1. 1 Le cassis: ladaptogne de la Gemmothrapie Philippe ANDRIANNE Botaniste, Prsident de lAssociation Internationale de Gemmothrapie (AIG) Copyright AIG asbl 2014

2. 2 Annes 60 : Dr. Pol Henry, un mdecin belge, commence les premires recherches sur les applications thrapeutiques des extraits bourgeons Annes 70: Dr Pol Henry publie les rsultats de ses recherches et appelle cette nouvelle thrapie base de bourgeons Phytembryothrapie Annes 80: Dr Max Ttau, un mdecin homopathe franais, et dautres mdecins europens continuent les recherches et exprimentations. Il donne le nouveau nom Gemmothrapie (du latin gemmae qui signifie bourgeon, et aussi pierre prcieuse). La vente seffectue en pharmacies (macrats D1). 2 Histoire de la gemmothrapie 3. 3 En 1995 : Ph. Andrianne introduit la forme concentre (macrat- mre), la triple macration Eau/Alcool/Glycrine ainsi que les premiers complexes de gemmothrapie. Aujourdhui: Des scientifiques comme Ph. Andrianne, Dr. J. Milkers, Dr. Pittera, Dr. J.C. Leunis et d autres travers le monde continuent dvelopper la gemmothrapie sur base de recherches scientifiques approfondies. 3 Histoire de la gemmothrapie 4. 44 La gemmothrapie est une forme de phytothrapie globale qui utilise les bourgeons et les jeunes pousses darbres et darbustes prpars ltat frais au 1/20me, par macration directe dans un mlange eau-alcool-glycrine. Les bourgeons sont forms par des tissus embryonnaires et renferment toutes les proprits de larbre. La gemmothrapie 5. 55 Dfinition de la gemmothrapie La gemmothrapie est une thrapeutique base sur la mise en valeur de lnergie biologique potentielle des vgtaux et des minraux. Dr. P. Henry (Mdecin Bruxelles) Extrait de : Gemmothrapie : thrapeutique par les extraits embryonnaires vgtaux , p.7, Introduction la mthode (1re phrase) Bourgeon de cassis frais, vu par biolectrographie GDV 6. 6 les principes hydrosolubles certaines vitamines et acides les flavonodes les sels minraux les tanins et les polyphnols L EAU dissout Le mlange eau / alcool / glycrine Lutilisation des 3 solvants est importante car ils dissolvent des principes actifs diffrents. 7. 7 Le mlange eau / alcool / glycrine les alcalodes les acides les htrosides divers Les flavonoides les glucosides les vitamines LETHANOL dissout Lutilisation des 3 solvants est importante car ils dissolvent des principes actifs diffrents. 8. 88 Le mlange eau / alcool / glycrine cires phnols huiles essentielles flavonodes gommes matires colorantes etc.. et contribue stabiliser certaines molcules La GLYCERINE VEGETALE dissout Lutilisation des 3 solvants est importante car ils dissolvent des principes actifs diffrents. 9. 99 Le mlange eau / alcool / glycrine La glycrine (glycrol) fait partie de la constitution des membranes cellulaires (phosphoglycrides). Elle est naturellement produite lors de la fermentation alcoolique (gras du vin). Membrane cellulaire phospholipide 10. Les cultures de CASSIS (Ribes nigrum): dsherbage naturel par les oies 11. 1111 Les multi-usages du CASSIS (Ribes nigrum) Agro-alimentaire Dittique Fruits et feuilles de cassis 12. 1212 Les multi-usages du CASSIS (Ribes nigrum) Agro-alimentaire Dittique Confiture, gele, jus, glace, cocktails, apritifs (Kir), fruits frais, sirop, sauce 13. 1313 Les multi-usages du CASSIS (Ribes nigrum) Agro-alimentaire Dittique Poivre de cassis 14. 1414 Les multi-usages du CASSIS (Ribes nigrum) Agro-alimentaire Dittique Arome de cassis 15. 1515 Lhistoire du CASSIS (Ribes nigrum) Ch. LV : L arbre aux goutteux (Le cassis ?) (De gichtbaum) Le cassis est tout fait chaud : sa verdeur et sa verdure et sa sve n ont pas grande valeur, sauf si on les ajoute d autres plantes ou d autres condiments ; car, si on l ajoute d autres plantes, ceux-ci seront bien meilleurs pour la mdecine. Grce sa moelle, les artres reverdissent, comme les hommes. Et si la moelle de cet arbre a t blesse, il en est affaibli Physica, Le livre des subtilits des cratures divines Hildegarde de Bingen 16. 1616 Lhistoire du CASSIS (Ribes nigrum) 17. 1717 Lhistoire du CASSIS (Ribes nigrum) 18. 1818 Lhistoire du CASSIS (Ribes nigrum) Synthse historique des proprits mdicinales anciennes Systme nerveux - fortifie le cerveau - purge le cerveau - apoplexie - sommeil lthargique - redonne le mouvement 19. 1919 Lhistoire du CASSIS (Ribes nigrum) Synthse historique des proprits mdicinales anciennes Systme respiratoire - empche de s enrhumer 20. 2020 Lhistoire du CASSIS (Ribes nigrum) Synthse historique des proprits mdicinales anciennes Systme digestif - tempre la bile - chasse les vers - gurit l estomac - donne de l apptit 21. 2121 Lhistoire du CASSIS (Ribes nigrum) Synthse historique des proprits mdicinales anciennes Systme rnal - dissout la pierre - chasse la gravelle - hydropisie 22. 2222 Lhistoire du CASSIS (Ribes nigrum) Synthse historique des proprits mdicinales anciennes Systme sanguin - cordial (fortifie le cur) - reverdit les artres - purifie le sang 23. 2323 Lhistoire du CASSIS (Ribes nigrum) Synthse historique des proprits mdicinales anciennes Antidote - contre-poison - piqre 24. 2424 Lhistoire du CASSIS (Ribes nigrum) Synthse historique des proprits mdicinales anciennes Favorise laction des autres plantes mdicinales 25. 2525 Lhistoire du CASSIS (Ribes nigrum) Synthse historique des proprits mdicinales anciennes Maladies des femmes Antidouleur de l accouchement 26. 2626 Lhistoire du CASSIS (Ribes nigrum) Synthse historique des proprits mdicinales anciennes En usage externe : - petite vrole - enflure du visage - attire le venin - rysiple - coupure - topique universel - panaris 27. 2727 Le bourgeon de CASSIS (Ribes nigrum) 28. 2828 Fig. 7. Antioxidant capacities (DPPH, mg TE g-1 DW) of extracts (made with glycine buffer, pH 3) from buds of black currant: fresh material, frozen or lyophilised material stored for one week, extracts from fresh buds frozen or lyophilised for one week. Jessica Tabarta, Claire Keversa,b, Arnaud Sipelb, Jol Pincemailc, Jean-Olivier Defraigne c, Jacques Dommes a : Optimisation of extraction of phenolics and antioxidants from black currant leaves and buds and of stability during storage Food Chemistry (2007), vol. 105, iss. 3, pp. 1268-1275. 29. 29 Ascorbic Acid, Phenolic Acid, Flavonoid, and Carotenoid Profiles of Selected Extracts from Ribes nigrum (J. Tabart & alii, J.Agric Food Chemistry, 2011, 59, 4763-70) 30. 30 Ascorbic Acid, Phenolic Acid, Flavonoid, and Carotenoid Profiles of Selected Extracts from Ribes nigrum (J. Tabart & alii, J.Agric Food Chemistry, 2011, 59, 4763-70) 31. 31 Antioxidant Capacity of Black Currant Varies with Organ, Season, and Cultivar (J. Tabart & alii, J.Agric Food Chemistry, 2006 32. 32 Antioxidant Capacity of Black Currant Varies with Organ, Season, and Cultivar (J. Tabart & alii, J.Agric Food Chemistry, 2006 33. 6 mai 2014 - Sminaire de Gemmothrapie scientifique CASSIS: Nom latin : Ribes nigrum 19 polyphnols doss sur 52 tests CCM 366 mm: P. apolaire P. polaire Normes de GEMMOTHERAPIE 2014 rev 0 34. 6 mai 2014 - Sminaire de Gemmothrapie scientifique CASSIS: CCM 366 mm Normes de GEMMOTHERAPIE 2014 rev 0 P. apolaire P. polaire 35. 3535 Cassis Ribes nigrum Articulations Systme nerveux Systme respiratoire Systme sanguin Systme rnal Peau Systme digestif Le macrat-mre de CASSIS (Ribes nigrum) 36. 36 Ribes nigrum Systme SANGUIN (1) Anti-iatrogne 37. Hpatoprotecteur Querctine Cui Y, Han Y, Yang X, Sun Y, Zhao Y. : Protective effects of quercetin and quercetin-5',8-disulfonate against carbon tetrachloride-caused oxidative liver injury in mice. Molecules. 2013 Dec 27;19(1):291- 305. Hpatoprotecteur Querctine Molina MF, Sanchez-Reus I, Iglesias I, Benedi J. : Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol Pharm Bull. 2003 Oct;26(10):1398- 402.. Hpatoprotecteur (bisphnol A) Querctine Sangai NP, Verma RJ, Trivedi MH. : Testing the efficacy of quercetin in mitigating bisphenol A toxicity in liver and kidney of mice. Toxicol Ind Health. 2012 Sep 28. Cassis Anti-Iatrogne 38. Hpatoprotecteur Rutine Khan RA, Khan MR, Sahreen S. : CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat. BMC Complement Altern Med. 2012 Oct 8;12:178. Hpatoprotecteur Rutine Sikder K, Kesh SB, Das N, Manna K, Dey S. : The high antioxidative power of quercetin (aglycone flavonoid) and its glycone (rutin) avert high cholesterol diet induced hepatotoxicity and inflammation in Swiss albino mice. Food Funct. 2014 Apr 17.. Cassis Anti-Iatrogne 39. 39 Chimioprotecteur et effets secondaires de chimiothrapie Ribes nigrum Systme SANGUIN (1) Anti-iatrogne 40. Cassis - Chimioprotecteur Chemoprotecteur Acide ferulique Taniguchi H, Hosoda A, Tsuno T, Maruta Y, Nomura E. : Preparation of ferulic acid and its application for the synthesis of cancer chemopreventive agents. Anticancer Res. 1999 Sep-Oct;19(5A):3757- 61. ChmoprotecteurAcide gallique Vijaya Padma V, Sowmya P, Arun Felix T, Baskaran R, Poornima P. : Protective effect of gallic acid against lindane induced toxicity in experimental rats. Food Chem Toxicol. 