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springer.com/librarybooks6 Springer News 12/2010Biomedicine
R. Aphasizhev, University o Caliornia, Irvine, CA,
USA (Ed.)
RNA and DNA EditingMethods and Protocols
Te recent expansion in diversity o RNA and
DNA editing types has stimulated the developmento many unique genetic, molecular, biochemical,
and computational approaches to biological
issues. In RNA and DNA Editing: Methods and
Protocols, leading experts in the eld introduce
methods developed over the last ew years to study
editing substrates, mechanisms o specicity, and
unctions o RNA and DNA editing enzymes and
complexes. Sections o the book are dedicated to
state-o-the art techniques which enable investiga-
tion o uracil insertion/deletion RNA editing in
mitochondrion o rypanosoma brucei, adenosine
to inosine RNA editing, cytidine to uracil RNA and
DNA editing, as well as tRNA editing and RNA
modications.
Features
7 Features cutting-edge methodologies ocused
on the study o this diverse eld o study
7 Includes unique genetic, molecular, biochem-
ical, and computational approaches 7 Contains
expert tips and implementation advice
From the contentsTree-Dimensional Reconstruction o rypano-
soma brucei Editosomes Using Single-Particle
Electron Microscopy.- iCODA: RNAi-Based
Inducible Knock-In System in rypanosoma
brucei.- Perturbing A-to-I RNA Editing Using
Genetics and Homologous Recombination.- Laser
Microdissection and Pressure Catapulting o SingleHuman Motor Neurons or RNA Editing Analysis.-
Biochemical Identication o A-to-I RNA Editing
sites by the Inosine Chemical Erasing (ICE)
Method.- Identiying mRNA Editing Deaminase
argets by RNA-Seq.- Mouse and Other Rodent
Models o C to U RNA Editing.- In vivo Analysis
o RNA Editing in Plastids.- Identiying Specic
rans-Factors o RNA Editing in Plant Mitochon-
dria by Multiplex Single Base Extension yping.
Fields of interestHuman Genetics; Enzymology
Target groups
Proessional/practitioner
A. Ayed, University o Toronto, ON, Canada; T. Hupp,
University o Edinburgh, Scotland, UK (Eds.)
p53
Tis volume, p53, was developed primarily as a
resource or access to key ideas in the eld that
have developed over the years including howtransgenics have been used to study p53, how
clinical genetics have identied and studied muta-
tions in p53 ound in human cancers, how p53
can be regulated by post-translational modica-
tion, and how key drug targets have been dened,
namely MDM2, which has provided undamental
approaches or dening how p53 can be acti-
vated with potential ly therapeutic eect. Te
key concepts in the chapters included provide a
perspective on key paradigms in the p53 eld.
Features
7 Discusses P53 Mutations in Human Cancers
7 Chapter on Regulation and Function o the
Original p53-Inducible p21 Gene 7 Presents keyideas in the eld
ContentsP53 Mutations in Human Cancers: Selection
versus Mutagenesis.- Lessons on p53 rom Mouse
Models.- P63, P73: Te Guardians Elder
Brothers.- Te Regulation o p53 Protein Function
by Phosphorylation.- Te p53-Mdm2 Loop: A
Critical Juncture o Stress Response.- Coopera-
tion between MDM2 and MDMX in the Regula-
tion o p53.- Regulation and Function o the
Original p53-Inducible p21 Gene.- p53 Localiza-
tion.- Modes o p53 Interactions with DNA in the
Chromatin Context.- p53s Dilemma in ranscrip-
tion: Analysis by Microarrays.- umor Viruses andp53.- p53 and Immunity.
Fields of interestCancer Research
Target groupsResearch
E. Ballestar, Bellvitge Biomedical Research Institute
(IDIBELL), Barcelona, Spain (Ed.)
Epigenetic Contributions inAutoimmune Disease
Tis volume ocuses on the relevance o epigenetic
mechanisms in autoimmune disease. It providesnew directions or uture research in autoimmune
disease.
Features7 Overview o some o the key concepts in
epigenetics, chromatin and the interaction with
transcription actors 7 Shows the specic inu-
ence o environmental actors to inuence or
trigger the autoimmune response 7 Discusses the
possibilities o using epigenetics-based therapies in
the context o autoimmune diseases 7 Presents
the application o novel methods to characterize
the epigenetic prole
ContentsAN INRODUCION O EPIGENEICS.-
CHROMAIN MECHANISMS REGULAING
GENE EXPRESSION IN HEALH AND
DISEASE.- EPIGENEIC CONROL OF
LYMPHOCYE DIFERENIAION.- EPIGEN-
EIC CONROL IN IMMUNE FUNCION.-
DNA MEHYLAION AND B-CELL AUOR
EACIVIY.- ENVIRONMENAL AGENS
AND AUOIMMUNE DISEASES.- EPIGEN-
EIC DYSREGULAION OF EPSEIN-BARR
VIRUS LAENCY AND DEVELOPMEN OF
AUOIMMUNE DISEASE.- DOES GENOMIC
IMPRINING PLAY A ROLE IN AUOIMMU-
NIY?.- A NEW EPIGENEIC CHALLENGE:
SYSEMIC LUPUS ERYHEMAOSUS.-EPIGENEIC DEREGULAION IN RHEUMA-
OID ARHRIIS.- PROSPECS FOR EPIGEN-
EIC COMPOUNDS IN HE REAMEN
OF AUOIMMUNE DISEASE.- PROFILING
EPIGENEIC ALERAIONS IN DISEASE.
