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  • 7/25/2019 CHOIX DE TEXTES MDICAUX

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    CONSTANA NI

    CHOIX DE TEXTES

    MDICAUXI-re partie

    Editura Universitii din ORADEA I.S.B.N. : 978 !"! #" #$"% 9$"#%

    CONSTANA NI

    CHOIX

    DE

    TEXTES

    MDICAUX

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    EDITURA UNIVERSITII DIN ORADEAISBN : 978 606 10 1203 9

    2013

    Ree!e"#$ :Prof. univ. Dr. Gavril Cornuiu Conf. univ. Dr. Ligia Olivia Burt

    Te%"&!e'()*(!e : Ing. Caius- Vasiliu Harangu

    C&+e!*(: Limagerie u s!st"me nerveu# $r%seau# e neurones ans notre &erveau

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    E'$*,!( U"$-e!.$*/#$$ '$" ORADEA ISBN: 978 606 10 1203 9

    C&e)#$( CCMI 2013

    SOMMAIRE

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    ANTIBIOTIUES : 4( $" ', !e,e. e. .&,)%e. !.$.*("*e. )&"*$",e"* 'e .e ,*$+$e! D@& (")e..$* 'e *!&,-e! 'e "&,-ee. &),e.

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    20D aprs ora)ie anco, Antibioti%ues,in : Sciencee' Vie/Horssrie, No. 261,/ dc. 2012, p.69 5.

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    21Ibidem,p. 0.

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    22Ibidem, p.0.23Ibidem, p. 1 2.

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    Ce**e &!e +e!("e"*e '$*e )&".*$*,*$&""ee= ($"*$e"* $"*5!$*'e ( )e,e ,("' G ( .e)&"'e ( COX 2 &" "e ( *!&,-e >,(.$e"* (($. '(". e. )e,e. .($"e. ($. ee (++(!(Z* (..$-ee"*e" )(. 'e )%&) '@ ,.,!e (!*$),($!e '@ $"e)*$&" Ee (&"'e .,$*ee"* '(". e. *$..,. (5!e... -&$!e 'e. *,e,!. )(")!e,.e. S&,..( !,e e. &,*&". 'e !5(5e= .e ,*$+$e"* e* (,5e"*e"* e-&,e 'e ( '&,e,! e* '@(,*!e. )(!()*!$.*$>,e. 'e @$"((*$&" 4e. COX 1 ( &""e= e* COX 2 ( (,-($.e= .&"* +!e.>,e$'e"*$>,e. : &" e. (++ee 'e. $.&e";e.= Ce+e"'("* >,e>,e.+e*$*e. '$!e")e. e"*!e e. 'e, &e),e. &"* ($* "(Z*!e @ e.+&$!

    >,e e. AINS ', ,*,! +&,!!($e"* )%&$.$! e,! )$e e* .@ (**(>,e! GCOX2 ( )%("*e e= 'e. &;e!. $"((*&$!e. .(". *&,)%e! GCOX1 ( &""e e= ', &5$. A&!. e. (&!(*&$!e. .e .&"* (").'(". ,"e )&,!.e e!"e +&,! *!&,-e! )e. &),e. .e)*$-e. D(".e. $e. = 'e ( !e)%e!)%e .e +!&$e 'G ," AINS 'e *!&$.$,e e. '&.e. ($e. .,$.e"* G e"!(;e! ( '&,e,! &, ( $,e e"

    !e-(")%e .&" e$)()$*e '(". e *!($*ee"* 'e. (('$e. )(!'$&-(.),($!e. a ,"e (.&!+*$&" >,&*$'$e""e '@ (.+$!$"e G ($e '&.e '$$",e!($* 'e 2 [ e !$.>,e 'e !)$'$-e. '@$"(!)*,. D(". e. +(>,e**e..("5,$"e. $ "@; ( 'e. COX1 D, )&,+ ,"e ($e '&.e 'e @&!'!e'e 0 5 '@ (.+$!$"e .,$* G !e',$!e 'e 9 [ ( &!(*$&" +(! e.+(>,e**e. 'e *%!&&("e 5"!(*e,! 'e )($&*. D@& @ee* %&!(5$>,e 'e @(.+$!$"e

    56

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    Ce* ee* ',!e &"5*e+. )(! @ (.+$!$"e &>,e '$"$*$-ee"*( );)&&;5"(.e e" ,$ 5!e("* .&" 5!&,+ee"* ()e*; O! )&ee. +(>,e**e. "@&"* +(. 'e "&;(, ee. "e +e,-e"* +(. !e)&".*!,$!e'e "&,-ee. COX I (,* >,e 'e "&,-ee. +(>,e**e. .e &!e"*

    +&,! >,e ', *%!&&("e e* .&" )&!*,e e.)e,e. 'e ( +(!&$ ', -($..e(, .("5,$" >,$ .&"* '&*e. 'e "&;(,!5",e 'e +!&.*();)$"e. >,$ '$(*e"* e. -($..e(, e*.@&++&.e"* G @ (5!5(*$&" 'e. +(>,e**e.

