 1.721711 548 62.90252 6.252

P26639 TARS 2.209003 1.895454 1.444028 1.849495 723 83.38187 6.668

Q5VXM9 RPF2 1.538456 3.678034 0.954767 2.057086 208 24.14272 9.466

B4DR63 PSMC1 1.705552 1.869939 1.787746 367 41.1412 5.008

P54577 YARS 1.594293 1.83622 1.715257 528 59.1061 7.049

P49588 AARS 1.528437 1.649384 1.588911 968 106.7432 5.529

P20839-2 IMPDH1 1.951442 1.657952 1.804697 489 52.56405 6.639

Q9Y678 COPG1 1.755991 2.746038 1.335984 1.946004 874 97.65547 5.465

B4DUC5 CSE1L 1.779767 1.741506 1.760637 754 85.4181 5.478

Q9NZP5 OR5AC2 1.502034 1.906181 1.133634 1.51395 309 35.28065 8.939

Decreased Proteins

Accession Gene Name A: 131/128 B: 131/128 C: 131/128 average # AAs MW [kDa] calc. pI

P14854 COX6B1 0.757329 0.370079 0.408104 0.511837 86 10.18572 7.049

P56385 ATP5I 0.656519 0.355847 0.61265 0.541672 69 7.928326 9.349

P38646 HSPA9 0.643269 0.744843 0.621853 0.669988 679 73.63478 6.164

O43852 CALU 0.757461 0.647413 0.615452 0.673442 315 37.08354 4.64

F8W1A4 AK2 0.895767 0.521958 0.570225 0.66265 232 25.61431 7.826

H7BYD0 NDUFA5 0.473911 0.506902 0.490407 112 13.08984 5.148

P13073 COX4I1 0.483846 0.765167 0.556132 0.601715 169 19.56405 9.51

P56381 ATP5E 0.520223 0.661011 0.590617 51 5.776108 9.92

P24752 ACAT1 0.638064 0.687537 0.508238 0.61128 427 45.17065 8.851

Q07021 C1QBP 0.539476 0.617432 0.63902 0.598643 282 31.34261 4.843

P51809 VAMP7 0.593834 1.216902 0.666516 0.825751 220 24.91897 8.602

Q8NE86-3 MCU 0.419177 1.259917 0.395554 0.691549 302 35.13636 7.489

P53007 SLC25A1 0.657693 0.838483 0.552905 0.683027 311 33.991 9.891

C9JFR7 CYCS 0.500598 0.686837 0.429284 0.538906 101 11.32596 9.657

of 313

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C9IZ01 GFM1 0.587804 0.935326 0.620201 0.714444 591 65.9928 8.06

P13284 IFI30 0.963744 0.568155 0.601458 0.711119 250 27.94501 4.881

O75439 PMPCB 0.659306 0.939695 0.498041 0.699014 489 54.3315 6.83

Q7Z650 MTHFD2 0.605882 0.492332 1.147144 0.748453 248 26.83225 7.181

H0YD18 NUCB2 0.551343 0.921066 0.543678 0.672029 73 8.61033 5.034

Q9BTU6 PI4K2A 0.652547 1.177311 0.596076 0.808645 479 53.98861 8.294

B4E2S7 LAMP2 0.649824 0.942853 0.612689 0.735122 363 39.78684 5.668

Q9Y2R0 COA3 0.623199 0.654097 0.638648 106 11.72413 9.598

P10909-4 CLU 0.598794 0.528685 0.836291 0.65459 416 48.77213 6.712

Q86SX6 GLRX5 0.514122 0.561141 0.537631 157 16.61754 6.786

F6SBX2 IARS2 0.556246 0.910806 0.564131 0.677061 940 105.972 6.481

O43837-2 IDH3B 0.658972 0.485092 0.572032 383 41.86035 7.591

F8W785 GOLIM4 0.976545 0.554716 0.377185 0.636148 668 78.71265 4.742

B7Z5H3 MAOB 0.323261 0.335428 0.837279 0.498656 411 46.50874 8.28

Q16795 NDUFA9 0.566084 0.292001 0.429042 377 42.48257 9.803

F5H5G8 SUCLA2 0.553651 0.361274 0.304975 329 36.0117 5.389

O15118 NPC1 0.944163 0.426973 0.604628 0.658588 1278 142.0736 5.364

Q8TB61-3 SLC35B2 0.649797 1.490369 0.617971 0.919379 383 42.09994 9.349

Q9Y4W6 AFG3L2 0.58911 0.37502 0.482065 797 88.52819 8.661

F5H5E2 PLBD2 0.581519 0.596116 0.588818 557 61.84515 6.8

O60313 OPA1 0.466151 0.235485 0.627159 0.442931 960 111.5608 7.87

P03891 MT-ND2 0.52364 0.559293 0.541467 347 38.93475 9.833

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268

268

Table S6. Results analyzed with GeneCoDis3

Biological Process

Id Items Items_Details Support

(size: 94)

Reference

Support (size:

34208)

Hyp Hyp_c Genes

1 GO:0006915 apoptotic process (BP) 8 594 2E-04 0.003 PSMC5,PSMC1,CSE1L,YARS,LGALS

1,OPA1,CYCS,PSMD3

2 GO:0009615 response to virus (BP) 3 144 0.007 0.027 CLU,HSPB1,ENO1

4 GO:0007165 signal transduction (BP) 11 1176 4E-04 0.005 PTGES3,RANBP1,HSP90AA1,TXN,Y

WHAZ,YARS,SLC35B2,LGALS1,S100

A11,ANXA5,ANXA1

11 GO:0006508 proteolysis (BP) 5 543 0.017 0.04 PSMC5,PSMC1,PMPCB,AFG3L2,PAR

K7

13 GO:0008283 cell proliferation (BP) 5 312 0.002 0.013 PTGES3,MIF,TXN,CSE1L,ANXA7

15 GO:0006986 response to unfolded protein (BP) 4 51 1E-05 3E-04 HSPB1,HSP90AA1,HSPA8,HSP90AB1

16 GO:0006810 transport (BP) 6 604 0.006 0.024 SLC25A1,GOLIM4,TXN,CYCS,NDUF

A5,NDUFA9

20 GO:0051384 response to glucocorticoid

stimulus (BP)

3 84 0.002 0.013 ASS1,ANXA3,ANXA1

23 GO:0045087 innate immune response (BP) 4 309 0.011 0.032 CLU,MIF,TXN,HSP90AB1

26 GO:0043065 positive regulation of apoptotic

process (BP)

3 178 0.013 0.036 CLU,ANXA5,ANXA1

35 GO:0045892 negative regulation of

transcription, DNA-dependent

(BP)

4 401 0.025 0.049 YWHAQ,PSMC5,ENO1,HSPA8

36 GO:0042493 response to drug (BP) 6 301 2E-04 0.003 MAOB,ASS1,YWHAZ,LGALS1,PARK

7,ANXA1

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37 GO:0021680 cerebellar Purkinje cell layer

development (BP)

1 9 0.024 0.048 AARS

39 GO:0005975 carbohydrate metabolic process

(BP)

5 290 0.001 0.011 SLC25A1,PRPS1,ENO1,PGAM1,PFKP

40 GO:0006418 tRNA aminoacylation for protein

translation (BP)

6 43 2E-09 2E-07 GARS,NARS,TARS,YARS,IARS2,AA

RS

41 GO:0010467 gene expression (BP) 13 408 1E-10 3E-08 RPS16,EEF2,GARS,NARS,TARS,PAB

PC1,RPS9,YARS,IARS2,EIF4A1,AAR

S,RPS11,EIF1AX

42 GO:0006414 translational elongation (BP) 4 93 1E-04 0.002 RPS16,EEF2,RPS9,RPS11

44 GO:0055086 nucleobase-containing small

molecule metabolic process (BP)

4 77 6E-05 0.001 TXN,NME2,IMPDH1,APRT

45 GO:0015949 nucleobase-containing small

molecule interconversion (BP)

2 18 0.001 0.01 TXN,NME2

49 GO:0007596 blood coagulation (BP) 10 457 5E-07 2E-05 C1QBP,PPIA,TUBA4A,CLU,YWHAZ,

CALU,VCL,PFN1,ANXA5,LAMP2

56 GO:0006805 xenobiotic metabolic process

(BP)

3 136 0.006 0.024 MAOB,NQO1,GSTP1

58 GO:0007584 response to nutrient (BP) 2 89 0.025 0.049 ASS1,COX4I1

60 GO:0031325 positive regulation of cellular

metabolic process (BP)

1 9 0.024 0.048 FASN

61 GO:0031018 endocrine pancreas development

(BP)

5 121 2E-05 5E-04 RPS16,CLU,RPS9,RPS11,ANXA1

62 GO:0006006 glucose metabolic process (BP) 4 98 2E-04 0.002 SLC25A1,ENO1,PGAM1,PFKP

64 GO:0006096 glycolysis (BP) 5 45 2E-07 8E-06 LDHB,ENO1,LDHA,PGAM1,PFKP

67 GO:0002474 antigen processing and

presentation of peptide antigen

via MHC class I (BP)

3 94 0.002 0.016 PSMC5,PSMC1,PSMD3

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69 GO:0044267 cellular protein metabolic process

(BP)

10 284 6E-09 4E-07 TUBA1C,RPS16,EEF2,TUBA4A,TUB

B6,PABPC1,RPS9,EIF4A1,RPS11,EIF1

AX

70 GO:0048545 response to steroid hormone

stimulus (BP)

2 23 0.002 0.013 MAOB,ASS1

71 GO:0043200 response to amino acid stimulus

(BP)

2 29 0.003 0.015 AARS,GSTP1

75 GO:0000209 protein polyubiquitination (BP) 3 107 0.003 0.017 PSMC5,PSMC1,PSMD3

79 GO:0008652 cellular amino acid biosynthetic

process (BP)

2 34 0.004 0.02 ASS1,PHGDH

80 GO:0006564 L-serine biosynthetic process

(BP)

1 4 0.011 0.03 PHGDH

84 GO:0006950 response to stress (BP) 4 155 9E-04 0.009 HSPB1,HSP90AA1,HSPA8,HSP90AB1

87 GO:0051258 protein polymerization (BP) 4 29 1E-06 4E-05 TUBA1C,TUBB,TUBA4A,TUBB6

88 GO:0007018 microtubule-based movement

(BP)

4 90 1E-04 0.002 TUBA1C,TUBB,TUBA4A,TUBB6

89 GO:0006412 translation (BP) 8 241 4E-07 1E-05 RPS16,EEF2,TARS,PABPC1,RPS9,EIF

4A1,RPS11,EIF1AX

90 GO:0006413 translational initiation (BP) 2 41 0.006 0.022 EIF3M,EIF1AX

92 GO:0000278 mitotic cell cycle (BP) 6 304 2E-04 0.003 TUBB,TUBA4A,PSMC5,PSMC1,HSP9

0AA1,PSMD3

93 GO:0000082 G1/S transition of mitotic cell

cycle (BP)

3 145 0.008 0.027 PSMC5,PSMC1,PSMD3

94 GO:0000084 S phase of mitotic cell cycle (BP) 3 112 0.004 0.019 PSMC5,PSMC1,PSMD3

97 GO:0071222 cellular response to

lipopolysaccharide (BP)

2 43 0.006 0.023 ASS1,GSTP1

103 GO:0022904 respiratory electron transport

chain (BP)

7 86 4E-09 3E-07 COX6B1,COX4I1,ATP5E,ATP5I,CYC

S,NDUFA5,NDUFA9

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proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

271

271

104 GO:0006120 mitochondrial electron transport,

NADH to ubiquinone (BP)