Fields of interestBiomedicine general; Gene Function
Target groupsResearch
Discount groupP
Due February 2011
2011. 250 p. 57 illus., 1 in color. (Methods in Molecular
Biology, Volume 718) Hardcover
7
$119.00ISBN 978-1-61779-017-1
Discount groupP
Due March 2011
2011. XVI, 200 p. 59 illus., 3 in color. (Molecular Biology
Intelligence Unit, Volume 1) Hardcover
7
$189.00ISBN 978-1-4419-8230-8
Discount groupP
Due January 2011
2011. XVI, 178 p. 22 illus. (Advances in Experimental
Medicine and Biology, Volume 711) Hardcover
7
$189.00ISBN 978-1-4419-8215-5
http://www.springer.com/978-1-61779-017-1http://www.springer.com/978-1-61779-017-1http://www.springer.com/978-1-4419-8230-8http://www.springer.com/978-1-4419-8230-8http://www.springer.com/978-1-4419-8215-5http://www.springer.com/978-1-4419-8215-5http://www.springer.com/978-1-4419-8215-5http://www.springer.com/978-1-4419-8230-8http://www.springer.com/978-1-61779-017-1 -
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springer.com/librarybooks8 Springer News 12/2010Biomedicine
U. N. Das, UND Lie Science, Shaker Heights, OH, USA
Molecular Basis o Health andDisease
Te book describes how the balance between
pro- and anti-inammatory molecules is related
to health and disease. It is suggested that manydiseases are initiated and their progress is inu-
enced by inammatory molecules and a decrease
in the production and/or action o anti-inam-
matory molecules and this imbalance between
pro- and anti-inammatory molecules seems to
have been initiated in the perinatal period. Tis
implies that strategies to prevent and manage
various adult diseases should start in the perinatal
period. An alteration in the metaolism o essential
atty acids and their anti-inammatory molecules
such as lipoxins, resolvins, protecitns, maresins
and nitrolipids seems to play a major role in the
pathobiology o several adult diseases. Based on
these concepts, novel therapeutic approaches in
the management o insulin resistance, obesity,type 2 diabetes mellitus, metabolic syndrome,
cancer, lupus, rheumatoid arthritis and other auto-
immune diseases are presented.
Features
7 Perinatal origins o adult diseases 7 Adult
diseases as low-grade systemic inammatory
conditions 7 Inammation as the basis o
obesity, insulin resistance, metabolic syndrome
and cancerImbalance in the pro- and anti-inam-
matory molecules as the basis o adult diseases
7 Altered metabolism o essential atty acids and
eicosanoids in the pathobiology o adult diseases
Fields of interestBiomedicine general; Human Physiology;
Molecular Medicine
Target groupsProessional/practitioner
T. L. DeWeese, M. Laiho, Johns Hopkins University,
Baltimore, MD, USA (Eds.)
Molecular Determinants oRadiation Response
Molecular Determinants o Radiation Response
includes chapters by expert authors who detailthe present understanding o key DNA damage
response pathways and proteins. Te chapters
include comprehensive discussions on where and
how specic alterations in unction o these path-
ways and proteins result in substantive modica-
tions o cellular response to DNA injury. Given the
importance o therapies that induce DNA injury
in the management o human disease, this book
is timely and relevant or basic and translational
researchers, as well as clinicians alike.
Features
7 Includes chapters by expert authors who detail
the present understanding o key DNA damage
response pathways and proteins 7 Presentscomprehensive discussions on where and how
specic alterations in unction o these pathways
and proteins result in substantive modications o
cellular response to DNA injury 7 A timely and
relevant text or basic and translational researchers
From the contentsMolecular Basis o the DNA Damage Responses.-
AM signaling and DNA Damage.- H2AX in
DNA Damage Response.- Dynamic Imaging o
DNA Damage Foci.- DNA Damage Signaling
Downstream o AM.- Checkpoint Control
and Radiation.- Chromatin Responses to DNA
Damage.-DNA Damage Response and Senes-
cence.- C. elegans and DNA Damage.- Modulationo Radiation Responses Opportunities or Tera-
peutic Exploitation.- Te Stem Cell and Radia-
tion.- Role o the Cell Membrane in Signaling
Radiation Injury.- Hypoxia and Modulation o
Cellular Radiation Response.- Role o PARP and
PARP Inhibition in Cellular Response to Radia-
tion.- Anti-angiogenic Terapies and Radiation
Responses.- Gene Terapy and Radiation.- Radia-
tion-mediated Molecular argeting.
Fields of interestCancer Research; Pharmacology/oxicology
Target groups
Research
A. El-Baz, Bioengineering Department, University
o Louisville, KY, USA; R. Acharya U, Department
o Computer and Electrical Engineering, Ngee Ann
Polytechnic, Singapore; M. Mirmehdi, Department o
Computer Science, University o Bristol, England;
J. Suri, Biomedical Technologies Inc., Denver, CO, &
Af- Idaho State University, Idaho, ID, USA (Eds.)
Multi ModalityState-o-the-Art MedicalImage Segmentation andRegistration MethodologiesVolume 1
With the advances in image guided surgery or
cancer treatment, the role o image segmenta-
tion and registration has become very critical.
Te central engine o any image guided surgery
product is its ability to quantiy the organ or
segment the organ whether it is a magnetic reso-
nance imaging (MRI) and computed tomography
(C), X-ray, PE, SPEC, Ultrasound, and Molec-ular imaging modality. Sophisticated segmentation
algorithms can help the physicians delineate better
the anatomical structures present in the input
images, enhance the accuracy o medical diagnosis
and acilitate the best treatment planning system
designs. Te ocus o this book in towards the state
o the art techniques in the area o image segmen-
tation and registration.
Features7 3D Deormable models or medical imaging
segmentation 7 Covers skin, lung, brain and
retinal cancers Ultrasound and MRI image
registration 7 Advanced techniques in brain
segmentation and registration
Fields of interestBiomedicine general; Biomedical Engineering;
Image Processing and Computer Vision
Target groupsProessional/practitionerDiscount group
P
Due March 2011
2011. XX, 1460 p. Hardcover
7
approx. $239.00ISBN 978-94-007-0494-7
Discount groupP
Due March 2011
2011. Approx. 350 p. 34 illus., 25 in color. (Current Cancer
Research) Hardcover
7
approx. $159.00ISBN 978-1-4419-8043-4
Discount groupP
Due February 2011
2011. 650 p. 250 illus., 125 in color. Hardcover
7
approx. $239.00ISBN 978-1-4419-8194-3
http://www.springer.com/978-94-007-0494-7http://www.springer.com/978-94-007-0494-7http://www.springer.com/978-1-4419-8043-4http://www.springer.com/978-1-4419-8043-4http://www.springer.com/978-1-4419-8194-3http://www.springer.com/978-1-4419-8194-3http://www.springer.com/978-1-4419-8194-3http://www.springer.com/978-1-4419-8043-4http://www.springer.com/978-94-007-0494-7 -
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springer.com/librarybooks 9Springer News 12/2010 Biomedicine
A. El-Baz, Bioengineering Department, University
o Louisville, USA; R. Acharya U, Department o
Computer and Electrical Engineering, Ngee Ann
Polytechnic, Singapore; A. Laine, Department o
Biomedical Engineering, Columbia University, USA;
J. Suri, Biomedical Technologies Inc., Denver, CO, &
Af.- Idaho State University, Idaho, ID, USA (Eds.)
Multi ModalityState-o-the-Art MedicalImage Segmentation andRegistration MethodologiesVolume II
With the advances in image guided surgery or
cancer treatment, the role o image segmenta-
tion and registration has become very critical.
Te central engine o any image guided surgery
product is its ability to quantiy the organ or
segment the organ whether it is a magnetic reso-
nance imaging (MRI) and computed tomography
(C), X-ray, PE, SPEC, Ultrasound, and Molec-ular imaging modality. Sophisticated segmentation
algorithms can help the physicians delineate better
the anatomical structures present in the input
images, enhance the accuracy o medical diagnosis
and acilitate the best treatment planning system
designs. Te ocus o this book in towards the state
o the art techniques in the area o image segmen-
tation and registration.
Features7 Combining Registration and Segmentation
echniques 7 Segmentation Application to Pros-
thesis Design and Brain 7 Role o Segmentation
in Autistic and Normal Brains 7 Ocular Termo
graphic Sequence Analysis 7 3D UltrasoundImage Segmentation
Fields of interestBiomedicine general; Imaging / Radiology; Image
Processing and Computer Vision
Target groupsResearch
Z. Kahn, T. Tot, Uppsala University, Sweden (Eds.)
Breast Cancer, aHeterogeneous Disease EntityThe Very Early Stages
Te volume raises attention to the need o a
completely new approach to breast cancer basedon the knowledge collected on early breast cancer
in the past two decades. Te chapters are contrib-
uted by experts o all the elds participating in
the clinical research and care o breast cancer. Te
practical importance o such a book is underlined
by the increasing number o breast cancer cases,
and also the increasing proportion o early stage-
cases. Te ultimate goal o the book is to point to
the heterogeneous nature o the disease which is
more striking and has more importance in care at
the very early stages than at the more advanced
stages. Te book recommends the utilization o
all the inormation provided by multimodality
imaging and special pathological methods, a new
classication system and therapeutic guidelinessince early breast cancers should not be treated
based on experience obtained with palpable
tumors. No similar book has been yet released to
the market.
Features7 Proposes a new approach (paradigm shif)
Multidisciplinary basis 7 Healthcare importance
and practicability 7 Similar book is absent on the
market 7 Relatively wide readership
Fields of interestCancer Research; Human Physiology; Pharma-
cology/oxicology
Target groupsProessional/practitioner
R. P. Rij, University Nijmegen, The Netherlands (Ed.)
Antiviral RNAiConcepts, Methods, and Applications
Viruses and RNAi share an intricate relationship
at many levels. RNAi is an important antiviral
deense mechanism in plants and invertebrates,microRNAs o viral or cellular origin aect
many aspects o virus biology, and replication
o many, i not all, mammalian viruses can be
suppressed by RNAi. Antiviral RNAi: Concepts,
Methods, and Applications provides a collection
o protocols or the analysis o viral small RNAs
and natural antiviral RNAi responses as well as or
the development and optimization o RNAi-based
antiviral drugs. As RNAi is a central regulatory
mechanism in the cell, the methods in this volume
can also be applied out o the context o a virus
inection.
Features
7 Includes cutting-edge methods and proto-cols 7 Provides step-by-step detail essential or
reproducible results 7 Contains key notes and
implementation advice rom the experts
From the contentsDeense and counter-deense in the RNAi-based
antiviral immune system in insects.- RNAi and
cellular miRNAs in inections by mammalian
viruses .- Viral miRNAs.- Progress in RNAi-based
antiviral therapeutics.- Chemical modication
o small interering RNA.- Viral small RNA
cloning and sequencing.- Visitor, an inormatic
pipeline or analysis o viral siRNA sequencing
datasets.- Computational prediction o viral
miRNAs.- Detection o Viral microRNAs byNorthern Blot Analysis.- Detection o viral
microRNA with S1 Nuclease Protection assay.-
Characterization o RISC associated adenoviral
small RNAs.- Identication o Viral Suppressors
o RNAi by a Reporter Assay in Drosophila S2
Cell Culture.- Dicer assay in Drosophila S2 cell
extract.- Slicer activity in Drosophila melanogaster
S2 extract.- Gel Mobility Shif Assays or RNA-
binding viral RNAi suppressors.
Fields of interestHuman Genetics; Virology
Target groups
Proessional/practitioner
Discount groupP
Due February 2011
2011. 650 p. 250 illus., 125 in color. Hardcover
7
approx. $239.00ISBN 978-1-4419-8203-2
Discount groupP
Due March 2011
2011. X, 490 p. Hardcover
7
$209.00ISBN 978-94-007-0488-6
Discount groupP
Due April 2011
2011. 355 p. 58 illus., 19 in color. (Methods in Molecular
Biology, Volume 721) Hardcover
7
approx. $139.00ISBN 978-1-61779-036-2
http://www.springer.com/978-1-4419-8203-2http://www.springer.com/978-1-4419-8203-2http://www.springer.com/978-94-007-0488-6http://www.springer.com/978-94-007-0488-6http://www.springer.com/978-1-61779-036-2http://www.springer.com/978-1-61779-036-2http://www.springer.com/978-1-61779-036-2http://www.springer.com/978-94-007-0488-6http://www.springer.com/978-1-4419-8203-2 -
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springer.com/librarybooks10 Springer News 12/2010Biomedicine
S. D. Satyanarayanajois, University o Louisiana,
Monroe, LA, USA (Ed.)
Drug Design and DiscoveryMethods and Protocols
Research in the pharmaceutical sciences and
medicinal chemistry has taken an important newdirection in the past two decades with a ocus on
large molecules, especially peptides and proteins,
as well as DNA therapeutics. In Drug Design and
Discovery: Methods and Protocols, leading experts
provide an in-depth view o key protocols that are
commonly used in drug discovery laboratories.
Covering both classic and cutting-edge techniques,
this volume explores computational docking,
quantitative structure-activity relationship
(QSAR), peptide synthesis, labeling o peptides and
proteins with uorescent labels, DNA-microarray,
zebrash model or drug screening, and other
analytical screening and biological assays that are
routinely used during the drug discovery process.
Features
7 Explores computational, spectroscopic, analyt-
ical, purication, and molecular biology methods,
as well as cellular assays 7 Provides an in-depth
view o protocols used most commonly in drug
discovery laboratories 7 Features expert tips and
vital implementation advice
From the contentsVirtual Screening or Lead Discovery.- Computer-
Aided Drug Discovery and Development.- Using
Active Site Mapping and Receptor-Based Pharma-
cophore ools: Prelude to Docking and De Novo/
Fragment-Based Ligand Design.- Methods or
Evaluation o Structural and Biological Propertieso Anti-Invasive Natural Products.- Solid-Phase
Peptide Synthesis Using Microwave Irradia-
tion.- Fluorescent and Lanthanide Labeling or
Ligand Screens, Assays, and Imaging.- DNA-
Directed Assembly Microarray or Protein and
Small Molecule Inhibitor Screening.- Selection o
Peptide Ligands or Human Placental ranscytosis
Systems Using In vitro Phage Display.