    R.,*(*: ( +!e$,e 'e 2 G 0 [ 'e

    ( +&+,(*$&" )&,!!($* ," &$"'!e !$.>,e '@ $"(!)*,. e" +!e"("*>,&*$'$e""ee"* 'e @ (.+$!$"e !,'e")e +&,!*("* >,("* G @ee*+!-e"*$ 'e @ (.+$!$"e

    Te!!($" '@ ()*$&" 'e @ (.+$!$"e32

    O" )&""(Z* 'e+,$. 1971 e *e!!($" .,! e>,e (5$* @(.+$!$"e I)&e")e +(! ( $!(*$&" '@()$'e (!()%$'&"$>,e )&".*$*,("* 'e (e!("e )e,($!e Ce $+$'e e.* ,*$$. +(! @ e";e COX +&,!(&!)e! ( .;"*%,e ( .;"*%,e 4( .,+e! (.+$!$"e .e!( +,. e$)()e)&"*!e @$"((*$&" )(! ee (,!( '(-("*(5e '@($"$*. (-e) COX2( (,-($.e = e";e

    4e. &),e. ()*$-e. 'e. ("*$$"((*&$!e. "&" .*!&K'$e". 'e.e)&"'e 5"!(*$&" &"* ee. ,"e ($"$* (-e) COX2 'e, )e"*. &$..,+!$e,!e G @ ($"$* (-e) COX1 B&>,("* COX2 ($. +(!5"("*COX1 $. .&"* +!e.)!$*. .(". !$.>,e '@,)

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    &!. 'e. +&,..e. '@ $"((*$&" ',e. G @ (!*%!&.e ,"e ,.,!e 'e.)(!*$(5e. (!*$),($!e.

    4e. AINS .*$,e"* '@ (,*("* $e, e (!)% +%(!()e,*$>,e

    >,e 'e, (,*!e. $"'$)(*$&". .e +!&$e"* G @ %&!$&" : ( +!-e"*$&"', )(")e! ', )&" e* )ee 'e ( (('$e '@ A%e$e! De. *,'e.+$'e$&&5$>,e. &"* '@ &!e. e* 'G *($ >,e ( +!$.e !5,$,e'e &!*($* +(! )(")e! ', )&" 'e @&!'!e 'e [ M($. 'e 1 G20[ 'e )e. +e!.&""e. '-e&++e"* 'e. ,)

    E" $"%$("* e. COX2 e. AINS .,++!$e!($e"* ( 5e" &$. e !$.>,e '@ ,),e: e. &),e. >,$ e" .&"* e. +!$")$+e. ()*$. &"* *&,*e. * ')&,-e!*e. (-("*>,e @&" )&""($..e @ e$.*e")e 'e COX2

    5!

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    4@ (.+$!$"e G ($e '&.e e.* (,..$ $"'$>,e +&,! ,**e! )&"*!e e

    !*!)$..ee"* +!&-&>,e +(! 'e. '+*. 5!($..e, 'e. (!*

    ( )!$.e )(!'$(>,e e" +!e"("* !5,$

    Ce+e"'("* e. +!&)%($". AINS &"* ," '(,* : $. "e .e $e"*G ( COX2 >,e 'e (W&" *!(".$*&$!e D@ & e. !e)%e!)%e. .,! ,"e .,+e! (.+$!$"e = >,$ .e!($* "&" .e,ee"* )e"* &$. +,. ()*$-e .,!( COX2 >,e .,! ( COX1 )&"*!($!ee"* G @(.+$!$"e ($. 'e+,. '.(!e!($* G (($. @ e";e G @$".*(! 'e @(.+$!$"e S,!( )e"*($"e 'e -(!$(*$&". &),($!e. )&".*!,$*e. '(". e. (&!(*&$!e. ( "&,-ee &),e AHS .e &"*!e +!&e**e,.e in vitroe* in vivo )%e e !(*

    4@ (.+$!$"e )&(* .,! *&,. e. !&"*.33

    4@(.+$!$"e &>,e ( .;"*%,$ *(+$..e"* @e.*&() @(.+$!$"e e"*!(Z"e,"e ($..e 'e +!&',)*$&" 'e ,),. ,"e (,5e"*(*$&" 'e. .)!*$&".

    33Ibidem,p. 4.

    59

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    ()$'e. e* ,"e (*!(*$&" 'e ( ,>,e,.e U" ee* .e)&"'($!e -$*(-e) ( .,+e! (.+$!$"e 3 I"((*$&" : U" *!(,(*$.e ')e")%e ( '$(*(*$&" 'e. -($..e(, ())&+(5"e 'e !&,5e,! e* )%(e,! &)(e. ($".$ >,e @ ()

    ),,(*$&" ', .!, '(". e. *$..,. .. &e',e**e. .("5,$". e" )(. 'e e..,!e a '(". )e )(. e .("5 )&(5,eM($. '(". 'e. -($..e(, .("5,$". (*!. e *%!&&("e !$.>,e'@ e"*!(Z"e! ( &!(*$&" 'e )($&*. &.*!,("* ( )$!),(*$&" *%!&&.e 4@ (.+$!$"e e+L)%e ( .;"*%

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    A44ERIES : S&!*$! ', (;!$"*%e3

    U" ( >,$ "e '(*e +(. '@%$e! Q

    4@%$.*&$!e !()&"*e >,e e +%(!(&" M",e. 'e )e 5e"!e "e (">,e"* +(. He,!e,.ee"* $. "e .&"* +(. *&,. (,..$ 5!(-e. Q

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    C&e"* e. (e!5,@ ,"e )!$.e '@(e!5$e .e ')e")%e $ (,* >,@,"e .,.*(")e *!("5

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    4e. (e!5$e. ),*("e. +e,-e"* L*!e ',e. (, .$+e )&"*()* 'e@ (e!5,$ .e )!&$* (5!e.. (&!. >,e +e!.&""e "e ,$ -e,* (,)," ( Q E" .&$ e +&e" ( +&,..$,$ e+$>,e >,e )e!*($"e. +e!.&""e. +e,-e"* e. *&,)%e!&, e. !e.+$!e! .(". >,e )e( +!&-&>,e )%e e, ( &$"'!e !()*$&" Se,ee"* -&$G : +(!&$. @ &!5("$.e e. +!e"' +&,! 'e '("5e!e, (5!e..e,!. e* ')e")%e .&" '$.+&.$*$ 'e 'e".e ($( &,! )&+!e"'!e )e >,$ .e +(..e (&!. '(". e )&!+. $ (,*+&"5e! '(". @$"$"$ +e*$* (, )&e,! 'e "&*!e .;.*

    Ce )("$.e !e+&.e .,! ," .;.*

    (&!. )e >,@&" (++ee ," (e!5

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    U" .&'(* 'e )%&) : @%$.*($"e36

    4&!.>,e @&!5("$.e !e")&"*!e @(e!5

    *($!e !(5$* ',e. C@e.* >,e @%$.*($"e +&..,$($* 5&"e! e. *$..,. +!&-&>,("* (,..$ $e" e '$.5!(*$e, &e',$-&"* (+$$e! e* +!&&"5e! .&" ()*$&"

    A$".$ ," .e, )("$.e e Le +&,! *&,* e &"'e +!&',$**&,*e ,"e .!$e 'e .;+*e. '$e!e"*. A, +!$"*e+. @ (e!5$e (+,. )&,!("*e e.* e !%,e 'e. &$". = S&,-e"* &" (..&)$e .&,.)e**e (++e(*$&" 'e, *;+e. 'e .$5"e.: ( !%$"$*e e* ( )&"&")*$-$*eO" ( e "e >,$ )&,e (&"'(e"* G )(,.e 'e ( +!e$,$ (!&$e"* e* !&,5$..e"* G )(,.e 'e ( .e)&"'e4e. *e!",e

    36Ibidem,p. 22 23.

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    e"*. $"*e+e.*$. ())&+(5"e"* e *&,* C@e.* ( ("$e.*(*$&" +!$-$5$e 'e. (e!5$e. (, +&e". >,$ .e !+("'e"* e" >,("*$* '(".@($! G )e**e .($.&" M($. )e( +e,* L*!e (,..$ ( )&".>,e")e '@,"e(e!5$e (, +&$. '@("$(, (, ()(!$e". (, &$.$..,!e.

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    'e. ,!*$)($!e. 5"!($.. -&$!e ," )%&) ("(+%;()*$>,e C@ e.* (!()*$&" (e!5$>,e ( +,. 5!(-e : ( *e".$&" (!*e!$ee )%,*e !,*(ee"* e +&,. 'e-$e"* $("* e. e*!e$*. .e !e!&$'$..e"*He,!e,.ee"* )e**e .,+e! (e!5$e e.* *!,e >,$ .e +!L*ee $e, G @ e+$)(*$&" +.;)%&&5$>,e S($"e De"*$ +.;)%&&5,e

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    I "e +e,* +,. .e +!&*5e! "&!(ee"* e* *&,*e. .e. !()*$&". +.;)%&&5$>,e. e" .&"* (e)*e.

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    +(5"e (($. )e( "e @ ( +&. e &$"'!e +!&,@ G 17(". C@ e.* G )e**e +&>,e >,@ &"* ',* e. )!$.e. '@ (.*%e "&)*,!"e. @($ )&e") +(! $$"e! e. +,e. e .,$. (&!. 'e-e",(e!5$>,e G ( +&,..$

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    40Ibidem, p. 25.

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    4e. *!(-(, &"* )($!ee"* &"*! >,e e. '&.e. $"$"$*.$(e.&',($e"* @()*$&" 'e )e .;.*,($* ,"e $,"&.*$,(*$&" e" %$-e! e* ,"e

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    43Ibidem, p. 26.44Ibidem,p. 26

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    H&&+(*%$e : >,(*!e "$-e(, '@()*$&"6

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    46Ibidem,p.2!.

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    51Ibidem,p. 30.52Ibidem,p. 31.

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