2 36 0.004 0.022 NDUFA5,NDUFA9

106 GO:0055114 oxidation-reduction process (BP) 8 233 3E-07 1E-05 COX6B1,TXN,PHGDH,IDH3B,PARK7

,IMPDH1,MTHFD2,NDUFA9

109 GO:0006916 anti-apoptosis (BP) 7 200 1E-06 4E-05 CLU,HSPB1,YWHAZ,HSPA9,ANXA5,

ANXA1,GSTP1

114 GO:0042981 regulation of apoptotic process

(BP)

4 205 0.003 0.017 PSMC5,PSMC1,LGALS1,PSMD3

125 GO:0016070 RNA metabolic process (BP) 11 257 1E-10 2E-08 RPS16,PSMC5,PSMC1,HSPB1,PABPC

1,RPS9,YWHAZ,HSPA8,EIF4A1,RPS1

1,PSMD3

126 GO:0043066 negative regulation of apoptotic

process (BP)

6 272 1E-04 0.002 CLU,HSPB1,MIF,NME2,ANXA1,GST

P1


interleukin-1 beta production

(BP)

1 5 0.014 0.034 GSTP1


ubiquitin-protein ligase activity

involved in mitotic cell cycle

(BP)

3 65 8E-04 0.009 PSMC5,PSMC1,PSMD3

131 GO:0016032 viral reproduction (BP) 8 329 4E-06 1E-04 RPS16,PPIA,PSMC5,RANBP1,PSMC1,

RPS9,RPS11,PSMD3

132 GO:0051437 positive regulation of

ubiquitin-protein ligase activity

involved in mitotic cell cycle

(BP)

3 71 0.001 0.01 PSMC5,PSMC1,PSMD3

134 GO:0034641 cellular nitrogen compound


7 200 1E-06 4E-05 ACAT1,CKB,ASS1,PSMC5,PSMC1,N

QO1,PSMD3

of 313

Ant

ioxi

dant

s &

Red

ox S

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Pero

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doxi

n 6

is a

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fac

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and

proo

f co

rrec

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The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

272

272

135 GO:0031145 anaphase-promoting

complex-dependent proteasomal

ubiquitin-dependent protein

catabolic process (BP)

3 80 0.001 0.012 PSMC5,PSMC1,PSMD3

136 GO:0051439 regulation of ubiquitin-protein

ligase activity involved in mitotic

cell cycle (BP)

3 75 0.001 0.01 PSMC5,PSMC1,PSMD3

137 GO:0006977 DNA damage response, signal

transduction by p53 class

mediator resulting in cell cycle

arrest (BP)

3 66 8E-04 0.009 PSMC5,PSMC1,PSMD3

138 GO:0000216 M/G1 transition of mitotic cell

cycle (BP)

3 78 0.001 0.011 PSMC5,PSMC1,PSMD3

139 GO:0016071 mRNA metabolic process (BP) 11 223 3E-11 1E-08 RPS16,PSMC5,PSMC1,HSPB1,PABPC

1,RPS9,YWHAZ,HSPA8,EIF4A1,RPS1

1,PSMD3

140 GO:0006521 regulation of cellular amino acid


4 51 1E-05 3E-04 PSMC5,PSMC1,NQO1,PSMD3

141 GO:0000075 cell cycle checkpoint (BP) 3 131 0.006 0.022 PSMC5,PSMC1,PSMD3

142 GO:0006911 phagocytosis, engulfment (BP) 1 9 0.024 0.048 VAMP7

143 GO:0006457 protein folding (BP) 9 182 2E-09 2E-07 TUBA1C,PPIA,TUBA4A,TUBB6,HSP

90AA1,HSPA8,AARS,HSPA9,HSP90A

B1

148 GO:0006200 ATP catabolic process (BP) 6 82 1E-07 6E-06 PSMC5,PSMC1,HSP90AA1,HSPA8,A

TP5E,ATP5I

149 GO:0071363 cellular response to growth factor

stimulus (BP)

2 46 0.007 0.026 CLU,PFN1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

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doxi

n 6

is a

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itial

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p of

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aran

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.108

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Thi

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and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

273

273

150 GO:0051260 protein homooligomerization

(BP)

2 86 0.024 0.049 ACAT1,ANXA5

151 GO:0042776 mitochondrial ATP synthesis

coupled proton transport (BP)

2 13 6E-04 0.007 ATP5E,ATP5I

154 GO:0008629 induction of apoptosis by

intracellular signals (BP)

2 43 0.006 0.023 CLU,CYCS

155 GO:0030168 platelet activation (BP) 8 234 3E-07 1E-05 PPIA,TUBA4A,CLU,YWHAZ,CALU,

VCL,PFN1,LAMP2

163 GO:0051054 positive regulation of DNA


2 3 2E-05 5E-04 ANXA3,PFN1

165 GO:0031100 organ regeneration (BP) 3 53 4E-04 0.005 EIF4A1,ANXA3,GSTP1

169 GO:0008219 cell death (BP) 4 156 9E-04 0.009 GARS,CLU,HSPB1,AFG3L2

171 GO:0032355 response to estradiol stimulus

(BP)

3 89 0.002 0.014 ASS1,ANXA1,GSTP1

176 GO:0045454 cell redox homeostasis (BP) 2 55 0.01 0.031 GLRX5,TXN

182 GO:0006164 purine nucleotide biosynthetic

process (BP)

2 18 0.001 0.01 PRPS1,IMPDH1

183 GO:0006144 purine base metabolic process

(BP)

3 34 1E-04 0.002 PRPS1,IMPDH1,APRT

192 GO:0006415 translational termination (BP) 3 87 0.002 0.014 RPS16,RPS9,RPS11

193 GO:0019058 viral infectious cycle (BP) 3 91 0.002 0.014 RPS16,RPS9,RPS11

194 GO:0019083 viral transcription (BP) 3 82 0.002 0.012 RPS16,RPS9,RPS11


coagulation (BP)

1 4 0.011 0.03 ANXA5

196 GO:0044255 cellular lipid metabolic process

(BP)

3 128 0.005 0.026 SLC25A1,ACAT1,FASN

198 GO:0006221 pyrimidine nucleotide

biosynthetic process (BP)

1 7 0.019 0.041 PRPS1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

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fac

tor

in th

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itial

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p of

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dria

l cle

aran

ce a

nd is

ups

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pat

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.108

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Thi

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and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

274

274

199 GO:0007420 brain development (BP) 3 179 0.013 0.037 ACAT1,CKB,PHGDH

200 GO:0006892 post-Golgi vesicle-mediated

transport (BP)

2 40 0.005 0.026 HSPA8,VAMP7

202 GO:0000086 G2/M transition of mitotic cell

cycle (BP)

3 115 0.004 0.02 TUBB,TUBA4A,HSP90AA1

206 GO:0006166 purine ribonucleoside salvage

(BP)

1 4 0.011 0.03 APRT

207 GO:0045964 positive regulation of dopamine


1 3 0.008 0.026 MAOB

208 GO:0006168 adenine salvage (BP) 1 3 0.008 0.026 APRT

210 GO:0009116 nucleoside metabolic process

(BP)

2 16 9E-04 0.009 PRPS1,APRT

211 GO:0046651 lymphocyte proliferation (BP) 1 5 0.014 0.034 IMPDH1

215 GO:0006979 response to oxidative stress (BP) 3 110 0.004 0.018 PRDX6,CLU,NQO1

216 GO:0046952 ketone body catabolic process

(BP)

1 4 0.011 0.03 ACAT1

218 GO:0006914 autophagy (BP) 2 48 0.008 0.027 NPC1,PARK7

219 GO:0050821 protein stabilization (BP) 3 53 4E-04 0.005 IFI30,CLU,PARK7

220 GO:0006094 gluconeogenesis (BP) 3 42 2E-04 0.003 SLC25A1,ENO1,PGAM1

222 GO:0006928 cellular component movement

(BP)

5 95 7E-06 2E-04 TUBB,HSPB1,TXN,VCL,ANXA1

224 GO:0001843 neural tube closure (BP) 2 51 0.009 0.027 PFN1,OPA1

226 GO:0009636 response to toxin (BP) 3 71 0.001 0.01 MAOB,NQO1,GSTP1

230 GO:0010033 response to organic substance

(BP)

2 45 0.007 0.025 PFN1,ANXA5

231 GO:0043588 skin development (BP) 2 43 0.006 0.023 PTGES3,AARS

232 GO:0002576 platelet degranulation (BP) 7 79 2E-09 2E-07 PPIA,TUBA4A,CLU,CALU,VCL,PFN1

,LAMP2

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

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pat

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(do

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.108

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336)

Thi

s ar

ticle

has

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n pe

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and

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and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

275

275

235 GO:0030163 protein catabolic process (BP) 3 41 2E-04 0.003 PSMC5,PSMC1,AFG3L2

236 GO:0043312 neutrophil degranulation (BP) 2 5 7E-05 0.001 ANXA3,VAMP7

239 GO:0007005 mitochondrion organization (BP) 2 30 0.003 0.016 PARK7,OPA1

245 GO:0022900 electron transport chain (BP) 2 42 0.006 0.023 TXN,CYCS

250 GO:0090136 epithelial cell-cell adhesion (BP) 1 8 0.022 0.045 VCL

252 GO:0042535 positive regulation of tumor

necrosis factor biosynthetic

process (BP)

1 9 0.024 0.048 HSPB1

259 GO:0006633 fatty acid biosynthetic process

(BP)

2 53 0.009 0.029 PTGES3,FASN

260 GO:0001516 prostaglandin biosynthetic

process (BP)

2 15 8E-04 0.009 PTGES3,MIF

267 GO:0051084 'de novo' posttranslational protein

folding (BP)

3 36 1E-04 0.002 TUBA1C,TUBA4A,TUBB6

268 GO:0030644 cellular chloride ion homeostasis

(BP)

1 4 0.011 0.03 CKB

273 GO:2000060 positive regulation of protein

ubiquitination involved in

ubiquitin-dependent protein

catabolic process (BP)

1 7 0.019 0.041 CLU


presentation of exogenous

peptide antigen via MHC class II

(BP)

1 7 0.019 0.041 IFI30

281 GO:0006090 pyruvate metabolic process (BP) 2 21 0.002 0.012 LDHB,LDHA

284 GO:0001889 liver development (BP) 2 75 0.018 0.042 ACAT1,ASS1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

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p of

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l cle

aran

ce a

nd is

ups

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e PI

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pat

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(do

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.108

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Thi

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ticle

has

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and

acc

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atio

n, b

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and

proo

f co

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The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

276

276


interleukin-1 beta production

(BP)

1 5 0.014 0.034 HSPB1

287 GO:0006428 isoleucyl-tRNA aminoacylation

(BP)

1 2 0.005 0.022 IARS2

292 GO:0071460 cellular response to cell-matrix

adhesion (BP)

1 4 0.011 0.03 GSTP1

295 GO:0019047 provirus integration (BP) 1 8 0.022 0.045 PPIA

297 GO:0000302 response to reactive oxygen

species (BP)

1 9 0.024 0.048 GSTP1

298 GO:0000288 nuclear-transcribed mRNA

catabolic process,

deadenylation-dependent decay

(BP)

2 48 0.008 0.027 PABPC1,EIF4A1

301 GO:0000266 mitochondrial fission (BP) 1 6 0.016 0.038 OPA1

304 GO:0045429 positive regulation of nitric oxide


2 27 0.003 0.017 HSP90AA1,HSP90AB1

305 GO:0043122 regulation of I-kappaB

kinase/NF-kappaB cascade (BP)