2011 Apr;49(4):991-8. ChmoprotecteurIsoquercitrine Magalingam KB, Radhakrishnan A, Haleagrahara N. : Protective effects of flavonol isoquercitrin, against 6-hydroxy dopamine (6-OHDA)-induced toxicity in PC12 cells. BMC Res Notes. 2014 Jan 21;7:49. 41. 41 Chimioprotecteur et effets secondaires de chimiothrapie Ribes nigrum Systme SANGUIN (1) Dtoxifiant sanguin mdicamenteux thyliqueAnti-iatrogne 42. Protecteur hpatornal Acide gallique Nirala SK, Li P, Bhadauria M, Guo G. : Combined effects of gallic acid and propolis on beryllium- induced hepatorenal toxicity. Integr Zool. 2008 Sep;3(3):194-207. Cassis Hpatoprotecteur 43. 43 Prventif contre oxydation du nickel (action hpatique) Acide caffique Pari L, Prasath A. : Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats. Chem Biol Interact. 2008 May 28;173(2):77-83. Chlateur de mtaux (action hpatique) Acide caffique Ikeda H, Kimura Y, Masaki M, Iwahashi H. : Caffeic acid inhibits the formation of 1-hydroxyethyl radical in the reaction mixture of rat liver microsomes with ethanol partly through its metal chelating activity. J Clin Biochem Nutr. 2011 May;48(3):187-93. Dtoxification mtaux lourds Querctine Shukla R, Barve V, Padhye S, Bhonde R. : Reduction of oxidative stress induced vanadium toxicity by complexing with a flavonoid, quercetin: a pragmatictherapeutic approach for diabetes. Biometals. 2006 Dec;19(6):685-93 Hpatoprotecteur Acide gallique Kanai S, Okano H. : Mechanism of the protective effects of sumac gall extract and gallic acid on the progression of CCl4-induced acute liver injury in rats. Am J Chin Med. 1998;26(3-4):333-41. PubMed PMID: 9862021. Cassis Dtoxifiant sanguin 44. Dj mentionn anciennement dans le Trait de 1724 (page 14) : De tous les antidotes ou contrepoisons que les mdecins ont connu jusqu lheure quil est, lexprience fait voir que le cassis et le plus prompt et le plus efficace en son opration contre toute sorte de venin (note 10) et en 1768 : , nous avons parmi nous un Antidote fouverain & un prfervatif certain contre une infinit de maladies aufquelles lhumanit eft fujette, & qui opre des effets qui tiennent du prodige par le peu de temps quil demande pour faire clater fes vertus miraculeuses (Trait de Gemmothrapie, Ph. Andrianne, p. 141,Note 21) 45. Dpendance alcoolique Acide gallique Kanbak G, Canbek M, Olak A, Kartkaya K, Sentrk H, Bayramolu G, Bal C, Gl B, Ozmen A. : Preventive role of gallic acid on alcohol dependent and cysteine protease-mediated pancreas injury. Mol Biol Rep. 2012 Dec;39(12):10249-55 Modre les effets hpatiques Catchine Bharrhan S, Koul A, Chopra K, Rishi P. : Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model. PLoS One. 2011;6(6):e20635. Rgule mtabolisme thanol Naringine Seo HJ, Jeong KS, Lee MK, Park YB, Jung UJ, Kim HJ, Choi MS. : Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. Life Sci. 2003 Jul 4;73(7):933-46. PubMed PMID: 12798418. Cassis Dtoxifiant thylique 46. 46 Chimioprotecteur et effets secondaires de chimiothrapie Ribes nigrum Systme SANGUIN (1) Dtoxifiant sanguin mdicamenteux thylique Anti-infectieux Anti-iatrogne 47. Antibactrien Acide hydroxybenzoi que Fukahori M, Akatsu S, Sato H, Yotsuyanagi T. : Relationship between uptake of p-hydroxybenzoic acid esters by Escherichia coli and antibacterial activity. Chem Pharm Bull (Tokyo). 1996 Aug;44(8):1567-70. Antibactrien (E.Coli) Catchine Chunmei D, Jiabo W, Weijun K, Cheng P, Xiaohe X. Investigation of anti-microbial activity of catechin on Escherichia coli growth by microcalorimetry. Environ Toxicol Pharmacol. 2010 Nov;30(3):284-8. Antibactrien (E.Coli) Catchine Okubo S, Sasaki T, Hara Y, Mori F, Shimamura T. : [Bactericidal and anti-toxin activities of catechin on enterohemorrhagic Escherichia coli]. Kansenshogaku Zasshi. 1998 Mar;72(3):211-7. Japanese Cassis Anti-Infectieux 48. Antibactrien Rhamntine URI J, CSOBAN G, VIRAGH E. : The antibacterial effect of the flavonol-dyestuff, rhamnetin. Acta Physiol Hung. 1951;2(2):223-8. PubMed PMID: 14877554. Antibactrien Querctine Yousef MI, Omar SA, El-Guendi MI, Abdelmegid LA. : Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem Toxicol. 2010 Nov;48(11):3246-61. Cassis Anti-Infectieux 49. 49 Chimioprotecteur et effets secondaires de chimiothrapie Ribes nigrum Systme SANGUIN (1) Dtoxifiant sanguin mdicamenteux thylique Rgule la coagulation Anti-infectieux Anti-iatrogne 50. Protecteur hmodynamique Rutine Bhandary B, Piao CS, Kim DS, Lee GH, Chae SW, Kim HR, Chae HJ. : The protective effect of rutin against ischemia/reperfusion-associated hemodynamic alteration through antioxidant activity. Arch Pharm Res. 2012 Jun;35(6):1091-7. Cassis Rgule la coagulation 51. 51 Chimioprotecteur et effets secondaires de chimiothrapie Ribes nigrum Systme SANGUIN (1) Dtoxifiant sanguin mdicamenteux thylique Rgule la coagulation Anti-infectieux Artriopathies diverses Anti-iatrogne 52. Anti- inflammatoire vasculaire Acide caffique Moon MK, Lee YJ, Kim JS, Kang DG, Lee HS. : Effect of caffeic acid on tumor necrosis factor-alpha- induced vascular inflammation in human umbilical vein endothelial cells. Biol Pharm Bull. 2009 Aug;32(8):1371-7. PubMed PMID: 19652376. Action rtinienneMyrictine Chen R, Hollborn M, Grosche A, Reichenbach A, Wiedemann P, Bringmann A, Kohen L. : Effects of the vegetable polyphenols epigallocatechin-3- gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells. Mol Vis. 2014 Mar 3;20:242-58. eCollection 2014. PubMed PMID: 24623967; PubMed Central PMCID: PMC3945811 Cassis Artriopathies diverses 53. Action vasculaire Acide gallique Gil-Longo J, Gonzlez-Vzquez C. : Vascular pro- oxidant effects secondary to the autoxidation of gallic acid in rat aorta. J Nutr Biochem. 2010 Apr;21(4):304-9. Amliore circulation coronaire Catchine Weng WL. [The effect of d-catechin on the rheology of blood in patients with coronary heart disease]. Zhong Yao Tong Bao. 1984 Sep;9(5):38-9. Chinese. Cassis Artriopathies diverses 54. Le fait que la moelle du cassis exerce une action mdicinale sur les artres qui reverdissent est mentionn lheure actuelle dans les proprits du bourgeon (artriopathies diverses) mais pas en phytothrapie classique. (Trait de Gemmothrapie, Ph. Andrianne, p. 140,Note 5) 55. 55 Chimioprotecteur et effets secondaires de chimiothrapie Ribes nigrum Systme SANGUIN (1) Dtoxifiant sanguin mdicamenteux thylique Rgule la coagulation Artrite de Horton Anti-infectieux Artriopathies diverses Anti-iatrogne 56. 56 Ribes nigrum Systme SANGUIN (2) Hmatogne Anti-anmique 57. Leucmie Acactine Watanabe K, Kanno S, Tomizawa A, Yomogida S, Ishikawa M. : Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade. Oncol Rep. 2012 Jan;27(1):204-9. Anti-leucmie Acide gallique Chandramohan Reddy T, Bharat Reddy D, Aparna A, Arunasree KM, Gupta G, Achari C, Reddy GV, Lakshmipathi V, Subramanyam A, Reddanna P. : Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-B inactivation. Toxicol In Vitro. 2012 Apr;26(3):396- 405. Leucmie Myrictine Dimas K, Demetzos C, Angelopoulou D, Kolokouris A, Mavromoustakos T. : Biological activity of myricetin and its derivatives against human leukemic cell lines in vitro. Pharmacol Res. 2000 Nov;42(5):475-8. PubMed PMID: 11023711. Cassis Anti-anmique 58. Prventif leucmie Querctine Spagnuolo C, Russo M, Bilotto S, Tedesco I, Laratta B, Russo GL. : Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia. Ann N Y Acad Sci. 2012 Jul;1259:95- 103. Leucmie Rutine Lin JP, Yang JS, Lin JJ, Lai KC, Lu HF, Ma CY, Sai- Chuen Wu R, Wu KC, Chueh FS, Gibson Wood W, Chung JG. : Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo. Environ Toxicol. 2012 Aug;27(8):480-4. Cassis Anti-anmique 59. 59 Ribes nigrum Systme SANGUIN (2) Vasculo-protecteur Activit vasculo- adaptative Hmatogne Anti-anmique 60. Action sur endothlium vasculaire Catchine Bhardwaj P, Khanna D, Balakumar P. / Catechin averts experimental diabetes mellitus-induced vascular endothelial structural and functional abnormalities. Cardiovasc Toxicol. 2014 Mar;14(1):41-51. Protecteur endothlium vasculaire Acide chlorognique Chang C, Chen J, Wong H. [Protective effects of organic acids on human vascular endothelial cells]. Zhonghua Yu Fang Yi Xue Za Zhi. 2001 Protection neurovasculaire Apignine Liu R, Zhang T, Yang H, Lan X, Ying J, Du G. : The flavonoid apigenin protects brain neurovascular coupling against amyloid--induced toxicity in mice. J Alzheimers Dis. 2011;24(1):85-100. Action cardio- vasculaire Naringine Alam MA, Kauter K, Brown L. : Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats. Nutrients. 2013 Feb 27;5(3):637-50. Cassis Vasculo-protecteur 61. Athrosclrose Naringine Chanet A, Milenkovic D, Deval C, Potier M, Constans J, Mazur A, Bennetau-Pelissero C, Morand C, Brard AM. : Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. J Nutr Biochem. 2012 May;23(5):469-77. Protecteur vasculaire chez diabtique Querctine Ajay M, Achike FI, Mustafa AM, Mustafa MR. : Effect of quercetin on altered vascular reactivity in aortas isolated from streptozotocin-induced diabetic rats. Diabetes Res Clin Pract. 