heart failure - respicardia€¦ · proportion of patients with ≥50% reduction in ahi at 6 months...

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Pump Stress Impaired Left Ventricular Function Adverse Myocardial Remodeling Apnea & Hypopnea Hypoxia & Arousals Ischemia & Inflammation Poor Sleep Quality & Efficiency, Cognitive Difficulties Heart Failure CSA Increased Sympathetic Drive

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Page 1: Heart Failure - Respicardia€¦ · Proportion of patients with ≥50% reduction in AHI at 6 months Control [N=72]* 0 20 20 40 40 60 60 80 80 100 Treatment [N=58] 7% 14% 19% 6% 7%

Pump Stress

Impaired Left Ventricular

Function

Adverse Myocardial Remodeling

Apnea & Hypopnea

Hypoxia & Arousals

Ischemia & Inflammation

Poor Sleep Quality & E�ciency, Cognitive Di�culties

HeartFailure

CSA Increased Sympathetic

Drive

Page 2: Heart Failure - Respicardia€¦ · Proportion of patients with ≥50% reduction in AHI at 6 months Control [N=72]* 0 20 20 40 40 60 60 80 80 100 Treatment [N=58] 7% 14% 19% 6% 7%

100% [95% CI]

41% Di�erence Between Groups

p<0.0001

Treatment[N=68]

Control[N=73]

51%

11%

80%

60%

40%

20%

0%

Proportion of patients with ≥50% reduction in AHI at 6 months

Control[N=72]*

0

20

20

40

40

60

60

80

80

100Treatment

[N=58]

7%

14%

19% 6%7%

61%

26%

Patients (%)p<0.0001

60%

Marked or ModerateImprovement

Mild Improvement

No Change

Worsened

ESS Mean Change from

Baseline (points)[95%CI]

Control[N=73]

Treatment[N=58]

0

-2

2

4

6

p<0.0001

3.6

-0.1

remedē System treatment at 12 months

100%

50%

0%

-50%

-100%

Improvement in AHI from Baseline

N=54

Worsened in AHI from Baseline