1 9 0.024 0.048 HSPB1

306 GO:0033591 response to L-ascorbic acid (BP) 1 8 0.022 0.045 GSTP1

310 GO:0002674 negative regulation of acute

inflammatory response (BP)

2 6 1E-04 0.002 ANXA1,GSTP1

311 GO:0050709 negative regulation of protein

secretion (BP)

1 9 0.024 0.048 ANXA1

312 GO:0044262 cellular carbohydrate metabolic

process (BP)

2 10 3E-04 0.004 LDHB,LDHA

314 GO:0042026 protein refolding (BP) 1 7 0.019 0.041 HSP90AA1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

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in th

e in

itial

ste

p of

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dria

l cle

aran

ce a

nd is

ups

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(do

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.108

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Thi

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has

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and

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proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

277

277


nitric-oxide synthase biosynthetic

process (BP)

1 3 0.008 0.026 GSTP1

324 GO:0071364 cellular response to epidermal

growth factor stimulus (BP)

1 8 0.022 0.045 GSTP1

327 GO:0070301 cellular response to hydrogen

peroxide (BP)

2 23 0.002 0.013 PARK7,ANXA1

333 GO:0060206 estrous cycle phase (BP) 1 5 0.014 0.034 ANXA1


kinase activity (BP)

2 49 0.008 0.028 HSPB1,GSTP1

340 GO:0006165 nucleoside diphosphate

phosphorylation (BP)

1 5 0.014 0.034 NME2

343 GO:0007017 microtubule-based process (BP) 2 18 0.001 0.01 TUBA1C,TUBB

344 GO:0019432 triglyceride biosynthetic process

(BP)

2 33 0.004 0.019 SLC25A1,FASN

345 GO:0043297 apical junction assembly (BP) 1 7 0.019 0.041 VCL

348 GO:0045040 protein import into mitochondrial

outer membrane (BP)

1 4 0.011 0.03 HSP90AA1

352 GO:0006002 fructose 6-phosphate metabolic

process (BP)

1 7 0.019 0.041 PFKP

353 GO:0030388 fructose 1,6-bisphosphate


1 6 0.016 0.038 PFKP

354 GO:0002218 activation of innate immune

response (BP)

2 45 0.007 0.025 TXN,HSP90AB1

355 GO:0035338 long-chain fatty-acyl-CoA


2 18 0.001 0.01 SLC25A1,FASN

358 GO:0071157 negative regulation of cell cycle

arrest (BP)

1 9 0.024 0.048 MIF

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

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e PI

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pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

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n pe

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and

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n, b

ut h

as y

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yedi

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and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

278

278

360 GO:0051561 elevation of mitochondrial

calcium ion concentration (BP)

1 5 0.014 0.034 MCU

361 GO:0035786 protein complex oligomerization

(BP)

1 1 0.003 0.015 MCU

362 GO:0006851 mitochondrial calcium ion

transport (BP)

1 2 0.005 0.022 MCU

366 GO:0035726 common myeloid progenitor cell

proliferation (BP)

1 1 0.003 0.015 GSTP1

367 GO:0010804 negative regulation of tumor

necrosis factor-mediated

signaling pathway (BP)

1 4 0.011 0.03 GSTP1



1 2 0.005 0.022 GSTP1

370 GO:0060547 negative regulation of necrotic

cell death (BP)

1 4 0.011 0.03 GSTP1

372 GO:0071638 negative regulation of monocyte

chemotactic protein-1 production

(BP)

1 1 0.003 0.015 GSTP1

374 GO:0032872 regulation of stress-activated

MAPK cascade (BP)

1 6 0.016 0.038 GSTP1


stress-activated MAPK cascade

(BP)

1 6 0.016 0.038 GSTP1

376 GO:0035732 nitric oxide storage (BP) 1 1 0.003 0.015 GSTP1

378 GO:0032930 positive regulation of superoxide

anion generation (BP)

1 5 0.014 0.034 GSTP1

379 GO:0070664 negative regulation of leukocyte

proliferation (BP)

1 1 0.003 0.015 GSTP1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

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(do

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.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

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and

acc

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d fo

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n, b

ut h

as y

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yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

279

279

380 GO:0048147 negative regulation of fibroblast

proliferation (BP)

2 20 0.001 0.012 IFI30,GSTP1


proteasomal ubiquitin-dependent

protein catabolic process (BP)

1 7 0.019 0.041 HSP90AB1

382 GO:0042921 glucocorticoid receptor signaling

pathway (BP)

1 8 0.022 0.045 PTGES3

383 GO:0010739 positive regulation of protein

kinase A signaling cascade (BP)

1 5 0.014 0.034 MIF

384 GO:0060081 membrane hyperpolarization

(BP)

1 5 0.014 0.034 PARK7

386 GO:0030705 cytoskeleton-dependent

intracellular transport (BP)

2 5 7E-05 0.001 TUBA1C,TUBB

388 GO:0006110 regulation of glycolysis (BP) 1 6 0.016 0.038 PGAM1

391 GO:0042063 gliogenesis (BP) 1 3 0.008 0.026 ANXA1

393 GO:0006400 tRNA modification (BP) 1 8 0.022 0.045 AARS

394 GO:0043030 regulation of macrophage

activation (BP)

1 6 0.016 0.038 MIF

396 GO:0007599 hemostasis (BP) 1 9 0.024 0.048 ANXA7


keratinocyte differentiation (BP)

1 9 0.024 0.048 NME2

401 GO:0046653 tetrahydrofolate metabolic

process (BP)

1 7 0.019 0.041 MTHFD2

402 GO:0000289 nuclear-transcribed mRNA

poly(A) tail shortening (BP)

2 23 0.002 0.013 PABPC1,EIF4A1

403 GO:0008053 mitochondrial fusion (BP) 1 8 0.022 0.045 OPA1

404 GO:0006099 tricarboxylic acid cycle (BP) 2 26 0.002 0.016 IDH3B,SUCLA2

406 GO:0035767 endothelial cell chemotaxis (BP) 1 7 0.019 0.041 HSPB1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

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(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

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and

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epte

d fo

r pu

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n, b

ut h

as y

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ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

280

280

407 GO:0070365 hepatocyte differentiation (BP) 1 6 0.016 0.038 ANXA1

410 GO:0060765 regulation of androgen receptor

signaling pathway (BP)

1 7 0.019 0.041 PARK7

411 GO:0043308 eosinophil degranulation (BP) 1 2 0.005 0.022 VAMP7

412 GO:0030260 entry into host cell (BP) 1 4 0.011 0.03 PPIA

413 GO:0019896 axon transport of mitochondrion

(BP)

1 2 0.005 0.022 OPA1

414 GO:0007007 inner mitochondrial membrane

organization (BP)

1 2 0.005 0.022 OPA1

415 GO:0006105 succinate metabolic process (BP) 1 8 0.022 0.045 SUCLA2

416 GO:0006435 threonyl-tRNA aminoacylation

(BP)

1 3 0.008 0.026 TARS


serine/threonine kinase activity

(BP)

1 6 0.016 0.038 HSPB1

419 GO:0009156 ribonucleoside monophosphate


1 4 0.011 0.03 PRPS1

420 GO:0044249 cellular biosynthetic process (BP) 1 4 0.011 0.03 PRPS1

421 GO:0046632 alpha-beta T cell differentiation

(BP)

1 6 0.016 0.038 ANXA1


prostaglandin biosynthetic

process (BP)

1 5 0.014 0.034 ANXA1

423 GO:0031340 positive regulation of vesicle

fusion (BP)

1 4 0.011 0.03 ANXA1

425 GO:0009396 folic acid-containing compound


1 6 0.016 0.038 MTHFD2

426 GO:0034418 urate biosynthetic process (BP) 1 2 0.005 0.022 PRPS1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

281

281

427 GO:0042267 natural killer cell mediated

cytotoxicity (BP)

1 7 0.019 0.041 TUBB

429 GO:0010046 response to mycotoxin (BP) 1 2 0.005 0.022 ASS1

431 GO:0006104 succinyl-CoA metabolic process

(BP)

1 4 0.011 0.03 SUCLA2

432 GO:0033555 multicellular organismal response

to stress (BP)

1 7 0.019 0.041 LGALS1

433 GO:0046950 cellular ketone body metabolic

process (BP)

1 5 0.014 0.034 ACAT1

434 GO:0043441 acetoacetic acid biosynthetic

process (BP)

1 3 0.008 0.026 ACAT1

435 GO:0046951 ketone body biosynthetic process

(BP)

1 5 0.014 0.034 ACAT1

436 GO:0007041 lysosomal transport (BP) 1 6 0.016 0.038 NPC1

437 GO:0051788 response to misfolded protein

(BP)

1 3 0.008 0.026 CLU

440 GO:0045069 regulation of viral genome

replication (BP)

1 2 0.005 0.022 PPIA

441 GO:0021675 nerve development (BP) 1 9 0.024 0.048 AFG3L2


presentation of exogenous

peptide antigen via MHC class I

(BP)

1 2 0.005 0.022 IFI30

443 GO:0060013 righting reflex (BP) 1 7 0.019 0.041 AFG3L2

444 GO:0043456 regulation of pentose-phosphate

shunt (BP)

1 1 0.003 0.015 PGAM1

445 GO:0015918 sterol transport (BP) 1 5 0.014 0.034 NPC1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

282

282

446 GO:0019752 carboxylic acid metabolic process

(BP)

1 8 0.022 0.045 MIF

447 GO:0010044 response to aluminum ion (BP) 1 3 0.008 0.026 MAOB

448 GO:0006421 asparaginyl-tRNA

aminoacylation (BP)

1 2 0.005 0.022 NARS

449 GO:0048747 muscle fiber development (BP) 1 6 0.016 0.038 AFG3L2

451 GO:0043534 blood vessel endothelial cell

migration (BP)

1 8 0.022 0.045 HSPB1


export from nucleus (BP)

1 4 0.011 0.03 TXN

453 GO:0014063 negative regulation of serotonin

secretion (BP)

1 2 0.005 0.022 MAOB

454 GO:0006177 GMP biosynthetic process (BP) 1 3 0.008 0.026 IMPDH1

455 GO:0009992 cellular water homeostasis (BP) 1 2 0.005 0.022 ANXA7

456 GO:0034333 adherens junction assembly (BP) 1 6 0.016 0.038 VCL

457 GO:0006734 NADH metabolic process (BP) 1 7 0.019 0.041 IDH3B

458 GO:0006102 isocitrate metabolic process (BP) 1 6 0.016 0.038 IDH3B

459 GO:0051583 dopamine uptake (BP) 1 2 0.005 0.022 PARK7

460 GO:2000277 positive regulation of oxidative

phosphorylation uncoupler

activity (BP)

1 1 0.003 0.015 PARK7

461 GO:0042743 hydrogen peroxide metabolic

process (BP)

1 2 0.005 0.022 PARK7

462 GO:0006419 alanyl-tRNA aminoacylation

(BP)

1 3 0.008 0.026 AARS

463 GO:0090344 negative regulation of cell aging

(BP)

1 6 0.016 0.038 MIF

464 GO:0006781 succinyl-CoA pathway (BP) 1 1 0.003 0.015 SUCLA2

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

283

283

465 GO:0051131 chaperone-mediated protein

complex assembly (BP)

1 7 0.019 0.041 HSP90AA1

466 GO:0071400 cellular response to oleic acid

(BP)

1 3 0.008 0.026 ASS1

467 GO:0061077 chaperone-mediated protein

folding (BP)

1 3 0.008 0.026 CLU

468 GO:0070389 chaperone cofactor-dependent

protein refolding (BP)

1 5 0.014 0.034 PTGES3

469 GO:0006089 lactate metabolic process (BP) 1 3 0.008 0.026 LDHB

470 GO:0034120 positive regulation of erythrocyte

aggregation (BP)

1 1 0.003 0.015 LGALS1

471 GO:0009142 nucleoside triphosphate


1 2 0.005 0.022 NME2

472 GO:0045682 regulation of epidermis

development (BP)

1 4 0.011 0.03 NME2

473 GO:0043039 tRNA aminoacylation (BP) 1 5 0.014 0.034 AARS

474 GO:0060430 lung saccule development (BP) 1 5 0.014 0.034 PTGES3

475 GO:0046963 3'-phosphoadenosine

5'-phosphosulfate transport (BP)

1 1 0.003 0.015 SLC35B2

476 GO:0006015 5-phosphoribose 1-diphosphate


1 2 0.005 0.022 PRPS1

477 GO:0006426 glycyl-tRNA aminoacylation

(BP)

1 2 0.005 0.022 GARS

478 GO:0006437 tyrosyl-tRNA aminoacylation

(BP)

1 1 0.003 0.015 YARS

479 GO:0070125 mitochondrial translational

elongation (BP)

1 2 0.005 0.022 GFM1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

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cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

284

284


homooligomerization (BP)

1 3 0.008 0.026 CLU

481 GO:0002553 histamine secretion by mast cell

(BP)

1 2 0.005 0.022 YWHAZ

482 GO:0006526 arginine biosynthetic process

(BP)

1 2 0.005 0.022 ASS1

483 GO:0033158 regulation of protein import into

nucleus, translocation (BP)

1 4 0.011 0.03 TXN

484 GO:0071242 cellular response to ammonium

ion (BP)

1 3 0.008 0.026 ASS1


nuclear-transcribed mRNA

catabolic process,

nonsense-mediated decay (BP)

1 1 0.003 0.015 PABPC1

486 GO:0000053 argininosuccinate metabolic

process (BP)

1 2 0.005 0.022 ASS1

487 GO:0046604 positive regulation of mitotic

centrosome separation (BP)

1 1 0.003 0.015 RANBP1

488 GO:0015966 diadenosine tetraphosphate


1 1 0.003 0.015 GARS

489 GO:0006278 RNA-dependent DNA replication

(BP)

1 2 0.005 0.022 PPIA

490 GO:0019061 uncoating of virus (BP) 1 1 0.003 0.015 PPIA

491 GO:0046101 hypoxanthine biosynthetic

process (BP)

1 1 0.003 0.015 PRPS1

492 GO:0072229 metanephric proximal convoluted

tubule development (BP)

1 1 0.003 0.015 ACAT1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

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ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

285

285

493 GO:0006843 mitochondrial citrate transport

(BP)

1 1 0.003 0.015 SLC25A1

Molecular Function


(size: 94)

Reference

Support (size:

34208)

Hyp Hyp_c Genes

3 GO:0008233 peptidase activity (MF) 5 493 0.012 0.022 PSMC5,PSMC1,PMPCB,AFG3L2,PAR

K7

5 GO:0016740 transferase activity (MF) 8 616 3E-04 0.003 ACAT1,PRPS1,FASN,NME2,PI4K2A,

PFKP,AK2,GSTP1

7 GO:0005524 ATP binding (MF) 22 1489 8E-11 5E-09 PRPS1,CKB,ASS1,PSMC5,GARS,PSM

C1,NARS,TARS,HSP90AA1,HSPA8,Y

ARS,IARS2,EIF4A1,AARS,NME2,AF

G3L2,SUCLA2,HSPA9,PI4K2A,PFKP,

AK2,HSP90AB1

8 GO:0005515 protein binding (MF) 40 4463 1E-12 2E-10 C1QBP,ASS1,PRDX6,PTGES3,YWHA

Q,PPIA,PSMC5,CLU,PSMC1,HSPB1,H

SP90AA1,ENO1,PABPC1,FASN,MIF,

NUCB2,RPS9,EIF3M,NPC1,TXN,NQO

1,CSE1L,YWHAZ,HSPA8,EIF4A1,NM

E2,SUCLA2,PARK7,HSPA9,CALU,V

CL,ANXA7,S100A11,ANXA1,HSP90A

B1,OPA1,VAMP7,CYCS,GSTP1,MCU

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

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wed

and

acc

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d fo

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atio

n, b

ut h

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yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

286

286

9 GO:0000166 nucleotide binding (MF) 34 2120 8E-18 2E-15 TUBA1C,PRPS1,CKB,ASS1,TUBB,EE

F2,TUBA4A,PSMC5,GARS,GFM1,PS

MC1,TUBB6,NARS,TARS,HSP90AA1

,PABPC1,FASN,LDHA,HSPA8,YARS,

IARS2,EIF4A1,AARS,NME2,PHGDH,

AFG3L2,SUCLA2,HSPA9,PI4K2A,PF

KP,MTHFD2,HSP90AB1,OPA1,NDUF

A9

10 GO:0009055 electron carrier activity (MF) 7 174 6E-07 2E-05 GLRX5,MAOB,TXN,NQO1,PHGDH,I

DH3B,CYCS

11 GO:0016887 ATPase activity (MF) 6 139 2E-06 6E-05 PSMC5,CLU,PSMC1,HSP90AA1,ATP

5E,ATP5I

13 GO:0005509 calcium ion binding (MF) 7 662 0.002 0.014 NUCB2,ANXA3,CALU,ANXA7,S100

A11,ANXA5,ANXA1

15 GO:0016301 kinase activity (MF) 6 227 4E-05 5E-04 PRPS1,CKB,YWHAZ,NME2,PI4K2A,

PFKP

24 GO:0005102 receptor binding (MF) 4 259 0.006 0.015 PSMC5,MIF,PFN1,ANXA1

28 GO:0003824 catalytic activity (MF) 6 371 6E-04 0.005 ACAT1,PMPCB,IARS2,IMPDH1,PI4K

2A,MTHFD2

29 GO:0016874 ligase activity (MF) 8 370 9E-06 2E-04 ASS1,GARS,NARS,TARS,YARS,IARS

2,AARS,SUCLA2

30 GO:0004017 adenylate kinase activity (MF) 1 9 0.024 0.039 AK2

34 GO:0005525 GTP binding (MF) 7 373 8E-05 8E-04 TUBA1C,TUBB,EEF2,TUBA4A,GFM1

,TUBB6,OPA1

35 GO:0003924 GTPase activity (MF) 7 231 4E-06 8E-05 TUBA1C,TUBB,EEF2,TUBA4A,GFM1

,TUBB6,OPA1

37 GO:0000287 magnesium ion binding (MF) 6 178 1E-05 2E-04 PRPS1,ENO1,IDH3B,PI4K2A,MTHFD

2,OPA1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

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evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

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ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

287

287

38 GO:0048306 calcium-dependent protein

binding (MF)

2 37 0.005 0.016 ANXA7,S100A11

39 GO:0016787 hydrolase activity (MF) 8 971 0.005 0.018 PRDX6,PSMC5,PSMC1,EIF4A1,ATP5

E,PGAM1,PLBD2,MTHFD2

43 GO:0042803 protein homodimerization

activity (MF)

9 514 1E-05 2E-04 ACAT1,PRPS1,MAOB,TARS,HSP90A

A1,LGALS1,PARK7,S100A11,ANXA1

46 GO:0008536 Ran GTPase binding (MF) 1 12 0.032 0.049 RANBP1

47 GO:0005198 structural molecule activity (MF) 6 225 4E-05 5E-04 TUBA1C,TUBB,TUBA4A,TUBB6,VC

L,ANXA1

48 GO:0051287 NAD binding (MF) 3 38 2E-04 0.001 LDHB,PHGDH,IDH3B

49 GO:0016491 oxidoreductase activity (MF) 10 437 4E-07 2E-05 MAOB,PRDX6,LDHB,FASN,LDHA,N

QO1,PHGDH,IDH3B,IMPDH1,MTHF

D2

50 GO:0003743 translation initiation factor

activity (MF)

3 58 6E-04 0.005 EIF3M,EIF4A1,EIF1AX

52 GO:0003854 3-beta-hydroxy-delta5-steroid

dehydrogenase activity (MF)

1 7 0.019 0.033 NDUFA9

54 GO:0008137 NADH dehydrogenase

(ubiquinone) activity (MF)

2 37 0.005 0.016 NDUFA5,NDUFA9

55 GO:0016616 oxidoreductase activity, acting on

the CH-OH group of donors,

NAD or NADP as acceptor (MF)

3 29 7E-05 9E-04 LDHA,IDH3B,NDUFA9

57 GO:0042277 peptide binding (MF) 2 38 0.005 0.017 TUBB,PPIA

62 GO:0016853 isomerase activity (MF) 4 119 3E-04 0.003 PTGES3,PPIA,MIF,PGAM1

65 GO:0000049 tRNA binding (MF) 2 30 0.003 0.011 YARS,AARS

67 GO:0051082 unfolded protein binding (MF) 7 120 4E-08 2E-06 PTGES3,PPIA,HSP90AA1,HSPA8,AF

G3L2,HSPA9,HSP90AB1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

288

288

68 GO:0022857 transmembrane transporter

activity (MF)

2 42 0.006 0.015 ATP5E,ATP5I

71 GO:0005543 phospholipid binding (MF) 2 59 0.012 0.022 ANXA5,ANXA1

72 GO:0005544 calcium-dependent phospholipid

binding (MF)

4 26 8E-07 2E-05 ANXA3,ANXA7,ANXA5,ANXA1

77 GO:0017111 nucleoside-triphosphatase

activity (MF)

3 74 0.001 0.009 PSMC5,PSMC1,AFG3L2

80 GO:0015035 protein disulfide oxidoreductase

activity (MF)

2 29 0.003 0.011 GLRX5,TXN

81 GO:0051787 misfolded protein binding (MF) 1 8 0.022 0.036 CLU

87 GO:0003735 structural constituent of ribosome

(MF)

3 157 0.009 0.02 RPS16,RPS9,RPS11

88 GO:0004859 phospholipase inhibitor activity

(MF)

3 10 2E-06 6E-05 ANXA3,ANXA5,ANXA1


NADH or NADPH (MF)

1 11 0.03 0.046 NDUFA5

100 GO:0016747 transferase activity, transferring

acyl groups other than

amino-acyl groups (MF)

2 30 0.003 0.011 ACAT1,FASN

102 GO:0048037 cofactor binding (MF) 2 21 0.002 0.011 FASN,PHGDH

104 GO:0003746 translation elongation factor

activity (MF)

2 26 0.002 0.014 EEF2,GFM1

105 GO:0005200 structural constituent of

cytoskeleton (MF)

2 74 0.018 0.032 TUBB,TUBA4A

106 GO:0008143 poly(A) RNA binding (MF) 1 9 0.024 0.039 PABPC1

107 GO:0019843 rRNA binding (MF) 2 23 0.002 0.012 RPS9,RPS11

108 GO:0016208 AMP binding (MF) 1 10 0.027 0.043 APRT

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

289

289

109 GO:0004749 ribose phosphate

diphosphokinase activity (MF)

1 5 0.014 0.025 PRPS1

110 GO:0050220 prostaglandin-E synthase activity

(MF)

1 3 0.008 0.018 PTGES3

111 GO:0008158 hedgehog receptor activity (MF) 1 9 0.024 0.039 NPC1

112 GO:0004128 cytochrome-b5 reductase activity

(MF)

1 8 0.022 0.036 NQO1

114 GO:0004129 cytochrome-c oxidase activity

(MF)

