Reactions 1488, p32 - 15 Feb 2014

Temozolomide

Fatigue and lymphopenia: case reportA 55-year-old woman developed fatigue and lymphopenia

while receiving temozolomide [route, duration of treatment toreactions onset and outcomes not stated].

The woman was diagnosed with grade II infiltratingastrocytic gliomatosis cerebri, and began receivingtemozolomide 150 mg/m2/day for 5 days every 28 days. Shesubsequently developed grade I fatigue and grade Ilymphopenia. At last follow-up, she continued to receivetemozolomide beyond 24 courses with no significant toxicity.

Author comment: "She continues TMZ [temozolomide]which she tolerates well, with only grade I fatigue and grade Ilymphopenia."Flowers A. Extended treatment with temozolomide prolongs progression freesurvival in a patient with astrocytic gliomatosis cerebri. Neuro-Oncology 15(Suppl. 3): iii108, Nov 2013 [abstract] - USA 803099436

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Reactions 15 Feb 2014 No. 14880114-9954/14/1488-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved