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Dra. Carmen Aída Martínez

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Page 1: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

Dra. Carmen Aída Martínez

Page 2: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

Nucleótido

• Base nitrogenada

• Monosacárido pentosa

• Grupo fosfato

Nucleósido:

• Base nitrogenada

• Monosacárido pentosa

Page 3: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

Nucleótido

• Base nitrogenada

• Monosacárido pentosa

• Grupo fosfato

Nucleósido:

• Base nitrogenada

• Monosacárido pentosa

Page 4: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

Las bases nitrogenadas se dividen en:

• Adenina

• Guanina PURINAS

• Citosina

• Timina

• Uracilo

PIRIMIDINAS

Page 5: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

Constituyentes de los ácidos nucleicos (ADN y ARN)

Moneda energética (ATP, GTP)

Page 6: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

Mediadores celulares ( AMPc y GMPc )

Constituyentes de coenzimas (NAD, FAD, CoA)

Page 7: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

Portadores de intermediarios

activados (UDP-galactosa, CDP-

diacilglicerol, S-adenosilmetionina)

Efectores alostéricos

Page 8: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

Dieta Rescate Síntesis de novo

Page 9: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:
Page 10: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

Síntesis del 5-fosforribosil 1 pirofosfato

Page 11: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:
Page 12: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:
Page 13: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:
Page 14: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:
Page 15: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:
Page 16: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:
Page 17: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

oligonucleotidos

mononucleotidos Desnaturalización

Page 18: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

nucleotidasas

nucleosidos

nucleosidasas

Page 19: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:
Page 20: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

Gota Hiperuricemia Sx. Lesch Nyhan

Page 21: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:
Page 22: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

Uracilo

Page 23: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:
Page 24: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:
Page 25: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

β-alanina:

• CMP y UMP

β-aminoisobutirato:

• TMP

CO2 y amoníaco

Page 26: Dra. Carmen Aída Martínez · C02 a c c Glycine a Glutamine Aspartate ac @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS:

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