Institut de recherche expérimentale et clinique (IREC)

NCP Wallonie – 16 février 2017

Pr JL GALA, MD, PhDSrt: 02/764 33 32

Programmes de recherche européens pour les débutants: ”témoignage”

Technological transfer unit - Applied sciences

Spin-off Service to Soc

CTMA / DLD-Bio

R&D Clinical / Ops applicationsTransfert

DNA-based diseases

Bio-markers / -sensors

Dx infectious diseases:

pathogens, virulence &

resistance…

OBJECTIVE

Diagnosis

BE-Defence(DLD)

DLD-Bio

RESOURCES

BioEngineering

Biostatistics

Bioinformatics

BioMed genomics

Multidisciplinary !

Knowledge Engineering

Academic (UCL)

& Clinical pole (CUSL)

Clinical Genetic Testing

Genetic Research

CTMA (Center for Applied Molecular Technologies)

« Academic - Military - Industrial » Interface

EU

Commission

Bio threats

Biomedical

EU Defense

Agency NATO

networks

CTMA DLD-Bio / IREC

EU Space

Agency

Military partners

Community of User for a Safe and Resilent society (EC/ DG HOME)

Academic partners

Inte

rnat

ional

Nat

ional

Industrial

partnership and

valorisation

UCL and CUSL

Academic hospital

Light Fiedable Laboratories (n=3)

Response

time

Selectivity Sensitivity Warning Detection Identifi-

cation

Monito-

ring

Survey /

recce

Molecular

Genetics --- + +++ + +

Immuno - ++ - + -

Optical

detection ? ? +++ ? ? + +

Physical

detection ++ + - ++ +

Hybrid

Technologies

Holy Grail for Diagnostic Innovation: Hybrid identification methods !

Holy Grail

MAIN GOALS : Identification on-site – External support: DRC !Need for robust, reliable, affordable and user-friendly technologies

Bukavu

Investigating the changing endemic Orthopoxvirus (monkeypox)

in Kananga, Occidental Kasaï (DR Congo) 2009. Progressive

developement of the laboratory capacity, deployed in FP7-

PRACTICE (Pionki, PL, 2014) and FP7-EDEN (Bologna, IT, 2016)

Kananga

- Re-equipping and strenghtening local Dx capabilities (infectious

diseases) in South Kivu province (DR Congo) since 2012.

- Surveillance of local pathogen genetics: V.cholerae; ESBL-

producing Enterobacteria

Rapidly deployable laboratory in a major crisis situation like an EBOLA outbreak: the challenge is to use sophisticated technologies in the fiels (DNA-Identification; Point

of care testing; Rapid diagnostic tests !)

Limited space - biosafey measures mandatory - rapid, reliable and safe tests needed !

H2020BioEDEP, JIP-CBRN, CBRN Cat B

COST, PASR, FP7 Horizon 2020

IAP/ARTES20Phase-1Phase-2

CBRN-SIBCRAScience for Peace & Sec (SPS)

EDA

Marshall plan Biowin, Waleo, WBHealthFEDERErasmus Mundi

Regional / FederalR&D

BE-MOD RHID PIC - Internat. CooperationBrain-Belspo

ECESA

NATO

IMG-S (open forum)

MED, LANDDLD, MSP, HFM

BE-Biotech MATRIX (SME’s, Industries)

Multiple Sources of Funding

Service to Society

Strategic Objectives at EU level

1. FP7-SEC-PRACTICE (2011): Preparedness and Resilience against CBRN Terrorism using Integrated Concepts and Equipment

2. FP7- SEC-MIRACLE (2013): MobIle Laboratory for the Rapid Assessment of CBRN Threats Located within and outside the EU (CTMA Coordination)

3. FP7-SEC-EDEN (2013): End-user driven DEmo for CBRNE

4. H2020-DRS-REACHING OUT (2016): DRS-03-2015demonstRation of EU effective lArge sCale tHreat and crIsis maNaGement OUTside the EU.

5. H2020-DRS-PANDEM (2015) PANDemic Risk and Emergency Management

B-LiFE - IAP/ARTES20: Biological Light Fieldable laboratory for Emergencies (CTMA Coordination)- Feasibility (Phase 1): 2012-2013- Demo (Phase 2): 2014-2017

EU SPACE AGENCYEU COMMISSION- FP7/ H2020-SEC

POCT/RDT

1. EBLN-EMS4 - Database of B-agents (Genetic profiling of deadly B-agents)

2. JIP-CBRN call-1 & -2: - BFREE (CBRN mixed samples handling and analysis)

- RACED (monitoring of decontamination

EU DEFENSE AGENCY

RW / BIOWIN

1. WB HEALTH: Biobactil

2. BIOWIN: ALLERT (Handheld Allergens Detector /Détecteur portable d’allergènes alimentaires;

3. WALInnov: TOXINE-ID - 7/6/2016 : Kick Off May 2017

H2020 PROJECTS STARTING IN 2017

1. H2020-SEC-05-DRS (2016): ENCIRCLE (coordination) Chemical, biological, radiological and nuclear (CBRN) cluster

2. H2020-SEC-21–GM (2016): eNOTICE (coordination) EU Network Of CBRN TraIning CEnters

3. H2020-SEC/DRS-EuroBioTox (2016): Validation of biological toxins

measurement after an incident: development of tools and proceduresfor quality control (Au-2016). 57 institutions – 23 countries