Fields of interestPharmacology/oxicology; Laboratory Medicine
Target groupsProessional/practitioner
M. Schwanstecher, TU Braunschweig, Germany (Ed.)
Diabetes Perspectives inDrug Therapy
Te chapters o this book report cutting-edge
research on molecular events in adiposity and type
2 diabetes, thus opening the way or innovativedrug-based therapeutic strategies. It addresses
all those who wish to keep in touch with recent
developments in the eld.
Features7 Features excellent reviews o international
experts on cutting edge diabetes research
7 Provides a detailed up to date overview o
cellular and molecular mechanisms involved in
obesity driven development o type 2 diabetes
7 Focuses on potential novel drug targets, thus
opening the way or innovative strategies in
diabetes and obesity therapy
ContentsPreace. argeting type 2 diabetes. Dual acting
and pan-PPAR activators as potential anti-diabetic
therapies. GLP-agonists and Dipeptidyl-Peptidase
IV Inhibitors. Cannabinoids and endocan-
nabinoids in metabolic disorders with ocus on
diabetes. SGL Inhibitors as New Terapeutic
ools in the reatment o Diabetes. Inhibitors
o 11b-hydroxysteroid dehydrogenase type 1 in
antidiabetic therapy. Nampt and its potential role
in inammation and type 2 diabetes. Inhibition
o ganglioside biosynthesis as a novel therapeutic
approach in insulin resistance. Overcoming Insulin
Resistance with Ciliary Neurotrophic Factor. Ter-
mogenesis and related metabolic targets in
anti-diabetic therapy. Interleukin targeted therapyor metabolic syndrome and type 2 diabetes. Fruc-
tose-1, 6-Bisphosphatase Inhibitors or Reducing
Excessive Endogenous Glucose Production in ype
2 Diabetes.
Fields of interestPharmacology/oxicology; Human Physiology;
Cell Biology
Target groupsResearch
K. Sderhll, Uppsala University, Sweden (Ed.)
Invertebrate Immunity
It can be seen that the insects are the still attracting
most research and researchers. However, an
increasing interest is emerging to study new inver-
tebrate groups, especially those where the genome
is known. Even though Drosophila has been andstill is an excellent model or immune studies, it is
now clear that there are great dierences between
immune responses in Drosophila and that o
several other invertebrates, which indeed calls or
more research on other invertebrates
Features
7 Describes diversity between dierent inverte-
brate animal groups 7 Shows that the prophe-
noloxidase activating system and the induction
o the oll pathway in an insect share the same
proteolytic cascade 7 Displays a growing interest
in invertebrate immunity, which is the study o the
link between physiology and immunity
ContentsCnidarian immunity: a tale o two barriers.-
gastropod immunobiology.- bivalve immunity.-
earthworm immunity.- lech immunity: rom brain
to peripheral - responses.- innate immunity in
c. elegans.- immunocompetent molecules and
their response network in horseshoe crabs.- tick
innate immunity.- beetle immunity.- immunity in
lepidopteran insects.- y immunity: recognition o
pathogens and induction o immune responses.-
mosquito immunity.- crustacean immunity.-
echinoderm immunity.- urochordate immunity.
Fields of interest
Biomedicine general; Immunology
Target groupsResearch
Discount groupP
Due February 2011
2011. 275 p. 78 illus., 6 in color. (Methods in Molecular
Biology, Volume 716) Hardcover
7
$119.00ISBN 978-1-61779-011-9
Discount groupP
Due April 2011
2011. Approx. 400 p. (Handbook o Experimental
Pharmacology, Volume 203) Hardcover
7
approx. $469.00ISBN 978-3-642-17213-7
Discount groupP
Due January 2011
2011. XXIV, 314 p. 63 illus., 13 in color. (Advances in
Experimental Medicine and Biology, Volume 708)
Hardcover
7
$209.00ISBN 978-1-4419-8058-8
http://www.springer.com/978-1-61779-011-9http://www.springer.com/978-1-61779-011-9http://www.springer.com/978-3-642-17213-7http://www.springer.com/978-3-642-17213-7http://www.springer.com/978-1-4419-8058-8http://www.springer.com/978-1-4419-8058-8http://www.springer.com/978-1-4419-8058-8http://www.springer.com/978-3-642-17213-7http://www.springer.com/978-1-61779-011-9 -
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springer.com/librarybooks 11Springer News 12/2010 Biomedicine
R. L. Thurmond, Johnson & Johnson Pharmaceutical
Research & Development, LLC, San Diego, CA, USA
(Ed.)
