département des biopolymères artificiels de l'ibmm (ibmm ... · rnjp 2015, la grande-motte,...

Benjamin Nottelet IBMM-DBA UMR 5247

Université Montpellier – ENSCM

Rencontres Nationales des Jeunes Polyméristes 2015

Département des Biopolymères Artificiels de

l'IBMM (IBMM-DBA):

Polymères pour la Santé.

About IBMM-DBA 2

Funded 30 years ago by

Dr. M. Vert

CHEMISTRY

Design & syntheses

BIOMEDICAL APPLICATIONS

Biological evaluations

CHARACTERI-SATION

Physico-chemistry

Rheology...

15 people + students

CHARACTE-RISATION

BIOLOGY

CHEMISTRY

RNJP 2015, La Grande-Motte, 3 juin 2015

Polymers for Health & Biomedical Applications

Multidisciplinarity

People at IBMM-DBA 3


Head

Jean Coudane PU

Assistant Professors & Researchers Technical Staff

PhDs &

Post-docs

Executive assistant

Xavier Garric PU Administration

Carine Carlin

Chemistry

Physico-chemistry

Biological Applications

Denis Durand MCU

Abdel El Ghzaoui MCU

Vincent Letouzey* PHU

Benjamin Nottelet MCU

Hélène Van Den Berghe MCU

Michel Vert DRE

Audrey Bethry IE

Mahfoud Boustta IR

Vincent Darcos IE

Stéphane Dejean T

Sylvie Hunger T

Cédric Paniagua AI

Assala Al Samad PhD

Edouard Girard* PhD

Stéphanie Huberlant* PhD

Salome Leprince PhD

Mira Younis PhD

Anita Schulz Post-doc

Sytze Buwalda Post-doc

* Medical students

4


Expertise & skills at IBMM-DBA

Modification of polyesters Customized & functional copolyesters

Biomaterials processing & evaluation

Post-polymerization modification

Surface modification

Processing

Scaffolds Degradation

Biological evaluations

Biomaterials & self-assembly

Elastomers Micelles, micro- &

nanoparticles Hydrogels

Functional monomers & copolymers

Controlled Polymerization

Macromolecular architectures

Poster 1 Poster 2

Poster 3 Poster 4

IBMM

DBA

5


Topics at IBMM-DBA

Drug delivery (micelles, nano and microparticules, coatings, hydrogels)

Biomaterials for advanced applications (medical imaging, bioactive surfaces, prodrugs)

Implantable medical devices (functional prostheses, scaffolds, tissue engineering)

Polymers for Health & Biomedical Applications

DOX

6


Topics at IBMM-DBA

Drug delivery : particles

Van-Tranh et al. Eur J Pharm Sci 2012

Morille M. et al. J Control Rel 2013

Patent WO2013144341

Better proliferation of hMSC Protection and controlled

release of TGF-b3

Copolymer

Mixture

7


Topics at IBMM-DBA

Drug delivery : gels

O

O

O

O

O

O

O

O

D-lactide

L-lactide

PDLA

PLLA

H. Nouailhas et al. J Applied Pol Sci 2011

PEG

PEG

PDLA

PLLA

Improved cristallinity

& stability

Stereocomplexes

Gel

0

10

20

30

40

50

60

70

80

0 5 10 15 20 25 30

0

10

20

30

0 1 2

Temps (jours)

BS

A lib

éré

e (

%)

2KL13/2KD12 (35%)

2KL13 (35%)

Decreased « burst effect »

Time (days)

Rele

ase

d B

SA

(%

)

Stereocomplexed

gel

Gel

8


Topics at IBMM-DBA

Implantable medical devices : thermosets

* O O

O On m

*

* O O

O O

I

n m

*

* O O

O O

S(CH2)6 SH

n m

*

i)

ii)

PCL

PCL-I

PCL-HDT

n m

*

* O O

O OS

(CH2)6 S

* O O

O O

S(CH2)6 S

n m

*

Redox

EMSS

a) b)

reduction

Reversibility

S

I

S

SH

SH

B. Nottelet et al. Polym. Chem. 2012

Tensile tests

9


Topics at IBMM-DBA

A. Leroy et al. Mater Sci Eng 2013

A. Leroy et al. Biomat Sci 2015

Degradable copolymers synthesis, evaluation & selection

Association with human mesenchymal stem cells Association with cross-linked bovine collagen

Excellent proliferation onto the scaffold

Expression of specific proteins (tenascin,

tenomodulin…)

Excellent proliferation of

ligamentocytes onto the scaffold

Development towards a ligament

patch

Implantable medical devices : thermoplastics

10


Topics at IBMM-DBA

Advanced biomaterials : active surfaces

C. Sardo et al. Biomacromolecules 2014

Mild photochemical functionalization

No metal Fast

Antibacterial

surface

Clickable PLA

surface

PLA surface

water/EtOH (1:1 , HCL 0.1N)

UV ,15 min

Collaboration Pr. G.Cavallaro (STEBICEF

Palermo, Itlay)

PHEA cationic derivative

Covalent grafting

80% biofilm decrease

11


Topics at IBMM-DBA

Optimum between grafting density and overall Gd3+ content

S. El Habnouni et al. Biomacromolecules 2013

WO2011004332

WO 2013084204

No need of high Gd3+ dose

Advanced biomaterials : medical imaging

IBMM-DBA : a summary

IBMM-DBA

Polymers for health &

biomedical applications

Polymer chemistry

Clinicians Industrial Partners

Innovation Feasibility

Benjamin Nottelet IBMM-DBA UMR 5247

Université Montpellier – ENSCM

Rencontres Nationales des Jeunes Polyméristes 2015

Département des Biopolymères Artificiels de

l'IBMM (IBMM-DBA):

Polymères pour la Santé.

Merci de votre attention

département des biopolymères artificiels de l'ibmm (ibmm ... · rnjp 2015, la grande-motte,...

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