Contractile Myofilaments

β Adrenergic ReceptorForwardMode

ReverseMode

Cell Membrane

Cytoplasm

α

L-T

ype

Cal

ciu

m C

han

nel

PKAPKA

PKA CAMKII

So

diu

m/C

alci

um

Exc

han

ger

Adenyl Cyclase

GRK

RYR

PLBSarcolipin

β Arrestin

SERCA

P

P

P P

P P

P

P

Troponin C

Ca2+

Ca2+

Ca2+

Ca2+

cAMP

Key & Abbreviations:

P

SarcoplasmicReticulum

FK506-Binding Protein

Indicates activation

Indicates desensitization/functional blockade

Indicates movement of Ca2+

Indicates phosphorylation

Indicates facilitation

cAMP Cyclic Adenosine Monophosphate

CAMKII Calcium/Calmodulin Kinase II

GRK G Protein-Coupled Receptor Kinase

PKA Protein Kinase A

PLB Phospholamban

RYR Ryanodine Receptor

SERCA Sarcoplasmic Reticulum Calcium ATPase

Triadin

Junctin

Calsequestrin 2Ca2+ Ca2+

Catecholamine

Contractile dysfunction in congestive heart failurewww.abcam.com

Copyright © 2011 Abcam, All Rights Reserved. Produced in collaboration with Dr. Kalpana Vijayan.

Heart failure related products from Abcam: www.abcam.com

081-09/09-PW

Featured antibodies

beta 2 Adrenergic Receptor (ab36956)

Clonality Applications Host Species cross reactivityP Flow Cyt, ICC/IF, WB Rb Hu, Ms, Rat

Cardiac Troponin T (ab45932)

Clonality Applications Host Species cross reactivityP ICC/IF, WB Rb Hu

Phospholamban (phospho S16) (ab15000)

Clonality Applications Host Species cross reactivityP IHC-Fr, WB Rb Hu, Ms, Rat, ChHm, Cow,

Hm, Rb

DHPR alpha 1 [S57-46] (ab84814)

Clonality Applications Host Species cross reactivityM IHC-Fr, IHC-P, IP, WB Ms Hu, Ms, Rat

Ryanodine Receptor [34C] (ab2868)

Clonality Applications Host Species cross reactivityM ICC/IF, IHC-Fr, IHC-P, IP, WB Ms Hu, Ms, Rat, Cow, Dog,

Rb, Shp

Product Clonality Applications Host Species Datasheet ProteinsReactivity www.abcam.com/ab…

alpha 1 Adrenergic Receptor P ICC/IF, WB Rb Hu, Ms, Rat, Dm, Zfsh 3462 -

alpha 1 Adrenergic Receptor M WB Ms Hu 54730 -

alpha 2a Adrenergic Receptor P ICC/IF, IHC-P, WB Rb Hu, Ms, Rat 65833 54291

beta 2 Adrenergic Receptor P ICC, ICC/IF, WB Chk Hu, Rat 13989 -

beta 2 Adrenergic Receptor P Flow Cyt, ICC/IF, WB Rb Hu, Ms, Rat 36956 -

CACNA1S P IHC-P, WB Rb Hu 96413 -

CACNA1S [1A] M IHC-Fr, IP, WB Ms Hu, Ms, Rat, Gpig, Rb, Zfsh 2862 -

Calsequestrin P IHC-P, IP, WB Rb Dog, Hu, Ms, Rtrout, Rat, Shp 3516 -

Calsequestrin 2 P IHC-P, WB Rb Hu 96387 93736

CaMKII alpha M ICC/IF, IP, WB Ms Hu 54925 60899

CaMKII alpha (phospho T286) P ICC/IF, IHC (PFA fixed), IHC-Fr, WB Rb Hu, Rat, Rb 5683 -

cardiac Troponin C [1A2] M AP, ELISA, IHC-P, sELISA, WB Ms Hu 8285 9932

Cardiac Troponin I P ICC/IF, IHC-P, WB Rb Hu, Ms, Pig 47003 9936

Cardiac Troponin I [284 (19C7)] M AP, ELISA, ICC/IF, IHC-FoFr, IHC-P, WB Ms Hu, Ms, Rat, Cat, Cow, Dog,

Fsh, Goat, Mk, Pig, Rb 19615 -

cardiac Troponin T P ICC/IF, WB Rb Hu 45932 9937

cardiac Troponin T [1F11] M AP, ELISA, ICC, ICC/IF, WB Ms Hu, Ms, Rat, Cat, Cow, Dog,

Fsh, Goat, Pig, Rb 10214 -

DHPR alpha 1 [S57-46] M IHC-Fr, IHC-P, IP, WB Ms Hu, Ms, Rat 84814 -

FKBP1B P ELISA, WB Rb Hu, Ms 82316 -

NCX1 [C2C12] M ICC/IF, IF, IHC-P, IP, WB Ms Hu, Rat, Dog, Gpig, Rb 2869 -

Phospholamban (phospho S16) P IHC-Fr, WB Rb Hu, Ms, Rat, ChHm, Cow,

Hm, Rb 15000 -

Phospholamban [2D12] M ICC/IF, IHC-P, IP, WB Ms Hu, Ms, Rat, Dog, Gpig, Pig,

Rb, Shp 2865 -

Ryanodine Receptor

(phospho S2808) P ELISA, IHC-P Rb Hu, Ms 59225 -

Ryanodine Receptor [34C] M ICC/IF, IHC-Fr, IHC-P, IP, WB Ms Hu, Ms, Rat, Cow, Dog,

Rb, Shp 2868 -

Sarcolipin/SLN P N/A Rb Fast track 25860 -

SERCA2 ATPase P ICC/IF, IHC-P, WB Rb Hu 77289 -

SERCA2 ATPase [2A7-A1] M ICC/IF, IHC-Fr, IHC-P, IP, WB Ms Hu, Ms, Rat, Dog, Gpig, Rb 2861 -