2 25 0.002 0.013 COX6B1,COX4I1

116 GO:0004822 isoleucine-tRNA ligase activity

(MF)

1 2 0.005 0.014 IARS2

119 GO:0043295 glutathione binding (MF) 1 8 0.022 0.036 GSTP1

120 GO:0046790 virion binding (MF) 1 6 0.016 0.029 PPIA

121 GO:0003729 mRNA binding (MF) 2 53 0.009 0.02 EIF4A1,PARK7

122 GO:0008135 translation factor activity, nucleic

acid binding (MF)

2 23 0.002 0.012 EIF4A1,EIF1AX

123 GO:0019205 nucleobase-containing compound

kinase activity (MF)

1 10 0.027 0.043 AK2

125 GO:0051920 peroxiredoxin activity (MF) 2 5 7E-05 8E-04 PRDX6,PARK7

126 GO:0016209 antioxidant activity (MF) 1 12 0.032 0.049 PRDX6

127 GO:0004111 creatine kinase activity (MF) 1 4 0.011 0.021 CKB

128 GO:0017048 Rho GTPase binding (MF) 2 25 0.002 0.013 VCL,PFN1

130 GO:0004550 nucleoside diphosphate kinase

activity (MF)

1 11 0.03 0.046 NME2

132 GO:0008426 protein kinase C inhibitor activity

(MF)

1 3 0.008 0.018 HSPB1

133 GO:0070095 fructose-6-phosphate binding

(MF)

1 5 0.014 0.025 PFKP

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

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and

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ergo

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yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

290

290

134 GO:0003872 6-phosphofructokinase activity

(MF)

1 3 0.008 0.018 PFKP

136 GO:0070026 nitric oxide binding (MF) 1 1 0.003 0.01 GSTP1

137 GO:0035730 S-nitrosoglutathione binding

(MF)

1 1 0.003 0.01 GSTP1

138 GO:0035731 dinitrosyl-iron complex binding

(MF)

1 1 0.003 0.01 GSTP1

139 GO:0008432 JUN kinase binding (MF) 1 8 0.022 0.036 GSTP1

140 GO:0019207 kinase regulator activity (MF) 1 2 0.005 0.014 GSTP1

142 GO:0008131 primary amine oxidase activity

(MF)

1 5 0.014 0.025 MAOB

143 GO:0045182 translation regulator activity

(MF)

1 7 0.019 0.033 RPS9

144 GO:0045155 electron transporter, transferring

electrons from

CoQH2-cytochrome c reductase

complex and cytochrome c

oxidase complex activity (MF)

1 2 0.005 0.014 CYCS

145 GO:0004459 L-lactate dehydrogenase activity

(MF)

2 5 7E-05 8E-04 LDHB,LDHA

146 GO:0030911 TPR domain binding (MF) 2 5 7E-05 8E-04 HSP90AA1,HSP90AB1

147 GO:0003720 telomerase activity (MF) 1 4 0.011 0.021 PTGES3

148 GO:0008494 translation activator activity (MF) 1 7 0.019 0.033 PABPC1

149 GO:0050662 coenzyme binding (MF) 2 20 0.001 0.01 ACAT1,NQO1

150 GO:0004829 threonine-tRNA ligase activity

(MF)

1 3 0.008 0.018 TARS

151 GO:0030235 nitric-oxide synthase regulator

activity (MF)

2 5 7E-05 8E-04 HSP90AA1,HSP90AB1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

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p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

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NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

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n pe

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and

acc

epte

d fo

r pu

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atio

n, b

ut h

as y

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ergo

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yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

291

291

152 GO:0019834 phospholipase A2 inhibitor

activity (MF)

2 3 2E-05 3E-04 ANXA3,ANXA1

155 GO:0004488 methylenetetrahydrofolate

dehydrogenase (NADP+) activity

(MF)

1 4 0.011 0.021 MTHFD2

156 GO:0016296 palmitoyl-[acyl-carrier-protein]

hydrolase activity (MF)

1 2 0.005 0.014 FASN

157 GO:0004320 oleoyl-[acyl-carrier-protein]


1 2 0.005 0.014 FASN

158 GO:0016295 myristoyl-[acyl-carrier-protein]


1 2 0.005 0.014 FASN

159 GO:0004487 methylenetetrahydrofolate

dehydrogenase (NAD+) activity

(MF)

1 2 0.005 0.014 MTHFD2

160 GO:0004477 methenyltetrahydrofolate

cyclohydrolase activity (MF)

1 3 0.008 0.018 MTHFD2

161 GO:0031177 phosphopantetheine binding

(MF)

1 3 0.008 0.018 FASN

162 GO:0000036 acyl carrier activity (MF) 1 5 0.014 0.025 FASN

163 GO:0000339 RNA cap binding (MF) 1 7 0.019 0.033 EIF4A1

164 GO:0042623 ATPase activity, coupled (MF) 1 11 0.03 0.046 HSPA8

165 GO:0001849 complement component C1q

binding (MF)

1 3 0.008 0.018 C1QBP

166 GO:0004315 3-oxoacyl-[acyl-carrier-protein]

synthase activity (MF)

1 2 0.005 0.014 FASN

167 GO:0030395 lactose binding (MF) 1 3 0.008 0.018 LGALS1

168 GO:0004634 phosphopyruvate hydratase

activity (MF)

1 4 0.011 0.021 ENO1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

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atio

n, b

ut h

as y

et to

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ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

292

292


a sulfur group of donors (MF)

1 2 0.005 0.014 IFI30

170 GO:0016868 intramolecular transferase

activity, phosphotransferases

(MF)

1 6 0.016 0.029 PGAM1

171 GO:0015137 citrate transmembrane transporter

activity (MF)

1 4 0.011 0.021 SLC25A1

172 GO:0015643 toxin binding (MF) 1 10 0.027 0.043 ASS1

173 GO:0004619 phosphoglycerate mutase activity

(MF)

1 4 0.011 0.021 PGAM1

174 GO:0004082 bisphosphoglycerate mutase

activity (MF)

1 4 0.011 0.021 PGAM1

175 GO:0004083 bisphosphoglycerate

2-phosphatase activity (MF)

1 4 0.011 0.021 PGAM1

176 GO:0004430 1-phosphatidylinositol 4-kinase

activity (MF)

1 4 0.011 0.021 PI4K2A

177 GO:0002055 adenine binding (MF) 1 1 0.003 0.01 APRT

178 GO:0003999 adenine

phosphoribosyltransferase

activity (MF)

1 1 0.003 0.01 APRT

179 GO:0015248 sterol transporter activity (MF) 1 2 0.005 0.014 NPC1

180 GO:0004775 succinate-CoA ligase

(ADP-forming) activity (MF)

1 3 0.008 0.018 SUCLA2

181 GO:0048154 S100 beta binding (MF) 1 4 0.011 0.021 S100A11

182 GO:0004816 asparagine-tRNA ligase activity

(MF)

1 2 0.005 0.014 NARS

183 GO:0072568 protein kinase C delta binding

(MF)

1 2 0.005 0.014 HSPB1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

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ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

293

293

184 GO:0003938 IMP dehydrogenase activity

(MF)

1 2 0.005 0.014 IMPDH1

185 GO:0002166 beta-dystroglycan binding (MF) 1 3 0.008 0.018 VCL

186 GO:0045294 alpha-catenin binding (MF) 1 7 0.019 0.033 VCL

187 GO:0004449 isocitrate dehydrogenase (NAD+)

activity (MF)

1 3 0.008 0.018 IDH3B

188 GO:0003985 acetyl-CoA C-acetyltransferase

activity (MF)

1 3 0.008 0.018 ACAT1

189 GO:0004813 alanine-tRNA ligase activity

(MF)

1 3 0.008 0.018 AARS

190 GO:0005092 GDP-dissociation inhibitor

activity (MF)

1 3 0.008 0.018 RANBP1

191 GO:0004617 phosphoglycerate dehydrogenase

activity (MF)

1 1 0.003 0.01 PHGDH

192 GO:0016936 galactoside binding (MF) 1 4 0.011 0.021 LGALS1

193 GO:0004673 protein histidine kinase activity

(MF)

1 1 0.003 0.01 NME2

194 GO:0016876 ligase activity, forming

aminoacyl-tRNA and related

compounds (MF)

1 2 0.005 0.014 AARS

195 GO:0002161 aminoacyl-tRNA editing activity

(MF)

1 1 0.003 0.01 AARS

196 GO:0046964 3'-phosphoadenosine

5'-phosphosulfate transmembrane

transporter activity (MF)

1 1 0.003 0.01 SLC35B2

197 GO:0004820 glycine-tRNA ligase activity

(MF)

1 2 0.005 0.014 GARS

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

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ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

294

294

198 GO:0005153 interleukin-8 receptor binding

(MF)

1 2 0.005 0.014 YARS

199 GO:0004831 tyrosine-tRNA ligase activity

(MF)

1 2 0.005 0.014 YARS

200 GO:0004314 [acyl-carrier-protein]

S-malonyltransferase activity

(MF)

1 2 0.005 0.014 FASN

201 GO:0008262 importin-alpha export receptor

activity (MF)

1 1 0.003 0.01 CSE1L

202 GO:0003955 NAD(P)H dehydrogenase

(quinone) activity (MF)

1 1 0.003 0.01 NQO1

203 GO:0015037 peptide disulfide oxidoreductase

activity (MF)

1 1 0.003 0.01 TXN

204 GO:0004167 dopachrome isomerase activity

(MF)

1 3 0.008 0.018 MIF

205 GO:0050178 phenylpyruvate tautomerase

activity (MF)

1 1 0.003 0.01 MIF

206 GO:0004312 fatty acid synthase activity (MF) 1 1 0.003 0.01 FASN

207 GO:0004313 [acyl-carrier-protein]

S-acetyltransferase activity (MF)

1 1 0.003 0.01 FASN

208 GO:0004316 3-oxoacyl-[acyl-carrier-protein]

reductase (NADPH) activity

(MF)

1 1 0.003 0.01 FASN

209 GO:0004317 3-hydroxypalmitoyl-[acyl-carrier

-protein] dehydratase activity

(MF)

1 1 0.003 0.01 FASN

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

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wed

and

acc

epte

d fo

r pu

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atio

n, b

ut h

as y

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yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

295

295

210 GO:0004319 enoyl-[acyl-carrier-protein]

reductase (NADPH, B-specific)

activity (MF)

1 1 0.003 0.01 FASN

211 GO:0031531 thyrotropin-releasing hormone

receptor binding (MF)

1 1 0.003 0.01 PSMC5

212 GO:0004055 argininosuccinate synthase

activity (MF)

1 1 0.003 0.01 ASS1

Cellular Components


(size: 94)

Reference

Support (size:

34208)

Hyp Hyp_c Genes

0 GO:0005634 nucleus (CC) 32 5441 1E-05 2E-04 GLRX5,C1QBP,ASS1,PTGES3,YWHA

Q,PPIA,PSMC5,COX4I1,GOLIM4,RA

NBP1,CLU,PSMC1,HSPB1,ENO1,PAB

PC1,NUCB2,TXN,CSE1L,YWHAZ,YA

RS,NME2,LGALS1,PARK7,ANXA7,I

MPDH1,PFN1,S100A11,APRT,RPF2,A

NXA1,CYCS,GSTP1

1 GO:0005622 intracellular (CC) 11 1962 0.019 0.048 RPS16,GFM1,HSPB1,HSP90AA1,RPS

9,HSPA8,LGALS1,RPS11,ANXA5,HS

P90AB1,GSTP1

2 GO:0005615 extracellular space (CC) 7 784 0.006 0.027 C1QBP,CLU,MIF,NUCB2,YARS,LGA

LS1,ANXA1

3 GO:0005576 extracellular region (CC) 11 1913 0.016 0.047 PPIA,TUBA4A,IFI30,CLU,MIF,NUCB

2,TXN,LGALS1,CALU,VCL,ANXA1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

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ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

