ne m o urs chil dre n s ho s p ita l...ne m o urs chil dre n ’s ho s p ita l curriculum vitae...

N E M O U R S C H I L D R E N ’ S H O S P I T A L

Curriculum Vitae

Date: October 2015

Terri H. Finkel, M.D., Ph.D.

Office Address: Nemours Children’s Hospital 13535 Nemours Parkway Orlando, Florida 32827 Email Address: [email protected] Education: 1971-75 B.S. Stanford University (Biology, with Honors) 1975-82 M.D. Stanford University 1976-84 Ph.D. Stanford University (Biochemistry/Biophysics) Pregraduate Training:

1971 Research Assistant, Department of Cardiology, Palo Alto Clinic, Palo Alto, CA

1972 Research Assistant, Department of Biology, V.A. Hospital, Long Beach, CA

1973-74 Student Researcher, Department of Biology, Stanford University, Stanford, CA

1973-74 Student Researcher, Ocular Pharmacology, Alza Corporation, Palo Alto

1973-75 Research Assistant, Honors Biology Research Program, Department of Pediatrics, Stanford Medical School, Stanford

1975 Research Assistant, National Bureau for Economic Research, Stanford University, Stanford

Sponsor: Victor Fuchs, MD Postgraduate Training and Fellowship Appointments:

1982-83 Internship (PL-1) in Pediatrics, Department of Medicine, Children's Hospital Medical Center, Longwood Avenue, Boston, MA

1983-84 Completion of PhD thesis 1984-86 Residency (PL-2, PL-3) in Pediatrics, University of

Colorado Health Sciences Center, Denver, CO 1985-86 Research Assistant, National Jewish Center for

Immunology & Respiratory Medicine, Denver, CO


Sponsor: Richard Johnston, M.D. 1986-87 Research Fellow in Basic Immunology, National

Jewish Center for Immunology and Respiratory Medicine

Sponsor: John C. Cambier, Ph.D. 1987-88 Howard Hughes Fellow in Basic Immunology, National

Jewish Center for Immunology and Respiratory Medicine

Sponsors: Philippa Marrack, Ph.D., John Kappler, Ph.D.

1987-90 Clinical Fellow in Rheumatology, National Jewish Center for Immunology and Respiratory Medicine

Sponsor: J. Roger Hollister, M.D. 1988-90 Arthritis Foundation Postdoctoral Fellow in Pediatric Rheumatology, National Jewish Center for

Immunology and Respiratory Medicine Faculty Appointments:

1990-95 Assistant Faculty Member, Divisions of Basic and Clinical Sciences, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine

1990-99 Lecturer, Graduate Course in Immunology, University of Colorado Health Sciences Center,

1991-95 Assistant Professor, Department of Biochemistry, Biophysics, and Genetics, and Department of Pediatrics, University of Colorado Health Sciences Center

1991-99 Graduate Faculty, Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center

1994-95 Assistant Professor, Department of Immunology, University of Colorado Health Sciences Center 1995-99 Associate Faculty Member, Divisions of Basic and

Clinical Sciences, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine

1995-99 Associate Professor, Departments of Pediatrics, Immunology, and Biochemistry & Molecular Genetics, University of Colorado Health Sciences Center

1998-99 Biomedical Sciences Program, University of Colorado Health Sciences Center

1999-2010 Associate Professor, with Tenure, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA


1999-2010 Associate Member Joseph Stokes, Jr. Research Institute, The Children's Hospital of Philadelphia, Philadelphia, PA

2000-2011 Immunology Graduate Group, University of Pennsylvania School of Medicine

2004-2011 Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine

2010-2011 Professor, with Tenure, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA

2011- Adjunct Professor, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA

2012- Adjunct Professor, Sanford-Burnham Medical Research Institute, Orlando, Florida (pending)

2012- Professor of Pediatrics and Biomedical Sciences (Affiliate Faculty), University of Central Florida (UCF) College of Medicine, Orlando, Florida

2015- Professor of Pediatrics, with tenure, UCF College of Medicine, Orlando, Florida

Hospital and Administrative Appointments:

1992-1999 Chief, Division of Rheumatology, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine

1993-1999 Director, Eleanore and Michael Stobin Laboratory for Pediatric Research, National Jewish Center for Immunology and Respiratory Medicine

1999-2011 Chief, Division of Rheumatology, Department of Pediatrics, The Children's Hospital of Philadelphia

1999-2011 Children’s Health Care Associates, The Children’s

Hospital of Philadelphia 2002-2008 Director, Immunology Program, Center for AIDS

Research, University of Pennsylvania 2002-2011 Director, BSL-3 Flow Cytometry Facility, The

Children’s Hospital of Philadelphia 2002-2011 Director, Vaccines and Immune Therapies Research

Affinity Group and the Center for Vaccines and Immune Therapies, Stokes Research Institute, The Children’s Hospital of Philadelphia

2007-2011 Divisional Champion, EPIC EHR Rheumatology Implementation

2011- Chair of Pediatrics and Pediatrician-in-Chief, Nemours Children’s Hospital (NCH), Orlando, Florida

2011- Chief Scientific Officer, NCH, Orlando, Florida


2013- Central Florida Senior Leadership Team, NCH, Orlando, Florida

2015 Acting Chief Medical Officer, NCH, Orlando, Florida

Specialty Certification: 1988 Pediatrics 1994, 2001, 2008 Pediatric Rheumatology

Licensure: Colorado (27545-inactive) Pennsylvania (MD-068299-L) Florida (ME111676) Awards, Honors and Membership in Honorary Societies:

1975 B.S. degree with Honors 1976 Stanford, A.M.A., California State, and Elks Club

Scholarships 1976-82 Medical Scientist Training Program, Stanford

University, USPHS Training 1976 Grant awarded by the National Institute of General

Medical Science 1982 Diplomate of the National Board of Medical Examiners 1988 Arthritis Foundation Postdoctoral Fellowship in

Pediatric Rheumatology 1989 Senior Rheumatology Scholar Award, American

College of Rheumatology 1990 Pediatric Rheumatology Award, American College of

Rheumatology 1995 Finalist, Elizabeth Glaser Award, Pediatric AIDS

Foundation 1996 Honored as a ‘Miracle Maker’ by the Children’s

Miracle Network 1996 Inducted into The Colorado Women's Hall of Fame 1999 Joseph L. Hollander Endowed Chair in Pediatric

Rheumatology, University of Pennsylvania 1999 Biography chronicled in the book “Women of

Consequence: The Colorado Women’s Hall of Fame”,

by Jeanne Varnell 2000 Tenure awarded, University of Pennsylvania 2000 Honorary Master of Arts, University of Pennsylvania 2001 Philadelphia Magazine's Top Docs for Children 2001 HHMI Rheumatology Fellowship Training Award 2001 “Hero” of the Arthritis Foundation Postdoctoral

Fellowship Program, for 'contributions to the field of arthritis'

2001 Biography chronicled in the book “The Children’s


Hospital of Philadelphia 1995-2001: A Hospital on the Move” by Shirley Bonnem

2002 The John Morgan Society, The University of Pennsylvania

2002 ACR REF Rheumatology Fellowship Training Award (awarded to the Division of Rheumatology, CHOP)

2003 “Hero Award” from the Eastern Pennsylvania Arthritis Foundation

2004 Lady Barbara Colyton Prize for Autoimmune Research, Awards of Excellence, University of Pennsylvania

2004 ACR REF Rheumatology Fellowship Training Award 2005 Philadelphia Magazine’s Top Docs for Children 2006 ACR REF Paula de Merieux Rheumatology

Fellowship Award for minority training 2006 Elected to membership in The Henry Kunkel Society,

Rockefeller University 2008 ACR REF Paula de Merieux Rheumatology

Fellowship Award for minority training 2009 ACR REF Rheumatology Fellowship Training Award 2009 Philadelphia Magazine’s Top Docs for Children 2010 ACR REF Paula de Merieux Rheumatology

Fellowship Award for minority training 2011 ACR REF Amgen Rheumatology Training Award 2011 America’s Top Doctor, Castle Connolly Medical Ltd.

(ranked in the top 1% of Pediatric Rheumatologists on the list of U.S. News Top Doctors)

2012 Keynote Speaker, Arthritis Foundation’s Orlando

Family Kick Off Luncheon 2012 America’s Top Doctor, Castle Connolly Medical Ltd.


2013 America’s Top Doctor, Castle Connolly Medical Ltd.


2014 America’s Top Doctor, Castle Connolly Medical Ltd.


2014 Entered into the Congressional Record of U.S. History for Women’s History Month as an outstanding woman leader

2014 Business Executive of the Year, Orlando Business Journal

2014 Orlando Life Top Doctor


Membership in Professional and Scientific Societies: International Societies: International Society for Gene Therapy and Molecular Biology Henry G. Kunkel Society for Translational Immunology National Societies:

American College of Rheumatology (Fellow) Arthritis Foundation Lupus Foundation American Association for the Advancement of Science American Association of Immunologists Molecular Medicine Society Society for Pediatric Research American Society for Investigative Pathology American Academy of Pediatrics, Section on Pediatric Rheumatology CARRA

Local Societies: Rocky Mountain Chapter, Arthritis Foundation Eastern Pennsylvania Chapter, Arthritis Foundation Rocky Mountain Rheumatism Society ONEDAY, The AIDS Family Project (Board of Directors, 1994-99) Philadelphia Rheumatism Society Tri-State (PA, DE, NJ) Pediatric Rheumatology Study Group

International Scientific Committees: Arthritis Research Editorial Board Meeting, Nice, France, June 2000 Membership Selection Committee, Henry Kunkel Society, 2008-1010

NIH/INCHARGE International Working Group, 2009-

National Scientific Committees: Special Reviewer, British Columbia Health Research Foundation,

November, 1992 Special Reviewer, NIH, NIAID, R29, May, 1993 National Institutes of Health, Consultant, 1993- Division of AIDS, NIH, NIAID, Division of AIDS, ad hoc review of the

Pathogenesis Program, Panel Member, May, 1993 Special Reviewer, NIH, NIAID, RFA, “Immune Reconstitution of HIV-

Infected Individuals”, March, 1994 National Cancer Institute, Consultant, 1994- Special Reviewer, NIH, NCI, Cleveland Clinic Foundation, “Biology of

Renal Cell Carcinoma”, June, 1994 Division of AIDS, NIH, NIAID, Non-Human Primate Models Workshop,

1994


Guest Reviewer, NIH, NIAID, AIDS & Related Research Study Section, November, 1995

Special Reviewer, Swiss National Science Foundation, November, 1995 Special Reviewer, Long Island Jewish Medical Center, Faculty

Research Award Program, March 1996. NIH, NIAID, AIDS & Related Research Study Section, 1996-1999 Fellowship Research Grant Advisory Board, Bayer Corporation, 1998-

1999 Special Reviewer, Arthritis Foundation, “The Wasie Foundation

Challenge for Juvenile Arthritis Research”, July, 2000 Data Safety Monitoring Board, NIAMS, 2000-2003 10th Annual Child Health Research Center Meeting, Bethesda,

Maryland, November 3, 2000 Pediatric Rheumatology Research Network, Founding Member, 2001- National Medical & Scientific Committee, Arthritis Foundation, 2001-

2003 AAP Planning Group, Rheumatology 2003 CME Course, 2001-2003 Subspecialty Reviewer for Allergy, Immunology & Rheumatology for the

2002 PAS Meeting in Baltimore, MD External Advisory Board, P01 AR048929, “Integrative Genomics and

JRA/JSpA)”, 2002-2004 Member, Childhood Arthritis & Rheumatology Research Alliance

(CARRA; formerly PRRN), 2002- National Medical & Scientific Council, Arthritis Foundation, 2003 NICHD Pediatric Scientist Development Program Selection Committee,

2005-2010 American College of Rheumatology T Cell Committee, 2009 Autoimmunity Center for Excellence Pediatric Advisory Council, 2010 Association of Medical School Pediatric Department Chairs, 2012- Steering Board Member, PEDSnet, A Pediatric Learning Health System,

2013- PEDSnet Workgroup: Strategic Relationships & Development of an LHS

Consortium, 2015-

Local Scientific Committees Lupus Symposium Panel, Lupus Foundation, 1989-99 Arthritis Foundation Grants Committee, 1992-94 Medical City Women’s Panel at the 2nd Annual Orlando Women’s

Conference, 2012 Chair, Associate Dean for Research Search Committee, University of

Central Florida College of Medicine, 2013 Editorial Positions:

1994-2005 Associate Editor, Journal of Immunology 1995-2003 Editor, Apoptosis


1997-2006 Editor, Journal of Clinical Immunology 1999-present Editor, Arthritis Research and Therapy

Ad-Hoc Reviewer: AIDS

AIDS Research and Human Retroviruses Archives of Dermatology Arthritis and Rheumatism Arthritis Care and Research Blood Cell Death and Differentiation Circulation Clinical and Diagnostic Laboratory Immunology Cytometry Immunity Journal of Acquired Immune Deficiency

Syndromes and Human Retrovirology Journal of Allergy and Clinical Immunology

Journal of Biological Chemistry Journal of Clinical Immunology Journal of Clinical Investigation Journal of Experimental Medicine Journal of Immunology Journal of Infectious Disease Journal of Rheumatology Journal of Virology Laboratory Investigation Molecular Medicine Today Nature Immunology Nature Medicine Nature Reviews Immunology PLoS Biology Proceedings of the National Academy of Sciences Virology

Academic Committees at National Jewish Medical and Research Center and UCHSC:

1990-92 NJCIRM Liaison, UCHSC Pediatric CRC Advisory Committee 1992-99 Executive Faculty Committee, Department of Pediatrics 1994-99 Credentials Committee 1994 TCH/NJC Affiliation Committee 1995 Clinical Laboratory Committee

Academic Committees at The Children’s Hospital of Philadelphia and The University of Pennsylvania 1999- Executive Faculty Committee, Department of Pediatrics