FL

NGS

POCT: Point-of-care testingRDT: Rapid Diagnostic Test testing

FL: Rapidly Fieldable LaboratoryNGS: Next Generation Sequencing

ABBREVIATIONS:

Opportunities:

Call SECURITY

CSA:

- Networking et maturation de l’idée - Faciliter l’accès au marché (ENCIRCLE)- Augmenter la visiblité (FP7-MIRACLE)

RIA: développement technologique innovant

Support de la CoU on Safe, Secure and Resilient Society

Contraintes:

Investissement temps: +++

Début: une « bonne » Idée !!!!! - discussion possible avec PO

Préparation du consortium: pas les « amis» mais les « meilleurs »

Bon coordinateur: expérience, trust and knowldege, good network – friendship useful but not compulsory

Contacts répétés : Skype, Telco , preparatory meeetings

Rédaction:

- Sentir le projet – avis PO si besoin

- Bien l’écrire (30 pages ! Dans un anglais de qualité !

- Workpackage - Milestones – Délivrables

- Budget : Partner: Travel, Workshops and Meetings / final conference [ invitation of stakeholders], Equipment, Dissemination, Audit

Third parties

Etre / se mettre en ordre administrativement PIC [Participant ID code] – LEAR (Legal Entity Appointed Representative)

Soumettre avant la deadline : Idéalement commencer un jour avant et updater jusqu’à la dernière minute

Attendre la sélection – NCP informé premierSign

Après sélection:

- Etablir le GA & CA

- Prévoir le KOM (normalement après signature du GA) : Date en concertation avec les partenaires et le PO – preparer Agenda

KOM = Début officiel du projet

Si coordination: beaucoup de travail admin, projet et de suivi de l’état d’avancement (WP, MS, D, Admin, Budget, Reports…..)

Réseau AVANT Publication du Call

FSIGN / LSIGN

LSIGN: Sign grant agreements

FSIGN: Sign financial statements

Aide financière?

- RBx: mécanisme d’aide au montage de projets de RDI :

Mécanisme connect - Innoviris : pas CSA !

- RW: Subvention Horizon Europe – pas pour les call 2016

Actuellement ces mécanismes d’aide à la préparation des projets ne sont plus garantis

Ressources internes

- Experienced staff:

- « Human factors » key of success

- Knowledge of the call and the objectives of the team unit and of the coordinator

- Flexibility, diplomacy, creativity and labour power, espcailly when deadline for submission gets closer and closer!

• Administrative and financial support:• Grant Agremeent / Consortium Agreement• Finances: budget per partner - Person/months - Direct / indirect costs• Time sheets ! (extremely boring … some administration (e.g. Univer.) requests them !)

EBOLA outbreakGuinea 2014-15

H2020 Reaching Out(IA-2015-

DRS-2015: Demonstration activity on large scale disasters and crisis

management and resilience of EU external assets against major

identified threats or causes of crisis

FP7-MIRACLECSA-2012 (coord)

FP7-SEC-2012MobIle Laboratory Capacity for the Rapid Assessment of CBRN Threats Located within and outside the EU

Consortium: Built on successive projects

B-LiFEEuropean Space Agency

IAP /ARTES20 – 2012(Coordination)

Military CBRN

CUSL/UCL :Molecular Genetics

FP7-SEC-2010Preparedness and Resilience

to a CBRN crisisLarge-scale Integrating Project (IP)

FP7-SEC-2012CBRNE Demo Phase IILarge-scale Integrating Project (IP)

Bio3R (PASR-2006)

FP7-CBRN Map(CSA-2009)

FP7-PRACTICE(IP-2010)

FP7-EDEN(IP-2012)

FP7-SEC-2009CBRNE map: road mapping study of CBRNE Demonstrator

H2020- PANDEM (CSA-2014)

H2020-DRS-2014PANDemic risk and Emergency Management

H2020- ENCIRCLECSA-2016 (coord)

H2020 - eNOTICECSA-2016 (coord)

H2020-SEC-21 Pan European Networks of practitioners and other actors in the field of security

H2020-SEC-21-2016Pan European Networks of practitioners and other actors in the field of security

H2020- Euro BioTox-2016 (enduser)

H2020-SEC/DRSValidation of biological toxins measurement after an incident: development of tools and procedures for quality control

Benefits

- Quality of own work

- Sharing with top experts

- Building a EU community of researchers with same or complementary objectives

- Put [Endusers–Customers / Industry-SMEs-Techno. providers / Academic Researchers] together

- Bringing EU policy inside the game: EU common objectives

- Boost adequation between the market and the needs

- Boost innovation and access to the market !

- Boost for new (future) projects !Endusers-guided innovations