296

296

5 GO:0005625 soluble fraction (CC) 10 390 1E-07 3E-06 LDHB,YWHAQ,GARS,NARS,HSPB1,

YWHAZ,YARS,AARS,ANXA7,PFKP

10 GO:0005737 cytoplasm (CC) 56 5302 2E-22 9E-21 TUBA1C,CKB,C1QBP,ASS1,PRDX6,P

TGES3,LDHB,YWHAQ,TUBB,EEF2,P

PIA,TUBA4A,PSMC5,GARS,RANBP1

,CLU,PSMC1,TUBB6,NARS,TARS,HS

PB1,HSP90AA1,ENO1,PABPC1,FASN

,MIF,NUCB2,RPS9,EIF3M,TXN,LDH

A,NQO1,CSE1L,YWHAZ,HSPA8,YA

RS,IARS2,AARS,NME2,LGALS1,AN

XA3,PARK7,HSPA9,VCL,IMPDH1,PF

N1,S100A11,APRT,PI4K2A,PFKP,AN

XA5,ANXA1,EIF1AX,HSP90AB1,VA

MP7,GSTP1

11 GO:0005739 mitochondrion (CC) 35 1394 1E-24 7E-23 GLRX5,SLC25A1,ACAT1,CKB,C1QB

P,MAOB,ASS1,LDHB,COX6B1,GARS

,COX4I1,CLU,GFM1,NARS,FASN,TX

N,LDHA,YWHAZ,PMPCB,IARS2,IDH

3B,AFG3L2,SUCLA2,ATP5E,PARK7,

HSPA9,ATP5I,AK2,MTHFD2,HSP90A

B1,OPA1,CYCS,MCU,NDUFA5,NDU

FA9

18 GO:0005743 mitochondrial inner membrane

(CC)

14 308 2E-13 5E-12 SLC25A1,ACAT1,MAOB,COX6B1,CO

X4I1,PMPCB,AFG3L2,ATP5I,AK2,OP

A1,CYCS,MCU,NDUFA5,NDUFA9

24 GO:0009986 cell surface (CC) 5 297 0.001 0.009 HSPB1,MIF,HSPA8,LGALS1,HSPA9

26 GO:0043202 lysosomal lumen (CC) 2 16 9E-04 0.006 IFI30,PLBD2

27 GO:0030529 ribonucleoprotein complex (CC) 4 132 5E-04 0.004 EEF2,PABPC1,RPS9,HSPA8

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

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and

acc

epte

d fo

r pu

blic

atio

n, b

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as y

et to

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ergo

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yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

297

297

31 GO:0005764 lysosome (CC) 5 179 1E-04 0.002 ASS1,PRDX6,IFI30,NPC1,LAMP2

32 GO:0005829 cytosol (CC) 46 2146 2E-30 3E-28 RPS16,PRPS1,CKB,ASS1,PRDX6,PTG

ES3,LDHB,TUBB,EEF2,PPIA,TUBA4

A,PSMC5,GARS,CLU,PSMC1,NARS,

TARS,HSPB1,HSP90AA1,ENO1,PABP

C1,FASN,NUCB2,RPS9,TXN,LDHA,N

QO1,YWHAZ,HSPA8,YARS,EIF4A1,

AARS,NME2,RPS11,PARK7,VCL,AN

XA7,IMPDH1,APRT,PGAM1,PFKP,EI

F1AX,HSP90AB1,CYCS,GSTP1,PSM

D3

33 GO:0005758 mitochondrial intermembrane

space (CC)

3 42 2E-04 0.002 COX6B1,OPA1,CYCS

36 GO:0005881 cytoplasmic microtubule (CC) 2 32 0.004 0.019 TUBA1C,TUBA4A

42 GO:0000502 proteasome complex (CC) 4 60 2E-05 3E-04 PSMC5,PSMC1,HSPB1,PSMD3

43 GO:0005697 telomerase holoenzyme complex

(CC)

1 6 0.016 0.044 PTGES3

45 GO:0005874 microtubule (CC) 4 262 0.006 0.026 TUBA1C,TUBB,TUBA4A,TUBB6

47 GO:0043234 protein complex (CC) 5 217 3E-04 0.003 YWHAQ,YWHAZ,VCL,ANXA1,GSTP

1

49 GO:0042470 melanosome (CC) 6 89 2E-07 3E-06 HSP90AA1,FASN,YWHAZ,HSPA8,C

ALU,HSP90AB1

51 GO:0070469 respiratory chain (CC) 3 43 2E-04 0.002 CYCS,NDUFA5,NDUFA9

52 GO:0005747 mitochondrial respiratory chain

complex I (CC)

2 39 0.005 0.026 NDUFA5,NDUFA9

53 GO:0005759 mitochondrial matrix (CC) 10 201 2E-10 6E-09 ACAT1,C1QBP,GARS,PMPCB,IARS2,

IDH3B,SUCLA2,ATP5E,CYCS,NDUF

A9

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

298

298

54 GO:0031966 mitochondrial membrane (CC) 3 66 8E-04 0.006 CLU,ANXA1,NDUFA9

55 GO:0005635 nuclear envelope (CC) 3 107 0.003 0.018 RANBP1,NPC1,ANXA7

64 GO:0042383 sarcolemma (CC) 2 66 0.014 0.044 ANXA5,ANXA1

65 GO:0001726 ruffle (CC) 2 72 0.017 0.044 NME2,S100A11

67 GO:0005797 Golgi medial cisterna (CC) 1 5 0.014 0.044 NUCB2

70 GO:0005753 mitochondrial

proton-transporting ATP

synthase complex (CC)

2 16 9E-04 0.006 ATP5E,ATP5I

72 GO:0005641 nuclear envelope lumen (CC) 1 7 0.019 0.047 TUBB

75 GO:0031902 late endosome membrane (CC) 2 66 0.014 0.044 NPC1,VAMP7

76 GO:0015629 actin cytoskeleton (CC) 3 180 0.014 0.048 TARS,VCL,PFN1

77 GO:0005840 ribosome (CC) 3 174 0.012 0.045 RPS16,RPS9,RPS11

78 GO:0022627 cytosolic small ribosomal

subunit (CC)

3 36 1E-04 0.002 RPS16,RPS9,RPS11

79 GO:0005765 lysosomal membrane (CC) 3 123 0.005 0.025 NPC1,LAMP2,VAMP7

86 GO:0015935 small ribosomal subunit (CC) 2 23 0.002 0.011 RPS16,RPS9

97 GO:0005741 mitochondrial outer membrane

(CC)

3 102 0.003 0.017 MAOB,ASS1,OPA1

98 GO:0030670 phagocytic vesicle membrane

(CC)

3 11 3E-06 5E-05 ANXA3,LAMP2,VAMP7

111 GO:0042587 glycogen granule (CC) 1 7 0.019 0.047 FASN

112 GO:0005945 6-phosphofructokinase complex

(CC)

1 3 0.008 0.034 PFKP

113 GO:0070062 extracellular vesicular exosome

(CC)

1 6 0.016 0.044 HSPA8

114 GO:0005626 insoluble fraction (CC) 2 44 0.007 0.028 HSPB1,ANXA7

117 GO:0045335 phagocytic vesicle (CC) 1 6 0.016 0.044 VAMP7

118 GO:0030061 mitochondrial crista (CC) 1 6 0.016 0.044 OPA1

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

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wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

299

299



synthase complex, catalytic core

F(1) (CC)

1 5 0.014 0.044 ATP5E

122 GO:0031088 platelet dense granule membrane

(CC)

1 5 0.014 0.044 LAMP2



synthase complex, coupling

factor F(o) (CC)

1 6 0.016 0.044 ATP5I

125 GO:0072563 endothelial microparticle (CC) 1 2 0.005 0.026 ANXA5

126 GO:0033018 sarcoplasmic reticulum lumen

(CC)

1 4 0.011 0.041 CALU

127 GO:0000015 phosphopyruvate hydratase

complex (CC)

1 4 0.011 0.041 ENO1

128 GO:0070852 cell body fiber (CC) 1 5 0.014 0.044 ASS1

129 GO:0030055 cell-substrate junction (CC) 1 4 0.011 0.041 VCL

130 GO:0042583 chromaffin granule (CC) 1 2 0.005 0.026 CLU

KEGG Pathways


(size: 94)

Reference

Support (size:

34208)

