ER stress: ≥3 arrays ≥ 0.7: 68 genes

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3h 6h 6h 3h 6h

EL-4 CTLL-2 Jurkat Primary thymocytes

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DNAJB1DNAJB4EGR1ASNSATF5DNAJB2DDIT3HERPUD1TRIB3ATF2ATF3ATF6APEX1B2MGADD45BHSPE1HSPH1AHSA1DNAJA1DNAJB6DNAJC3HSPA4BCREIF2S1FKBP5DERL1EIF2AK3HSPA4LHSPA9NFKB1HSPA5XBP1CALRSERP1HSF2HSPB9NFYABCL2BAXKDELR1CASP3HSF1BIRC2ATF1COPS5DNAJB11BAG1MAPK14TOR1AEDEM1PSEN1ARL6IP5ATOX1DHCR24BIRC5SEL1LGSK3BEDEM2TAPBPRTN4SCAPSEC61A1HYOU1SYVN1LMAN1MCFD2SOD1TOR1B

Electronic Supplementary Material (ESI) for Toxicology Research.This journal is © The Royal Society of Chemistry 2014

T cell activation: ≥3 arrays ≥ 0.7: 131 genes0.

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1µ

M

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0.2

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0.2

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3h 6h 6h 3h 6h

EL-4 CTLL-2 Jurkat Primary thymocytes

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M

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CD55EVI2AGPR18EGR1NR4A3CTLA4BTG2PELI1CCND2DUSP6ID2IL21RMAPRE2BCL6IL6STCD8AADORA2AFYNCFLARBCL2L1CD96ELK3CD52CD3GLATCDK6ITGA6KBTBD11IL18R1SATB1SH2D1ASYTL3STARD4CD3ECHD1NFATC3RALGPS1TCF12DUSP2BZW1ARHGEF7ZAP70AIM1RANEDEM1MAPK1STAT1INSIG2TESK1STAT5ABZW2LYSTTRAF5FOXP1MALAT1ISG20TBC1D19CD3DFAM3CMYCFAM101BPOLR1CATRCD247FYBNFKB1LTBNFKBIESOD1GZMBDDX21EIF2C2NOLC1ODC1TFRCMAPKAPK2LTASPOCK2P4HA1IL24TNFSF9GNASIFITM1NIPA2CPLX1CD80RASSF6CDKN1AELL2CXCL10CCL4CD69DUSP1KLF6RELSIAH2FOSGEMJUNIFNGFOSL2GADD45BJUNBNR4A2MTSS1TNFATF3KLF9MAP3K8RGS16RGS2IL10RFX1BAG3PMAIP1KLF10ZFP36PPP1R15BBIRC3NFKBIAICAM1TSC22D3SLC7A5CDKN1BZFP36L1IER3TIMP1IRF4SOCS3PRDM1SPP1

Apoptosis: ≥3 arrays ≥ 0.7: 184 genes

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EL-4 CTLL-2 Jurkat Primary thymocytes

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DPF1CDKN1ABAG2BAG3TNFRSF10BBARD1BCL10BCL2L11GADD45BJMYMDM4PMAIP1SIAH2TNFAIP3BIRC7PPARDBMFPPM1FPPP1R13LIER3BIRC3NFKBIADDIT3CHAC1TRIB3LITAFSQSTM1BCAR1TNFSF9BFARDEDD2API5GLRX2CD3EDIABLOBAXAXIN1TNFRSF1ABIRC2CASP3NUP62CSE1LUTP11LMRPS30RNF130RRAGCBREDAPNME6PRKCEBADCIAPIN1NUDT2NME1PHBAKT1EIF2AK2DFFBDAD1FAIMBCL2L1CASP9TESK2ARHGEF6DNM2DHCR24EBAG9BIRC5NME3CD3GNDUFA13CUL4AFASTKTRADDITGB2LCKEIF4G2PDCD6IPCRADDELMOD2PDCD10ELMO3LGALS1BCAP29FADDBCAP31EI24SLC25A4PRDX2CUL3EMP3ZDHHC16BAG1TIA1DAXXPSMC5MCL1PDCD6RNF34ELMO2MTCH1UBOX5TRAF7DDX41SIPA1PURACASP8BIRC6BNIP2PURBRAD21ELMO1CASP2PPP2CACUL1PDCD7DEDDSART1ERCC3PPP2R1ATIAL1MAPK1TRAF6BNIP3LPPP1R13BF2RESPL1RTN4ADORA2APTPN6STK3PPP2R1BCFLARCUL5ING4MAP3K10PDCD4STK4GPR65ERCC2TAOK2TRAF5IFIH1MALT1APAF1CALRAVENNOTCH2DUSP22CTNNAL1TNFRSF21TNFRSF12ABCL2L13APTXRAF1BAG5RABEP1DNAJA3MAEABAG4CUL2UBE4BSGPL1BRCA1SH3GLB1FAF1NFKB1SIRT1E2F1BIDSCARB1MAP3K5TRAF3EEF1E1PTENCASP8AP2TRAF4TBRG4SMNDC1STK17BGZMBYARSBCL2TRIM35