2006 Jul;73(1):1-7. Protecteur hmorragie crbrale Epicatchine Chang CF, Cho S, Wang J. : (-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways. Ann Clin Transl Neurol. 2014 Apr 1;1(4):258-271 Cassis Vasculo-protecteur 62. 62 Ribes nigrum Systme SANGUIN (2) Vasculo-protecteur Activit vasculo- adaptative Anti- inflammatoire (endothlium) Hmatogne Anti-anmique 63. 63 Ribes nigrum Systme SANGUIN (2) Vasculo-protecteur Activit vasculo- adaptative Hypotension Anti- inflammatoire (endothlium) Hmatogne Anti-anmique 64. 64 Ribes nigrum Systme SANGUIN (2) Vasculo-protecteur Activit vasculo- adaptative Hypotension Anti- inflammatoire (endothlium) Hmatogne Anti-anmique Hypertension (feuille) 65. Active la NO synthtase des cellules endothliales Epicatchine Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F. : (-)-epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide,and related signaling pathways. Hypertension. 2010 Jun;55(6):1398-405. Amliore fonction endothliale Querctine Perez-Vizcaino F, Duarte J, Andriantsitohaina R. : Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols. Free Radic Res. 2006 Oct;40(10):1054-65. Cassis Action vasorelaxante endothlium 66. Cassis - Hypertension (vasodilatateur endothmium J. Tabart) Hypertension Isoquercitrine Gasparotto Junior A, Gasparotto FM, Loureno EL, Crestani S, Stefanello ME, Salvador MJ, da Silva- Santos JE, Marques MC, Kassuya CA. : Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: evidence for the inhibition of angiotensin converting enzyme. J Ethnopharmacol. 2011 Mar 24;134(2):363-72 Hypertension Myrictine Godse S, Mohan M, Kasture V, Kasture S. : Effect of myricetin on blood pressure and metabolic alterations in fructose hypertensive rats. Pharm Biol. 2010 May;48(5):494-8. Hypertension Querctine Gao H, Chen C, Huang S, Li B. : Quercetin attenuates the progression of monocrotaline- induced pulmonary hypertension in rats. J Biomed Res. 2012 Mar;26(2):98-102. 67. Cassis - Hypertension (vasodilatateur endothlium J. Tabart -feuille) Hypertension Querctine Mackraj I, Govender T, Ramesar S. : The antihypertensive effects of quercetin in a salt- sensitive model of hypertension. J Cardiovasc Pharmacol. 2008 Mar;51(3):239-45. Hypertension rno-vasculaire Querctine Garca-Saura MF, Galisteo M, Villar IC, Bermejo A, Zarzuelo A, Vargas F, Duarte J. : Effects of chronic quercetin treatment in experimental renovascular hypertension. Mol Cell Biochem. 2005 Feb;270(1- 2):147-55. Hypertension rno-vasculaire Querctine Montenegro MF, Neto-Neves EM, Dias-Junior CA, Ceron CS, Castro MM, Gomes VA, Kanashiro A, Tanus-Santos JE. : Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension. Naunyn Schmiedebergs Arch Pharmacol. 2010 Oct;382(4):293-301. 68. 68 69. 69 Suite dantibiothrapie Ribes nigrum Systme SANGUIN (2) Vasculo-protecteur Activit vasculo- adaptative Hypotension Anti- inflammatoire (endothlium) Hmatogne Anti-anmique Phlbotonique Hypertension (feuille) 70. 70 Anti-inflammatoire ( cortisone-like ) Ribes nigrum Systme ARTICULAIRE (1) 71. Cassis - Anti-inflammatoire Neuro- inflammation Acactine Huang WC (1), CJ Liou. : Dietary acacetin reduces airway hyperresponsiveness and eosinophil infiltration by modulating eotaxin-1 and th2 cytokines in the mouse model of asthma. Neuro- inflammation Acactine Ha SK (1), Moon E, Lee P, Ryu JH, Oh MS, Kim SY. Neurochem Res. 2012 Jul; 37 (7) :1560-7.Acacetin attenuates neuroinflammation via regulating the response rate LPs stimuli in vitro and in vivo Anti- inflammatoire Acide caffique dos Santos JS, Monte-Alto-Costa A. : Caffeic acid phenethyl ester improves burn healing in rats through anti-inflammatory and antioxidant effects. J Burn Care Res. 2013 Nov-Dec;34(6):682-8. Anti- inflammatoire Acide caffique Liu M, Song S, Li H, Jiang X, Yin P, Wan C, Liu X, Liu F, Xu J. : The protective effect of caffeic acid against inflammation injury of primary bovine mammary epithelial cells induced by lipopolysaccharide. J Dairy Sci. 2014 Mar 5. pii: S0022-0302(14)00166-0. 72. Anti- inflammatoire (IL-6, IL-1B) Acide caffique Zhang M, Zhou J, Wang L, Li B, Guo J, Guan X, Han Q, Zhang H. : Caffeic acid reduces cutaneous tumor necrosis factor alpha (TNF-), IL-6 and IL-1 levels and ameliorates skin edema in acute and chronic model of cutaneous inflammation in mice. Biol Pharm Bull. 2014;37(3):347-54. Diminue PAF Acide chlorognique Fuentes E, Caballero J, Alarcn M, Rojas A, Palomo I. Chlorogenic acid inhibits human platelet activation and thrombus formation. PLoS One. 2014 Mar5;9(3):e90699.. Cassis - Anti-inflammatoire 73. Anti- inflammatoire Acide chlorognique dos Santos MD, Almeida MC, Lopes NP, de Souza GE. Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull. 2006 Nov;29(11):2236-40. PubMed PMID: 17077520. Hwang SJ, Kim YW, Park Y, Lee HJ, Kim KW. Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells. Inflamm Res. 2014 Jan;63(1):81-90. Shi H, Dong L, Jiang J, Zhao J, Zhao G, Dang X, Lu X, Jia M. Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Toxicology. 2013 Jan 7;303:107- 14. Cassis - Anti-inflammatoire 74. Anti- inflammatoire Acide chlorognique Bagdas D, Cinkilic N, Ozboluk HY, Ozyigit MO, Gurun MS. Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain. J Nat Med. 2013 Oct;67(4):698-704. dos Santos MD, Almeida MC, Lopes NP, de Souza GE Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull. 2006 Nov;29(11):2236-40. PubMed PMID: 17077520. Cassis - Anti-inflammatoire 75. Anti- inflammatoire Acide ferulique Sakai S, Ochiai H, Nakajima K, Terasawa K. : Inhibitory effect of ferulic acid on macrophage inflammatory protein-2 production in a murine macrophage cell line, RAW264.7. Cytokine. 1997 Apr;9(4):242-8. PubMed PMID: 9112332. Anti- inflammatoire Acide ferulique Murakami A, Nakamura Y, Koshimizu K, Takahashi D, Matsumoto K, Hagihara K, Taniguchi H, Nomura E, Hosoda A, Tsuno T, Maruta Y, Kim HW, Kawabata K, Ohigashi H. : FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: comparison with ferulic acid. Cancer Lett. 2002 Jun 28;180(2):121-9. Cassis - Anti-inflammatoire 76. Anti- inflammatoire Acide gallique Kroes BH, van den Berg AJ, Quarles van Ufford HC, van Dijk H, Labadie RP. : Anti-inflammatory activity of gallic acid. Planta Med. 1992 Dec;58(6):499-504 Anti- inflammatoire Acide hydroxybenzoi que ADLER-HRADECKY C, KELENTEY B. : [On the toxicity and local analgesic activity of p-hydroxybenzoic acid esters]. Arch Int Pharmacodyn Ther. 1960 Oct 1;128:135-42. German. PubMed PMID: 13681509. Cassis - Anti-inflammatoire 77. Anti- inflammatoire Catchine Nakanishi T, Mukai K, Yumoto H, Hirao K, Hosokawa Y, Matsuo T. : Anti-inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria-derived factors. Eur J Oral Sci. 2010 Apr;118(2):145-50. Anti- inflammatoire Catchine Blache D, Durand P, Prost M, Loreau N. (+) : Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. Free Radic Biol Med. 2002 Dec 15;33(12):1670-80. Diminue cytokines pro- inflammatoires Catchine Noll C, Lameth J, Paul JL, Janel N. : Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice. Eur J Nutr. 2013 Apr;52(3):1243-50. Cassis - Anti-inflammatoire 78. Anti- inflammatoire Isoquercitrine Rogerio AP(1), Kanashiro A, Fontanari C, da Silva EV, Lucisano-Valim YM, Soares EG, Faccioli LH. : Anti- inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8. Cassis - Anti-inflammatoire Anti- inflammatoire Myrictine Hiermann A, Schramm HW, Laufer S. : Anti- inflammatory activity of myricetin-3-O-beta-D- glucuronide and related compounds. Inflamm Res. 1998 Nov;47(11):421-7. PubMed PMID: 9865500. Anti- inflammatoire Myrictine Wang SJ, Tong Y, Lu S, Yang R, Liao X, Xu YF, Li X. : Anti-inflammatory activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves. Planta Med. 2010 Oct;76(14):1492-6. 79. Inhibition IL-1 Beta Myrictine Lee YS, Choi EM. : Myricetin inhibits IL-1beta- induced inflammatory mediators in SW982 human synovial sarcoma cells. Int Immunopharmacol. 2010 Jul;10(7):812-4. Anti- inflammatoire Myrictine Tong Y, Zhou XM, Wang SJ, Yang Y, Cao YL. : Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves. Arch Pharm Res. 2009 Apr;32(4):527-33 Cassis - Anti-inflammatoire 80. Anti-PAF Myrictine Zang BX, Jin M, Wu W, Chen WM, Piao YZ, Li JR. : [Antagonistic effect of myricetin on platelet activing factor]. Yao Xue Xue Bao. 2003 Nov;38(11):831-3. Chinese. PubMed PMID: 14991995. Anti- inflammatoire Naringine Kawaguchi K, Maruyama H, Hasunuma R, Kumazawa Y. : Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin. Immunopharmacol Immunotoxicol. 2011 Dec;33(4):723-9. Cassis - Anti-inflammatoire 81. Anti- inflammatoire Querctine Abbey EL, Rankin JW. : Effect of quercetin supplementation on repeated-sprint performance, xanthine oxidase activity, and inflammation. Int J Sport Nutr Exerc Metab. 2011 Apr;21(2):91-6. Anti- inflammatoire Querctine Comalada M, Camuesco D, Sierra S, Ballester I, Xaus J, Glvez J, Zarzuelo A. : In vivo quercitrin anti- inflammatory effect involves release of quercetin, which inhibits inflammation through down- regulation of the NF-kappaB pathway. Eur J Immunol. 