Hyp Hyp_c Genes

1 Kegg:03013 RNA transport 3 145 0.008 0.023 PABPC1,EIF4A1,EIF1AX

2 Kegg:00010 Glycolysis / Gluconeogenesis 5 62 8E-07 1E-05 PFKP,LDHB,LDHA,ENO1,PGAM1

3 Kegg:00270 Cysteine and methionine

metabolism

2 36 0.004 0.015 LDHB,LDHA

of 313

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300

4 Kegg:00620 Pyruvate metabolism 3 39 2E-04 0.001 LDHB,LDHA,ACAT1

5 Kegg:00640 Propanoate metabolism 4 32 2E-06 2E-05 LDHB,LDHA,SUCLA2,ACAT1

8 Kegg:00230 Purine metabolism 5 158 8E-05 6E-04 PRPS1,APRT,NME2,IMPDH1,AK2

10 Kegg:04621 NOD-like receptor signaling

pathway

2 57 0.011 0.031 HSP90AA1,HSP90AB1

12 Kegg:00350 Tyrosine metabolism 2 39 0.005 0.017 MAOB,MIF

14 Kegg:00982 Drug metabolism - cytochrome

P450

2 70 0.016 0.04 MAOB,GSTP1

15 Kegg:00190 Oxidative phosphorylation 7 130 8E-08 2E-06 MT-ND2,NDUFA5,COX4I1,COX6B1,

ATP5I,ATP5E,NDUFA9

16 Kegg:04260 Cardiac muscle contraction 2 76 0.019 0.044 COX4I1,COX6B1

17 Kegg:05010 Alzheimer's disease 6 163 6E-06 7E-05 NDUFA5,CYCS,COX4I1,COX6B1,AT

P5E,NDUFA9

18 Kegg:05012 Parkinson's disease 8 129 3E-09 1E-07 MT-ND2,NDUFA5,CYCS,COX4I1,CO

X6B1,PARK7,ATP5E,NDUFA9

19 Kegg:05016 Huntington's disease 6 180 1E-05 1E-04 NDUFA5,CYCS,COX4I1,COX6B1,AT

P5E,NDUFA9

24 Kegg:00020 Citrate cycle (TCA cycle) 2 30 0.003 0.012 IDH3B,SUCLA2

25 Kegg:05200 Pathways in cancer 4 324 0.012 0.032 CYCS,GSTP1,HSP90AA1,HSP90AB1

27 Kegg:00360 Phenylalanine metabolism 3 16 1E-05 1E-04 PRDX6,MAOB,MIF

32 Kegg:04145 Phagosome 4 137 6E-04 0.003 TUBB6,LAMP2,TUBA1C,TUBA4A

36 Kegg:00330 Arginine and proline metabolism 3 54 5E-04 0.003 ASS1,CKB,MAOB

37 Kegg:03010 Ribosome 3 86 0.002 0.008 RPS9,RPS16,RPS11

38 Kegg:04141 Protein processing in

endoplasmic reticulum

3 159 0.01 0.029 HSP90AA1,HSP90AB1,HSPA8

39 Kegg:00260 Glycine, serine and threonine

metabolism

2 32 0.004 0.013 MAOB,PHGDH

40 Kegg:05152 Tuberculosis 3 172 0.012 0.033 CYCS,LAMP2,HSPA9

of 313

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301

42 Kegg:03018 RNA degradation 3 66 8E-04 0.004 PABPC1,ENO1,HSPA9

46 Kegg:05130 Pathogenic Escherichia coli

infection

5 54 4E-07 8E-06 YWHAZ,YWHAQ,TUBB6,TUBA1C,T

UBA4A

50 Kegg:05215 Prostate cancer 3 88 0.002 0.008 GSTP1,HSP90AA1,HSP90AB1

54 Kegg:00030 Pentose phosphate pathway 2 27 0.003 0.01 PRPS1,PFKP

58 Kegg:04540 Gap junction 3 88 0.002 0.008 TUBB6,TUBA1C,TUBA4A

60 Kegg:03050 Proteasome 3 40 2E-04 0.001 PSMD3,PSMC5,PSMC1

66 Kegg:04612 Antigen processing and

presentation

4 56 2E-05 1E-04 IFI30,HSP90AA1,HSP90AB1,HSPA8

71 Kegg:00380 Tryptophan metabolism 2 41 0.006 0.018 MAOB,ACAT1

72 Kegg:05131 Shigellosis 2 61 0.012 0.033 VCL,PFN1

77 Kegg:00061 Fatty acid biosynthesis 1 6 0.016 0.04 FASN

78 Kegg:00970 Aminoacyl-tRNA biosynthesis 6 40 1E-09 1E-07 TARS,GARS,NARS,YARS,AARS,IAR

S2

of 313

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302

302

Table S7. Differentially abundant proteins in group 1

Increased Proteins

Accession

Number

Gene Name 0.5 h 1 h 2 h 6 h 12 h # AAs MW

[kDa]

calc.

pI A:

127/126

B:

127/126

A:

128/126

B:

128/126

A:

129/126

B:

129/126

A:

130/126

B:

130/126

A:

131/126

B:

131/126

P60174-1 TPI1 4.85 1.60 6.78 2.10 8.25 2.21 3.95 2.01 6.99 2.77 249 26.65 6.90

K7ES20 CDKN2A 3.53 3.07 2.66 2.40 2.51 2.11 2.13 1.14 2.85 1.75 104 11.07 6.06

Q5TCI8 LMNA 3.20 2.45 1.19 0.73 1.23 0.80 0.80 0.30 0.49 0.25 491 55.73 7.02

P06753-3 TPM3 3.14 3.06 3.71 3.14 3.75 3.22 1.66 1.17 1.53 1.43 247 28.94 4.81

E9PND2 CSRP1 2.96 2.78 2.65 2.51 2.16 2.08 1.64 1.13 1.27 1.32 153 16.10 8.90

E9PS50 RPS13 2.70 2.30 2.34 1.73 2.19 1.19 2.63 1.29 2.72 1.69 116 12.45 10.08

Q5T8M8 ACTA1 2.64 2.05 2.39 2.10 2.01 1.94 1.32 1.10 1.29 1.24 287 32.03 5.41

Q92499 DDX1 2.45 1.75 1.30 1.02 1.27 0.92 1.46 0.91 1.27 1.08 740 82.38 7.23

P00966 ASS1 2.39 1.63 2.10 1.58 1.95 1.50 2.10 1.40 2.93 2.43 412 46.50 8.02

Q04637-6 EIF4G1 2.31 1.75 1.82 1.05 1.91 0.91 1.94 0.92 2.12 1.13 1403 154.71 5.16

V9GYJ7 GDI2 2.24 2.22 1.98 2.17 2.03 1.92 1.98 2.22 1.86 2.37 125 14.13 9.61

O43707 ACTN4 2.15 1.77 2.30 2.16 2.03 2.39 1.31 1.39 1.23 1.40 911 104.79 5.44

Q16401-2 PSMD5 2.11 1.92 2.27 1.93 2.21 2.05 2.00 1.78 2.39 2.20 461 51.28 5.44

P08133-2 ANXA6 2.09 1.53 2.05 1.38 2.07 1.48 1.38 1.08 1.35 1.32 641 72.38 5.60

P00338-5 LDHA 2.00 2.37 2.40 3.12 2.29 3.08 2.14 2.84 2.74 3.44 241 26.70 8.15

P23526-2 AHCY 1.95 1.89 1.50 1.69 1.52 1.51 1.74 1.32 1.84 1.93 404 44.63 6.47

P04083 ANXA1 1.89 1.72 1.64 1.47 1.51 1.41 1.26 1.12 1.02 1.39 346 38.69 7.02

Q27J81-2 INF2 1.89 2.48 1.97 2.04 2.06 2.31 1.23 1.48 1.17 1.46 1240 134.53 5.53

E9PFF2 TKT 1.85 1.85 2.22 1.97 2.40 2.25 1.23 1.55 1.32 1.74 334 36.43 7.77

P18206-2 VCL 1.84 2.01 1.39 1.48 1.39 1.30 2.11 1.28 1.89 1.54 1066 116.65 6.09

D6RC37 SUB1 1.79 1.87 2.12 1.44 2.15 1.56 2.01 1.09 3.06 1.65 65 7.11 9.85

B4DT77 ANXA7 1.68 1.82 1.40 1.39 1.32 1.49 0.88 1.05 0.82 0.93 336 37.78 7.18

of 313

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of.

303

303

J3QLR1 RUVBL1 1.68 1.52 1.33 1.23 1.41 1.33 1.43 1.37 2.23 2.09 131 14.72 6.16

E9PBS1 PAICS 1.66 1.66 1.49 1.54 1.42 1.21 1.65 1.08 1.68 1.75 413 45.62 6.68

J3KS60 ARHGDIA 1.66 1.66 1.79 1.83 1.99 2.07 1.61 1.80 2.03 2.06 92 9.94 4.32

E9PFD7 EGFR 1.65 1.53 1.21 1.09 1.07 1.07 0.95 0.83 1.05 0.91 1157 128.60 6.57

P07195 LDHB 1.61 1.87 1.66 1.85 1.60 1.98 1.49 1.73 1.77 2.04 334 36.62 6.05

P13498 CYBA 1.56 2.40 1.00 1.19 0.88 0.65 0.94 0.68 0.54 0.51 195 21.00 9.54

P12429 ANXA3 1.54 1.77 1.88 1.79 1.78 1.71 1.23 1.26 1.30 1.83 323 36.35 5.92

P04792 HSPB1 1.50 1.49 1.48 1.63 1.48 1.39 1.38 1.20 1.52 1.83 205 22.77 6.40

Decreased Proteins

Accession

Number


[kDa]

calc.

pI A:

127/126

B:

127/126

A:

128/126

B:

128/126

A:

129/126

B:

129/126

A:

130/126

B:

130/126

A:

131/126

B:

131/126

O43852-13 CALU 0.63 0.55 0.83 0.75 0.74 0.87 0.74 1.09 0.62 0.83 139 16.28 5.00

G5EA52 PDIA3 0.62 0.60 0.70 0.67 0.69 0.70 0.82 0.94 0.68 0.82 485 54.93 6.86

C9JP16 CRTAP 0.62 0.56 0.74 0.72 0.72 0.83 0.77 1.00 0.62 0.63 358 41.41 5.87

Q07065 CKAP4 0.61 0.66 0.70 0.66 0.66 0.65 0.77 0.81 0.61 0.70 602 65.98 5.92

K7EME0 ACAA2 0.60 0.58 0.75 0.75 0.72 0.82 0.63 0.81 0.76 0.55 342 36.26 7.91

O15027-2 SEC16A 0.57 0.65 0.91 0.97 0.96 0.84 1.17 1.51 1.06 1.22 2134 228.73 5.62

Q13217 DNAJC3 0.53 0.43 0.68 0.59 0.67 0.66 0.85 0.90 0.74 0.81 504 57.54 6.15

Q5JTJ3-3 COA6 0.53 0.62 0.51 0.60 0.40 0.63 0.37 0.55 0.26 0.45 79 9.42 7.74

Q5JPU3 PDHA1 0.52 0.60 0.60 0.85 0.65 1.07 0.58 1.16 0.61 0.65 109 12.58 4.91

P40926 MDH2 0.52 0.62 0.61 0.74 0.63 0.82 0.56 0.78 0.40 0.51 338 35.48 8.68

B4DKM5 VDAC2 0.51 0.67 0.92 0.79 0.91 0.92 0.74 1.04 0.95 0.84 255 27.46 5.47

B4DXE2 BAG2 0.50 0.55 0.81 0.88 0.75 0.85 0.71 1.03 0.80 0.93 178 20.18 6.29

Q86UP2-2 KTN1 0.49 0.55 0.47 0.63 0.49 0.70 0.72 1.07 0.59 0.87 1300 149.52 5.71

H0YFX9 H2AFJ 0.49 0.48 0.69 0.49 0.76 0.70 0.99 0.50 1.40 0.57 92 9.97 9.70

O94826 TOMM70A 0.48 0.58 0.64 0.85 0.54 0.74 0.55 0.63 0.62 0.64 608 67.41 7.12

of 313

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from

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304

304

X6RDD7 ACBD5 0.48 0.63 0.58 0.62 0.52 0.69 0.75 1.06 0.64 0.86 251 28.06 5.06

P69849 NOMO3 0.48 0.54 0.60 0.64 0.59 0.72 0.58 0.79 0.45 0.70 1222 134.05 5.67

P25705 ATP5A1 0.46 0.66 0.62 0.76 0.65 0.83 0.49 0.82 0.57 0.58 553 59.71 9.13

P62857 RPS28 0.45 0.31 1.26 0.86 1.29 0.90 0.99 0.75 1.38 0.94 69 7.84 10.70

E5RHJ2 ASPH 0.45 0.43 0.75 0.63 0.74 0.60 0.80 0.70 0.69 0.57 113 11.78 6.79

P35527 KRT9 0.44 0.44 0.47 0.87 0.58 0.34 0.59 0.73 0.55 1.45 623 62.03 5.24

H0YJW7 SLIRP 0.43 0.39 0.62 0.69 0.57 0.88 0.54 0.74 0.53 0.50 76 8.69 9.06

P36776-3 LONP1 0.43 0.57 1.03 1.10 1.06 1.30 0.81 1.40 0.66 0.95 763 85.59 6.04

H0YJZ8 KTN1 0.42 0.38 0.40 0.39 0.39 0.43 0.59 0.82 0.59 0.63 153 17.30 4.92

O43852-7 CALU 0.40 0.65 0.59 0.87 0.63 0.88 0.63 1.04 0.67 0.92 161 18.78 4.75

P51572 BCAP31 0.37 0.45 0.45 0.57 0.49 0.61 0.45 1.00 0.48 0.73 246 27.97 8.44

of 313

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The

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may

dif

fer

from

this

pro

of.