Histamine in Inammation
Te year 2010 marks the centennial or the iden-
tication o histamine and the rst glimpse o its
many physiological unctions. From these initialndings a rich tapestry o research has uncovered
roles or histamine in almost every physiological
process with new ndings emerging every year.
Tese diverse roles o histamine have made or
ertile ground or the discovery o novel therapeu-
tics, and these drugs have been so successul that
the term antihistamine has entered the common
lexicon. Tis book is an attempt to give a snapshot
in time as to the current understanding o the role
o histamine in just one important therapeutic
areainammation.
Features7 Provides an overview o the pharmacology o
the our histamine receptors and describes howhistamine is synthesized and the insights derived
rom mice where this synthesis is disrupted
7 Discusses the important role o histamine
in neurotransmission and or the treatment o
various neurological disorders 7 Explains the
uture o antihistamine research and the poten-
tial or novel antihistamines targeting the newest
members o the histamine receptor amilythe H3
and H4 receptors
ContentsOne Hundred Years o Histamine Research.-
Molecular Pharmacology o the Four Histamine
Receptors.- Histamine Synthesis and Lessons
Learned rom Histidine Decarboxylase DecientMice.- Histamine in Allergic Rhinitis.- Te Role
o Histamine in Ocular Allergy.- Te Role o Hista-
mine in Asthma.- Antihistamines in the reatment
o Urticaria.- Histamine and Antihistamines in
Atopic Dermatitis.- Histamine, Immune Cells and
Autoimunity.- Histamine in Neurotransmisi on
and Brain Diseases.- Histamine in Normal and
Malignant Cell Prolieration.- Te Future Antihis-
tamines: Histamine H3 and H4 Receptor Ligands.
Fields of interestBiomedicine general; Human Physiology
Target groups
Research
J. Vrkonyi, Semmelwies University, Budapest,
Hungary (Ed.)
The MyelodysplasticSyndromes
Features
7 Updated patient stratication or the dierenttherapeutical modalities 7 Updated disease clas-
sication 7 Update o the available therapies
Contents1. PREFACE.- 2. Te history o the Myelodys-
plastic Syndromes.- 3. Susceptibility to MDS: DNA
repair and detoxication genes.- 4. Myelodys-
plastic syndromes/neoplasms: Morphological
and Immunohistochemical eatures and standard
evaluation.- 5. Diagnostic Criteria and Clas-
sication o Myelodysplastic Syndromes.- 6.
Cytogenetics o MDS.- 7. Molecular changes in
myelodysplastic syndrome.- 8. Prognostic Scoring
in MDS.- 9. Flow Cytometry in Myelodysplastic
Syndromes.- 10. MDS as an Autoimmune Process.-11. Te Myelodysplastic Overlap Syndromes.- 12.
Iron and copper Metabolismin the Myelodysplastic
Syndromes.- 13. Pathogenesis and Management
o Iron Overload in MDS.- 14. Cytokines in MDS.
Abnormalities and treatment.- 15. Terapeutic
Modalities and new molecular targets in MDS.-
16. Haematopoietic Stem Cell ransplantation in
MDS or Adults.- 17. JMML and Myelodysplastic
Syndrome in children.
Fields of interestBiomedicine general; Hematology; Medicine/
Public Health, general
Target groupsProessional/practitioner
J. Zhou, G. Xie, Chinese Academy o Sciences,
Beijing, China; X. Yan, National Institute o Standards
and Technology (NIST), Rockville, MD, USA
Encyclopedia o TraditionalChinese Medicines MolecularStructures, Pharmacological
Activities, Natural Sources andApplicationsVol. 1: Isolated Compounds A-C
Tis set o six volumes provides a systematic
and standardized description o 23,033 chemical
components isolated rom 6,926 medicinal plants,
collected rom 5,535 books/articles published in
Chinese and international journals. A chemical
structure with stereo-chemistry bonds is provided
or each chemical component, in addition to
conventional inormation, such as Chinese and
English names, physical and chemical proper-
ties. It includes a name list o medicinal plants
rom which the chemical component was isolated.Furthermore, abundant pharmacological data or
nearly 8,000 chemical components are presented,
including experimental method, experimental
animal, cell type, quantitative data, as well as
control compound data. Te seven indexes allow
or complete cross-indexing.
Features7 For the rst time, a collection o more than
20,000 chemical components o medicinal plants
or studying CM is provided 7 Has a systematic
and integrated approach 7 With seven indexes
the inormation in the book can be retrieved in
multiple ways
ContentsIntroduction.- How to Use Tis Book.- Abbrevia-
tions and Symbols.- Cancer Cell Codes in Phar-
macological Models.-Isolated Compounds AC
(Entries 1-4594).
Fields of interestPharmaceutical Sciences/echnology; Pharma-
cology/oxicology; Biochemistry, general
Target groupsResearch
Discount groupP
Due March 2011
2011. XVIII, 144 p. 24 illus. (Advances in Experimental
Medicine and Biology, Volume 709) Hardcover
7
$189.00ISBN 978-1-4419-8055-7
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Due March 2011
2011. X, 490 p. Hardcover
7
$209.00ISBN 978-94-007-0439-8
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P
Due February 2011
2011. 594 p. Hardcover
7 $349.00
ISBN 978-3-642-16734-8
Also available as a setISBN 978-3-642-17733-0
http://www.springer.com/978-1-4419-8055-7http://www.springer.com/978-1-4419-8055-7http://www.springer.com/978-94-007-0439-8http://www.springer.com/978-94-007-0439-8http://www.springer.com/978-3-642-16734-8http://www.springer.com/978-3-642-16734-8http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-16734-8http://www.springer.com/978-94-007-0439-8http://www.springer.com/978-1-4419-8055-7 -
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springer.com/librarybooks12 Springer News 12/2010Biomedicine
J. Zhou, G. Xie, Chinese Academy o Sciences,
Beijing, China; X. Yan, National Institute o Standards
an Technology (NIST), Rockville, MD, USA
Encyclopedia o TraditionalChinese Medicines MolecularStructures, Pharmacological
Activities, Natural Sources andApplicationsVol. 2: Isolated Compounds D-G
Tis set o six volumes provides a systematic
and standardized description o 23,033 chemical
components isolated rom 6,926 medicinal plants,
collected rom 5,535 books/articles published in
Chinese and international journals. A chemical
structure with stereo-chemistry bonds is provided
or each chemical component, in addition to
conventional inormation, such as Chinese and
English names, physical and chemical proper-
ties. It includes a name list o medicinal plants
rom which the chemical component was isolated.Furthermore, abundant pharmacological data or
nearly 8,000 chemical components are presented,
including experimental method, experimental
animal, cell type, quantitative data, as well as
control compound data. Te seven indexes allow
or complete cross-indexing.
Features7 For the rst time, a collection o more than
20,000 chemical components o medicinal plants
or studying CM is provided 7 Has a systematic
and integrated approach 7 With seven indexes
the inormation in the book can be retrieved in
multiple ways
ContentsIsolated Compounds DG (Entries 4595-9185).
Fields of interestPharmaceutical Sciences/echnology; Pharma-
cology/oxicology; Biochemistry, general
Target groupsResearch
J. Zhou, Chinese Academy o Sciences, Beijing, China;
G. Xie, Beijing, China; X. Yan, National Institute o
Standards an Technology (NIST), Rockville, MD, USA
Encyclopedia o TraditionalChinese Medicines MolecularStructures, Pharmacological
Activities, Natural Sources andApplicationsVol. 3: Isolated Compounds H-M
Tis set o six volumes provides a systematic
and standardized description o 23,033 chemical
components isolated rom 6,926 medicinal plants,
collected rom 5,535 books/articles published in
Chinese and international journals. A chemical
structure with stereo-chemistry bonds is provided
or each chemical component, in addition to
conventional inormation, such as Chinese and
English names, physical and chemical proper-
ties. It includes a name list o medicinal plants
rom which the chemical component was isolated.Furthermore, abundant pharmacological data or
nearly 8,000 chemical components are presented,
including experimental method, experimental
animal, cell type, quantitative data, as well as
control compound data. Te seven indexes allow
or complete cross-indexing.
Features7 For the rst time, a collection o more than
20,000 chemical components o medicinal plants
or studying CM is provided 7 Has a systematic
and integrated approach 7 With seven indexes
the inormation in the book can be retrieved in
multiple ways
ContentsIsolated Compounds HM (Entries 9186-15227).
Fields of interestPharmaceutical Sciences/echnology; Pharma-
cology/oxicology; Biochemistry, general
Target groupsResearch
J. Zhou, G. Xie, Chinese Academy o Sciences,
Beijing, China; X. Yan, National Institute o Standards
an Technology (NIST), Rockville, MD, USA
Encyclopedia o TraditionalChinese Medicines MolecularStructures, Pharmacological
Activities, Natural Sources andApplicationsVol. 4: Isolated Compounds N-S
Tis set o six volumes provides a systematic
and standardized description o 23,033 chemical
components isolated rom 6,926 medicinal plants,
collected rom 5,535 books/articles published in
Chinese and international journals. A chemical
structure with stereo-chemistry bonds is provided
or each chemical component, in addition to
conventional inormation, such as Chinese and
English names, physical and chemical proper-
ties. It includes a name list o medicinal plants
rom which the chemical component was isolated.Furthermore, abundant pharmacological data or
nearly 8,000 chemical components are presented,
including experimental method, experimental
animal, cell type, quantitative data, as well as
control compound data. Te seven indexes allow
or complete cross-indexing.
Features7 For the rst time, a collection o more than
20,000 chemical components o medicinal plants
or studying CM is provided 7 Has a systematic
and integrated approach 7 With seven indexes
the inormation in the book can be retrieved in
multiple ways
ContentsIsolated Compounds NS (Entries 15228-20574).