2005 Feb;35(2):584-92. Cassis - Anti-inflammatoire 82. Anti- inflammatoire Querctine Das N, Sikder K, Bhattacharjee S, Majumdar SB, Ghosh S, Majumdar S, Dey S. : Quercetin alleviates inflammation after short-term treatment in high- fat-fed mice. Food Funct. 2013 Jun;4(6):889-98. Anti- inflammatoire Querctine Huang J, Zhu M, Tao Y, Wang S, Chen J, Sun W, Li S. : Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rat. J Pharm Pharmacol. 2012 Aug;64(8):1119-27 Cassis - Anti-inflammatoire 83. Anti- inflammatoire Querctine Indra MR, Karyono S, Ratnawati R, Malik SG. : Quercetin suppresses inflammation by reducing ERK1/2 phosphorylation and NF kappa B activation in Leptin-induced Human Umbilical Vein Endothelial Cells (HUVECs). BMC Res Notes. 2013 Jul 16;6(1):275. Anti- inflammatoire Querctine Konrad M, Nieman DC, Henson DA, Kennerly KM, Jin F, Wallner-Liebmann SJ. : The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. Int J Sport Nutr Exerc Metab. 2011 Aug;21(4):338-46. Cassis - Anti-inflammatoire 84. Anti- inflammatoire Rhamntine Jnawali HN, Lee E, Jeong KW, Shin A, Heo YS, Kim Y. : Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK. J Nat Prod. 2014 Feb 28;77(2):258- 63. Anti- inflammatoire Rutine Lee W, Ku SK, Bae JS. : Barrier protective effects of rutin in LPS-induced inflammation in vitro and in vivo. Food Chem Toxicol. 2012 Sep;50(9):3048-55. Anti- inflammatoire Rutine Sikder K, Kesh SB, Das N, Manna K, Dey S. : The high antioxidative power of quercetin (aglycone flavonoid) and its glycone (rutin) avert high cholesterol diet induced hepatotoxicity and inflammation in Swiss albino mice. Food Funct. 2014 Apr 17. Cassis - Anti-inflammatoire 85. Analgsique Acide chlorognique Bagdas D, Cinkilic N, Ozboluk HY, Ozyigit MO, Gurun MS. Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain. J Nat Med. 2013 Oct;67(4):698-704. dos Santos MD, Almeida MC, Lopes NP, de Souza GE Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull. 2006 Nov;29(11):2236-40. PubMed PMID: 17077520. Cassis - Analgsique 86. Analgsique Acide hydroxybenzoi que ADLER-HRADECKY C, KELENTEY B. : [On the toxicity and local analgesic activity of p- hydroxybenzoic acid esters]. Arch Int Pharmacodyn Ther. 1960 Oct 1;128:135-42. German. PubMed PMID: 13681509. Analgsique Myrictine Tong Y, Zhou XM, Wang SJ, Yang Y, Cao YL. : Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves. Arch Pharm Res. 2009 Apr;32(4):527-33 Cassis - Analgsique 87. Analgsique Acide chlorognique dos Santos MD, Almeida MC, Lopes NP, de Souza GE. Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull. 2006 Nov;29(11):2236-40. PubMed PMID: 17077520. Hwang SJ, Kim YW, Park Y, Lee HJ, Kim KW. Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells. Inflamm Res. 2014 Jan;63(1):81-90. Shi H, Dong L, Jiang J, Zhao J, Zhao G, Dang X, Lu X, Jia M. Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Toxicology. 2013 Jan 7;303:107-14. Cassis - Analgsique 88. Hyperalgsie thermique Querctine Anjaneyulu M, Chopra K. : Quercetin, a bioflavonoid, attenuates thermal hyperalgesia in a mouse model of diabetic neuropathic pain. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Sep;27(6):1001-5. Cassis Hyperalgsie thermique 89. 89 Anti-inflammatoire ( cortisone-like ) Ribes nigrum Systme ARTICULAIRE (1) 90. 90 Anti-inflammatoire ( cortisone-like ) Ribes nigrum Systme ARTICULAIRE (1) Amliore souplesse ligaments et tendons (tendinites) 91. 91 Anti-inflammatoire ( cortisone-like ) Ribes nigrum Systme ARTICULAIRE (1) Amliore souplesse ligaments et tendons (tendinites) Arthrites diverses (psoriasique, rhumatode, spondylarthrite ankylosante) 92. Cassis - Arthrites rhumatodes / Arthrites Arthrite rhumatode Acide gallique Yoon CH, Chung SJ, Lee SW, Park YB, Lee SK, Park MC. : Gallic acid, a natural polyphenolic acid, induces apoptosis and inhibits proinflammatory gene expressions in rheumatoid arthritis fibroblast- like synoviocytes. Joint Bone Spine. 2013 May;80(3):274-9. Arthrite auto- immune Naringine Ahmad SF, Zoheir KM, Abdel-Hamied HE, Ashour AE, Bakheet SA, Attia SM, Abd-Allah AR. : Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines. Cell Immunol. 2014 Feb;287(2):112-20 93. 93 Anti-inflammatoire ( cortisone-like ) Ribes nigrum Systme ARTICULAIRE (1) Amliore souplesse ligaments et tendons (tendinites) Arthroses (gonarthrose, coxarthrose, petites articulations) Arthrites diverses (psoriasique, rhumatode, spondylarthrite ankylosante)Bursites 94. Cassis - Inflammations articulaires Inflammation articulaire Rutine FASSBENDER HG, PIPPERT HK. : [Effect of rutin and hyaluronidase on the allergic-hypergic inflammation of the skin and joints]. Z Gesamte Exp Med. 1954;123(3):210-8. Undetermined Language. PubMed PMID: 13179671. 95. 95 Ribes nigrum Systme ARTICULAIRE (2) Maladie de Dupuytren Lombalgies Cervicalgies Maladie de Ledderhose Ostoporose 96. Ostoporose Naringine Wei M, Yang Z, Li P, Zhang Y, Sse WC. : Anti- osteoporosis activity of naringin in the retinoic acid- induced osteoporosis model. Am J Chin Med. 2007;35(4):663-7. PubMed PMID: 17708632. Ostoporose (aprs ovarectomie) Naringine Pang WY, Wang XL, Mok SK, Lai WP, Chow HK, Leung PC, Yao XS, Wong MS. : Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR- 106) cells. Br J Pharmacol. 2010 Apr;159(8):1693- 1703. PubMed PMID: 20397301; PubMed Central PMCID:PMC2925492. Cassis - Ostoporose 97. Ostoporose Naringine Wei M, Yang Z, Li P, Zhang Y, Sse WC. : Anti- osteoporosis activity of naringin in the retinoic acid- induced osteoporosis model. Am J Chin Med. 2007;35(4):663-7. PubMed PMID: 17708632. Ostoporose (aprs ovarectomie) Naringine Pang WY, Wang XL, Mok SK, Lai WP, Chow HK, Leung PC, Yao XS, Wong MS. : Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR- 106) cells. Br J Pharmacol. 2010 Apr;159(8):1693- 1703. PubMed PMID: 20397301; PubMed Central PMCID:PMC2925492. Cassis - Ostoporose 98. 98 Ribes nigrum Systme ARTICULAIRE (2) Consolide les fractures Maladie de Dupuytren Lombalgies Cervicalgies Maladie de Ledderhose Ostoporose 99. 99 Action ostoblastique Myrictine Hsu YL, Chang JK, Tsai CH, Chien TT, Kuo PL. : Myricetin induces human osteoblast differentiation through bone morphogenetic protein-2/p38 mitogen-activated protein kinase pathway. Biochem Pharmacol. 2007 Feb 15;73(4):504-14. Epub 2006 Oct 26. PubMed PMID: 17113042. Stimule diffrentiation osseuse Naringine Zhang P, Dai KR, Yan SG, Yan WQ, Zhang C, Chen DQ, Xu B, Xu ZW. : Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell. Eur J Pharmacol. 2009 Apr 1;607(1-3):1-5. Erratum in: Eur J Pharmacol. 2009 Sep 1;617(1-3):130. Peng- Zhang [corrected to Zhang, Peng]; Chao-Zhang [corrected to Zhang, Chao]; Bo-Xu [corrected to Xu, Bo]. PubMed PMID: 19326565. Structure osseuse Naringine Wood N. : The effects of dietary bioflavonoid (rutin, quercetin, and naringin) supplementation on physiological changes in molar crestal alveolar bone-cemento-enamel junction distance in young rats. J Med Food. 2004 Summer;7(2):192-6. PubMed PMID: 15298767. Cassis Consolide fractures 100. Mtabolisme osseux Naringine Wong RW, Rabie AB. : Effect of naringin on bone cells. J Orthop Res. 2006 Nov;24(11):2045-50. PubMed PMID: 16944474. Mtabolisme osseux Naringine Habauzit V, Sacco SM, Gil-Izquierdo A, Trzeciakiewicz A, Morand C, Barron D, Pinaud S, Offord E, Horcajada MN. : Differential effects of two citrus flavanones on bone quality in senescent male rats in relation to their bioavailability and metabolism. Bone. 2011 Nov;49(5):1108-16 Cassis Consolide fractures 101. 101 Rhumatismes dgnratifs, chroniques, pri-articulaires, RAA Ribes nigrum Systme ARTICULAIRE (2) Consolide les fractures Maladie de Dupuytren Lombalgies Cervicalgies Maladie de Ledderhose Ostoporose 102. 102 Ribes nigrum Systme ARTICULAIRE (3) Rgnre et protge le cartilage et les articulations 103. Collagne (stimule la greffe) Naringine Wong RW, Rabie AB. : Effect of naringin on bone cells. J Orthop Res. 2006 Nov;24(11):2045-50. PubMed PMID: 16944474. Cassis Rgnre le cartilage 104. 104 Ribes nigrum Systme ARTICULAIRE (3) Rgnre et protge le cartilage et les articulations Migraines musculo-tensives 105. 105 Ribes nigrum Systme SANGUIN Catabolisme de lacide urique, du cholestrol, de lure 106. Hypercholestr olmiant Acide coumarique Duchnowicz P, Broncel M, Podsdek A, Koter-Michalak M. : Hypolipidemic and antioxidant effects of hydroxycinnamic acids, quercetin, and cyanidin 3- glucoside in hypercholesterolemic erythrocytes (in vitro study). Eur J Nutr. 2012 Jun;51(4):435-43. Anti- hyperlipmie Acide gallique Latha RC, Daisy P. : Insulin-secretagogue, antihyperlipidemic and other protective effects of gallic acid isolated from Terminalia bellerica Roxb. In streptozotocin-induced diabetic rats. Chem Biol Interact. 2011 Jan 15;189(1-2):112-8. Hypocholestr olmiant Naringine Shin YW, Bok SH, Jeong TS, Bae KH, Jeoung NH, Choi MS, Lee SH, Park YB. : Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. Int J Vitam Nutr Res. 1999 Sep;69(5):341-7. PubMed PMID: 10526779. Cassis Cholestrol 107. Hypocholestr olmiant Naringine Kim SY, Kim HJ, Lee MK, Jeon SM, Do GM, Kwon EY, Cho YY, Kim DJ, Jeong KS, Park YB, Ha TY, Choi MS. : Naringin time-dependently lowers hepatic cholesterol biosynthesis and plasma cholesterol in rats fed high-fat and high-cholesterol diet. J Med Food. 2006 Winter;9(4):582-6. PubMed PMID: 17201649. Hypocholestr olmiant Naringine da Silva RR, de Oliveira TT, Nagem TJ, Pinto AS, Albino LF, de Almeida MR, de Moraes GH, Pinto JG. : [Hypocholesterolemic effect of naringin and rutin flavonoids]. Arch Latinoam Nutr. 2001 Sep;51(3):258-64. Portuguese. PubMed PMID: 11795241. Cassis Cholestrol 108. Hypolipmiant srique Querctine Egert S, Bosy-Westphal A, Seiberl J, Krbitz C, Settler U, Plachta-Danielzik S, Wagner AE, Frank J, Schrezenmeir J, Rimbach G, Wolffram S, Mller MJ. : Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double- blinded, placebo-controlled cross-over study. Br J Nutr. 2009 Oct;102(7):1065-74. Cholestrol Rhamntine Czeczot H. : Studies of the ability of rhamnetin and isorhamnetin to alkylatebacterial DNA. Acta Microbiol Pol. 1994;43(3-4):291-5. PubMed PMID: 7740978. Cassis Cholestrol 109. 109 Ribes nigrum Systme SANGUIN Catabolisme de lacide urique, du cholestrol, de lure Constricteur veineux capillaire Vaso-constricteur 110. Vaso- constricteur Acide gallique Sanae F, Miyaichi Y, Hayashi H. : Potentiation of vasoconstrictor response and inhibition of endothelium-dependent vasorelaxation by gallic acid in rat aorta. Planta Med. 2002 Aug;68(8):690-3. PubMed PMID: 12221589. Cassis Vasoconstricteur 111. 111 Ribes nigrum Systme SANGUIN Catabolisme de lacide urique, du cholestrol, de lure Maladie de Takayasu (thromboaortopathie) Constricteur veineux capillaire Vaso-constricteur 112. 112 Ribes nigrum Systme URO-GENITAL (1) Goutte 113. 113 Ribes nigrum Systme URO-GENITAL (1) Prostatite chronique Goutte 114. Cancer prostate Acactine Shen KH, Hung SH, Yin LT, Huang CS, Chao CH, Liu CL, Shih YW. Acacetin, a flavonoid, inhibits the invasion and migration of human prostate cancer DU145 cells via inactivation of the p38 MAPK signaling pathway. Mol Cell Biochem. 2010 Cancer prostate Acactine Kim HR, Park CG, Jung JY. : Acacetin (5,7-dihydroxy- 4'-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF- B/Akt signaling in prostate cancer cells. Int J Mol Med. 2014 Feb;33(2):317-24. Cassis Prostatite 115. Cancer prostate Acactine Singh RP, Agrawal P, Yim D, Agarwal C, Agarwal R. : Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis. 2005 Apr;26(4):845-54. Cancer prostate Acide caffique Lin HP, Lin CY, Liu CC, Su LC, Huo C, Kuo YY, Tseng JC, Hsu JM, Chen CK, Chuu CP. : Caffeic Acid phenethyl ester as a potential treatment for advanced prostate cancer targeting akt signaling. Int J Mol Sci. 2013 Mar 6;14(3):5264-83 Cassis Prostatite 116. Cancer prostate Acide gallique Kaur M, Velmurugan B, Rajamanickam S, Agarwal R, Agarwal C. : Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro- apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice. Pharm Res. 2009 Sep;26(9):2133-40. Cancer prostate Acide gallique Veluri R, Singh RP, Liu Z, Thompson JA, Agarwal R, Agarwal C. : Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis. 2006 Jul;27(7):1445-53 Cassis Prostatite 117. Cancer prostate Apignine Babcook MA, Gupta S. : Apigenin Modulates Insulin-like Growth Factor Axis: Implications for Prevention and Therapy of Prostate Cancer. Curr Drug Targets. 2012 Nov 6. Cancer prostate Apignine Franzen CA, Amargo E, Todorovi V, Desai BV, Huda S, Mirzoeva S, Chiu K, Grzybowski BA, Chew TL, Green KJ, Pelling JC. : The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism. Cancer Prev Res (Phila). 2009 Sep;2(9):830-41. Cassis Prostatite 118. Cancer prostate Apignine Gupta S, Afaq F, Mukhtar H. : Selective growth- inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. Biochem Biophys Res Commun. 2001 Oct 5;287(4):914-20. PubMed PMID: 11573952. Cancer prostate Apignine Gupta S, Afaq F, Mukhtar H. : Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells. Oncogene. 2002 May 23;21(23):3727-38. PubMed PMID: 12032841. Cassis Prostatite 119. Cancer prostate Apignine Kaur P, Shukla S, Gupta S. : Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study. Carcinogenesis. 2008 Nov;29(11):2210-7. Cancer prostate Apignine Shukla S, Gupta S. : Molecular mechanisms for apigenin-induced cell-cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells. Mol Carcinog. 2004 Feb;39(2):114-26. PubMed PMID: 14750216. Cassis Prostatite 120. Cancer prostate Apignine Shukla S, Gupta S. : Molecular targets for apigenin- induced cell cycle arrest and apoptosis in prostate cancer cell xenograft. Mol Cancer Ther. 2006 Apr;5(4):843-52. Cancer prostate Apignine Shukla S, MacLennan GT, Flask CA, Fu P, Mishra A, Resnick MI, Gupta S. : Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. Cancer Res. 2007 Jul 15;67(14):6925-35 Cassis Prostatite 121. Cancer prostate Apignine Shukla S, Gupta S. : Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K- Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells. Cell Cycle. 2007 May Cancer prostate Apignine Shukla S, Gupta S. : Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo study. Mol Carcinog. 2009 Mar;48(3):243-52. Cassis Prostatite 122. 122 Cancer prostate Apignine Shukla S, Bhaskaran N, Babcook MA, Fu P, Maclennan GT, Gupta S. : Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway. Carcinogenesis. 2014 Feb;35(2):452-60. Cancer prostate Apignine Oishi M, Iizumi Y, Taniguchi T, Goi W, Miki T, Sakai T. : Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2. PLoS One. 2013;8(2):e55922 Cancer prostate Apignine Mirzoeva S, Franzen CA, Pelling JC. : Apigenin inhibits TGF--induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src- dependent mechanism. Mol Carcinog. 2013 Jan 28. Cancer prostate Apignine Mirzoeva S, Kim ND, Chiu K, Franzen CA, Bergan RC, Pelling JC. : Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells. Mol Carcinog. 2008 Sep;47(9):686-700. Cassis Prostatite 123. Cancer prostate Apignine Pandey M, Kaur P, Shukla S, Abbas A, Fu P, Gupta S. : Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study. Mol Carcinog. 2012 Dec;51(12):952-62. Cancer prostate Apignine Sharma H, Kanwal R, Bhaskaran N, Gupta S. : Plant flavone apigenin binds to nucleic Acid bases and reduces oxidative DNA damage in prostate epithelial cells. PLoS One. 2014 Mar 10;9(3):e91588. Cancer prostate Catchine Bettuzzi S, Rizzi F, Belloni L. : Clinical relevance of the inhibitory effect of green tea catechins (GtCs) on prostate cancer progression in combination with molecular profiling of catechin-resistant tumors: an integrated view. Pol J Vet Sci. 2007;10(1):57-60. Review Cassis Prostatite 124. Cancer prostate Querctine Sharmila G, Bhat FA, Arunkumar R, Elumalai P, Raja Singh P, Senthilkumar K, Arunakaran J. : hemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in vivo model. Clin Nutr. 2013 Sep 3. Cassis Prostatite 125. 125 Cancer prostate Querctine Sharmila G, Athirai T, Kiruthiga B, Senthilkumar K, Elumalai P, Arunkumar R, Arunakaran J. Chemopreventive effect of quercetin in MNU and testosterone induced prostate cancer of Sprague- Dawley rats. Nutr Cancer. 2014;66(1):38-46. Cancer prostate Querctine Wang P, Heber D, Henning SM. : Quercetin increased the antiproliferative activity of green tea polyphenol (-)-epigallocatechin gallate in prostate cancer cells. Nutr Cancer. 2012;64(4):580-7. Cancer prostate Querctine Aalinkeel R, Bindukumar B, Reynolds JL, Sykes DE, Mahajan SD, Chadha KC, Schwartz SA. : The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down- regulating the expression of heat shock protein 90. Prostate. 2008 Dec 1;68(16):1773-89. Cancer prostate Querctine Lee DH, Szczepanski M, Lee YJ. : Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. Biochem Pharmacol. 2008 Jun 15;75(12):2345-55. Cassis Prostatite 126. Cancer prostate Querctine Nair HK, Rao KV, Aalinkeel R, Mahajan S, Chawda R, Schwartz SA. : Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63- 9. Cancer prostate Querctine Pratheeshkumar P, Budhraja A, Son YO, Wang X, Zhang Z, Ding S, Wang L, Hitron A, Lee JC, Xu M, Chen G, Luo J, Shi X. : Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. Cassis Prostatite 127. Cancer prostate Querctine Senthilkumar K, Arunkumar R, Elumalai P, Sharmila G, Gunadharini DN, Banudevi S, Krishnamoorthy G, Benson CS, Arunakaran J. : Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3). Cell Biochem Funct. 2011 Mar;29(2):87-95 Cancer prostate Querctine Tang SN, Singh C, Nall D, Meeker D, Shankar S, Srivastava RK. : The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition. J Mol Signal. 2010 Aug 18;5:14 Cassis Prostatite 128. 128 Insuffisance rnale Glomrulonphrite Ribes nigrum Systme URO-GENITAL (1) Prostatite chronique Goutte 129. Anti- inflammatoire rnal Rutine Arjumand W, Seth A, Sultana S. : Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFB, TNF- and caspase-3 expression in wistar rats. Food Chem Toxicol. 2011 Sep;49(9):2013-21. Cassis Glomrulonphrite 130. 130 Insuffisance rnale GlomrulonphriteDiurtique Ribes nigrum Systme URO-GENITAL (1) Prostatite chronique Goutte 131. 131 Ribes nigrum Systme URO-GENITAL (2) Kyste ovarien Maladie de La Peyronie Fibrome utrin Tonique des surrnales (maladie dAddison) 132. 132 Ribes nigrum Systme RESPIRATOIRE et ORL (1) Rhinites allergiques 133. Anti-viral (rhino-virus) Acide gallique Choi HJ, Song JH, Bhatt LR, Baek SH. : Anti-human rhinovirus activity of gallic acid possessing antioxidant capacity. Phytother Res. 2010 Sep;24(9):1292-6. Cassis - Rhinites 134. 134 Ribes nigrum Systme RESPIRATOIRE et ORL (1) Rhinites allergiques Rhino-pharyngites chroniques 135. Cassis - Rhino-pharyngites chroniques Anti- inflammatoire pulmonaire Naringine Nie YC, Wu H, Li PB, Luo YL, Long K, Xie LM, Shen JG, Su WW. : Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats. J Med Food. 2012 Oct;15(10):894-900. 136. 136 Ribes nigrum Systme RESPIRATOIRE et ORL (1) Rhinites allergiques Rhino-pharyngites chroniques Anti- oedmateux (dme de Quincke) 137. Cassis - dme de Quincke Anti-dme Acide gallique Trevisan G, Rossato MF, Tonello R, Hoffmeister C, Klafke JZ, Rosa F, Pinheiro KV, Pinheiro FV, Boligon AA, Athayde ML, Ferreira J. : Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice. Naunyn Schmiedebergs Arch Pharmacol. 2014 Apr 11. Anti-exudatif pulmonaire (dme) Naringine Lambev I, Krushkov I, Zheliazkov D, Nikolov N. : [Antiexudative effect of naringin in experimental pulmonary edema and peritonitis]. Eksp Med Morfol. 1980;19(4):207-12. Bulgarian. PubMed PMID: 7460808. 138. 138 Asthme Emphysme Ribes nigrum Systme RESPIRATOIRE et ORL (1) Rhinites allergiques Rhino-pharyngites chroniques Anti- oedmateux (dme de Quincke) 139. 139 Anti-asthmatiqueAcactine Huang WC (1), CJ Liou. : Dietary acacetin reduces airway hyperresponsiveness and eosinophil infiltration by modulating eotaxin-1 and th2 cytokines in the mouse model of asthma. Anti-asthmatiqueAcide gallique Dorsch W, Bittinger M, Kaas A, Mller A, Kreher B, Wagner H. : Antiasthmatic effects of Galphimia glauca, gallic acid, and related compounds prevent allergen-and platelet-activating factor-induced bronchial obstruction as well as bronchial hyperreactivity in guinea pigs. Int Arch Allergy Immunol. 1992;97(1):1-7. Anti-asthmatique (supprime osinophilie) Isoquercitrine Rogerio AP(1), Kanashiro A, Fontanari C, da Silva EV, Lucisano-Valim YM, Soares EG, Faccioli LH. : Anti- inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8. Cassis - Asthme 140. 140 Asthme Emphysme Ribes nigrum Systme RESPIRATOIRE et ORL (1) Rhinites allergiques Rhino-pharyngites chroniques Bronchites chroniques et aigus Anti- oedmateux (dme de Quincke) 141. Cassis - Bronchites chroniques Bronchite chronique du fumeur Naringine Luo YL, Zhang CC, Li PB, Nie YC, Wu H, Shen JG, Su WW. : Naringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smoke. Int Immunopharmacol. 2012 Jul;13(3):301-7. 142. 142 Asthme Emphysme Ribes nigrum Systme RESPIRATOIRE et ORL (1) Rhinites allergiques Sinusite Rhino-pharyngites chroniques Bronchites chroniques et aigus Anti- oedmateux (dme de Quincke) 143. 143 Protecteur ORL Ribes nigrum Systme RESPIRATOIRE et ORL (2) 144. Protecteur ORL Acide ferulique Fetoni AR, Eramo S, Troiani D, Paludetti G. : Therapeutic window for ferulic acid protection against noise-induced hearing loss in the guinea pig. Acta Otolaryngol. 2011 Apr;131(4):419-27. Cassis Protecteur ORL 145. 145 Protecteur ORL Ribes nigrum Systme RESPIRATOIRE et ORL (2) Laryngites Amygdalites 146. 146 Protecteur ORL Ribes nigrum Systme RESPIRATOIRE et ORL (2) Parotidites pidmiques Tracho- bronchites Laryngites Amygdalites 147. 147 Amygdalites Ribes nigrum Systme RESPIRATOIRE et ORL (3) Granulomatose de Wegener Laryngites 148. Fibroplaste pulmonaire Acide gallique Chuang CY, Liu HC, Wu LC, Chen CY, Chang JT, Hsu SL. : Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway. J Agric Food Chem. 2010 Mar 10;58(5):2943-51. Cassis Granulomatose de Wegener 149. 149 Amygdalites Ribes nigrum Systme RESPIRATOIRE et ORL (3) Granulomatose de Wegener Parotidites pidmiques Tracho- bronchites Laryngites 150. 150 Tonique Syndrome adynamique aigu Fatigue Somnolence Euphorisant Asthnies diverses Ribes nigrum Systme NERVEUX & IMMUNITAIRE (1) 151. Anti-dpresseur Querctine Anjaneyulu M, Chopra K, Kaur I. : Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice. J Med Food. 2003 Winter;6(4):391-5. Anti-dpresseur Acide gallique Chhillar R, Dhingra D. : Antidepressant-like activity of gallic acid in mice subjected to unpredictable chronic mild stress. Fundam Clin Pharmacol. 2013 Aug;27(4):409-18. Cassis - Asthnie 152. Concentration crbrale Rutine Pyrzanowska J, Piechal A, Blecharz-Klin K, Joniec- Maciejak I, Zobel A, Widy-Tyszkiewicz E. : Influence of long-term administration of rutin on spatial memory as well as the concentration of brain neurotransmitters in aged rats. Pharmacol Rep. 2012;64(4):808-16. PubMed PMID: 23087133. Cassis - Somnolence 153. 153 Tonique Syndrome adynamique aigu Fatigue Somnolence Euphorisant Asthnies diverses Ribes nigrum Systme NERVEUX & IMMUNITAIRE (1) Anti-oxydant Anti-dgnratif Immuno-rgulateur 154. Aggrgation amylode Myrictine Fiori J, Naldi M, Bartolini M, Andrisano V. : Disclosure of a fundamental clue for the elucidation of the myricetin mechanism of action as amyloid aggregation inhibitor by mass spectrometry. Electrophoresis. 2012 Nov;33(22):3380-6. Alhzeimer Naringine Wang D, Gao K, Li X, Shen X, Zhang X, Ma C, Qin C, Zhang L. : Long-term naringin consumption reverses a glucose uptake defect and improves cognitive deficits in a mouse model of Alzheimer's disease. Pharmacol Biochem Behav. 2012 Jul;102(1):13-20. Epub 2012 Mar 26. PubMed PMID: 22741174 Cassis Anti-dgnratif 155. 155 Tonique Syndrome adynamique aigu Fatigue Somnolence Euphorisant Asthnies diverses Ribes nigrum Systme NERVEUX & IMMUNITAIRE (1) Migraine chronique Anti-oxydant Anti-dgnratif Immuno-rgulateur 156. Neuro- inflammation Rutine Javed H, Khan MM, Ahmad A, Vaibhav K, Ahmad ME, Khan A, Ashafaq M, Islam F, Siddiqui MS, Safhi MM, Islam F. : Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type. Neuroscience. 2012 May 17;210:340-52. Neuro- inflammation Rutine Xu PX, Wang SW, Yu XL, Su YJ, Wang T, Zhou WW, Zhang H, Wang YJ, Liu RT. : Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing A oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014 May 1;264:173-80. Cassis - Migraines 157. Inflammation cerveau Naringine Cui QJ, Wang LY, Wei ZX, Qu WS. : Continual Naringin Treatment Benefits the Recovery of Traumatic Brain Injury in Rats Through Reducing Oxidative and Inflammatory Alterations. Neurochem Res. 2014 Apr 13. [Epub ahead of print] PubMed PMID: 24728904. Inflammation cerveau Naringine Gopinath K, Sudhandiran G. : Naringin modulates oxidative stress and inflammation in 3- nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway. Neuroscience. 2012 Dec 27;227:134-43. Cassis - Migraines 158. 158 Tonique Syndrome adynamique aigu Fatigue Somnolence Euphorisant Asthnies diverses Ribes nigrum Systme NERVEUX & IMMUNITAIRE (1) Choc anaphylactique Migraine chronique Anti-oxydant Anti-dgnratif Immuno-rgulateur 159. Diminue raction anaphylactique Acide chlorognique Qin HD, Shi YQ, Liu ZH, Li ZG, Wang HS, Wang H, Liu ZP. : Effect of chlorogenic acid on mast cell- dependent anaphylactic reaction. Int Immunopharmacol. 2010 Sep;10(9):1135-41. Cassis Choc anaphylactique 160. 160 Tonique Syndrome adynamique aigu Fatigue Somnolence Euphorisant Asthnies diverses Ribes nigrum Systme NERVEUX & IMMUNITAIRE (1) Choc anaphylactique Migraine chronique Mononuclose (suite) Anti-oxydant Anti-dgnratif Immuno-rgulateur 161. 161 Activit endocrine Activit gluco-corticode Activit hypophyso- cortico-surrnalienne Ribes nigrum Systme NERVEUX & IMMUNITAIRE (2) Adaptogne 162. Anxiolytique Acide gallique Mansouri MT, Soltani M, Naghizadeh B, Farbood Y, Mashak A, Sarkaki A. : A possible mechanism for the anxiolytic-like effect of gallic acid in the rat elevated plus maze. Pharmacol Biochem Behav. 2014 Feb;117:40-6. Anxiolytique Acide gallique Nagpal K, Singh SK, Mishra DN. : Optimization of brain targeted gallic acid nanoparticles for improved antianxiety-like activity. Int J Biol Macromol. 2013 Jun;57:83-91. Augmente la rsistance de la fatigue musculaire Epicatchine Nogueira L, Ramirez-Sanchez I, Perkins GA, Murphy A, Taub PR, Ceballos G, Villarreal FJ, Hogan MC, Malek MH. : (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589 (Pt18):4615-31. Cassis Adaptogne 163. Augmente l'adaptation l'endurance Epicatchine Httemann M, Lee I, Perkins GA, Britton SL, Koch LG, Malek MH. : (-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity. Clin Sci (Lond). 2013 Jun;124(11):663-74 Anxiolytique Myrictine Vissiennon C, Nieber K, Kelber O, Butterweck V. : Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin--are they prodrugs? J Nutr Biochem. 2012 Jul;23(7):733-40. Cassis Adaptogne 164. 164 Le bourgeon de cassis une plante adaptogne ? - Son action est inoffensive et cause peu de perturbation dans les diffrentes fonctions de lorganisme - Son action est non spcifique mais polyvalente (elle augmente la capacit gnrale de raction de lorganisme contre les influences nfastes) - Son action est normalisante, tant au niveau physique que psychique, indpendante de la direction de la pathologie. Le macrat-mre de CASSIS (Ribes nigrum) 165. 165 Le macrat-mre de CASSIS (Ribes nigrum) - La plante peut tre donne sans danger sur de longues priodes. - En MTC, les plantes adaptognes sont appeles Toniques suprieurs . Elles sont en relation avec la force vitale de lorganisme (Qi), avec le sang, avec la notion de tension, de vibration. 166. Durrafourd mentionne le cassis comme adaptogne et adaptonique. (Durrafourd C., Lapraz JC : Trait de phytothrapie clinique, mdecine et endobiognie, d. Masson, Paris, 2002, ISBN : 2-294-00596-1) (Trait de Gemmothrapie, Ph. Andrianne, p. 141,Note 32) Le macrat-mre de CASSIS (Ribes nigrum) 167. 167 Le macrat-mre de CASSIS (Ribes nigrum) Il tempre les effets secondaires des agents anti-mitotiques en exerant une action de dtoxification au niveau des organes agresss par ces molcules toxiques. La prsence importante darginine, de glycine et de nombreux flavonoides contribue expliquer cette action de dtoxification hpatique ainsi que llimination du cholestrol. 168. Dj voqu dans lancien Trait de Montaran en 1724 (pages 4-5) : Ceft un lixir qui entretient la fant, & qui fait que les perfonnes ges paroiffent plus jeunes quelles ne le font . (Trait de Gemmothrapie, Ph. Andrianne, p. 140,Note 8) 169. Ce que confirme le Trait du cassis de 1724 (page 12) : Enfin on peut coup feur dans toutes les maladies commencer les remdes par le cassis, il ne fera jamais mal perfonne, & on a fujet defprer quaprs tant dexprience il fera du bien tout (Trait de Gemmothrapie, Ph. Andrianne, p. 141,Note 28) 170. 170 Activit endocrine Activit gluco-corticode Activit hypophyso- cortico-surrnalienne Ribes nigrum Systme NERVEUX & IMMUNITAIRE (2) Hypoendocrinie Adaptogne Anti-allergique Allergies aigus Allergies aux mdicaments 171. Anti- histaminique Acide chlorognique Inami Y, Andoh T, Kuraishi Y. Prevention of topical surfactant-induced itch- related responses by chlorogenic acid through the inhibition of increased histamine production in the epidermis. J Pharmacol Sci. 2013;121(3):242-5. Epub 2013 Mar 1. Anti- histaminique Acide gallique Kim SH, Jun CD, Suk K, Choi BJ, Lim H, Park S, Lee SH, Shin HY, Kim DK, Shin TY. : Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. Toxicol Sci. 2006 May;91(1):123-31. Cassis Anti-allergique 172. Anti-allergique Acide chlorognique Oku H, Ogawa Y, Iwaoka E, Ishiguro K. Allergy-preventive effects of chlorogenic acid and iridoid derivatives from flower buds of Lonicera japonica. Biol Pharm Bull. 2011;34(8):1330-3. Anti-allergique Acide gallique Liu KY, Hu S, Chan BC, Wat EC, Lau CB, Hon KL, Fung KP, Leung PC, Hui PC, Lam CW, Wong CK : Anti- inflammatory and anti-allergic activities of Pentaherb formula, Moutan Cortex (Danpi) and gallic acid. Molecules. 2013 Feb 25;18(3):2483-500. Anti-allergique Apignine Li RR, Pang LL, Du Q, Shi Y, Dai WJ, Yin KS. : Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma. Immunopharmacol Immunotoxicol. 2010 Sep;32(3):364-70. Cassis Anti-allergique 173. 173 Anti-allergique Isoquercitrine Rogerio AP(1), Kanashiro A, Fontanari C, da Silva EV, Lucisano-Valim YM, Soares EG, Faccioli LH. : Anti- inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8. Anti-allergique Myrictine Medeiros KC, Figueiredo CA, Figueredo TB, Freire KR, Santos FA, Alcantara-Neves NM, Silva TM, Piuvezam MR. : Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin- sensitized mice. J Ethnopharmacol. 2008 Sep 2;119(1):41-6. Anti-allergique Querctine Shaik YB, Castellani ML, Perrella A, Conti F, Salini V, Tete S, Madhappan B, Vecchiet J, De Lutiis MA, Caraffa A, Cerulli G. : Role of quercetin (a natural herbal compound) in allergy and inflammation. J Biol Regul Homeost Agents. 2006 Jul-Dec;20(3- 4):47-52 Cassis Anti-allergique 174. 174 Activit endocrine Activit gluco-corticode Activit hypophyso- cortico-surrnalienne Ribes nigrum Systme NERVEUX & IMMUNITAIRE (2) Hypoendocrinie Allergies diverses (= draineur vrai) Adaptogne Anti-allergique Allergies aigus Allergies aux mdicaments 175. 175 Le macrat-mre de CASSIS (Ribes nigrum) DRAINEUR VRAI Agit faible dose Pas deffet secondaire dfavorable 176. 176 Le macrat-mre de CASSIS (Ribes nigrum) Leffet ping-pong Cet effet se produit lorsque les toxines dplaces, ne sont pas limines de lorganisme, mais quau contraire, elles sont r-accumules, crant ainsi des perturbations dans dautres organes, dues au manque dlimination efficace. 177. 177 Le macrat-mre de CASSIS (Ribes nigrum) DRAINEUR VRAI Action rgulatrice du mtabolisme cellulaire au niveau tissulaire. 178. 178 Ribes nigrum Systme NERVEUX & IMMUNITAIRE (3) Hypoendocrinie Action hypophyso- cortico-surrnale Immuno-rgulateur Grippe 179. Antiviral (influenza) Catchine Song JM, Park KD, Lee KH, Byun YH, Park JH, Kim SH, Kim JH, Seong BL. : Biological evaluation of anti- influenza viral activity of semi-synthetic catechin derivatives. Antiviral Res. 2007 Nov;76(2):178-85. Epub 2007 Aug 1. Cassis Grippe 180. 180 Frilosit Rsistance au froid Ribes nigrum Systme NERVEUX & IMMUNITAIRE (3) Hypoendocrinie Action hypophyso- cortico-surrnale Immuno-rgulateur Grippe Syndrme de dsadaptation 181. 181 Ribes nigrum Systme DIGESTIF Pancratites 182. Anti- inflammatoire sur tumeur pancras Catchine Krbitz C, Heise D, Redmer T, Goumas F, Arlt A, Lemke J, Rimbach G, Kalthoff H, Trauzold A. : picatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells. Cancer Sci. 2011 Apr;102(4):728-34. Stress oxydatif pancras Querctine Coskun O, Kanter M, Korkmaz A, Oter S. : Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res. 2005 Feb;51(2):117-23. Protecteur cellules pancratiques Querctine Adewole SO, Caxton-Martins EA, Ojewole JA. : Protective effect of quercetin on the morphology of pancreatic beta-cells of streptozotocin-treated diabetic rats. Afr J Tradit Complement Altern Med. 2006 Aug 28;4(1):64-74. Cassis Pancratite 183. 183 Ribes nigrum Systme DIGESTIF Pancratites Colites 184. 184 Colon irritable Rutine Kim H, Kong H, Choi B, Yang Y, Kim Y, Lim MJ, Neckers L, Jung Y. : Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease. Pharm Res. 2005 Sep;22(9):1499-509. Colon irritable Rutine Nones K, Dommels YE, Martell S, Butts C, McNabb WC, Park ZA, Zhu S, Hedderley D, Barnett MP, Roy NC. : The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene-deficient (mdr1a-/-) mice, a model of inflammatory bowel diseases. Br J Nutr. 2009 Jan;101(2):169-81. Colon irritable Rutine Rabikov M, Bautzov T, Gajdziok J, Dvokov K, Lamprecht A, Pellequer Y, Spilkov J. : Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: in vitro characteristics and in vivo evaluation. Int J Pharm. 2012 Jan 17;422(1-2):151-9. Cassis Colite 185. 185 Aigreurs estomac Ribes nigrum Systme DIGESTIF Gastrites Pancratites Colites 186. Antioxydant stomacal Rutine La Casa C, Villegas I, Alarcn de la Lastra C, Motilva V, Martn Calero MJ. : Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol. 2000 Jul;71(1-2):45-53. Activit antioxydante Acide caffique Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, Hirano T, Sugawara M, Iseki K. : In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int J Pharm. 2011 Jan 17;403(1-2):136- 8. Cassis Gastrite 187. Anti-ulcre stomacal Acide gallique Sen S, Asokkumar K, Umamaheswari M, Sivashanmugam AT, Subhadradevi V. : Antiulcerogenic effect of gallic Acid in rats and its effect on oxidant and antioxidant parameters in stomach tissue. Indian J Pharm Sci. 2013 Mar;75(2):149-55. Anti-ulcre Catchine Hamaishi K, Kojima R, Ito M. : Anti-ulcer effect of tea catechin in rats. Biol Pharm Bull. 2006 Nov;29(11):2206-13. PubMed PMID: 17077516. Cassis Gastrite 188. 188 Aigreurs estomacHpatites Ribes nigrum Systme DIGESTIF Gastrites Pancratites Colites Dyspepsies Gengivo-stomatites Stomatites aphteuses 189. Anti- inflammatoire hpatique Acide chlorognique Shi H, Dong L, Jiang J, Zhao J, Zhao G, Dang X, Lu X, Jia M. Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Toxicology. 2013 Jan 7;303:107- 14. Anti- inflammatoire hpatique Rutine Gao M, Ma Y, Liu D. : Rutin suppresses palmitic acids-triggered inflammation in macrophages and blocks high fat diet-induced obesity and fatty liver in mice. Pharm Res. 2013 Nov;30(11):2940-50. Cassis Hpatite 190. 190 Aigreurs estomacHpatites Ribes nigrum Systme DIGESTIF Dysphagie oesophagienne Gastrites Pancratites Colites Dyspepsies Anti- inflammatoire Gengivo-stomatites Stomatites aphteuses 191. 191 Ribes nigrum Systme CUTANE Psoriasis 192. Psoriasis Rutine BREMBACH H. : [Therapy of psoriasis and other skin diseases with rutin and calcium]. Munch Med Wochenschr. 1952 Jul 18;94(29):1475-8. Undetermined Language. PubMed PMID: 12982838. Cassis Psoriasis 193. 193 Ribes nigrum Systme CUTANE Psoriasis Anti-inflammatoire Topique universel 194. Dermoprotecteur Acide caffique Pluemsamran T, Onkoksoong T, Panich U. : Caffeic acid and ferulic acid inhibit UVA-induced matrix metalloproteinase-1 through regulation of antioxidant defense system in keratinocyte HaCaT cells. Photochem Photobiol. 2012 Jul- Aug;88(4):961-8. Cassis Topique universel 195. 195 Ribes nigrum Systme CUTANE Piqres dinsecte (usage externe et interne) Psoriasis Anti-inflammatoire Topique universel Dermatoses diverses 196. Diminue raction anaphylactique Acide chlorognique Qin HD, Shi YQ, Liu ZH, Li ZG, Wang HS, Wang H, Liu ZP. : Effect of chlorogenic acid on mast cell- dependent anaphylactic reaction. Int Immunopharmacol. 2010 Sep;10(9):1135-41. Cassis Piqure dinsecte 197. Dj mentionn anciennement dans le Trait de 1724 (page 14) : Sil y a des bleffures ou piqueures venimeufes des Moucherons, Frelons, Guefpes, il faut faire infufer tant foit peu quelques feuilles feiches dans du vin blanc, & aprs avoir feignez la playe, appliquer deffus les feuilles ; vous ferez le mme avec les boutons & lcorce du CASSIS, pille avec du vin blanc, & donne au malade. Si on na ni feuilles, ni boutons, ni corfe de Caffis, le Sirop de Caffis, quel venin quon ait dans le corps, le tirera, pourv quon en donne une ou deux bonnes cuilleres au malade (Trait de Gemmothrapie, Ph. Andrianne, p. 141,Note 13) 198. 198 Urticaires aigus et chroniques (dmangeaisons diverses, dermatites) Eczma sec, suintant et infect Ribes nigrum Systme CUTANE Piqres dinsecte (usage externe et interne) Psoriasis Anti-inflammatoire Topique universel Dermatoses diverses 199. Inflammation cutane Rutine FASSBENDER HG, PIPPERT HK. : [Effect of rutin and hyaluronidase on the allergic-hypergic inflammation of the skin and joints]. Z Gesamte Exp Med. 1954;123(3):210-8. Undetermined Language. PubMed PMID: 13179671. Cassis Eczma 200. 200 Rtinopathies diverses (rtinite pigmentaire, dcollement de rtine) Photophobie Ribes nigrum Systme OCULAIRE Acuit visuelle Myopie Nyctalopie 201. Rtinopathie diabtique Rutine LEVITT LM, CHOLST MR, et al. : Rutin therapy for increased capillary fragility and retinopathy associated with diabetes mellitus. Am J Med Sci. 1948 Feb;215(2):130-5. Cassis Rtinopathie 202. 202 Rtinopathies diverses (rtinite pigmentaire, dcollement de rtine) Photophobie Ribes nigrum Systme OCULAIRE Acuit visuelle Myopie Atrophie du nerf optique Nvrite du nerf optique Hmianopsie Nyctalopie 203. 203 Le macrat-mre de CASSIS (Ribes nigrum) Et les associations pour une efficacit suprieure 204. 204 Le macrat-mre de CASSIS (Ribes nigrum) Dans larthrose du sujet relativement jeune (40-60), il est possible dtablir un traitement associant la sve de bouleau aux bourgeons Ribes et Pinus Cest essentiellement la douleur et lankylose qui sont amliores et vont rgresser Cette triade [cassis, pin, vigne dans larthrose du sujet jeune] agit sur llment inflammatoire du type tendineux et synovial et sur llment contracturant : ligaments et muscles . Dr. Ttau, Gemmothrapie Clinique, Cahiers de Biothrapie, 1971, N 29, Fasc. 4, 3-31 205. 205 Le macrat-mre de CASSIS (Ribes nigrum) Dans les complexes de gemmothrapie 206. 206 Rquilibre le terrain allergique Procure rapidement un soulagement Maintient la vitalit sans accoutumance Stimule les forces de dfense du corps Gemmo-Complexe N 1 LE COMPLEXE ANTI-ALLERGIQUE Action synergique de 3 extraits : Cassis, Romarin, Propolis 207. 207 Gemmo-Complexe N 1 Anti-Allergique (Cassis, Romarin, Propolis) + C. Immunit GC09 + Complexe Vitamines B + Zn + Mn / Cu (Diathse allergique de Mntrier) + Orme (peau) + Noyer (allergies auto- immunes) en alternance + Figuier + Sve de bouleau + C. Dpuratif GC 07 208. 208 Soulage les gnes articulaires Amliore la souplesse Combat l usure des articulations Reminralise Soulage les maux de dos, les courbatures Action synergique de 4 extraits : Cassis, Pin, Vigne, Bouleau Gemmo-Complexe N 2 LE COMPLEXE ARTICULATION 209. 209 Gemmo-Complexe N 2 Articulations (Cassis, Pin, Vigne, Bouleau) + Sve de Bouleau enrichie aux extraits de bourgeons + Si organique (reconstitution cartilage) + Mn (co-facteur) + Rosier (articulation genou) + Ronce (genou, arthrose chronique) + Frne + Vigne vierge (main, doigts) + Cu + Prle + Sulfate chondrotine + Sulfate glucosamine (cartilage) + C. Dpuratif GC 07 + C. Ostoporose GC 13 210. 210 Gemmo-Complexe N 2 Articulation (Cassis, Pin, Vigne, Bouleau) + Peuplier + Olivier + Tilleul + C. Intgr de Ginkgo GC 08 + Myrtillier (micro-circulation) + Bromlase On notera limportance de la circulation sanguine pour lirrigation des articulations + C. Circ. Veineuse GC 17 211. 211 Gemmo-Complexe N 9 LE COMPLEXE IMMUNITE Stimule et renforce les dfenses naturelles de lorganisme Action prventive sur les maladies Evite la dminralisation en rtablissant lquilibre minral Favorise la croissance des os et des dents Apporte une sensation de bien-tre et stimule la forme Action synergique de 3 extraits : Sapin pectin, Rosier sauvage, Cassis 212. 212 Gemmo-Complexe N 9 Immunit (Sapin, Rosier, Cassis) + C. Anti-Allergique GC 01 + Vitamines C + Cu - Au - Ag + Noyer + Squoia / Chne ou C. Tonique GC 16 + Echinaca TM + Propolis + Ronce + Sve de bouleau 213. 213 Gemmo-Complexe N 15 LE COMPLEXE VOIES RESPIRATOIRES Action synergique de 4 extraits de bourgeons : Charme, Aulne, Rosier sauvage, Cassis Assainit les voies respiratoires Nettoie la muqueuse nasale Agit comme bouclier contre les attaques extrieures Renforce les dfenses naturelles 214. 214 Gemmo-Complexe N 15 Voies respiratoires (Charme, Aulne, Rosier sauvage, Cassis) Complexe Anti-Allergique CG 01 Ronce (emphysme) Sirops respiratoires Viorne (asthme) Noisetier (asthme) Khella (Amni visnaga) (HE en us. Ext.) (crise dasthme) + Cu 215. 215 Gemmo-Complexe N 16 LE COMPLEXE TONIQUE Procure rapidement du tonus tout lorganisme Lutte contre la fatigue et la somnolence Maintient la vitalit sans accoutumance Chasse la dprime et stimule la bonne humeur de faon durable Action synergique de 4 extraits : Squoia, Romarin, Cassis, Chne 216. 216 Gemmo-Complexe N 16 TONIQUE (Squoia, Romarin, Cassis, Chne) + C. Mmoire GC 10 + C. Sommeil GC 11 C. Immunit GC 09 + Figuier (dpression) + Bouleau Fleurs mles (impuissance, frigidit, hypothyrodie) + Olivier (nvrose) + Magnsium + Germanium + Vitamines C + Fer 217. 217 CASSIS et FIBROMYALGIE 218. Souvent dorigine multifactorielle, ce qui explique labsence de traitement standardis efficace. Notre dmarche, avec la sve de bouleau associe aux extraits de bourgeons de cassis et de bouleau, vise amliorer le confort de vie des patients fibromyalgiques en agissant comme draineur et anti- inflammatoire. 218 Introduction la Fibromyalgie 219. 219 CAUSES DE LA FIBROMYALGIE METAUX LOURDS (amalgames dentaires, vaccins, ) PLOMB, MERCURE, CADMIUM, ALUMINIUM, etc Cassis et Fibromyalgie 220. 220 Cassis et Fibromyalgie CAUSES FIBROMYALGIE PERTURBATION ELECTROMAGNETIQUES PERTURBATIONS TELLURIQUES (gobiologie) 221. 221 Cassis et Fibromyalgie CAUSES DE LA FIBROMYALGIE PSYCHISME / EMOTIONEL CARCAN / CONTRAINTE / BLOCAGES CROYANCES /STRESS / BOBO A L EXISTENCE / DEVALORISATION VIVRE QUI ON EST.. 222. 222 Cassis et Fibromyalgie CAUSES DE LA FIBROMYALGIE ORIGINE AUTO-IMMUNE Ex. : toxines intestinales (voir test endotoxine gram-) 223. 223 Cassis et Fibromyalgie LES TESTS PHOSPHATYDYL INOSITOL Molcule informationnelle de la membrane cellulaire Inhibition de son activit : fatigue chronique 224. 224 Cassis et Fibromyalgie ALIMENTATION / REMEDES EXTERNES Suppression du lait Apports en minraux (Mg) et oligo-lments (Mn, Cu, ), eau magntise Magntisme / Aimants Ionocinse : application de champs lectriques rguls 225. 225 Cassis et Fibromyalgie REMEDES HOMEOPATHIQUES Arnica 5CH Hypericum 5CH Rhus toxicodendron 5CH 226. 226 Le macrat-mre de BOULEAU (Betula verr.) 227. 6 mai 2014 - Sminaire de Gemmothrapie scientifique BOULEAU BLANC: Nom latin : Betula verrucosa 14 polyphnols doss sur 52 tests CCM 366 mm: P. apolaire P. polaire Normes de GEMMOTHERAPIE 2014 rev 0 228. 228 Le macrat-mre de BOULEAU (Betula verr.) Douleurs articulaires Systme ARTICULAIRE Ostoporose (reminralisant) Epiphysite vertbrale Msenchymopathie (collagnose) Croissance Adolescent 229. 229 Le macrat-mre de BOULEAU (Betula verr.) Anti-inflammatoire Systme ARTICULAIRE Stimule fabrication de los (ostoblastes) Dos douloureux PCE Arthrites diverses Bursite, Lumbago, Sciatique 230. 230 Le macrat-mre de BOULEAU (Betula verr.) Draineur du rein Systme RENAL Nphrite Trouble du mtabolisme phospho-calcique 231. 231 Sucres Sucrose 0 - 0.7 g/L Galactose 0.01 - 0.03 g/L Fructose 2.3 - 4.5 g/L Glucose 2.5 - 4.7 g/L Acides Malique 100 - 600 mg/L Phosphorique 10 - 60 mg/L Succinique 10 - 300 mg/L Citrique 5 - 20 mg/L Acides-phnols 7,8 to 10,4 mg EGA/L (1) Catchines +/- 1 mg CE/L La Sve de bouleau (composition) 232. 232 Hyperoside (Betuloside,Monotroposide) Querctine Lutoline Vitamine C Acides amins (17 diffrents dont lacide glutamique, ) Hormones vgtales (cytokines, ) Mucilages Minraux et oligo-lments divers La Sve de bouleau (composition) 233. 233 Teneurs en minraux Minraux (ppm)N Echan- tillon Ca Cu Fe K Mg Mn Na Zn 1 88,0 0,02 0,04 124,8 12,5 21,76 8,2 2,57 2 26,7 0,01