2000-03 HIV Executive Committee, Children’s Hospital 2001- Graduate Group in Immunology, University of Pennsylvania 2001-03 MAPS-CHRC Grants Committee, Children’s Hospital 2002- Penn Cancer Center Flow Cytometry Advisory Committee 2002- Executive Committee, Penn Center for AIDS Research 2003- MD/PhD Admissions Committee, University of Pennsylvania 2003-04 Recruitment Evaluation Committee 2003-05 Human Clinical Immunology Executive Committee 2003 Penn Orthopedics Review Committee 2003 Penn Lupus Clinical Trial Consortium

2004 Search Committee for Director of Joseph Stokes Research Institute, Chief Scientific Officer, and Senior Vice President for Research, Children’s Hospital

2005- Cell and Molecular Biology Graduate Group, UPenn 2005- Gene Therapy and Vaccines Program, UPenn 2005- Gene Therapy and Vaccines Seminar Committee, UPenn 2006 Search Committee for Section Chief/Endowed Chair in Pain

Management, Children’s Hospital 2007 Foerderer-Murray Awards Selection Committee, Children’s Hospital 2007- Executive Committee, Training Program in Rheumatology, University

of Pennsylvania 2007 Selection Committee, Lady Barbara Colyton Prize for Autoimmune

Research, Awards of Excellence, University of Pennsylvania 2008 Foerderer-Murray Awards Selection Committee 2008 Search Committee for Division Chief of Nephrology, Children’s

Hospital 2008 Search Committee for Division Chief of Rheumatology, UPenn 2008- Institutional Intellectual Property Advisory Committee (iiPAC),

Children’s Hospital 2009- Admissions Committee, Cell and Molecular Biology Graduate Group,

University of Pennsylvania 2009- Executive Committee, Gene Therapy and Vaccines Training Program,

Cell and Molecular Biology Graduate Group, UPenn 2009 Foerderer-Murray Awards Selection Committee, Children’s Hospital 2010- Member, Penn Institute for Immunology Academic and Operational Committees at Nemours Children’s Hospital and Lake Nona Medical

City (LNMC) 2011- Medical Executive Committee, NCH 2011 Managed Care Committee, NCH 2011 Research Strategic Metrics Working Group, Nemours Foundation 2012 Orlando Practice Transition Committee, NCH 2012- Clinical Research Review Committee (CRRC), Nemours Foundation 2012- Center for Pharmacometrics and Systems Pharmacology Leadership

Council, University of Florida College of Pharmacy, LNMC


2013- Quality & Safety Committee, NCH 2013 Lake Nona Institute, Institute of Medicine Program Committee, LNMC 2013- Nemours Research Oversight Committee, Nemours Children’s Health

System (NCHS) 2013- Senior Leadership Team, NCH 2013- Incident Command Team, NCH 2014- Lake Nona Life Project Advisor, LNMC 2014- Executive Team, NCH 2014- Telehealth Committee, NCHS 2015- Lake Nona Medical City Research Council, LNMC 2015- Nemours 2020 Strategy Management Committee, Nemours

Foundation Major Teaching and Clinical Responsibilities at The Children’s Hospital of Philadelphia and The

University of Pennsylvania: In charge of Adult and Pediatric Rheumatology Fellows and Pediatric and Family Practice Residents rotating through Pediatric Rheumatology Clinic (a total of ~40 fellows, ~60 residents, and ~20 medical students since 1999) Attending on the Pediatric Rheumatology service at The Children’s Hospital of

Philadelphia 3 months/year Pediatric Rheumatology Clinic & Fellow’s Clinic, The Children’s Hospital of

Philadelphia, two days/week ACGME approval of accreditation for Residency in Pediatric Rheumatology, 2000 (the first time in its 20 year history that the Rheumatology Program at CHOP has been accredited). Re-accredited in 2007 for 2008-2013 (without critique). Weekly Pediatric Rheumatology didactic sessions Weekly Pediatric Rheumatology textbook review sessions Monthly joint conferences with Pathology Monthly joint conferences with Radiology Member, Graduate Group in Immunology Member, Cell and Molecular Biology Graduate Group Course Instructor, Fall 2000-2001, Immunology 520 Course Instructor, Spring 2000-2004, Immunology 599


Mentor, Combined Degree (MD-PhD) Program

Speaker’s Bureau, CHOP, 2003-present

Thesis Committees: Marcela Maus, IGG student, 2000-2003

Title: Extensive Replicative Capacity of Human T Cells

Marina Kremyanskaya, IGG student, 2001-2005: Title: The Antigen Recognition and the Signal Transduction

Components of the B Cell Antigen Receptor are Differentially Localized Following BCR Aggregation

Maria Chen, CAMB GG student, 2003-2006

Title: Compartmentalization and Variation of Envelope gp160 from Various CNS Regions of SIVmac239-Infected Macaques

Mark F. Cotton, M.B.CH.B., M.Med(Paed), FCPaed(SA), DTM&H, DCH(SA),

Ph.D. in Medical Microbiology, Univ of Stellenbosch, 2004 Title: The Relevance of Apoptosis in the Pathogenesis of Human

Immunodeficiency Virus-1 Disease

Dominick Laddy, CAMB GG student, 2005-2008 Title: Vaccination Against Pathogenic Influenza with Synthetic

Consensus DNA Antigens

Emma Reuschel, CAMB GG student, 2008-2014 Title: Modulation of Apoptosis in HIV Infected T Cells NIH HIV Pathogenesis T32 fellowship CROI Young Investigator Award, 2011

Hui-Hui Han, Visiting Graduate Student, Shandong University, China

Alex Klatenhoff, CAMB Graduate Group

Lorenzo Ramirez, CAMB Graduate Group

Mentees:

Jason Shackelford, M.D., 1999-2002 Research Assistant Currently, University of Pittsburgh Resident in Internal Medicine.

Nithianandan Selliah, Ph.D., 1999-2008

Senior Research Associate


Elizabeth Glaser Pediatric AIDS Foundation Scholar Award, 1998-2000

Florence Murray Award, 2001-2002 Amaxa Travel Award, 2006 Currently, Assistant Professor, Boston University

Evan Fieldston, M.D., M.P.H., 2000-2002

Resident in Pediatrics ACR Medical and Graduate Student Achievement Award, 2001 ACR REF Medical Student Clinical Preceptorship, 2002 Currently, Robert Wood Johnson Scholar

Dennis DeSimone, M.S., 2000-2003

Research Assistant Currently, DO student at University of Virginia. Returned to the lab

for a 1-month rotation, Summer, 2006. Nili Feuerstein, Ph.D., 2000-2004

Senior Research Associate Currently, Senior Research Associate, UPenn

Jiyi Yin, Ph.D., 2000-2005

Postdoctoral fellow CROI Travel Award, 2005 Currently, Senior Research Associate, Washington University

School of Medicine

Randy Q. Cron, M.D., Ph.D., 2000-2007 Assistant Professor, UPenn, Tenure Track, effective July 1, 2000 Ethel Brown Foerderer Fund for Excellence Award, 2004-2006 2 Nickolett Family Awards for JRA Research, 2004-2006 Mary L. Smith Charitable Trust Award, 2001-2002 NIH RO1, 2002-2007 NIH R21, 2002-2005 MAPS-CHRC Award, 1999-2001 Arthritis National Research Foundation Award, 2002-2003 Center for AIDS Research Developmental Award, 2004-2005 Amgen Rheumatology Fellowship Mentor Award, 2004-2005 American Association of Immunologists Junior Faculty Travel Award,

2006 NIH R21, 2007-2009 Currently, Associate Professor and Division Chief, Pediatric

Rheumatology, University of Alabama

Maria Chen, M.D., Ph.D., 2001


CAMB Graduate student, lab rotation Stefania Gallucci, M.D., 2001-2009

Postdoctoral fellow NIH K22, 2003-2005 Lupus Foundation award, 2002-2003 Appointed as Research Assistant Professor, UPenn, effective

January 1, 2003 Florence Murray Award, 2003-2004 CFAR Developmental Award, 2004-2005 Arthritis Foundation Innovative Grant, 2006-2007 Lupus Foundation of America grant, 2007-2008 NIH R21, 2009-2011 NIH R01, 2009-2014 Currently, Associate Professor, Temple University

Zhengyu Ma, Ph.D., 2001-present

IGG Graduate Student, 2001-2006 AAI Travel Award, 2008 Center for Vaccines & Immune Therapies Grant, 2008 Center for AIDS Research Developmental Award, 2009 NIH R21, 2010-2012 Research Assistant Professor, UPenn, 2010-2012 AAI Junior Faculty Investigator Award, 2011 Senior Scientist, Nemours/AIDHC, 2012

Suzanne Beno, M.D., 2002

Pediatric Resident 2002 ACR Pediatric Resident Travel Award.

Ananya Bera Gupta, Ph.D., 2003-2004

Postdoctoral fellow Currently, Research Associate, UPenn

Una O’Doherty, M.D., Ph.D., 2008-2012

Assistant Professor, Department of Pathology, UPenn NIH R01, @004-2010 NIH K02, 2008-2013 NIH R21, 2009-2011

Shaheed Abdulhaqq, CAMB Graduate Group, 2008-2009 Lauren Jeang, UPenn Undergraduate, 2008-2010 Paul Vithayathil, UPenn Undergraduate, Summer 2009


Erika Crosby, CAMB Graduate Group, Summer 2009

Lehn Weaver, M.D., Ph.D., 2009-2012 Pediatric Resident Program Mentor for Dr. Weaver at the 2009

American College of Rheumatology Annual Scientific Meeting

AnneMarie Brescia, M.D., 2013-present Currently, Assistant Professor, A.I. duPont Hospital for Children NIH K23, 2014-2019

Rheumatology Fellows:

Lisabeth Scalzi, M.D., 1998-2002 Fellowship Award, American Heart Association, 2001-2003 NIH K23, 2004-2009 Assistant Professor, Cleveland Clinic, Cleveland, Ohio, July 2002 Currently, Assistant Professor of Medicine and Pediatrics, Division

of Rheumatology, Hershey Medical Center, Penn State University

Frida Gudmundsdottir, M.D., 1999-2001, deceased Established the Frida Fund for Training in Pediatric Rheumatology,

in her honor

Birgit Kovacs, M.D., 2000-2002 Fellow of the Year Award, Division of Rheumatology, UPenn, 2000 NIH NRSA grant, 2001 Postdoctoral Research Fellowship for Physicians, Howard Hughes

Medical Institute (HHMI), 2001-2004 Fellowship Award, Amgen Pharmaceuticals, 2001 ACR Distinguished Fellow Award, 2002 Currently, Associate Director, Immunology, Boehringer Ingelheim

Pharmaceuticals, Inc. and Adjunct Assistant Professor of Pediatrics, UPenn

Jon M. Burnham, Jr., M.D., M.S.C.E., 2001-2004 ACR REF Investigator Fellowship Award, 2002-2005 Nickolett Family 2004 Award for JRA Research ACR REF 2004 Pediatric Rheumatology Research Award Nickolett Family 2005 Award for JRA Research K23, NCCR, 2005-2010 American Society for Bone and Mineral Research, Harold Frost

Young Investigator Award, 2005 American Society for Bone and Mineral Research Young

Investigator Award, 2006 2008-2009 Foerderer Award


Currently, Assistant Professor, UPenn Esi DeWitt, M.D., M.S.C.E., 2002-2005 2002 ACR REF Rheumatology Fellowship Training Award NIH Pediatric Subspecialties T32 fellowship, 2003-2005 CHORD Fellowship, 2003-2004 Master’s of Clinical Epidemiology, CCEB, UPenn, 2005 Instructor, Department of Pediatrics, Duke University Medical

Center, 2005-2009 Currently, Assistant Professor, Cincinnati Children’s Hospital

Medical Center, University of Cincinnati Bita Arabshahi, M.D., 2003-2006 Nickolett Family 2004 Award for JRA Research Travel Award from the TMJ Association, 2005 EULAR Travel Award, 2005 Currently, faculty at George Washington University School of

Medicine at Inova Fairfax Hospital for Children, 2006 Frank Pessler, M.D., Ph.D., 2003-2007 Scholarship to attend the Microarray Course at CSH, 2003 NIH Rheumatology T32 Fellowship EULAR Travel Award, 2005 ACR REF Pediatric Rheumatology Research Awards, 2006 & 2007 Currently, Assistant Professor, Division of Rheumatology, University

of Dresden, Germany Timothy G. Beukelman, M.D., M.S.C.E., 2004-2007 NIH Rheumatology T32 fellowship Podium presentation, 2006 ACR Meeting NIH K12 Currently, Assistant Professor, Division of Pediatric Rheumatology,

University of Alabama Edward M. Behrens, M.D., 2004-2007 Howard Hughes Medical Institute award Four Schools Physician Scientist Fellowship Amgen Rheumatology Fellowship Award, 2004-2005 2005-2006 NIH Pediatric Subspecialties T32 Nickolett Family 2005 Award for JRA Research 2006 AAP Earl Brewer Research Award for Pediatric Rheumatology 2007 ACR REF Pediatric Rheumatology Research Award Arthritis Foundation Fellowship, 2007-2010 2007 ACR Distinguished Fellow Award Instructor, University of Pennsylvania, 2007-2009


K08 Bridge Funding, American College of Rheumatology, 2008 (declined)

NIH K12, 2008-2009 NIH K08, 2009-2014 HHMI Early Physician Scientist Career Award, 2009-2014 Arthritis Foundation Innovator Award, 2010-2012 Assistant Professor, UPenn, 2012- Chief, Division of Rheumatology, CHOP, 2014-

Tracey Brock-Wright, M.D., M.S.C.E., 2005-2008 ACR REF 2006 Paula de Merieux Rheumatology Fellowship Award

for minority training ACR REF Physician Scientist Development Award, 2008-2011 Currently, Assistant Professor, UTSW