Fields of interestPharmaceutical Sciences/echnology; Pharma-
cology/oxicology; Biochemistry, general
Target groupsResearch
Discount groupP
Due February 2011
2011. XVI, 574 p. Hardcover
7 $349.00
ISBN 978-3-642-16737-9
Also available as a setISBN 978-3-642-17733-0
Discount groupP
Due February 2011
2011. XVI, 755 p. Hardcover
7 $349.00
ISBN 978-3-642-16746-1
Also available as a setISBN 978-3-642-17733-0
Discount groupP
Due February 2011
2011. XVI, 672 p. Hardcover
7 $349.00
ISBN 978-3-642-16778-2
Also available as a setISBN 978-3-642-17733-0
http://www.springer.com/978-3-642-16737-9http://www.springer.com/978-3-642-16737-9http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-16746-1http://www.springer.com/978-3-642-16746-1http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-16778-2http://www.springer.com/978-3-642-16778-2http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-16778-2http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-16746-1http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-16737-9 -
7/30/2019 titres books biologie molculaire
8/8
springer.com/librarybooks 13Springer News 12/2010 Biomedicine
J. Zhou, G. Xie, Chinese Academy o Sciences,
Beijing, China; X. Yan, National Institute o Standards
an Technology (NIST), Rockville, MD, USA
Encyclopedia o TraditionalChinese Medicines MolecularStructures, Pharmacological
Activities, Natural Sources andApplicationsVol. 5: Isolated Compounds T-Z, References,
TCM Plants and Congeners
Tis set o six volumes provides a systematic
and standardized description o 23,033 chemical
components isolated rom 6,926 medicinal plants,
collected rom 5,535 books/articles published in
Chinese and international journals. A chemical
structure with stereo-chemistry bonds is provided
or each chemical component, in addition to
conventional inormation, such as Chinese and
English names, physical and chemical proper-
ties. It includes a name list o medicinal plantsrom which the chemical component was isolated.
Furthermore, abundant pharmacological data or
nearly 8,000 chemical components are presented,
including experimental method, experimental
animal, cell type, quantitative data, as well as
control compound data. Te seven indexes allow
or complete cross-indexing.
Features
7 For the rst time, a collection o more than
20,000 chemical components o medicinal plants
or studying CM is provided 7 Has a systematic
and integrated approach 7 With seven indexes
the inormation in the book can be retrieved in
multiple ways
ContentsIsolated Compounds Z (Entries 20575-23033).-
Reerences or Isolated Compounds.- CM
Original Plants and Congeners (Entries 0001-
6926).- Key Reerences.
Fields of interestPharmaceutical Sciences/echnology; Pharma-
cology/oxicology; Biochemistry, general
Target groupsResearch
J. Zhou, G. Xie, Chinese Academy o Sciences,
Beijing, China; X. Yan, National Institute o Standards
an Technology (NIST), Rockville, MD, USA
Encyclopedia o TraditionalChinese Medicines MolecularStructures, Pharmacological
Activities, Natural Sources andApplicationsVol. 6: Indexes
Tis set o six volumes provides a systematic
and standardized description o 23,033 chemical
components isolated rom 6,926 medicinal plants,
collected rom 5,535 books/articles published in
Chinese and international journals. A chemical
structure with stereo-chemistry bonds is provided
or each chemical component, in addition to
conventional inormation, such as Chinese and
English names, physical and chemical proper-
ties. It includes a name list o medicinal plants
rom which the chemical component was isolated.Furthermore, abundant pharmacological data or
nearly 8,000 chemical components are presented,
including experimental method, experimental
animal, cell type, quantitative data, as well as
control compound data. Te seven indexes allow
or complete cross-indexing.
Features7 For the rst time, a collection o more than
20,000 chemical components o medicinal plants
or studying CM is provided 7 Has a systematic
and integrated approach 7 With seven indexes
the inormation in the book can be retrieved in
multiple ways
ContentsIndexes.- Compound Pharmacological Activity
Index.- Compound Molecular Formula Index.-
Compound Side Name Index.- CM Plant English
Name Index.- CM Plant PINYIN and Chinese
Name Index.- CM Plant Eects Index.- CM
Plant Indications Index.
Fields of interestPharmaceutical Sciences/echnology; Pharma-
cology/oxicology; Biochemistry, general
Target groupsResearch
Discount groupP
Due February 2011
2011. XVI, 587 p. Hardcover
7 $349.00
ISBN 978-3-642-16740-9
Also available as a setISBN 978-3-642-17733-0
Discount groupP
Due February 2011
2011. XVI, 752 p. Hardcover
7 $349.00
ISBN 978-3-642-16743-0
Also available as a setISBN 978-3-642-17733-0
http://www.springer.com/978-3-642-16740-9http://www.springer.com/978-3-642-16740-9http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-16743-0http://www.springer.com/978-3-642-16743-0http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-16743-0http://www.springer.com/978-3-642-17733-0http://www.springer.com/978-3-642-16740-9