heart failure - respicardia€¦ · proportion of patients with ≥50% reduction in ahi at 6 months...
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Pump Stress
Impaired Left Ventricular
Function
Adverse Myocardial Remodeling
Apnea & Hypopnea
Hypoxia & Arousals
Ischemia & Inflammation
Poor Sleep Quality & E�ciency, Cognitive Di�culties
HeartFailure
CSA Increased Sympathetic
Drive
100% [95% CI]
41% Di�erence Between Groups
p<0.0001
Treatment[N=68]
Control[N=73]
51%
11%
80%
60%
40%
20%
0%
Proportion of patients with ≥50% reduction in AHI at 6 months
Control[N=72]*
0
20
20
40
40
60
60
80
80
100Treatment
[N=58]
7%
14%
19% 6%7%
61%
26%
Patients (%)p<0.0001
60%
Marked or ModerateImprovement
Mild Improvement
No Change
Worsened
ESS Mean Change from
Baseline (points)[95%CI]
Control[N=73]
Treatment[N=58]
0
-2
2
4
6
p<0.0001
3.6
-0.1
remedē System treatment at 12 months
100%
50%
0%
-50%
-100%
Improvement in AHI from Baseline
N=54
Worsened in AHI from Baseline