Pamela G. Weiss, M.D., M.S.C.E., 2005-2008 ACR REF Medical and Pediatric Resident Research Award Clinical Pharmacoepidemiology T32, 2006-2007 2006-2007 ACR REF Clinical Investigator Fellowship Award NIH F32, 2007-2008 ACR REF Clinical Investigator Fellowship Award, 2008-2010 ACR Distinguished Fellow Award, 2008 UPenn McCabe Award, 2008 ACR Bridge Award, 2010-2011 K23, NIAMS, 2011-2016 Currently, Assistant Professor, UPenn

Sharon Bout-Tabaku, M.D., M.S.C., 2006-2009 ACR REF 2008 Paula de Merieux Rheumatology Fellowship Award

for minority training NIH Rheumatology T32 fellowship M.S.C.E. candidate, CCEB, University of Pennsylvania Currently, Assistant Professor, Columbus Children’s Hospital, Ohio

State University Jay Mehta, M.D., 2006-2009 ITMAT Fellowship Award (declined) NIH Rheumatology T32 fellowship ACR REF Physician Scientist Development Award, 2009-2012 M.T.R. candidate, ITMAT, University of Pennsylvania Currently, Instructor, CHOP Currently, Assistant Professor, Einstein University, New York

Eric Hanson, M.D., 2005-2009 NIH Immunobiology T32 fellowship


2008 Penn Center for Clinical Immunology Jackson-Wade Fellowship

Currently, NIH Metzger Scholar Homaira Rahimi, M.D., M.T.R., 2008-2011

ACR REF 2009 Paula de Merieux Rheumatology Fellowship Training Award

Outstanding Poster Presentation, CHOP Fellows Poster Day, 2010 M.T.R., ITMAT, University of Pennsylvania Currently, Assistant Professor, University of Rochester

Current Senior Research Fellow:

Jiang Fang-Wang, M.D., 2000-present CROI Travel Award, 2005 Keystone Symposium Travel Award, 2008 Center for Vaccines & Immune Therapies Grant, 2009 Outstanding Poster Presentation, CHOP Fellows Poster Day, 2010 Senior Scientist, Nemours Children’s Hospital, 2012-present

Recent Rheumatology Fellows:

William Bernal, M.D., M.P.H., 2007-2012 ACR Divisional Training Award NIH Rheumatology T32 fellowship, 2008-2010 NIH Endocrinology T32 fellowship, 2010-2011

Scott Lieberman, M.D., Ph.D., 2007-2012

NIH Nephrology T32 fellowship, 2008-2010 Arthritis Foundation Postdoctoral Fellowship Award, 2010-2012 NIH K12, 2011-2013

Melissa Lerman, M.D., Ph.D., 2008-2012

2008 ACR REF Rheumatology Fellowship Training Award M.S.C.E. candidate, CCEB, University of Pennsylvania NIH Reproductive Epidemiology T32 fellowship Arthritis Foundation Scientist Development Award, 2011-2013

Cara Hoffart, D.O., 2009-2012 ACR REF/Amgen/Wyeth 2010 Rheumatology Fellowship Training

Award M.S.C.E. candidate, CCEB, University of Pennsylvania NIH CPCE Pharmacoepidemiology T32 fellowship

Scott Canna, M.D., 2009-2012 NIH Rheumatology T32 fellowship Arthritis Foundation Postdoctoral Fellowship Award, 2010-2013


NIH Loan Repayment Award, 2010

Andrea Knight, M.D., 2010-2012 ACR REF/Amgen/Wyeth 2011 Rheumatology Fellowship Training

Award NIH Pharmacoepidemiology T32 fellowship for 2011

Melissa Mizesko, M.D., 2010-2012 NIH Rheumatology T32 fellowship for 2011

Lehn Weaver, M.D., Ph.D., 2011-2012 Yongdon Zhao, M.D., Ph.D., 2011-2012

Course Director “Molecular and Cellular Immunology”, 12 lectures yearly Executive Committee, Training Program in Rheumatology, University of Pennsylvania, 2007-2012 Executive Committee, Cell and Molecular Biology Graduate Group, University of Pennsylvania, 2009-2012

Major Teaching and Clinical Responsibilities at Nemours Children’s Hospital and the UCF COM: Attending on the Pediatric Rheumatology service at Nemours Children’s

Hospital 6 months/year Pediatric Rheumatology Clinic, Nemours Children’s Hospital, one day/week Pending ACGME approval of accreditation for Residency in Pediatrics, anticipated 2017.

Teaching Lectures (past 7 years):

Feb 9, 2007 “What Turns T cells On?”, Stokes Scientific Symposium, The

Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania Feb 18, 2008 “What Turns T cells On? The Receptor Deformation Model of

TCR Triggering, Center for Vaccines and Immune Therapies Seminar Series, Children’s Hospital of Philadelphia,

Philadelphia, Pennsylvania March, 2008 “EPIC Implementation – The Good, The Bad & The Ugly”,

Leadership Briefing Meeting, Children’s Hospital of Philadelphia,

Philadelphia, Pennsylvania April 11, 2008 “The Receptor Deformation Model – A Solution to the TCR


Triggering Puzzle, Stokes Scientific Symposium, The Children’s

Hospital of Philadelphia, Philadelphia, Pennsylvania

June 4, 2008 “The Receptor Deformation Model of TCR Triggering”, Protein

Dynamics Club, The Children’s Hospital of Philadelphia,

Philadelphia, Pennsylvania April 16, 2009 “Genetics of Inflammatory Arthritis in Mouse and Man”, Human

Translational Immunology Series, University of Pennsylvania, Philadelphia, Pennsylvania

November, 2011 “Personalizing Drug Discovery for Childhood Arthritis and

Rheumatic Diseases”, 2011C BIOM 503: The Art of Making

Modern Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

January 19, 2012 “Genetics of JIA”, Florida Board of Managers Meeting, Nemours

Foundation, Jacksonville, Florida March 14, 2012 “Collaborative Research Opportunities at NCH and Medical

City”, Child Health Improvement Forum, Nemours Children’s

Hospital, Orlando, Florida March 30, 2012 “Lake Nona Medical City Roundtable”, presented to Dr. John

Holdren, Office of Science and Technology Policy, UCF COM, Orlando, Florida

Lectures by Invitation (past 7 years):

April 26, 2007 “Monomeric Agonist pMHC Triggers TCR Signaling Independent

of Endogenous Ligand”, Henry Kunkel Society, Rockefeller

University, New York, New York May, 2007 “Monomeric Agonist pMHC Triggers TCR Signaling Independent

of Endogenous Ligand”, 94th Annual Meeting of the American Association of Immunologists, Miami Beach, Florida

April 7, 2008 “The Receptor Deformation Model of TCR Triggering”, 95

th Annual Meeting of the American Association of Immunologists, San Diego, California

May 22, 2008 “The Receptor Deformation Model – A Solution to the TCR

Triggering Puzzle”, 16th Annual International Meeting of the

Henry Kunkel Society, Santa Margherita Ligure, Italy Oct 18, 2009 “Tracking JIA Predisposition Genes: Genome-Wide Association


to Next Generation Sequencing to Functional Relevance”,

Plenary Lecture, 2009 American College of Rheumatology Annual Scientific Meeting, Philadelphia, Pennsylvania

July 27, 2010 “Genetics of JIA”, AJAO National Conference, Philadelphia,

Pennsylvania Aug 30, 2010 “Genetics of Chronic Diseases of Childhood”, Martins Run

University, Media, Pennsylvania Nov 11, 2010 “Discovery and Replication of JIA Predisposition Genes by

Genome-Wide Association and Validation of Candidates in Fibroblast-Like Synoviocytes”, 2010 American College of Rheumatology Annual Scientific Meeting, Atlanta, Georgia

May 5, 2011 “Translating Personalized Medicine to Pediatric Disease”,

University of Florida, Gainesville, Florida September, 2011 “Personalizing Drug Discovery for Childhood Arthrit is and

Rheumatic Diseases”, Autoimmunity Research Symposium, The

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania March, 2012 “Nemours Children’s Hospital”, panelist for Medical City

presentations to Dr. John Holdren, Assistant to the President of the United States for Research and Technology Policy, University of Central Florida, Orlando, Florida

April, 2012 “Nemours Children’s Hospital and Medical City Collaborations”,

Women Who Mean Business panelist, Orlando, Florida http://www.bizjournals.com/orlando/news/2012/02/24/nominees-

for-women-who-mean-business.html?page=all December, 2012 “Translating Personalized Medicine to Pediatric Disease”,

Pediatrics Grand Rounds, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma

April, 2013 “Leveraging the Electronic Medical Record for Clinical Research

in Pediatric Rheumatology”, Children’s Hospital of Atlanta,

Atlanta, Georgia August, 2013 “Kids Get Arthritis Too”; “Kids Get Lupus Too BUT Please Don’t

Order an ANA”, Cape Cod Pediatrics for the Primary Care Physician Conference, Hyannis, MA

Organizing Roles in Scientific Meetings:

http://www.bizjournals.com/orlando/news/2012/02/24/nominees-for-women-who-mean-business.html?page=all

http://www.bizjournals.com/orlando/news/2012/02/24/nominees-for-women-who-mean-business.html?page=all


September, 1994 Mechanisms of T-Cell Death, Tutorial Leader, Laboratory of Tumor Cell Biology Meeting, National Cancer Institute, Bethesda, Maryland

September, 1995 Mechanisms of T-Cell Death, Tutorial Leader, Laboratory of

Tumor Cell Biology Meeting, National Cancer Institute, Bethesda, Maryland

November, 1995 T Cell Signaling and Activation, Workshop Chairman, 24 th

Annual Autumn Immunology Conference, Chicago, Illinois February, 1997 T Cell Dysfunction in HIV Infection, Minisymposium Chair,

American Association of Immunologists Annual Meeting, San Francisco, California

2001-2003 Program Committee for the AAP 2002 International Pediatric

Rheumatology Meeting, Snowmass, Colorado

April, 2008 T Cell Signaling, Block Symposium Chair, AAI 2008 Meeting, San Diego, California

May, 2008 Membership Selection Committee, 16 th Annual International

Meeting of the Henry Kunkel Society, Santa Margherita Ligure, Italy

December, 2008 Membership Selection Committee, 17 th Annual International

Meeting of the Henry Kunkel Society, Rockefeller University, New York, New York

July, 2009 Abstract Selection Committee, 2009 American College of

Rheumatology Annual Scientific Meeting, Philadelphia, Pennsylvania

October, 2009 Abstract Session Moderator, “T cells in autoimmune diseases”,

2009 American College of Rheumatology Annual Scientific Meeting, Philadelphia, Pennsylvania

June, 2011 Fellow’s Research Day, Training Grant in Rheumatic Diseases,

University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

March, 2012 Nemours Center for Cancer and Blood Disorders Strategy

Retreat, AI duPont Hospital for Children, Wilmington, Delaware January, 2012 Pediatric Grand Rounds, Nemours Children’s Clinic, Orlando,


Florida

February, 2012 Translational Science Research Seminars, Nemours Children’s

Hospital, Orlando, Florida November, 2012 Nemours Children’s Hospital Grand Rounds, Orlando, Florida May, 2014 Nemours Children’s Hospital M&M, Orlando, Florida April, 2016 Trainee Science Day, sponsored by the Lake Nona Medical City

Research Council, Orlando, Florida July, 2016 5th International Conference on Engineering Frontiers in

Pediatric and Congenital Heart Disease

Bibliography: Research Publications, peer reviewed:

1. Henning, S., Helman, T.A., Kretchmer, N.: Studies on normal and precocious appearance of jejunal sucrase in suckling rats. Biology of the Neonate 26:249-262, 1975.

2. Helman, T.A.: Correction of a motility defect in nonmotile mutants of Myxococcus

xanthus, Ph.D. Thesis. Stanford University. Stanford, Calif. 1984. 3. Finkel, T.H., Pabst, M.J., Suzuki, H., Guthrie, L.A., Forehand, J.R., Phillips, W.A.,

Johnston, R.B., Jr.: Priming of neutrophils and macrophages for enhanced release of superoxide anion by the calcium ionophore ionomycin: Implications for regulation of the respiratory burst. Journal of Biological Chemistry 262:12589-12596, 1987.

4. Finkel, T.H., McDuffie, M., Kappler, J.W., Marrack, P., Cambier, J.C.: Both

immature and mature T cells mobilize Ca++ in response to antigen receptor crosslinking. Nature 330:179-181, 1987.

5. Finkel, T.H., Cambier, J.C., Kubo, R.T., Born, W.K., Marrack, P., Kappler, J.W.:

The thymus has two functionally distinct populations of immature cortical T cells: One population is deleted by ligation of TCR. Cell 58:1047-1054, 1989.

6. Finkel, T. H., Marrack, P., Kappler, J.W., Kubo, R.T., Cambier, J.C.: Alpha beta

TCR and CD3 transduce different signals in immature T cells: Implications for selection and tolerance. Journal of Immunology 142:3006-3012, 1989.

7. Blackman, M., Finkel, T.H., Kappler, J.W., Cambier, J.C., Marrack, P.: Altered

antigen receptor signalling in anergic T cells from self-tolerant T cell receptor beta-chain transgenic mice. Proceedings of the National Academy of Sciences


U.S.A. 88:6682-6686, 1991. PMC52152 8. Finkel, T.H., Kubo, R.T., Cambier, J.C.: T cell development and transmembrane

signaling: Changing biologic responses through an unchanging receptor. Immunology Today 12:79-85, 1991.

9. Punt, J.A., Kubo, R.T., Saito, T., Finkel, T.H., Kathiresan, S., Blank, K.J.,

Hashimoto, Y.: Surface expression of a T cell receptor (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins. Journal of Experimental Medicine 174:775-783, 1991. PMC2118962

10. Carbone, A., Harbeck, R., Dallas, A., Nemzee, D., Finkel, T., O’Brien, R., Kubo,

R., Born, W.: Alpha beta T-lymphocyte depleted mice, a model for gamma delta T-lymphocyte functional studies. Immunological Reviews 120:35-50, 1991.

11. Finkel, T.H., Kappler, J. W., Marrack, P.: Immature thymocytes are protected from

deletion early in ontogeny. Proceedings of the National Academy of Sciences U.S.A. 89:3372-3374, 1992. PMC48869

12. Banda, N.K., Bernier, J., Kurahara, D.K., Kurrle, R., Haigwood, N., Sekaly, R. -P.,

Finkel, T.H.: Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. Journal of Experimental Medicine 176:1099-1106, 1992. PMC2119378

13. Finkel, T.H., Török, T.J., Ferguson, P.J., Durigon, E.L., Zaki, S.R., Leung, D.Y.M.,

Harbeck, R.J., Gelfand, E.W., Saulsbury, F.T., Hollister, J.R., Anderson, L.J.: Chronic parvovirus B19 infection and systemic necrotizing vasculitis: Opportunistic pathogen or aetiologic agent. Lancet 343:1255-1258, 1994.

14. Levy, A.L., Kurahara, D.K., and Finkel, T.H.: Resistance to deletion in a population of immature αβ+ thymocytes in vivo. J. Allergy & Clin. Immunol. Vol. 93, No. 1:179, 1994.

15. Rozdzial, M.M., Kubo, R.T., Turner, S.L., Finkel, T.H.: Developmental regulation

of the TCR zeta-chain: Differential expression and tyrosine phosphorylation of the TCR zeta-chain in resting immature and mature T-lymphocytes. Journal of Immunology 153:1563-1580, 1994.

16. Finkel, T.H., Banda, N.K.: Indirect mechanisms of HIV pathogenesis: how does

HIV kill T cells? Current Opinion in Immunology 6:605-615, 1994. 17. Kaufman-Paterson, R., Burkly, L.C., Kurahara, D.K., Dunlap, A., Flavell, R.A.,

Finkel, T.H.: Thymic development in human CD4 transgenic mice: Positive selection occurs after commitment to the CD8 lineage. Journal of Immunology 153:3491-3503, 1994.


18. Finkel, T. H., Tudor-Williams, G., Banda, N. K., Cotton, M. C., Curiel, T., Monks,

C., Baba, T., Ruprecht, R., Kupfer, A.: Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV-infected lymph nodes. Nature Medicine 1:129-134, 1995. With accompanying editorials: News & Views, Nature Medicine 1:118-120, 1995.

19. Finkel, T.H., Monks, C., Casella, C.R., Cotton, M.F., Banda, N.K., Kupfer, A., Ikle,

D., Baba, T.W., Ruprecht, R.M.: Apoptosis and HIV disease. Nature Medicine 1:386-387, 1995.

20. Rozdzial, M.M., Malissen, B., Finkel, T.H.: Tyrosine-phosphorylated T cell

receptor zeta chain associates with the actin cytoskeleton upon activation of mature T lymphocytes. Immunity 3:623-633, 1995.

21. Banda, N.K., Satterfield, W.C., Steimer, K., Kurrle, R., Finkel, T.H.: Resistance to

AIDS in chimpanzees is correlated with lack of gp120-induced anergy and priming for apoptosis. Apoptosis 1:49-62, 1996.

22. Paterson, R.L.K., Lack, G., Domenico, J.M., Delespesse, G., Leung, D.Y.M.,

Finkel, T.H., Gelfand, E.W.: Triggering through CD40 promotes IL-4-induced CD23 production and enhanced soluble CD23 release in atopic disease. European Journal of Immunology 26:1979-1984, 1996.

23. Cotton, M.F., Casella, C., Rapaport, E.L., Tseng, P.-O., Marschner, S., Finkel,

T.H.: Apoptosis in HIV-1 infection. Behring Institute Mitteilungen, 97:220-231, 1996.

24. Casella, C.R., Finkel, T.H.: Mechanisms of lymphocyte killing by HIV. Current

Opinion in Hematology 4:24-31, 1997. 25. Leung, D.Y., Sullivan K.E., Brown-Whitehorn, T.F., Fehringer, A.P., Allen S.,

Finkel, T.H., Washington, R.L., Makida, R., Schlievert, P.M.: Association of toxic shock syndrome toxin-secreting and exfoliative toxin-secreting Staphylococcus aureus with Kawasaki Syndrome complicated by coronary artery disease. Pediatric Research 42:268-272, 1997.

26. Cotton, M.F., Ikle, D.N., Rapaport, E.L., Marschner, S., Tseng, P.-O., Kurrle, R.,

Finkel, T.H.: Apoptosis of CD4+ and CD8+ T cells isolated immediately ex vivo correlates with disease severity in human immunodeficiency virus type 1 infection. Pediatric Research 42:656-664, 1997.

27. Erdman, D.D., Anderson, B.C., Torok, T., Finkel, T.H., Anderson, L.J.: Possible

transmission of parvovirus B19 from intravenous immune globulin. Journal of Medical Virology 53:233-36, 1997.


28. Selliah, N., Finkel, T.H.: Cutting Edge: JAK3 activation and rescue of T cells from

HIV gp120-induced unresponsiveness. Journal of Immunology “Cutting Edge” 160:5697-5701, 1998.

29. Rozdzial, M.M., Pleiman, C.P., Cambier, J.C., Finkel, T.H.: pp56Lck mediates TCR

zeta-chain binding to the microfilament cytoskeleton. Journal of Immunology 161:5491-5499, 1998.

30. Rapaport, E.R., Casella, C.R., Ikle, D., Mustafa, F., Isaak, D., Finkel, T.H.:

Mapping of HIV-1 determinants of apoptosis in infected T cells. Virology 252:407-417, 1998.

31. Bousvaros, A., Sundel, R., Thorne, G.M., McIntosh, K., Cohen, M., Erdman, D.D.,

Perez-Atayde, A., Finkel, T.H., Colin, A.A.: Parvovirus B19 associated interstitial lung disease, hepatitis and myositis. Pediatric Pulmonology 26:365-369, 1998.

32. Casella, C.R., Rapaport, E.L., Finkel, T.H.: Vpu mediates increased susceptibility

of HIV-1 infected cells to Fas killing. Journal of Virology 73:92-100, 1999. PMC103812

33. Finkel, T.H., Hunter, D.J., Paisley, J.E., Finkel, R.S., Larsen, G.L.: Drug-induced

lupus in a child after treatment with zafirlukast (Accolate®). With accompanying editorial. Journal of Allergy & Clinical Immunology 103:533-534, 1999.

34. Paterson, R.K., Bluëthmann, H., Tseng, P., Dunlap, A., Finkel, T.H.: Development

and function of autospecific dual TCR+ T lymphocytes. International Immunology 11:113-119, 1999.

35. Finkel, T.H.: Killing HIV-infected cells by transduction with an HIV protease-

activated caspase-3 protein [commentary for JAMA HIV/AIDS Web site]. Available at http://www.ama-assn.org/AIDS. Posted March 19, 1999.

36. Marschner, S., Freiberg, B.F., Kupfer, A., Hunig, T., Finkel, T.H.: Ligation of the

CD4 receptor induces activation-independent down-regulation of L-selectin. Proceedings of the National Academy of Sciences U.S.A. 96:9763-9768, 1999. PMC22284

37. Finkel, T.H.: Potential use of a caspase against HIV. Journal of the American

Medical Association 282:1021-1022, 1999. 38. Angkachatchai, V., Finkel, T.H.: ADP-ribosylation of rho by C3 ribosyltransferase

inhibits IL-2 production and sustained calcium flux in activated T cells. Journal of Immunology 163:3819-3825, 1999.

http://www.ama-assn.org/AIDS


39. Artlett, C.M., Ramos, R., Jiminez, S.A., Patterson, K., Miller, F.W., Rider, L.G.: Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies. Childhood Myositis Heterogeneity Collaborative Group (Finkel, T.H.). Lancet 356:2155-2156, 2000.

40. Cron, R.Q., Finkel, T.H.: Nabumetone induced pseudoporphyria in childhood

[letter]. Journal of Rheumatology 27:1817-1818, 2000. 41. Rider, L.G., Artlett, C.M., Foster, C.B., Foster, A., Neeman A.T., Chanock, S.J.,

Jimenez, S.A., Miller F.W., and the Childhood Myositis Heterogeneity Collaborative Study Group (Finkel, T.H.): Polymorphisms in the IL-1 receptor antagonist gene VNTR are possible risk factors for juvenile idiopathic inflammatory myopathies. Clinical Experimental Immunology 121:47-52, 2000.

42. Selliah, N., Finkel, T.H.: Biochemical mechanisms of HIV induced T cell apoptosis.

Cell Death and Differentiation 8:127-136, 2001. 43. Artlett, C.M., Miller, F.W., Rider, L.G.; Childhood Myositis Heterogeneity

Collaborative Study Group (Finkel, T.H.): Persistent maternally derived peripheral microchimerism is associated with the juvenile inflammatory myopathies. Rheumatology 40:1279-1284, 2001.

44. Selliah, N., Finkel, T.H.: HIV-1 NL4-3, but not IIIB, inhibits JAK3/STAT5 activation

in CD4+ T cells. Virology 286:412-421, 2001. 45. Myers, L.K., Higgins, G.C., Finkel, T.H., Reed, A.M., Thompson, J.W., Walton,

R.C., Hendricks, J., Kerr, N.C., Pandya-Lipman, R.K., Shlopov, B., Statstny, P., Postlethwaithe, A.E., .Kang, A.H.: Juvenile arthritis and autoimmunity to type II collagen. Arthritis and Rheumatism 44:1775-1781, 2001.

46. Gottfried, J.A., Finkel, T.H., Hunter, J.V., Carpentieri, D.F., Finkel, R.S.: Central

nervous system Sjögren's syndrome in a child: Case report and review of the literature. Journal of Child Neurology 16:683-685, 2001.

47. Marschner, S., Hunig, T., Cambier, J.C., Finkel, T.H.: Ligation of human CD4

interferes with antigen-induced activation of primary T cells. Immunology Letters 82:131-139, 2002.

48. Kovacs, B., Maus, M.V., Riley, J.L., Derimanov, G.S., Koretzky, G.A., June, C.H.,

Finkel, T.H.: Human CD8+ T-cells do not require the polarization of lipid rafts for activation and proliferation. Proceedings of the National Academy of Sciences U.S.A. 99:15006-15011, 2002. PMC137535

49. Selliah, N., Shackelford, J., Wang, J.-F., Traynor, T., Yin, J., Finkel, T.H.: T-cell

signaling and apoptosis in HIV disease. Immunologic Research 27:247-260, 2003.


50. Fieldston, A.B., Albert, D.A., Finkel, T.: Hypertension and elevated ESR as

diagnostic features of Takayasu arteritis in children. Journal of Clinical Rheumatology 9:156-163, 2003.

51. Feuerstein, N., Shivers, D., Chen, F., Eisenberg, R.A., Finkel, T.H.: Chronic GVH

prevents anergy in bone marrow self-reactive B cells: a selective increase in post-endoplasmic reticulum processing and trafficking to the cell surface of autoreactive IgM receptors. International Immunology 15:975-985, 2003.

52. Wang, J.-F., Marschner, S., Finkel, T.H.: CXCR4 engagement is required for HIV-

1 induced L-selectin shedding. Blood 103:1218-1221, 2004. 53. Yin, J., Chen, M.F., Finkel, T.H.: Differential gene expression during HIV-1

infection analyzed by suppression subtractive hybridization. AIDS 18:587-596, 2004.

54. Finkel, T.H.: Tracking synapse-associated TCRs. Nature Immunology 5:117,

2004.

55. Maus, M.V.*, Kovacs, B.*, Kwok, W.W., Nepom, G.T., Schlienger, K., Riley, J.L., Allman, D., Finkel, T.H., June, C.H.: Extensive replicative capacity of human central memory T cells. Journal of Immunology 172:6675-6683, 2004. *These authors contributed equally to this work.

56. Feuerstein, N., DeSimone, D.C., Eisenberg, R.A., Finkel, T.H.: Chronic GVH is

associated with a decrease in Ig light chain receptor editing in bone marrow self reactive B cells. European Journal of Immunology 34:1361-1370, 2004.

57. Trigone, D., Rettig, P., Finkel, T.H., Cron, R.Q.: Graves disease and juvenile

idiopathic arthritis. Pediatric Rheumatology On-Line Journal 3:226-228, 2005. 58. Kovacs, B., Parry, R.V., Ma, Z., Shivers, D., Freiberg, B.A., Thomas, A.K.,

Rutherford, R., Rumbley, C.A., Riley, J.L., Finkel, T.H.: Ligation of CD28 alone by its natural ligand CD86 induces lipid raft polarization in human CD4 T cells. Journal of Immunology 175:7848-7854, 2005.

59. Targoff, I.N., Mamyrova, G., Trieu, E.P., Perurena, O., Koneru, B., O’Hanlon, T.P.,

Miller, F.W., Rider, L.G.; Childhood Myositis Heterogeneity Study Group (T.H. Finkel): A novel autoantibody to a 155-kd protein is associated with dermatomyositis. Arthritis and Rheumatism 54:3682-8689, 2006.

60. Selliah, N., Zhang, M., DeSimone, D., Kim, H., Brunner, M., Ittenbach, R., Rui, H.,

Cron, R.Q., Finkel, T.H.: The gamma c-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T-cells. Virology 344:283-291,


2006. 61. Cron, R.Q., Banddyopadhyay, R., Genin, A., Brunner, M., Kersh, G.J., Yin, J.,

Finkel, T.H., Crow, M.K.: Early growth response-1 is required for CD154 transcription. Journal of Immunology 176:811-820, 2006. PMC1424665

62. Fitch, P.G., Rettig, P., Burnham, J.M., Finkel, T.H., Yan, A.C., Cron, R.Q.:

Treatment of pediatric localized scleroderma with methotrexate. Journal of Rheumatology 33:609-614, 2006.