305

305

Table S8. Differentially abundant proteins in group 2

Increased Proteins

Accession

Number


[kDa]

calc.

pI C:

127/126

D:

127/126

C:

128/126

D:

128/126

C:

129/126

D:

129/126

C:

130/126

D:

130/126

C:

131/126

D:

131/126

K4DIB9 CRIP1 5.57 1.96 1.87 1.95 8.60 2.39 1.28 0.84 1.10 1.12 46 4.86 8.70

P09132 SRP19 4.11 2.84 2.35 1.16 5.50 5.53 1.57 0.88 1.83 1.13 144 16.15 9.85

P61254 RPL26 3.30 1.66 1.71 1.13 4.44 1.90 1.16 0.90 1.13 1.10 145 17.25 10.55

P15531 NME1 2.48 1.90 1.45 1.45 2.39 2.30 1.52 1.10 1.57 1.33 152 17.14 6.19

Q96K76-2 USP47 2.38 1.56 1.65 1.03 2.85 2.46 1.31 0.92 1.41 0.94 1287 147.13 5.07

Q96GT9 XAGE2 2.36 3.27 1.71 2.02 2.55 6.89 1.55 1.32 1.41 1.62 111 12.35 5.20

B8ZZQ6 PTMA 2.30 1.51 1.85 1.58 2.17 1.66 1.53 1.04 1.57 1.33 107 11.75 3.81

O00625 PIR 2.14 1.63 1.88 1.45 1.83 1.36 1.74 1.30 1.93 1.53 290 32.09 6.92

P67936 TPM4 2.07 2.01 1.70 1.67 2.05 1.90 1.19 0.89 1.23 1.10 248 28.50 4.69

Q2M389 KIAA1033 2.07 1.67 0.72 1.21 3.08 2.06 1.00 0.92 0.72 0.73 1173 136.32 7.44

A6NN80 ANXA6 2.00 1.68 1.11 1.34 2.34 1.90 0.85 1.08 0.75 1.13 667 75.23 5.67

Q99569-2 PKP4 1.97 2.16 1.18 1.48 2.56 4.84 0.96 0.71 0.89 0.30 1149 127.07 8.95

H3BQQ2 ZNF598 1.93 1.80 1.47 1.24 2.12 2.52 1.25 0.82 1.34 1.12 849 93.23 8.53

O15355 PPM1G 1.90 1.68 1.32 1.51 2.59 2.71 1.22 0.89 1.11 1.14 546 59.23 4.36

Q16643 DBN1 1.89 1.95 1.70 1.87 1.66 2.25 1.28 1.33 1.18 1.28 649 71.39 4.45

E9PRZ9 C11orf58 1.85 1.75 0.99 0.86 2.60 3.45 0.87 0.85 0.83 1.04 90 10.03 5.95

O00151 PDLIM1 1.84 1.98 1.62 1.66 1.76 3.46 1.24 0.91 1.18 1.14 329 36.05 7.02

P61956-2 SUMO2 1.79 2.08 1.36 1.75 2.11 3.18 1.22 0.90 1.27 1.42 71 8.11 5.41

H0YA26 PANK4 1.75 1.92 1.25 1.28 2.15 2.31 1.20 1.05 0.93 1.59 473 53.04 6.30

P09493-3 TPM1 1.75 2.89 1.87 3.44 1.49 2.80 1.22 1.21 1.43 1.41 284 32.86 4.78

O43765 SGTA 1.75 1.62 1.50 1.66 1.78 1.50 1.34 1.16 1.68 1.21 313 34.04 4.87

C9JL85 MTPN 1.74 1.78 1.45 1.69 1.57 1.76 1.41 1.58 1.62 1.71 52 5.70 4.78

of 313

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from

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306

306

Q16401-2 PSMD5 1.72 1.65 1.28 1.57 1.41 2.05 1.13 1.17 0.70 1.36 461 51.28 5.44

H0Y547 ATP11A 1.72 1.54 1.26 1.17 1.93 2.26 1.11 0.96 1.23 1.04 935 106.55 6.42

A6NJA2 USP14 1.69 1.97 1.28 1.42 1.57 3.01 1.33 1.09 1.25 1.19 448 51.05 5.92

P31949 S100A11 1.66 1.81 1.51 1.66 1.84 1.77 1.32 1.15 1.28 1.42 105 11.73 7.12

P30041 PRDX6 1.62 1.83 1.59 1.84 1.57 1.68 1.43 1.39 1.64 1.77 224 25.02 6.38

P68036-2 UBE2L3 1.61 1.95 1.28 2.13 1.78 1.47 1.25 1.22 1.31 1.65 122 14.11 8.92

P49321-4 NASP 1.60 1.51 1.91 1.28 1.74 1.47 2.27 1.18 1.89 1.44 724 78.40 4.27

Q9H0U4 RAB1B 1.60 2.16 1.11 0.94 1.46 5.94 1.04 0.68 1.16 0.82 201 22.16 5.73

P25815 S100P 1.58 1.64 1.46 1.28 1.50 1.97 1.42 1.18 1.49 1.46 95 10.39 4.88

Q5VT79 ANXA8L2 1.56 1.63 1.45 1.60 1.30 1.65 1.21 1.00 1.14 1.30 327 36.84 5.63

P07951-2 TPM2 1.55 1.59 1.60 1.41 1.52 1.30 1.09 0.95 0.97 0.85 284 32.97 4.67

P20962 PTMS 1.54 2.30 1.62 1.68 1.53 3.23 1.51 1.18 1.69 1.43 102 11.52 4.16

Q9NRX4-2 PHPT1 1.54 1.65 1.55 1.58 1.64 2.70 1.60 1.06 1.81 1.80 124 13.66 7.47

C9J8Q1 NFU1 1.53 1.77 1.41 1.00 1.48 2.39 1.27 0.99 1.39 1.04 96 10.44 4.12

Q8N392-2 ARHGAP18 1.51 1.53 0.97 1.05 1.73 2.93 1.16 1.03 1.23 1.05 618 70.12 6.11

Decreased Proteins

Accession

Number


[kDa]

calc.

pI C:

127/126

D:

127/126

C:

128/126

D:

128/126

C:

129/126

D:

129/126

C:

130/126

D:

130/126

C:

131/126

D:

131/126

P10109 FDX1 0.62 0.46 0.77 0.69 0.57 0.47 0.62 0.58 0.54 0.39 184 19.38 5.83

Q96EC8 YIPF6 0.61 0.59 0.76 0.71 0.60 0.57 0.85 1.02 0.78 0.96 236 26.24 5.64

O15400-2 STX7 0.61 0.64 0.78 0.77 0.59 0.53 0.88 1.01 0.84 0.94 239 27.38 5.12

Q00325-2 SLC25A3 0.61 0.64 0.75 0.81 0.61 0.59 0.78 1.04 0.68 0.83 361 39.93 9.36

Q5T8A0 MRPS2 0.61 0.64 0.79 0.97 0.71 0.69 0.53 0.89 0.45 0.63 270 30.46 9.60

P02765 AHSG 0.60 0.34 0.51 0.33 0.60 0.44 0.50 0.33 0.46 0.47 367 39.30 5.72

P68431 HIST1H3A 0.58 0.42 0.61 0.33 0.58 0.23 0.78 0.37 0.94 0.47 136 15.39 11.12

Q5T0H9 GSN 0.58 0.31 0.83 0.52 0.53 0.29 0.76 0.51 0.79 0.60 485 52.34 5.34

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

307

307

O75531 BANF1 0.57 0.59 0.63 0.74 0.60 0.76 0.93 0.87 0.85 0.77 89 10.05 6.09

O43493-2 TGOLN2 0.57 0.55 0.52 0.64 0.56 0.57 0.60 0.79 0.56 0.68 437 45.85 5.63

Q96I59 NARS2 0.57 0.58 0.74 0.64 0.54 0.84 0.62 0.69 0.45 0.47 477 54.06 7.24

P51572 BCAP31 0.56 0.56 0.61 0.59 0.60 0.53 0.63 0.82 0.59 0.79 246 27.97 8.44

F5H7V7 NDUFA8 0.56 0.59 0.70 0.77 0.49 0.50 0.60 0.75 0.52 0.53 128 14.92 7.25

E2QRH7 ELOVL5 0.55 0.55 0.63 0.56 0.65 0.63 0.54 0.58 0.52 0.67 289 34.18 9.48

J3QLR8 MRPS23 0.53 0.62 0.67 0.81 0.51 0.62 0.60 0.71 0.43 0.40 152 17.51 9.63

O14949 UQCRQ 0.52 0.54 0.73 0.74 0.60 0.41 0.58 0.81 0.54 0.62 82 9.90 10.08

K7EIR2 C19orf70 0.52 0.51 0.70 0.64 0.50 0.51 0.69 0.58 0.63 0.60 88 9.69 8.76

O75475-3 PSIP1 0.48 0.66 0.74 0.57 0.48 0.57 0.84 0.65 0.79 0.76 329 37.25 9.23

B7Z4M1 RTN3 0.46 0.46 0.61 0.63 0.43 0.37 0.71 0.72 0.66 0.65 123 12.74 7.83

I3L0Y5 ATP5G1 0.45 0.50 0.59 0.65 0.50 0.51 0.70 0.94 0.61 1.11 98 10.03 10.01

J3KS17 APOH 0.45 0.35 0.65 0.55 0.46 0.35 0.77 0.43 0.56 0.52 104 11.65 6.49

Q9UBR2 CTSZ 0.45 0.59 0.62 0.74 0.47 0.48 0.63 0.98 0.62 1.02 303 33.85 7.11

Q9P2G1 ANKIB1 0.35 0.55 0.52 0.69 0.25 0.42 0.75 0.61 0.74 0.63 1089 121.92 5.11

Q9NYJ1 COA4 0.34 0.56 0.46 0.57 0.36 0.90 0.37 0.56 0.30 0.51 87 10.13 6.04

C9JKR2 ALB 0.21 0.34 0.25 0.24 0.23 0.31 0.25 0.22 0.25 0.25 417 47.26 6.35

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

308

308

Table S9. Primers used for Q-PCR

Primers for Q-PCR

Gene

names Organism

GenBank

Accession Forward Primer Reverse Primer

Size

(bp)

HMGB1 Human NM_002128 TATGGCAAAAGCGGACAAGG CTTCGCAACATCACCAATGGA 196

HSPB1 Human NM_001540 ACGGTCAAGACCAAGGATGG AGCGTGTATTTCCGCGTGA 104

PRDX6 Human NM_004905 GTGACAGCTCGTGTGGTGTT CTGGGGTGGCAACCCTTTT 151

COX4I1 Human NM_001861 GAGAAAGTCGAGTTGTATCGCA GCTTCTGCCACATGATAACGA 139

ATP5B Human NM_001686 CCTGTCAGGGACTATGCGG TCCTTACTGTGCTCTCACCCA 205

COX6B1 Human NM_001863.4 CTACAAGACCGCCCCTTTTGA GCAGAGGGACTGGTACACAC 163

HSPA9 Human NM_004134.6 TGGTGAGCGACTTGTTGGAAT ATTGGAGGCACGGACAATTTT 160

FASN Human NM_004104.4 ACAGCGGGGAATGGGTACT GACTGGTACAACGAGCGGAT 188

PARK2 Human NM_013987 GTGTTTGTCAGGTTCAACTCCA GAAAATCACACGCAACTGGTC 129

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

309

309

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

310

310

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

311

311

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

312

312

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

313

313

of 313

Ant

ioxi

dant

s &

Red

ox S

igna

ling

Pero

xire

doxi

n 6

is a

cru

cial

fac

tor

in th

e in

itial

ste

p of

mito

chon

dria

l cle

aran

ce a

nd is

ups

trea

m o

f th

e PI

NK

1-Pa

rkin

pat

hway

(do

i: 10

.108

9/ar

s.20

15.6

336)

Thi

s ar

ticle

has

bee

n pe

er-r

evie

wed

and

acc

epte

d fo

r pu

blic

atio

n, b

ut h

as y

et to

und

ergo

cop

yedi

ting

and

proo

f co

rrec

tion.

The

fin

al p

ublis

hed

vers

ion

may

dif

fer

from

this

pro

of.

peroxiredoxin 6 is a crucial factor in the initial step...

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