63. Mamyrova, G., O’Hanlon, T.P., Monroe, J.B., Carrick, D.M., Malley, J.D., Adams,

S., Reed, A.M., Shamim, E.A., Janes-Newton, L., Miller, F.W., Rider, L.G., and The Childhood Myositis Heterogeneity Collaborative Study Group (Finkel, T.H.): Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians. Arthritis and Rheumatism 54:3979-3987, 2006. PMC2063456

64. Yin, J., Ma, Z., Selliah, N., Shivers, D.K., Cron, R.Q., Finkel, T.H.: Effective gene

suppression using small interfering RNA in hard-to transfect human T cells. Journal of Immunological Methods 312:1-22, 2006.

65. Wang, J., Shackelford, J.M., Casella, C.R., Shivers, D.K., Rapaport, E.L., Liu, B.,

Yu, X.-F., Finkel, T.H.: The Vif accessory protein alters the cell cycle of human immunodeficiency virus type 1 infected cells. Virology 359:243-252, 2007. PMC1934563

66. Behrens, E.M., Sriram, U., Shivers, D.K., Ma, Z., Finkel, T.H., Gallucci, S.:

Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity. Journal of Immunology 178:6268-6279, 2007.

67. Weiss, P.F., Carao, D., Pollock, A., Finkel, T.H., Smith, S.: Takayasu arteritis

presenting as cerebral aneurysms in an 18 month old: A case report. Pediatric Rheumatology On-Line Journal 6:4-16, 2008. PMC2248586

68. Ma, Z., Sharp, K.A., Janmey, P.A., Finkel, T.H.: Surface anchored monomeric

pMHCs alone trigger TCR with high sensitivity. PLoS Biology 6:e43, 2008. Highlighted by Editors’ Choice in Science 319:1460, 2008. PMC2253636

69. Ma, Z., Janmey, P.A., Finkel, T.H.: The receptor deformation model of TCR

triggering. FASEB Journal 22:1002-1008, 2008. PMC2679516 70. Behrens, E.M., Beukelman, T., Gallo, L., Sprangler, J., Margalit Rosenkranz, M.,

Arkachaisri, T., Ayala, R., Groh, B., Finkel, T.H., Cron, R.Q. Evaluation of the presentation of systemic onset Juvenile Rheumatoid Arthritis: Data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR). Journal of Rheumatology 35:343-348, 2008.


71. Wang, J.-F., Shackelford, J.M., Selliah, N., Shivers, D.K., O’Neill, E., Garcia, J.V.,

Muthumani, K., Weiner, D., Yu, X.-F., Gabuzda, D., Finkel, T.H.: The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest. DNA & Cell Biology 27:267-277, 2008.

72. Bingham, A., Mamyrova, G., Rother, K.I., Oral, E., Cochran, E., et al.; Childhood

Myositis Heterogeneity Study Group (Finkel, T.H.): Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity. Medicine 87:70-86, 2008.

73. Behrens, E.*, Finkel, T.H.*, Bradfield, J.P., Kim, C., Linton, L., Casalunovo, T.,

Frackelton, E.C., Santa, E., Otieno, G., Glessner, J.T., Chiavacci, R., Grant, S.F.A., Hakonarson, H.: Association of the TRAF1–C5 locus on chromosome 9 with Juvenile Idiopathic Arthritis. Arthritis & Rheumatism 58:2206-2208, 2008. *equal contribution

74. Zhang, K., Birochak, J., Passo, M.H., Glass, D.N., Thompson, S., Finkel, T.,

Filipovich, A., Grom, A.A.: Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 gene polymorphisms. Arthritis & Rheumatism 58:2892-2896, 2008. PMC2779064

75. Selliah, N., White, S., Zoltick, P., Sawaya, B.E., Finkel, T.H.*, Cron, R.Q.*: FOXP3

inhibits HIV-1 infection of CD4 T-cells via inhibition of LTR transcriptional activity. Virology 381:161-167, 2008. *equal contribution. PMC2591021

76. Mamyrova, G., O'Hanlon, T.P., Sillers, L., Malley, K., James-Newton, L., Parks,

C.G., Cooper, G.S., Pandey, J.P., Miller, F.W., Rider, L.G.; Childhood Myositis Heterogeneity Collaborative Study Group, (Finkel, T.H.): Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis. Arthritis & Rheumatism 58:3941-3950, 2008.

77. Ma, Z., Finkel, T.H.: TCR triggering by force. Trends in Immunology 31:1-6, 2010.

PMC2679516

78. Rider, L., Wu, L., Mamyrova, G., Targoff, I, Miller, F., for the Childhood Myositis Heterogeneity Collaborative Study Group, (Finkel, T.H.): Environmental factors preceding illness onset in the juvenile idiopathic inflammatory myopathies. Rheumatology 49:2381-2390, 2010.

79. Ardoin SP, Schanberg LE, Sandborg C, Yow E, Barnhart HX, Mieszkalski Kl, Ilowite

NT, von Scheven E, Eberhard A, Levy DM, Kimura Y, Silverman E, Bowyer SL, Punaro L, Singer NG, Sherry DD, McCurdy D, Klein-Gitelman M, Wallace C, Silver R, Wagner-Weiner L, Higgins GC, Brunner HI, Jung LK, Imundo L, Soep JB, Reed AM; APPLE investigators. (Finkel, T.H.): Laboratory markers of cardiovascular

http://proxy.library.upenn.edu:5567/pubmed/19035492?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

http://proxy.library.upenn.edu:5567/pubmed/19035492?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

http://www.ncbi.nlm.nih.gov/pubmed/20861207


risk in pediatric SLE: the APPLE baseline cohort. Lupus. 2010 Oct;19(11):1315-25. doi: 10.1177/0961203310373937.

80. Wang, J.-F., Reuschel, E., Shackelford, J.M., Jeang, L., Shivers, D., Diehl, A., Yu,

X.-F., Finkel, T.H.: HIV-1 Vif promotes the G1-to-S phase cell cycle transition. Blood 227: 1260-1269, 2011.

81. Ma, Z., Janmey, P.A., Sharp, K.A., Finkel, T.H.: Improved method of preparation

of supported planar lipid bilayers as artificial membranes for antigen presentation. Microscopy Research and Technique 74: 1174-1185, 2011.

82. Weiss, P.F., Klink, A.J., Behrens, E.., Sherry, D.D., Finkel, T.H., Feudtner, C.,

Keren, R.: Enthesitis in an inception cohort of enthesitis-related arthritis. Arthritis Care and Research 63: 1307-1312, 2011.

83. Molitoris, J.K., McColl, K., Swerdlow, S., Matsuyama, M., Lam, M., Finkel, T.H.,

Matsuyama, S., Distelhorst, C.W.: Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes. Journal of Biological Chemistry 286: 30181-30189, 2011.

84. Ma, Z., Finkel, T.H.: Mechanical force in T cell receptor signal initiation. Frontiers

in Immunology 3: 217, 2012. doi: 10.3389/fimmu.2012.00217. 85. Ombrello, M., Remmers, E.F., Grom, A.A., Thomson, W., Martini, A., Gattorno, M.,

Ozen, S., Gul, A., Bohnsack, J.F., Zeft, A.S., Mellins, E.D., Park, J.L., Len, C., Satorius, C., Russo, R.A.G., Finkel, T.H., Yeung, R.S.M., Schneider, R., Prahalad, S., Glass, D.N., Allen, R.C., Wulffraat, N., Quartier, P., Hilario, M.O.E., Murray, K., Oliveira, S., Anton, J., Hinks, A., Zeggini, E., Langefeld, C., Thompson, S., Chaitow, J., Ellis, J., Singh, D., Cavalvanti, A., Bica, B., Sztajnbok, F., Hakonarson, H., Siminovitch, K.A., Minden, K., Haas, P., Schwarz, T., Kastner, D.L., Woo, P.: Systemic juvenile idiopathic arthritis is associated with HLA-DRB1 in Europeans and Americans of European descent. Pediatric Rheumatology Online Journal 10 (Suppl 1) 2012.

86. Shah, M., Mamyrova, G., Targoff, I.N., Huber, A.M., Malley, J., Rice, M., Miller,

F.W., Rider, L.G.; Childhood Myositis Heterogeneity Collaborative Study Group, (Finkel, T.H.): The clinical phenotypes of the juvenile idiopathic inflammatory myopathies. Medicine (Baltimore) 92: 25-41, 2013.

87. Cheng, T., Choi, Y., Finkel, T.H., Tsao, P.Y., Ji, M.Q., Eisenberg, R.A. Tumor

Necrosis Factor-Receptor Associated Factor 1 influences KRN/I-Ag7 mouse arthritis autoantibody production. Journal of Clinical Immunology 33(4): 759-66, 2013.

88. Shah, M. Targoff, I.N., Rice, M.M., Miller, F.W., Rider, L.G.; Childhood Myositis


Hertogeneity Collaborative Study Group (Finkel, T.H.). Brief report: ultraviolet radiation exposure is associated with clinical and autoantibody phenotypes in juvenile myositis. Arthritis and Rheumatism 65(7): 1934-41, 2013.

89. Rider L.G., Shah M., Mamyrova G.*, Huber A.M.*, Rice M.M., Targoff I.N., Miller

F.W., with the Childhood Myositis Heterogeneity Collaborative Study Group (Finkel T.H.). The Autoantibody Phenotypes of the Juvenile Idiopathic Inflammatory Myopathies. Medicine (Baltimore) 92: 223-243, 2013. *equal contribution

90. Mamyrova G., Katz J.D., Jones R.V., Targoff I.N., Lachenbruch P.A., Jones O.Y.,

Miller F.W., Rider L.G., with the Childhood Myositis Heterogeneity Collaborative Study Group (Finkel T.H.). Clinical and Laboratory Features Distinguishing Juvenile Polymyositis and Muscular Dystrophy in Children. Arthritis Care and Research 65(12): 1969-75, 2013.

91. Miller F.W.*, Cooper R.G.*, Vencovsky J., Rider L.G., Danko K., Wedderburn L.R.,

Lundberg I.E., Pachman L.M., Reed A.M., Ytterberg S.R., Padyukov L., Selva-O'Callaghan A., Radstake T., Isenberg D.A., Chinoy H., Ollier W.E.R., O'Hanlon T.P., Peng B., Lee A., Lamb J.A., Chen W., Amos C.I.**, Gregersen P.K.**, with the Myositis Genetics Consortium (Finkel T.H.). Genome-wide Association Study of Dermatomyositis Reveals Genetic Overlap with other Autoimmune Disorders. Arthritis and Rheumatism 65(12): 3239-47, 2013. *,**equal contribution

92. Huber, A.M., Mamyrova, G., Lachenbruch, P.A., Lee, J.A., Katz, J.D., Targoff, I.N.,

Miller, F.W., Rider, L.G., with the Childhood Myositis Heterogeneity Study Group (Finkel, T.H.). Early illness features associated with mortality in the Juvenile Inflammatory Myopathies. Arthritis Care and Research 66(5):732-40, 2014. doi: 10.1002/acr.22212.

93. Zhang, M., Ma, Z., Selliah, N., Weiss, G., Genin, A., Finkel, T.H., Cron, R.Q. The

impact of Nucleofection on the activation state of primary human CD4 T cells. Journal of Immunological Methods 408:123-131, 2014.

94. Ellis, J.A., Scurrah, K.J., Li, Y.R., Ponsonby, A.L., Chavez, R.A., Pezic, A., Dwyer,

T., Akikusa, J.D., Allen, R.C., Becker, M.L., Thompson, S.D., Lie, B.A., Flato, B., Forre, O., Punaro, M., Wise, C., Finkel, T.H., Hakonarson, H., Munro, J.E.: Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis. The Journal of Steroid Biochemistry and Molecular Biology 145C:113-120, 2014. doi: 10.1016/j.jsbmb.2014.10.012.

95. Ma, Z., LeBard, D.N., Loverde S.M., Sharp, K.A., Klein, M.L., Discher, D.E.,

Finkel, T.H.: TCR triggering by pMHC ligands tethered on surfaces via poly (ethylene glycol) depends on polymer length. PLoS ONE 2014 Nov 10;9(11):e112292. doi: 10.1371/journal.pone.0112292. eCollection 2014.


96. Yan, J., Tingey C., Lyde, R., Gorham, T.C., Choo, D.K., Muthumani, A., Myles, D.,

Weiner, L.P., Kraynyak, K.A., Reuschel, E.L., Finkel, T.H., Kim, J.J., Sardesai, N.Y., Ugen, K.E., Muthumani, K., Weiner, D.B.: Novel and enhanced anti -melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model. Cancer Gene Therapy 2014 Dec;21(12):507-17. doi: 10.1038/cgt.2014.56. Epub 2014 Nov 14.

97. Ellis, J.A., Scurrah, K.J., Li, Y.R., Ponsonby, A.L., Chavez, R.A., Pezic, A., Dwyer,

T., Akikusa, J.D., Allen, R.C., Becker, M.L., Thompson, S.D., Lie, B.A., Flatø, B., Førre, O., Punaro, M., Wise, C., Finkel, T.H., Hakonarson, H., Munro, J.E.: Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis. Journal of Steroid and Biochemical Molecular Biology. 2015 Jan;145:113-20. doi: 10.1016/j.jsbmb.2014.10.012. Epub 2014 Oct 18.

98. Ellis, J.A Chiaroni-Clarke, R.C., Li, Y.R., Munro, J.E., Chavez, R.A., Scurrah, K.J.,

Pezic, A., Akikusa, J.D., Allen, R.C., Piper, S.E., Becker, M.L., Thompson, S.D., Lie, B.A., Flato, B., Forre, O., Punaro, M., Wise, C., Saffery, R., Finkel, T.H., Hakonarson, H., Ponsonby, A.L.: The association of PTPN22 rs2476601 with Juvenile Idiopathic Arthritis is specific to females. Genes & Immunity. 2015 Aug 20. Doi:10.1038/gene.2015.32 [Epub ahead of print]. PMID: 26291515

99. Li, Y.R., Li, J., Zhao, S.D., Bradfield, J., Mentch, F., Maggadottir, SM., Hou, C.,

Abrams, D., Chang, D., Gao, F., Guo, Y., Wei, Z., Connoly, J., Cardinale, C., Bakay, M., Glessner, J., Kao, C., Thomas, K.A., Qui, H., Chiavacci, R., Kim, C., Wang, F., Snyder, J., Richie, M.D., Flatø, B., Førre, O. Denson L., Thompson, S.D., Becker, M.L., Guthery, S.L., Latiano, A., Perez, E., Resnick, E., Russell, R.K., Wilson, D.C., Silverberg, M.S., Annese, V., Lie, B.A., Punaro, M., Dubinsky, M., Monos, D., Strisciuglio, C., Staiano, A., Miele, E., Kugathasan, S., Ellis, J.A., Munro, J.E., Sullivan. K., Wise, C., Chapel, H., Cunningham-Rundles, C., Grant, S.F.A., Orange, J.S., Sleiman, P.S., Behrens, E.M., Griffiths, A., Satsangi, J., Finkel, T.H., Keinan, A., Luning Prak, E.T., Polychronakos, C., Baldassano, R.H., Li, H., Keating, B., Hakonarson, H.: Meta analysis of shared genetic architecture in pediatric autoimmune diseases. Nature Medicine. 2015 Sep;21(9):1018-27. Doi:10.1038/nm.3933. Epub 2015 Aug 24. PMID: 26301688

100. Li, Y.R., Zhao, S.D., Li, J., Bradfield, J., Mohebnasab, M.,, Steel, L.,, Kobie, J.,

Abrams, D., Mentch, F., Glessner, J., Guo, Y., Wei, Z., Connolly, J., Cardinale, C., Bakay, Li, D., Maggadottir, S.M., Thomas, K.A., Qui, H., Chiavacci, R., Kim, C., Wang, F., Snyder, J., Flatø, B., Førre, O., Denson L., Thompson, S.D., Becker, M.L., Guthery, S.L., Latiano, A., Perez, E., Resnick, E., Strisciuglio, C., Staiano, A., Miele, E., Silverberg, M.S., Lie, B.A., Punaro, M., Russell, R.K., Wilson, D.C., Dubinsky, M., Monos, D., Annese, V., Munro, J.E., Wise, C., Chapel, H.,




Cunningham-Rundles, C., Orange, J.S., Behrens, E.M., Sullivan, K., Kugathasan, S., Griffiths, A., Satsangi, J., Grant, S.F.A., Sleiman, P.S., Finkel, T.H., Polychronakos, C., Baldassano, R.H., Luning Prak, E.T., Ellis, J.A., Li, H., Keating, B., Hakonarson, H.: Genetic sharing and heritability of pediatric age of onset autoimmune diseases. Nature Communications. 2015 Oct9;6:8442. Doi: 10.1038/ncomms9442. PMID: 26450413

101. Reuschel, E.L., Wang, J.F., Shivers, D.K., Muthumani, K., Weiner, D.B., Zhengyu,

M., Finkel, T.H.: REDD1 is essential for optimal T cell proliferation and survival. PLoS ONE. 2015 Aug24;10(8):e0136323. Doi: 10.1371/journal.pone.0136323. eCollection 2015. PMID: 26301899

Research Publications, submitted for publication or in preparation: 1. Finkel, T.H., Wang, W., Wei, Z., Zhang, H., Behrens, E.M., Reuschel, E.L., Limou,

S., Wise, C., Punaro, M., Becker, M.L., Munro, J.E., Flato, B., Forre, O., Thompson, S., Langefeld, C.D., Glass, D.N., Glessner, J.T., Kim, C.E., Frackelton, E., Shivers, D.K., Thomas, K.A., Chiavacci, R.M., Hou, C., Qui, H., Mentch, F., Wang, K., Winkler, C.A., Lie, B.A., Ellis, J.A., Hakonarson, H.: Variants in CXCR4 associate with Juvenile Idiopathic Arthritis susceptibility. Journal of Clinical Investigation, submitted for publication.

2. Kirino, Y., Ombrello, M.J., Gül, A., Wang, K., Meguro, A., Mizuki, N., Yang, B.,

Gadina, M., Cosan, F., Ustek, D., Siminovitch, K.A., Xie, G., Gregersen, P.K., Baldassano, R.N., Kugathasan, S., Polychronakos, C., Ollier, W.E.R., Kaklamani, V.G., Kaklamanis, P., Young-Hun Cho, Y.-H., Bang, D., Criswell, L.A., Chung, S.A., Behrens, T., Graham, R., Petri, M., Lee, A., Mayes, M.D., Tan, F., Assassi, S., Agarwal, S., Arnett, F.C., Gorlova, O., Varga, J., Hinchcliff, M., Wigley, F.M., Hummers, L.K., Spigarelli, M., Grom, A.A., Finkel, T.H., Sullivan, K., Satorius, C., Le, J.M., Sun, H.-W., Amos, C.I., Sugita, S., Mochizuki, M., Hama, M., Takeno, M., Inoko, H., Ohno, S., Ishigatsubo, Y., Hakonarson, H., Kastner, D.L., Remmers, E.F.: Copy number variation study identifies LEPREL1 (P3H2) intron 1 deletion protecting from multiple inflammatory diseases. Submitted for publication.

3. ARChiVe Consortium: Evaluation of schemes for classifying Wegener’s

Granulomatosis in a pediatric vasculitis registry cohort. Submitted for publication.

4. Baida, G., Bhalla, P., Yuen, K., Guo, S., Finkel, T.H., Lesovaya, E., Yakubovskaya, M., Kirsanov, G., Lavker, R., Budunova, I.: REDD1 dissociated therapeutic and adverse effects of topical steroids in skin. Submitted for publication.

5. Wang, J.-F., Reuschel, E.L., O’Doherty, U., Yu, X.-F., Finkel, T.H. A cautionary

note: HIV-1Env vectors pseudotyped with an HIV-1 envelope are capable of multiple rounds of infection. PLoS Pathogens, in revision.


Abstracts (representative, past 6 years): 1. Wang, J.-F., Shackelford, J.M., Selliah, N., Shivers, D.K., O’Neill, E., Garcia J.V.,

Muthumani, K., Weiner, D., Yu, X.F., Gabuzda, D., Finkel, T.H.: The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest. (Presented at the Keystone Symposium on HIV-1 Pathogenesis, Banff, Calary, Canada, March 2008).

2. Ma, Z., Janmey, P.A., Finkel, T.H.: The receptor deformation model of TCR

triggering. Experimental Biology 2008. (Presented in a podium session and poster session at the 95th annual meeting of the American Association of Immunologists, San Diego, California, April 2008).

3. Ma, Z., Janmey, P.A., Finkel, T.H.: The receptor deformation model – a novel

solution to the TCR triggering puzzle. Arthritis & Rheumatism 58:S847, 2008. (Presented at the ACR/ARHP Annual Scientific National Meeting, San Francisco, California, October 2008).

4. Ma, Z., Janmey, P.A., Finkel, T.H.:. The receptor deformation model – a solution

to the TCR triggering puzzle, 16 th Annual International Meeting of the Henry Kunkel Society, Santa Margherita Ligure, Italy, 2008

5. McKenna, P.M., Hallberg, P.L., Barnard, R.J.O., Zhang, Hangchun, H.,

Cunningham, M.E., Finkel, T., Hazuda, D.J., Miller, M.D.: Quantitative assessment of NNRTI barrier to resistance using FACSorting and a new HIV-1 reporter cell line. (Presented at the 9th Annual Symposium on Antiviral Resistance, Richmond, Virginia, November 16-19, 2008).

6. Ma, Z., Janmey, P.A., Finkel, T.H.: pMHC ligand anchored on a plastic surface via

a 61 nm flexible poly(ethylene glycol) linker triggers the TCR: implications for the mechanism of TCR signal initiation. (Presented at the 96 th Annual Meeting of the American Association of Immunologists. J Immunol, 2009; 182: 35.18).

7. Finkel, T.H., Behrens, E.M., Choi, Y., Eisenberg, R.A., Dapprich, J., Monos, D.S.,

Hakonarson, H: Tracking JIA predisposition genes from genome-wide association studies to next generation sequencing to functional relevance. (Podium presentation at a Plenary Session at the 2009 American College of Rheumatology Annual Scientific Meeting, Philadelphia, Pennsylvania).

8. Weiss, P.F., Klink, A.J., Behrens, E.M., Sherry, D.D., Finkel, T.H., Ramos, M.,

Grundmeier, R., Keren, R., Feudtner, C.: Prevalence of enthesitis in pediatric patients with Enthesitis-Related Arthritis. (Presented at the 2010 American College of Rheumatology Annual Scientific Meeting, Atlanta, Georgia.)

9. Finkel, T.H., Zhang, H., Lie, B., Behrens, E., Becker, M., Wise, C., Punaro, M.,

Reuschel, E., Shivers, D., Flato, B., Forre, O., Munro, J., Ellis, J., Hakonarson, H.:


Discovery and replication of JIA predisposition genes by genome-wide association and validation of candidates in fibroblast-like synoviocytes. (Podium presentation at the 2010 American College of Rheumatology Annual Scientific Meeting, Atlanta, Georgia.)

10. Reuschel, E., Yin, J., Rossi, J., Dropulic, B., Wang, J.F., Selliah, N., Finkel, T.H.:

Modulation of apoptosis in HIV infected T cells. (Poster presentation and recipient of a Young Investigator Award at the 18 th Conference on Retroviruses and Opportunistic Infections, Boston, Massachusetts, February 27-March 2, 2011).

11. Ma, Z., Janmey, P.A., Finkel, TH.: Dependence of TCR triggering on ligand three-

dimensional freedom. (Podium presentation at the 98 th Annual Meeting of the American Association of Immunologists, San Francisco, California, June, 2011. J Immunol, 2011; 186:109.19).

12. Ma, Z., Han, H., Finkel, T.H.: T cells autonomously disengage from functional

antigen presenting cells after entering the G1 phase of cell cycle. (Podium presentation at the 99 th Annual Meeting of the American Association of Immunologists, Honolulu, Hawaii, May, 2013.)

13. Ma, Z., Han, H., Finkel, T.H.: T cells autonomously disengage from functional

antigen presenting cells after entering the G1 phase of cell cycle. (Podium presentation at the Biennial Northeast Regional IDeA Conference. Newark, DE, August, 2013.)

14. Ma Z, Finkel TH. How T cells see antigen: the role of mechanical force in TCR

triggering. (Podium presentation at the COBRE Retreat. Wilmington, DE, September, 2013.)

15. Y.R. Li, J. Li, J.A. Ellis, S. Kugathasan, M.L. Becker, A. Latiano, E. Perez, R.K.

Russell, D.C. Wilson, M.S. Silverberg, V. Annese, B.A. Lie, M. Punaro, M.C. Dubinsky, C. Strisciuglio, A. Staiano, E. Miele, C. Wise, H. Chapel, C. Cunningham-Rundles, J.S. Orange, A.M. Griffiths, J. Satsangi, T.H. Finkel, C. Polychronakos, R.N. Baldassano, E.T.L. Prak, H. Li, B.J. Keating, H. Hakonarson: The Genetic Landscape of Pediatric Autoimmune Diseases. (Presented at ASHG 2014 in San Diego, California, October 18-22, 2014).

Editorials, Reviews, Chapters, including participation in committee reports: 1. Kappler, J.W., Finkel, T.H., Marrack, P.: Selection of the T cell repertoire in the

thymus. In: Progress in Immunology, vol. VII Springer Verlag, Berlin, pp. 265, 1989.

2. Marrack, P., Blackman, M., Burgert, H., McCormack, J., Finkel, T.H., Kappler,

J.W.: T-cell repertoire and thymus. In: Symposia on Quantitative Biology, Vol. 54 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp. 105, 1990.


3. Finkel, T.H., Kubo, R.T.: The molecular basis of signalling via the T cell antigen

receptor complex in mature and developing T cells. In: Ligands, Receptors and Signal Transduction in Regulation of Lymphocyte Function. J.C. Cambier, Ed., American Society for Microbiology, Washington, D.C., pp. 197-266, 1990.

4. Finkel, T.H., Cotton, M.C., Banda, N.K.: Apoptosis as a mechanism of CD4+ T cell

death in HIV infection. In: Apoptosis in AIDS and Cancer, L. D. Tomei, Ed., 1994. 5. Finkel, T.H.: Division of AIDS Ad Hoc Review of the Pathogenesis Program,

Bethesda, MD, May, 1993. 6. Gelfand, E.W., Finkel, T.H.: The T-lymphocyte system. In: Immunologic Disorders

in Infants and Children, Fourth Edition. E. R. Stiehm, Ed., W.B. Saunders Company, Philadelphia, pp. 14-34, 1996.

7. Finkel, T.H.: Approach to the child with joint pain. In: Rheumatology Secrets. S.

West, Ed., Hanley & Belfus, Inc., Philadelphia, PA, pp. 401-408, 1996. 8. Finkel, T.H.: Juvenile systemic connective tissue diseases. In Rheumatology

Secrets. S. West, Ed., Hanley & Belfus, Inc., Philadelphia, PA, pp. 413-420, 1996. 9. Finkel, T.H., Casella, C.R.: AIDS and cell death. In: Cell Death: Significance and

Directions. Z. Zakeri, J. Tilly, R.A. Lockshin, Eds., Wiley-Liss, pp. 289-318, 1998. 10. Eisenberg, R., Schumacher, H.R., Finkel, T.H., Ehrlich, G.E.: In memoriam:

Joseph Lee Hollander, MD, 1910-2000. Arthritis & Rheumatism 43:1430, 2000. PMID: 11857258.

11. Cron, R.Q., Finkel, T.H.: Approach to the child with joint pain. In: Rheumatology

Secrets, 2nd ed., S. West, Ed., Hanley & Belfus, Inc., Philadelphia, PA, pp. 483-490, 2002.

12. Cron, R.Q., Finkel, T.H.: Juvenile systemic connective tissue diseases. In

Rheumatology Secrets, 2nd ed., S. West, Ed., Hanley & Belfus, Inc., Philadelphia, PA, pp. 495-502, 2002.

13. Finkel, T.: Kids get lupus too, but please don’t order an ANA. PedsUniversity.org ,

2014. http://www.pedsuniversity.org/Education/tabid/106/ctl/playCeCourse/mid/556/ItemId/363/Default.aspx

Books: None

Alternative Media:

http://www.pedsuniversity.org/Education/tabid/106/ctl/playCeCourse/mid/556/ItemId/363/Default.aspx

http://www.pedsuniversity.org/Education/tabid/106/ctl/playCeCourse/mid/556/ItemId/363/Default.aspx


1. “Spanning Gaps Between Lymphocytes”. Cell, January 25, 1991, p. 233. 2. “Does HIV-1 Kill T Lymphocytes by Inducing Cell Suicide?”. Journal of NIH

Research, March, 1992, p. 65. 3. “AIDS: The Unanswered Questions”. Science 260, May, 1993, p. 1256. 4. “Chimpanzees: The Ultimate Long-Term Survivors?”. Journal of NIH Research,

July 1993, p. 79. 5. Microbiological Reviews 57: 223, 1993 6. “Cell Suicide and AIDS”. National Public Radio, Summer, 1993 . 7. “A New Look at AIDS”. New Directions 21, No. 4, 1993. 8. “Parvovirus and Vasculitis”. National Public Radio, May, 1994. 9. “Disease 'Trigger' Found: Virus Can Lead to Rare Illness”. The Denver Post, May

28, 1994, p. 1B. 10. “Blood-Vessel Disease Linked to Virus”. Minneapolis Star Tribune, May 29, 1994. 11. “In Search of the Cure for AIDS”. Rolling Stone, Issue 679, April 7, 1994, p. 55. 12. “Gallo's Meeting: A Scientific 'Folk Festival”. The Scientist, November 14, 1994, p.

5.

13. “Apoptosis in HIV Infection” by G. Pantaleo & A.S. Fauci. News & Views, Nature Medicine 1:118-120, 1995.

14. “Apoptosis and HIV Disease” by W. Lu & J.-M. Andrieu. Letters to the Editor,

Nature Medicine 1:386-387, 1995. 15. “Researchers Air Alternative Views on How HIV Kills Cells”. Science, August 25,

1995, p. 1044. 16. “Complex Complexes: Signaling at the TCR”. Immunity, September, 1996, p. 197. 17. “Death by Design”. San Francisco Chronicle, January, 1997, Zone 6, pp. 1 & 5. 18. “Joint Effort”. Denver Rocky Mountain News, February 21, 1999, pp. 10 -11F. 19. “Women of Consequence: The Colorado Women’s Hall of Fame , by Jeanne

Varnell, 1999.


20. “Philadelphia: A Tradition of Rheumatology”. Philadelphia Rheumatism Society,

prepared for the American College of Rheumatology Meeting, 2000, p. 42.

21. The Children's Hospital of Philadelphia 1995-2001 A Hospital on the Move: A Report on Change by Shirley Bonnem, Research, p. 259-261.

22. May 2001 issue of Philadelphia Magazine Top Docs for Kids.

23. “Cell Research Uncovers Intriguing Clues to ‘Trojan Horse’ Gene in HIV Infection” .

[John Ascenzi, PR], April, 2004.

24. Philadelphia Magazine Top Doctors, 2005.

25. “Novel Lab Technique Expands Researchers’ Toolbox; Interfering RNA Silences

Genes in “Slippery” Immune Cells”. [John Ascenzi, PR], May 8, 2006.

26. “UPenn’s Tat Offensive Against HIV; Using RNAi to Thwart the Virus”. RNAi News,

Volume 4, number 19, May 11, 2006, pp. 7-8.

27. RNAiNSIDER "Upenn's Tat Offensive Against HIV; Using RNAi to Thwart the Virus (volume 4, #19, www.rnainews.com), June 11, 2006.

28. “Pulling on the TCR”. Editors’ Choice, Science Signalling, Science 319:1460,

2008.

29. “Pediatric Researchers Find Possible ‘Master Switch’ Gene in Juvenile Arthritis”.

[John Ascenzi, PR], July 1, 2008.

30. “HIV Makes Protein That May Help Virus’s Resurgence”. [John Ascenzi, PR],

February 24, 2011.

31. “Genetics of JA”. Arthritis Foundation Research Highlights, 2011. 32. “Nemours to Specialize in Children’s Rare Diseases such as Juvenile Arthritis”.

Orlando Sentinel, 2012. http://articles.orlandosentinel.com/2012-04-01/health/os-juvenile-arthritis-doctor-20120401_1_arthritis-foundation-s-florida-rheumatologist-juvenile-arthritis

33. “Pediatric Rheumatologists share their stories.” American Academy of Pediatrics,

Section on Rheumatology, 2013. http://www.aap.org/en-us/about-the-aap/Committees-Councils-Sections/Section-on-Rheumatology/Pages/Testimonials.aspx

34. “Nemours Awarded Grant to Create a Research Network Focused on Improving

http://www.rnainews.com/

http://articles.orlandosentinel.com/2012-04-01/health/os-juvenile-arthritis-doctor-20120401_1_arthritis-foundation-s-florida-rheumatologist-juvenile-arthritis

http://articles.orlandosentinel.com/2012-04-01/health/os-juvenile-arthritis-doctor-20120401_1_arthritis-foundation-s-florida-rheumatologist-juvenile-arthritis

http://www.aap.org/en-us/about-the-aap/Committees-Councils-Sections/Section-on-Rheumatology/Pages/Testimonials.aspx

http://www.aap.org/en-us/about-the-aap/Committees-Councils-Sections/Section-on-Rheumatology/Pages/Testimonials.aspx


Healthcare for Children Across the Country.” [Josh Wilson, PR], December 22,

2013.

35. “Nemours, other children’s hospitals win grant to link data”. Orlando Sentinel,

December 22, 2013. http://www.orlandosentinel.com/news/local/breakingnews/os-nemours-reserach-grant-network-20131222,0,3339912.story

36. “$7 Million Dollar Grant”. Nemours on WESH-ORD (NBC) – Orlando, FL,

December 22, 2013.

37. “Nemours awarded $7M pediatric health grant.” Orlando Business Journal, December 24, 2013. http://bizj.us/tz98p

38. “Cast of characters: The latest intel on movers and shakers”. Orlando Business Journal. December 27, 2013. http://m.bizjournals.com/orlando/print-edition/2013/12/27/cast-of-characters-the-latest-intel.html?r=full

39. “Nemours to Launch Two of the Largest Pediatric Studies Ever”. Nemours.org, September 18, 2015; National Public Radio, September 21, 2015; Orlando Economic Development Commission, September 30, 2015.

40. “Nemours Launches Two Studies Using Large Database”. Orlando Sentinel,

October 10, 2015. http://www.orlandosentinel.com/health/vital-signs/os-nemours-pedsnet-studies-20151009-post.html

Patents: 1. Finkel, T.H., Rozdzial, M.M.: “Product and Process to Regulate Actin

Polymerization in T Lymphocytes”. U.S. Patent #5,976,819, issued November 2, 1999.

2. Finkel, T.H., Casella, C.R.: “Screening Methods for the Identification of

Compounds that Modulate Apoptosis in Immunodeficiency Virus Infected Cells”.

U.S. Patent #5,976,786, issued November 2, 1999.

3. Finkel, T.H., Rozdzial, M.M.: “Product and Process to Regulate Actin

Polymerization in T Lymphocytes”. U.S. Patent #6,500,430 B1, issued December 31, 2002.

4. Finkel, T.H., Yin, J.: “Cellular Genes Regulated by HIV-1 Infection and Methods of

Use Thereof”. U.S. Patent #7,288,644 B2, issued October 30, 2007.

5. Finkel, T.H., Yin, J.: “Cellular Genes Regulated by HIV-1 Infection and Methods of Use Thereof”. U.S. Patent #7,405,292, issued July 29, 2008.

http://www.orlandosentinel.com/news/local/breakingnews/os-nemours-reserach-grant-network-20131222,0,3339912.story

http://www.orlandosentinel.com/news/local/breakingnews/os-nemours-reserach-grant-network-20131222,0,3339912.story

http://m.bizjournals.com/orlando/print-edition/2013/12/27/cast-of-characters-the-latest-intel.html?r=full

http://m.bizjournals.com/orlando/print-edition/2013/12/27/cast-of-characters-the-latest-intel.html?r=full

http://www.orlandosentinel.com/health/vital-signs/os-nemours-pedsnet-studies-20151009-post.html

http://www.orlandosentinel.com/health/vital-signs/os-nemours-pedsnet-studies-20151009-post.html


6. Finkel, T.H., Yin, J.: “Cellular Genes Regulated by HIV-1 Infection and Methods of

Use Thereof”. U.S. Patent #7,994,147, issued June 2011. 7. Finkel, T.H., Yin, J.: “Cellular Genes Regulated by HIV-1 Infection and Methods of

Use Thereof”. U.S. Patent #8,334,275 B2, issued December 18, 2012. 8. Finkel, T.H., Wang, J., Blobel, G.A., Kaduake, S.: “Compositions and Methods for

the Treatment of HIV”. CHOP.0563-12/our ref. 3460-P05355US00, U.S. Provisional Patent, Application Serial #61/513,200, filed July 29, 2011; U.S. Patent, Application #PCT/US2012/048809, filed July 30, 2012, priority date July 29, 2012; Publication #WO20130019710 A1, publication date Feb 7, 2013. Entered the National Phase on January 29, 2014.

9. Hakonarson, H., Zhang, H., Finkel, T.H: “CXCR4 as a Susceptibility Locus and

Potential Therapeutic Target in Juvenile Idiopathic Arthritis (JIA) and Methods of Use Thereof for the Treatment and Diagnosis of the Same”. U.S. Provisional

Patent, OTT Ref. No. 0517P, filed November 11, 2010; Continuation in part PCT/US2001/60430, filed November 11, 2011; National Phase filed May 13, 2013.

Licenses: 1. Finkel, T.H., Kubo, R.: Mouse Anti-TCR Zeta Antibody to Southern Biotechnology

Associates. 2. Finkel, T.H., Kubo, R.: Anti-Human TCR Zeta mAb to Upstate Pharmaceuticals,

NY. 3. Finkel, T.H., Kubo, R.: Anti-Human TCR Zeta mAb to Santa Cruz Biotechnology. 4. Finkel, T.H., Zhang, H., Hakonarson, H.: Genetic Diagnostics for JIA to

Medgenics. Research Support (see Grant pages following)


PPAASSTT GGRRAANNTT SSUUPPPPOORRTT

NAME Dr. Terri H. Finkel DEPARTMENT Pediatrics DATE September, 2015__

Name of Grant Period of

Aw ard

Grant C Role in Grant** % Effort Funding Source Current

Annual Direct

Cost

Additional

Comments***

1. “Mechanisms of TCR Mediated

Transmembrane Signaling in Immature

and Mature Thymocytes”

1988-1991 PG Principal Investigator 80 Arthritis Foundation $40,666 Postdoctoral

Fellow ship Grant

2. “TCR- -Actin Association in Activation,

Anergy, and Development”

01/01/90 –

08/31/02

R01 Principal Investigator 25 NIH

R01 AI30575

$179,453

3. “The Effects of HIV gp120 on

Thymocyte Maturation”

01/01/90 –

12/31/92

PG Project Leader Arthritis Foundation $30,500 Aw arded to

postdoctoral fellow

4. “Molecular Basis of HIV Induced Immune

Suppression”

04/01/90 –

03/31/95

PP Project Leader 20 NIH

P01

$60, 536

5. “Function of Memory T Cells and

Acquisition of T Cell Memory”

03/01/90 –

11/30/02


P01 AI22295

$100,002

6. “Crosslinking CD4 by HIV gp120 Primes

T Cells for Activation-Induced

Apoptosis”

01/01/92 –

12/31/93

PG Project Leader Pediatric AIDS

Foundation

$36,298 Aw arded to

postdoctoral fellow

7. “Detection of Programmed Cell Death of

CD4+ Lymphocytes in Children w ith HIV

Infection”

09/21/93 –

06/30/94

CT Principal Investigator 5 National Jew ish

Medical and

Research Center

$11,000 CIC Protocol;

Single center

8. “Selection Within the Peripheral T Cell

Repertoire: Memory and Anergy”

11/01/93 –

10/31/96

PP Project Leader 10 NIH $60,000

9. “Mechanisms and Inhibition of Apoptosis

in AIDS”

03/01/94 –

02/28/95

PG Principal Investigator 25 American Found

AIDS Research

$50, 000

10. Pediatrics AIDS Foundation Student

Internship Program

06/01/94 –

09/01/94


Foundation

$2,000 Aw arded to summer

student



Aw ard

Grant C Role in Grant** % Effort Funding Source Current

Annual Direct

Cost

Additional

Comments***

11. “Mechanism and Role of T Cell Receptor-

Cytoskeletal Interactions in Health &

Cancer”

09/01/94 –

08/31/95

PP Project Leader University of

Colorado Cancer

Center

$8,500 Aw arded to

postdoctoral fellow

12. DAAD Scholarship

09/01/94 –

08/31/97

TG Project Leader DAAD Scholarship,

Germany

$25,000 Aw arded to graduate

student 13. “Evaluation of Changes in HIV-1 Burden

in Peripheral Blood & Lymphoid Tissue”

01/01/95 –

09/30/96

FG Co-Principal Investigator 5 NIH $71,250 Multicenter; NO1

14. “Programmed Cell Death (Apoptosis) of

CD4+ T Cells in Children w ith HIV

Infection”

01/01/95 –

11/30/96


M01 RR000051

Sub# 0946

$12,000 University of

Colorado CRC

Protocol 15. “The Clinical Relevance of Apoptosis in

Pediatric HIV Infection”

01/01/95 –

12/31/97


Foundation

$22,000 Aw arded to

postdoctoral fellow 16. “Dual TCR+ T Cells: Origin, Function and

Role in Autoimmunity”

10/95 – 10/96 PG Principal Investigator 5 Lupus Foundation $5,000

17. “TCR-z-Actin Association in Activation,

Anergy, and Development”

07/01/96 –

06/30/99

PG Principal Investigator 25 Arthritis Foundation $75,000 Funding accepted for

2 months – overlap

w /NIH

18. “How do HIV-1 Gene Products Prevent

Apoptosis?”

09/01/96 –

08/31/98

TG Project Leader NIH $23,700 NRSA aw arded to

postdoctoral fellow 19. “Dual TCR T Lymphocytes and

Autoimmunity in the NZB X NZW Lupus

Mouse”

01/01/97 –

06/30/98

PG Project Leader Arthritis Foundation $24,000 Aw arded to

postdoctoral fellow

20. “A Tolerogen for dsDNA Antibodies” 06/01/97 –

12/01/98

IG Co-Principal Investigator 5 La Jolla

Pharmaceutical

$125,000 Multicenter

21. “Role of Streptococcal and

Staphylococcal Toxins in HSP”

1998 – 2000 CT Principal Investigator 5 NIH M01 RR000051

Sub #1075

$3,750 University of

Colorado CIC Protocol


Name of Grant Period of Aw ard Grant C Role in Grant** %

Effort

Funding Source Current

Annual Direct

Cost

Additional Comments***

22. “Role of Small G Proteins in TCR-

Cytoskeleton Interaction”

03/01/98 –

02/28/00

TG Project Leader NIH

T32

$25,420 NRSA aw arded to

postdoctoral fellow

23. “Outcomes in Juvenile Rheumatoid

Arthritis”

1999-2000 PG Project Leader American College of

Rheumatology

Aw arded to medical

student 24. “Basic Immune Mechanisms and

Immunologic Disease”

07/01/98 –

06/30/03

TG Training Faculty NIH

T32

25. "K.K. Hansen Fellow ship Fund for AIDS

Research"

07/01/98 –

06/30/99

TG Project Leader NJMRC $1,500 Aw arded to postdoctoral

fellow 26. "Research Training in Rheumatology" 05/01/96 –

04/30/01

TG Project Director NIH

T32

27. "Training Program in Immunology" 09/01/96 –

07/31/01


T32 AI00048-21

28. "Training Program in Pediatric

Immunology"

09/01/96 –

08/31/01


T32 AI07365

29. “Biochemical Mechanism(s) of HIV-

induced T-Cell Unresponsiveness and

Apoptosis”

01/01/98 –

12/31/99

PG Project Leader Elizabeth Glaser

Pediatric AIDS

Foundation

$34,000 Scholar aw ard for

postdoctoral fellow

30. “Immune Activation in Neonatal SIV

Pathogenesis”

09/01/96 –

08/31/02

R01 Principal Investigator 20 NIH

R01 AI40003

$133,286

31. “A Tw elve-Week Open-Label Study of

Etodolac ER Dosing in Patients w ith

Juvenile Rheumatoid Arthritis"

2000 IG Principal Investigator Wyeth-Ayerst $8,055

32. Florence Murray 2001-2002 PG Mentor Stokes Research

Institute

$30,000 Aw arded to Postdoctoral

Fellow

33. "BSL3 Ultra-High Speed Flow

Cytometer" 03/31/03

PP Principal Investigator 10 NIH

RR15865

$458,590

34. "Regulation of Apoptosis by Cellular

Target Genes in HIV-1 Infection"

2001-2004 PG Mentor How ard Hughes

Medical Institute


Fellow 35. “ACR REF 2002 Clinic Investigator

Fellow ship Aw ard”

2002-2004 PG Mentor ARC/REF $95,000 Aw arded to Fellow



Aw ard

Grant C Role in Grant** %

Effort

Funding Source Current Annual

Direct Cost


36. “Interactions Betw een the Fas and TCR

Signaling Pathw ays:

06/01/02

PG Principal Investigator 10 W.W. Smith

Charitable Trust

$83,000

37. “CHORD” 2003-2004 IG Co-Mentor Centocor $40,000 Aw arded to Fellow

38. “Effects of Chronic GVH on B-cell

Receptor Editing”

07/01/03 –

06/30/04

PG Principal Investigator 5 University

Research

Foundation

$25,000

39. “Role of JAK3 Expression and Activation

in in vivo IL-2 Therapy in Children”

1998-2002 CT

Phase I/II

Co-Investigator NIH

ACTG 299

Multicenter;

ACTG Sub-project

40. "Meloxicam in JRA" 2001-2002 IG Co-Principal Investigator Boehringer

Ingelheim

$13,729

41. "ACR Pediatric Resident Travel Aw ard” 2002 PG Mentor ACR Aw arded to resident

42. "CD28, NFkB and the Immune Synapse" 2001-2002 IG Mentor Amgen

Pharmaceuticals


Fellow

43. "ACR Medical Student Clinical

Preceptorship in Rheumatology"

Summer 2002 PG Co-Mentor ACR/REF $5,000 Aw arded to medical

student

44. "ACR REF Rheumatology Fellow Training

Aw ard"

2002-2003 PG/IG Principal Investigator ACR/REF/ Amgen $25,000 Aw arded to fellow

45. “Activating Anti-HIV Dendritic Cells by

Abnormal Cell Death“

07/01/04 –

06/30/05

PP Co-Investigator 2.5% NIH CFAR $40,000 Penn CFAR

46. “Inhibition of HIV-Induced Apoptosis by

Host Target Genes”

09/01/02 –

08/31/05

FG Principal Investigator 10% NIH

R21 AI054233

$150,000

47. "Amgen Rheumatology Fellow ship

Aw ard"

2004-2006 PG/IG Principal Investigator ACR/REF/ Amgen $25,000 Fellow ship training

48. Kahn Foundation Endow ment 2002-2006 PG Principal Investigator Kahn Foundation $11,300

49. “Nickolett Family Aw ard for JRA

Research”

12/31/03 –

12/30/06

PG Director Nickolett Family $50,000 Aw arded to PIs Cron and

Burnham



Aw ard


Effort


Annual Direct

Cost


50. “DNA, Protein and Cellular Vaccines for

Cancer and Infectious Disease, including

Agents of Bioterror”

07/01/04 –

06/30/06

PG Principal Investigator 2.5% State of

Pennsylvania

$160,000

51. “Genetics of Renal Disease” 07/01/05 –

06/30/06

PG Principal Investigator NIH M01 RR000240

- 6784

$10,000 CHOP GCRC Protocol

52. “Lentiviral Therapy for Acquired and

Congenital Immunodeficiency Diseases”

2005-2006 PG Principal Investigator 10% Foerderer-Murray $48,000

53. “Anergy & Apoptosis: Role & Mechanism in

HIV Pathogenesis”

07/01/94 –

06/30/07

R01 Principal Investigator 20% NIH

R01 AI35513

$287,000

54. “Anergy & Apoptosis: Role & Mechanism in

HIV Pathogenesis” – Supplement: "Vif and

Cell Cycle"

07/01/02 –

06/30/07

R01 Principal Investigator 5% NIH

R01 AI35513S

$75,001

55. “Web-Based Data Collection - Improving

Outcomes for Children w ith Rheumatic

Disease”

06/01/06 –

05/31/09

PG Principal Investigator Arthritis Foundation $17,000

56. “Signal Initiation from the T-cell Antigen

Receptor by Mechanical Force”

06/05/09 –

10/31/09


1R21 AI078387-S1

$20,644

57. “High-throughput Selection for HIV-1

Resistant Viruses”

06/01/08 –

05/31/10

IG Principal Investigator Merck

Pharmaceuticals

$36,000

58. “Suicide of HIV-1 Infected Cells by TAT-

Inducible Expression of shRNA”

08/15/06 –

07/31/10

FG

Principal Investigator 10% NIH

1R41 AI071927

$203,330 Lentigen Corporation

59. “Mechanism of Autoreactivity in SLE" 12/01/04 –

1/30/11

R01 Co-Investigator 7.5% NIH

R01 AI063623

$21,324

60. “Genetics of Juvenile Idiopathic Arthritis” 09/30/09 –

09/29/11

RC1 Principal Investigator 10% NIH

AR058606

$303,500

61. “Signal Initiation from the T-cell Antigen

Receptor by Mechanical Force”

07/01/08 –

06/30/12


1R21 AI078387

$246,938

62. “Genomics of JIA” 01/01/09 –

12/31/13

PG Principal Investigator 10% Moran Family

Fund

$50,000



Aw ard


Effort


Annual Direct

Cost


63. “Effect of Modulating Apoptosis on HIV-1

Infection”

07/01/09 –

06/30/12

TG Project Leader NIH

T32

$36,000 Aw arded to graduate

student

64. “Training in Pediatric Rheumatology” 01/01/11 –

12/31/16

PG Principal Investigator Sani Family

Foundation

$25,000

65. “Regulation of Type I IFNs in Tolerance and

Autoimmunity”

04/01/09 –

03/31/13

RO1 Co-Investigator NIH $250,000

66. “Potential Application of a BET Antagonist to

Inhibit HIV Replication and Latent Infection”

11/01/11 –

12/31/12

FG Principal Investigator 5% W.W. Smith

Foundation

$91,000

67. “Understanding HIV Escape using Atomic

Force Microscopy”

07/01/10 –

06/30/13


1R21 AI087516

$150,000

68. “Genetics of JIA” 07/01/11 –

06/30/13

PG Co-Principal Investigator CHRI $104,201

*For Grant Category, use code in bold from the follow ing menu: R01 NIH RO1 PP NIH Program Project, Center or Core Grants FG Federal Grants – Other (including other individual NIH grants and grants

from VA, NSF, Dept. of Energy, etc.)

CT Clinical Trails O Other TG Training Grants IG Industrial Grants (including pharmaceutical) PG Private Foundation Grants

**For program projects, specify w hether PI, co-leader or project leader. For center, core and training grants, similarly specify your role. *** Include any additional, brief information. For clinical trails, e.g., specify if multicenter or single center and indicate role of Nemours site. Explain any grants in Other category.


CCUURRRREENNTT GGRRAANNTT SSUUPPPPOORRTT

NAME Dr. Terri H. Finkel DEPARTMENT Pediatrics DATE September, 2015__


Aw ard


Effort


Annual Direct

Cost


1. “Center for Pediatric Research” 09/07/04 –

06/30/19

PP Co-Investigator 5% NIH/NIGMS

8P20GM103464

$1,489,295

2. “Use of a BET Antagonist to Control and

Cure HIV Infection”

11/01/11 –

11/30/14

PG Principal Investigator 5% Gates Grand

Challenges

Exploration

$100,000

3. “PEDSNet: A National Pediatric Learning

Health System –

Phases I & II”

04/15/14 –

05/30/19

FG Senior Institutional Lead PCORI $437,508 Multicenter – Nemours

is one of 8 Integrated

Pediatric Health

Delivery Systems

aw arded $9,000,000

4. “The Role of Vitamin D in Determining Risk

of Developing Juvenile Idiopathic Arthritis”

01/01/12 – PG Co-Investigator NHMRC, Australian

Government

APP1026349

5. “Redirect T cell specif icity to IgE-expressing

B cells for severe allergic asthma”

07/01/15 –

06/30/17

FG Co-Investigator 2.5% NIH

R21AI119841

$300,000




**For program projects, specify w hether PI, co-leader or project leader. For center, core and training grants, similarly specify your role. *** Include any additional, brief information. For clinical trails, e.g., specify if multicenter or single center and indicate role of Nemours site. Explain any grants in Other category.


PPEENNDDIINNGG GGRRAANNTT SSUUPPPPOORRTT

NAME Dr. Terri H. Finkel DEPARTMENT Pediatrics DATE September, 2015

Name of Grant Period of Aw ard Grant C Role in Grant** %

Effort

Funding Source Current Annual

Direct Cost


1. Pediatric Scientif ic Center of

Excellence

FG Institutional Scientif ic Lead PCORI 20,000,000

children in this cohort




**For program projects, specify w hether PI, co-leader or project leader. For center, core and training grants, similarly specify your role. *** Include any additional, brief information. For clinical trails, e.g., specify if multicenter or single center and indicate role of Nemours site. Explain any grants in Other

category.


OOTTHHEERR CCOONNTTRRIIBBUUTTIIOONNSS TTOO CCLLIINNIICCAALL RREESSEEAARRCCHH Name Dr. Terri H. Finkel Department Pediatrics Name of Trial Sponsor Status

Active/ Complete

Role Local P.I., patient recruiter

Name of National PI and Affiliation

No. Recruited by faculty

Total N of Study

Childhood Myositis Heterogeneity Collaborative

Study Group

NIH Active Co-Investigator Dr. Lisa Rider

NIH

10

INternational Childhood ARthritis Genetics

(INCHARGE) Consortium: A Genome Wide

Association Study of Childhood Arthritis

UK Active Local P.I. Dr. Patricia Woo, Great

Orman Street

48 5,000

CARRA: Accelerating Tow ard an Evidence Based

Culture in Pediatric Rheumatology

NIH Active Local P.I. Dr. Laura Schanberg 500 10,000

Systemic JIA GWAS NIH Active Co-Investigator Dr. Daniel Kastner 50 780

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